Skeletal muscle is a massive insulin-sensitive tissue in the body.Loss of muscle mass is associated with mitochondrial dysfunction,and is often a result of diabetes.Insulin deficiency or insulin resistance can only be...Skeletal muscle is a massive insulin-sensitive tissue in the body.Loss of muscle mass is associated with mitochondrial dysfunction,and is often a result of diabetes.Insulin deficiency or insulin resistance can only be seen as reduced skeletal muscle mass.Diabetes is caused by insulin deficiency or insulin resistance;however,insulin resistance is not unique to diabetics.Insulin resistance also exists in many diseases.展开更多
Diabetes mellitus(DM)is a progressive metabolic disease characterized by chronic hyperglycemia and caused by different degree of pancreatic islet dysfunction and/or insulin resistance(IR).Long course DM can lead to a ...Diabetes mellitus(DM)is a progressive metabolic disease characterized by chronic hyperglycemia and caused by different degree of pancreatic islet dysfunction and/or insulin resistance(IR).Long course DM can lead to a variety of macrovascular and microvascular complications which involve artery vessels,heart,kidney,retina,nervous system,etc.In recent years,DM has attracted more and more attention due to its high morbidity and mortality.In addition to achieve effective glycemic control,prevention of complications has also been considered a priority for type 2 diabetes mellitus(T2DM)management.Herein,we provide a comprehensive overview on the pharmacotherapeutics for T2DM and perspectives on the future directions of basic and translational research on anti-diabetic therapy and pharmatheutical development of new drugs.展开更多
文摘Skeletal muscle is a massive insulin-sensitive tissue in the body.Loss of muscle mass is associated with mitochondrial dysfunction,and is often a result of diabetes.Insulin deficiency or insulin resistance can only be seen as reduced skeletal muscle mass.Diabetes is caused by insulin deficiency or insulin resistance;however,insulin resistance is not unique to diabetics.Insulin resistance also exists in many diseases.
基金supported by the National Natural Science Foundation of China(NSFC)(No.81770809).
文摘Diabetes mellitus(DM)is a progressive metabolic disease characterized by chronic hyperglycemia and caused by different degree of pancreatic islet dysfunction and/or insulin resistance(IR).Long course DM can lead to a variety of macrovascular and microvascular complications which involve artery vessels,heart,kidney,retina,nervous system,etc.In recent years,DM has attracted more and more attention due to its high morbidity and mortality.In addition to achieve effective glycemic control,prevention of complications has also been considered a priority for type 2 diabetes mellitus(T2DM)management.Herein,we provide a comprehensive overview on the pharmacotherapeutics for T2DM and perspectives on the future directions of basic and translational research on anti-diabetic therapy and pharmatheutical development of new drugs.
