BACKGROUND Insulin pump therapy is a real breakthrough in managing diabetes Mellitus,particularly in children. It can deliver a tiny amount of insulin and decreases the need for frequent needle injections. It also hel...BACKGROUND Insulin pump therapy is a real breakthrough in managing diabetes Mellitus,particularly in children. It can deliver a tiny amount of insulin and decreases the need for frequent needle injections. It also helps to maintain adequate and optimal glycemic control to reduce the risk of metabolic derangements in different tissues.Children are suitable candidates for pump therapy as they need a more freestyle and proper metabolic control to ensure adequate growth and development.Therefore, children and their caregivers should have proper education and training and understand the proper use of insulin pumps to achieve successful pump therapy. The pump therapy continuously improves to enhance its performance and increase its simulation of the human pancreas. Nonetheless, there is yet a long way to reach the desired goal.AIM To review discusses the history of pump development, its indications, types, proper use, special conditions that may enface the children and their families while using the pump, its general care,and its advantages and disadvantages.METHODS We conducted comprehensive literature searches of electronic databases until June 30, 2022,related to pump therapy in children and published in the English language.RESULTS We included 118 articles concerned with insulin pumps, 61 were reviews, systemic reviews, and meta-analyses, 47 were primary research studies with strong design, and ten were guidelines.CONCLUSION The insulin pump provides fewer needles and can provide very tiny insulin doses, a convenient and more flexible way to modify the needed insulin physiologically, like the human pancreas, and can offer adequate and optimal glycemic control to reduce the risk of metabolic derangements in different tissues.展开更多
目的分析初诊2型糖尿病(Diabetes Mellitus Type 2,T2DM)患者采用达格列净联合胰岛素泵治疗取得的效果。方法选取2022年7月—2023年6月山东国欣颐养集团枣庄医院治疗的96例T2DM初诊患者为研究对象,以随机数表法分为两组,每组48例。对照...目的分析初诊2型糖尿病(Diabetes Mellitus Type 2,T2DM)患者采用达格列净联合胰岛素泵治疗取得的效果。方法选取2022年7月—2023年6月山东国欣颐养集团枣庄医院治疗的96例T2DM初诊患者为研究对象,以随机数表法分为两组,每组48例。对照组接受胰岛素泵治疗,观察组在其基础上联用达格列净治疗。比较两组首次血糖达标时每日胰岛素用量、每日胰岛素用量(停泵前)、血糖达标时间、胰岛素抵抗指数、胰岛β细胞功能指数,以及不良反应发生情况。结果观察组血糖首次达标时每日胰岛素用量(43.60±8.44)U、停泵前每日胰岛素用量(25.50±7.50)U均低于对照组的(52.65±7.58)U、(32.40±7.85)U,血糖达标时间(4.79±1.78)d短于对照组的(6.50±2.05)d,差异有统计学意义(t=5.527、4.403、4.364,P均<0.05)。治疗后,观察组胰岛素抵抗指数低于对照组,胰岛β细胞功能指数高于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论初诊T2DM患者在胰岛泵的基础上联用达格列净不仅能够促进血糖快速达标,减少胰岛素用量,且改善胰岛功能。展开更多
目的探讨达格列净联合胰岛素泵强化治疗对老年2型糖尿病(T_(2)DM)患者胰岛功能的影响。方法选取2019年8月至2022年8月接受治疗的80例老年T_(2)DM患者作为研究对象,按照抽签法将其分为对照组和研究组,每组40例。对照组给予二甲双胍联合...目的探讨达格列净联合胰岛素泵强化治疗对老年2型糖尿病(T_(2)DM)患者胰岛功能的影响。方法选取2019年8月至2022年8月接受治疗的80例老年T_(2)DM患者作为研究对象,按照抽签法将其分为对照组和研究组,每组40例。对照组给予二甲双胍联合胰岛素泵强化治疗,研究组给予达格列净联合胰岛素泵强化治疗。比较两组的治疗效果。结果治疗后,研究组的空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平及糖化血红蛋白(HbA1c)低于对照组(P<0.05)。治疗后,研究组的体重、体质指数(BMI)低于对照组(P<0.05)。治疗后,研究组的空腹胰岛素(FINS)水平与稳态模型胰岛β细胞分泌指数(HOMA-β)高于对照组,稳态模型胰岛素抵抗指数(HOMA-IR)低于对照组(P<0.05)。治疗后,研究组的谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平高于对照组,丙二醛(MDA)水平低于对照组(P<0.05)。结论达格列净联合胰岛素泵强化治疗老年T_(2)DM患者的效果显著,可有效降低血糖指标、体重以及BMI,并改善胰岛功能。展开更多
文摘BACKGROUND Insulin pump therapy is a real breakthrough in managing diabetes Mellitus,particularly in children. It can deliver a tiny amount of insulin and decreases the need for frequent needle injections. It also helps to maintain adequate and optimal glycemic control to reduce the risk of metabolic derangements in different tissues.Children are suitable candidates for pump therapy as they need a more freestyle and proper metabolic control to ensure adequate growth and development.Therefore, children and their caregivers should have proper education and training and understand the proper use of insulin pumps to achieve successful pump therapy. The pump therapy continuously improves to enhance its performance and increase its simulation of the human pancreas. Nonetheless, there is yet a long way to reach the desired goal.AIM To review discusses the history of pump development, its indications, types, proper use, special conditions that may enface the children and their families while using the pump, its general care,and its advantages and disadvantages.METHODS We conducted comprehensive literature searches of electronic databases until June 30, 2022,related to pump therapy in children and published in the English language.RESULTS We included 118 articles concerned with insulin pumps, 61 were reviews, systemic reviews, and meta-analyses, 47 were primary research studies with strong design, and ten were guidelines.CONCLUSION The insulin pump provides fewer needles and can provide very tiny insulin doses, a convenient and more flexible way to modify the needed insulin physiologically, like the human pancreas, and can offer adequate and optimal glycemic control to reduce the risk of metabolic derangements in different tissues.
文摘目的分析初诊2型糖尿病(Diabetes Mellitus Type 2,T2DM)患者采用达格列净联合胰岛素泵治疗取得的效果。方法选取2022年7月—2023年6月山东国欣颐养集团枣庄医院治疗的96例T2DM初诊患者为研究对象,以随机数表法分为两组,每组48例。对照组接受胰岛素泵治疗,观察组在其基础上联用达格列净治疗。比较两组首次血糖达标时每日胰岛素用量、每日胰岛素用量(停泵前)、血糖达标时间、胰岛素抵抗指数、胰岛β细胞功能指数,以及不良反应发生情况。结果观察组血糖首次达标时每日胰岛素用量(43.60±8.44)U、停泵前每日胰岛素用量(25.50±7.50)U均低于对照组的(52.65±7.58)U、(32.40±7.85)U,血糖达标时间(4.79±1.78)d短于对照组的(6.50±2.05)d,差异有统计学意义(t=5.527、4.403、4.364,P均<0.05)。治疗后,观察组胰岛素抵抗指数低于对照组,胰岛β细胞功能指数高于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论初诊T2DM患者在胰岛泵的基础上联用达格列净不仅能够促进血糖快速达标,减少胰岛素用量,且改善胰岛功能。
文摘目的探讨达格列净联合胰岛素泵强化治疗对老年2型糖尿病(T_(2)DM)患者胰岛功能的影响。方法选取2019年8月至2022年8月接受治疗的80例老年T_(2)DM患者作为研究对象,按照抽签法将其分为对照组和研究组,每组40例。对照组给予二甲双胍联合胰岛素泵强化治疗,研究组给予达格列净联合胰岛素泵强化治疗。比较两组的治疗效果。结果治疗后,研究组的空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平及糖化血红蛋白(HbA1c)低于对照组(P<0.05)。治疗后,研究组的体重、体质指数(BMI)低于对照组(P<0.05)。治疗后,研究组的空腹胰岛素(FINS)水平与稳态模型胰岛β细胞分泌指数(HOMA-β)高于对照组,稳态模型胰岛素抵抗指数(HOMA-IR)低于对照组(P<0.05)。治疗后,研究组的谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平高于对照组,丙二醛(MDA)水平低于对照组(P<0.05)。结论达格列净联合胰岛素泵强化治疗老年T_(2)DM患者的效果显著,可有效降低血糖指标、体重以及BMI,并改善胰岛功能。
