提出了在A d Hoc网络中一种基于移动Agen t的密钥管理及认证方法.移动Agen t在网络中根据一定的运行策略进行移动,并不断地和所经历的节点进行数据交换,在此基础上形成一个节点信息矩阵表,矩阵表中包含了密钥信息.各节点使用其身份作为...提出了在A d Hoc网络中一种基于移动Agen t的密钥管理及认证方法.移动Agen t在网络中根据一定的运行策略进行移动,并不断地和所经历的节点进行数据交换,在此基础上形成一个节点信息矩阵表,矩阵表中包含了密钥信息.各节点使用其身份作为公钥,主密钥由各节点的私钥分享,从而形成基于身份的门限分布式密钥管理.该方法使用很少的Agen t获得较多的全局信息并快速交换密钥信息,减少了系统的开销,具有很高的效率和鲁棒性.展开更多
The canalicular membrane represents the excretory pole of hepatocytes.Bile is an important route of elimination of potentially toxic endo-and xenobiotics(including drugs and toxins),mediated by the major canalicular t...The canalicular membrane represents the excretory pole of hepatocytes.Bile is an important route of elimination of potentially toxic endo-and xenobiotics(including drugs and toxins),mediated by the major canalicular transporters:multidrug resistance protein 1(MDR1, ABCB1),also known as P-glycoprotein,multidrug resistance-associated protein 2(MRP2,ABCC2),and the breast cancer resistance protein(BCRP,ABCG2).Their activities depend on regulation of expression and proper localization at the canalicular membrane,as regulated by transcriptional and post-transcriptional events,respectively.At transcriptional level,specific nuclear receptors(NR)s modulated by ligands,co-activators and co-repressors,mediate the physiological requirements of these transporters.This complex system is also responsible for alterations occurring in specific liver pathologies.We briefly describe the major ClassⅡNRs, pregnane X receptor(PXR)and constitutive androstane receptor(CAR),and their role in regulating expression of multidrug resistance proteins.Several therapeutic agents regulate the expression of relevant drug transporters through activation/inactivation of these NRs.We provide some representative examples of the action of therapeutic agents modulating liver drug transporters, which in addition,involve CAR or PXR as mediators.展开更多
By using Pedersen's verifiable secret sharing scheme and the theory of crossvalidation, we propose an a-nonymous payment protocol which have following features: protecting theconfidentiality of sensitive payment i...By using Pedersen's verifiable secret sharing scheme and the theory of crossvalidation, we propose an a-nonymous payment protocol which have following features: protecting theconfidentiality of sensitive payment information from spying by malicioushosts; using a trustedthird party in a minimal way; verifying the validity of the share by the merchant; allowing agent toverify that the product which it is a-bout to receive is the one it is paying for; keeping thecustomer anonymous.展开更多
基金Grants from Agencia Nacional de Promoción Científicay Tecnológica (PICT N° 05-26306)Consejo Nacional de Investigaciones Científicasy Técnicas (PIP N° 6442)Universidad Nacional de Rosario,Argentina
文摘The canalicular membrane represents the excretory pole of hepatocytes.Bile is an important route of elimination of potentially toxic endo-and xenobiotics(including drugs and toxins),mediated by the major canalicular transporters:multidrug resistance protein 1(MDR1, ABCB1),also known as P-glycoprotein,multidrug resistance-associated protein 2(MRP2,ABCC2),and the breast cancer resistance protein(BCRP,ABCG2).Their activities depend on regulation of expression and proper localization at the canalicular membrane,as regulated by transcriptional and post-transcriptional events,respectively.At transcriptional level,specific nuclear receptors(NR)s modulated by ligands,co-activators and co-repressors,mediate the physiological requirements of these transporters.This complex system is also responsible for alterations occurring in specific liver pathologies.We briefly describe the major ClassⅡNRs, pregnane X receptor(PXR)and constitutive androstane receptor(CAR),and their role in regulating expression of multidrug resistance proteins.Several therapeutic agents regulate the expression of relevant drug transporters through activation/inactivation of these NRs.We provide some representative examples of the action of therapeutic agents modulating liver drug transporters, which in addition,involve CAR or PXR as mediators.
文摘By using Pedersen's verifiable secret sharing scheme and the theory of crossvalidation, we propose an a-nonymous payment protocol which have following features: protecting theconfidentiality of sensitive payment information from spying by malicioushosts; using a trustedthird party in a minimal way; verifying the validity of the share by the merchant; allowing agent toverify that the product which it is a-bout to receive is the one it is paying for; keeping thecustomer anonymous.
