The overall teaching design for the junior middle school English unit aims to maximize the use of teaching resources by using the unit as the central theme,integrating it throughout all sections and related activities...The overall teaching design for the junior middle school English unit aims to maximize the use of teaching resources by using the unit as the central theme,integrating it throughout all sections and related activities.This approach continually reinforces students’understanding and retention of individual lesson content while fostering their core literacy and skills.It promotes a comprehensive development of students’listening,speaking,reading,and writing skills,allowing them to engage repeatedly with the language materials until they internalize them as part of their language proficiency.展开更多
To improve locomotion and operation integration, this paper presents an integrated leg-arm quadruped robot(ILQR) that has a reconfigurable joint. First, the reconfigurable joint is designed and assembled at the end of...To improve locomotion and operation integration, this paper presents an integrated leg-arm quadruped robot(ILQR) that has a reconfigurable joint. First, the reconfigurable joint is designed and assembled at the end of the legarm chain. When the robot performs a task, reconfigurable configuration and mode switching can be achieved using this joint. In contrast from traditional quadruped robots, this robot can stack in a designated area to optimize the occupied volume in a nonworking state. Kinematics modeling and dynamics modeling are established to evaluate the mechanical properties for multiple modes. All working modes of the robot are classified, which can be defined as deployable mode, locomotion mode and operation mode. Based on the stability margin and mechanical modeling, switching analysis and evaluation between each mode is carried out. Finally, the prototype experimental results verify the function realization and switching stability of multimode and provide a design method to integrate and perform multimode for quadruped robots with deployable characteristics.展开更多
Despite the pressing demand for integrated spectrometers,a solution that deliver high-performance while being practically operated is still missing.Furthermore,current integrated spectrometers lack reconfigurability i...Despite the pressing demand for integrated spectrometers,a solution that deliver high-performance while being practically operated is still missing.Furthermore,current integrated spectrometers lack reconfigurability in their performance,which is highly desirable for dynamic working scenarios.This study presents a viable solution by demonstrating a userfriendly,reconfigurable spectrometer on silicon.At the core of this innovative spectrometer is a programmable photonic circuit capable of exhibiting diverse spectral responses,which can be significantly adjusted using on-chip phase shifters.The distinguishing feature of our spectrometer lies in its inverse design approach,facilitating effortless control and efficient manipulation of the programmable circuit.By eliminating the need for intricate configuration,our design reduces power consumption and mitigates control complexity.Additionally,our reconfigurable spectrometer offers two distinct operating conditions.In the Ultra-High-Performance mode,it is activated by multiple phase-shifters and achieves exceptional spectral resolution in the picometer scale while maintaining broad bandwidth.On the other hand,the Ease-of-Use mode further simplifies the control logic and reduces power consumption by actuating a single-phase shifter.Although this mode provides a slightly degraded spectral resolution of approximately 0.3 nm,it prioritizes ease of use and is wellsuited for applications where ultra-fine spectral reconstruction is not a primary requirement.展开更多
Bone screws are devices used to fix implants or bones to bones.However,conventional screws are mechanically fixed with thread and often face long-term failure due to poor osseointegration.To improve osseointegration,s...Bone screws are devices used to fix implants or bones to bones.However,conventional screws are mechanically fixed with thread and often face long-term failure due to poor osseointegration.To improve osseointegration,screws are evolving from solid and smooth to porous and rough.Additive manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and rough.This paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw breakage.Next,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing osseointegration.At the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore shape.In addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi structure.At the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated screws.Simultaneously,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated screws.AM osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength.展开更多
An integrated quantum probe for magnetic field imaging is proposed,where the nitrogen–vacancy(NV)center fixed at the fiber tip is located on the periphery of flexible ring resonator.Using flexible polyimide(PI)as the...An integrated quantum probe for magnetic field imaging is proposed,where the nitrogen–vacancy(NV)center fixed at the fiber tip is located on the periphery of flexible ring resonator.Using flexible polyimide(PI)as the substrate medium,we design a circular microstrip antenna,which can achieve a bandwidth of 140 MHz at Zeeman splitting frequency of 2.87 GHz,specifically suitable for NV center experiments.Subsequently,this antenna is seamlessly fixed at a three-dimensional-printed cylindrical support,allowing the optical fiber tip to extend out of a dedicated aperture.To mitigate errors originating from processing,precise tuning within a narrow range can be achieved by adjusting the conformal amplitude.Finally,we image the microwave magnetic field around the integrated probe with high resolution,and determine the suitable area for placing the fiber tip(SAP).展开更多
To enhance our talent cultivation model through“school-enterprise cooperation and industry-teaching fusion”,we aim to improve the“4321”Industry-Education Integration System.This includes actively promoting the use...To enhance our talent cultivation model through“school-enterprise cooperation and industry-teaching fusion”,we aim to improve the“4321”Industry-Education Integration System.This includes actively promoting the use of case banks and project banks in teaching to develop students’practical engineering skills through hands-on application of professional knowledge.Additionally,landscape design courses emphasize practical learning experiences to implement the fundamental goal of“cultivating morality”.Guided by enhancing students’practical skills,we ensure alignment with course objectives and professional training requirements,emphasizing the seamless integration of theory and practice.展开更多
Integrated sensing and communication(ISAC) is considered an effective technique to solve spectrum congestion in the future. In this paper, we consider a hybrid reconfigurable intelligent surface(RIS)-assisted downlink...Integrated sensing and communication(ISAC) is considered an effective technique to solve spectrum congestion in the future. In this paper, we consider a hybrid reconfigurable intelligent surface(RIS)-assisted downlink ISAC system that simultaneously serves multiple single-antenna communication users and senses multiple targets. Hybrid RIS differs from fully passive RIS in that it is composed of both active and passive elements, with the active elements having the effect of amplifying the signal in addition to phase-shifting. We maximize the achievable sum rate of communication users by collaboratively improving the beamforming matrix at the dual function base station(DFBS) and the phase-shifting matrix of the hybrid RIS, subject to the transmit power constraint at the DFBS, the signal-to-interference-plus-noise-ratio(SINR) constraint of the radar echo signal and the RIS constraint are satisfied at the same time. The builtin RIS-assisted ISAC design problem model is significantly non-convex due to the fractional objective function of this optimization problem and the coupling of the optimization variables in the objective function and constraints. As a result, we provide an effective alternating optimization approach based on fractional programming(FP) with block coordinate descent(BCD)to solve the optimization variables. Results from simulations show that the hybrid RIS-assisted ISAC system outperforms the other benchmark solutions.展开更多
Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have ...Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have revealed that astrocytes exhibit two distinct states of intracellular calcium activity:(1)graded subcellular localized clusters with independently active microdomains,likely influenced by nearby synaptic events,and(2)whole-cell astrocyte calcium surges,believed to result from the coordinated activation of multiple synapses.Notably,astrocyte calcium responses are not solely graded;instead,a spatial threshold of intracellular calcium activity can be overcome to elicit an astrocyte calcium surge.Together these calcium responses,in turn,initiate downstream signaling pathways capable of modifying synaptic communication and overall network activity.In summary,astrocytes can function as integrators of local synaptic events,actively contributing to information processing within the brain.展开更多
BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohor...BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.展开更多
According to the operational characteristics of the logistics networks for the third party logistics supplier (3PLS), the forward and reverse logistics networks together for 3PLS under the uncertain environment are ...According to the operational characteristics of the logistics networks for the third party logistics supplier (3PLS), the forward and reverse logistics networks together for 3PLS under the uncertain environment are designed. First, a fuzzy model is proposed by taking multiple customers, multiple commodities, capacitated facility location and integrated logistics facility layout into account. In the model, the fuzzy customer demands and transportation rates are illustrated by triangular fuzzy numbers. Secondly, the fuzzy model is converted into a crisp model by applying fuzzy chance constrained theory and possibility theory, and one hybrid genetic algorithm is designed for the crisp model. Finally, two different examples are designed to illustrate that the model and solution discussed are valid.展开更多
A wideband monolithic optoelectronic integrated receiver with a high-speed photo-detector,completely compatible with standard CMOS processes,is designed and implemented in 0.6μm standard CMOS technology.The experimen...A wideband monolithic optoelectronic integrated receiver with a high-speed photo-detector,completely compatible with standard CMOS processes,is designed and implemented in 0.6μm standard CMOS technology.The experimental results demonstrate that its performance approaches applicable requirements,where the photo-detector achieves a -3dB frequency of 1.11GHz,and the receiver achieves a 3dB bandwidth of 733MHz and a sensitivity of -9dBm for λ=850nm at BER=10-12.展开更多
Natural environment and historical humanities are the two elements constituting regional features.The construction of urban park should search design language from regional features.The author,taking Dongshan Park in ...Natural environment and historical humanities are the two elements constituting regional features.The construction of urban park should search design language from regional features.The author,taking Dongshan Park in Qianxi County,Hebei Province as an example,discussed how to search local natural environment features,reasonably exploit cultural resources and integrate regional features from the establishment of planning theme to the expression of designing details.展开更多
This paper deals with the research of the GPS/INS integrated navigation system applying Extended Kalman Filter, which involves integrated principles, scheme and technology of combining with real INS and GPS receiver d...This paper deals with the research of the GPS/INS integrated navigation system applying Extended Kalman Filter, which involves integrated principles, scheme and technology of combining with real INS and GPS receiver data. Emphases are placed on the modeling of system errors and implementation of the integrated system. Both loose and tightly coupled GPS/INS integrated in schemes are analyzed. On the basis of our experience accumulated in the research of GPS/INS for many years, the GPS/INS integrated navigation developing system is developed. It can be put into efficient and economic use in the study and design of integrated navigation system. It plays an important role in the aeronautical and astronautical fields in China. This system is not only a computer aided design software but also a semi physical simulation system by obtaining real INS and GPS receiver data. So the key software unit of the developing system could be conveniently transferred into practical engineering software in actual hardware integrated system. The application of this system shows that the design ideas and integrated scheme of this development system are successful, and can achieve good navigation result.展开更多
The concurrent subspace design (CSD) framework has been used to conduct a preliminary design optimization of an electric powered, unmanned air vehicle (EPUAV) operating at a low Reynolds number. A multidisciplinary sy...The concurrent subspace design (CSD) framework has been used to conduct a preliminary design optimization of an electric powered, unmanned air vehicle (EPUAV) operating at a low Reynolds number. A multidisciplinary system analysis that includes aerodynamics, weights, propulsion, performance and stability and control has been developed for this class of vehicles. The CSD framework employs artificial neural network based response surfaces to provide approximations to the design space. The EPUAV system includes 25 continuous and 4 discrete design variables. The CSD framework was able to identify feasible designs with significant weight reductions relative to any previously considered (i.e. initial database) designs. This was accomplished with a limited number of system analyses. The results also demonstrate the nature of this design framework adaptive to changes in design requirements.展开更多
Taking a microwave product as an example, a system of integrated assembly structure design is presented. Getting design constraints from the upstream design section through product data management(PDM), the system gen...Taking a microwave product as an example, a system of integrated assembly structure design is presented. Getting design constraints from the upstream design section through product data management(PDM), the system generates the assembly scheme using the case? based method, then assigns the design requirements into each component of the assembly. The detail design for each component can be performed under these design constraints. In order to practise concurrent design, the system sends the final design result to the upstream section and downstream section through PDM to achieve information sharing and integration.展开更多
A behavioral model of the photodiode is presented.The model describes the relationship between photocurrent and incident optical power,and it also illustrates the impact of the reverse bias to the variation of the jun...A behavioral model of the photodiode is presented.The model describes the relationship between photocurrent and incident optical power,and it also illustrates the impact of the reverse bias to the variation of the junction capacitance.According to this model,the photodiode and a CMOS receiver circuit are simulated and designed simultaneously under a universal circuit simulation environment.展开更多
Orthogonal frequency division multiplexing (OFDM) waveform enables radar and communication functions simultaneously, which encounters low angle resolution and poor data rate for traditional single input single output ...Orthogonal frequency division multiplexing (OFDM) waveform enables radar and communication functions simultaneously, which encounters low angle resolution and poor data rate for traditional single input single output (SISO) systems. To solve these problems, an integrated radar and communication system (IRCS) with multiple input multiple output (MIMO) OFDM waveform is proposed. The different limitations of radar and communication in designing such a system are investigated. Then, an optimization problem is devised to obtain suitable system parameters, including the number of subcarriers, subcarrier spacing, number of symbols, pulse repetition frequency (PRF) and length of cyclic prefix (CP). Finally, to satisfy the requirements of both radar and communication, the IRCS parameters are derived in three typical cases. Several numerical results are presented to illustrate the demands of radar and communication, inconsistent or consistent, for the IRCS parameters and the superiority of the proposed system.展开更多
This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oi...This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing. Problems can be found and settled during designing, w hich will increase designing efficiency and one-time success rate and realize o ptimum designing for products.展开更多
文摘The overall teaching design for the junior middle school English unit aims to maximize the use of teaching resources by using the unit as the central theme,integrating it throughout all sections and related activities.This approach continually reinforces students’understanding and retention of individual lesson content while fostering their core literacy and skills.It promotes a comprehensive development of students’listening,speaking,reading,and writing skills,allowing them to engage repeatedly with the language materials until they internalize them as part of their language proficiency.
基金Supported by National Natural Science Foundation of China (Grant Nos. 52375003, 52205006)National Key R&D Program of China (Grant No. 2019YFB1309600)。
文摘To improve locomotion and operation integration, this paper presents an integrated leg-arm quadruped robot(ILQR) that has a reconfigurable joint. First, the reconfigurable joint is designed and assembled at the end of the legarm chain. When the robot performs a task, reconfigurable configuration and mode switching can be achieved using this joint. In contrast from traditional quadruped robots, this robot can stack in a designated area to optimize the occupied volume in a nonworking state. Kinematics modeling and dynamics modeling are established to evaluate the mechanical properties for multiple modes. All working modes of the robot are classified, which can be defined as deployable mode, locomotion mode and operation mode. Based on the stability margin and mechanical modeling, switching analysis and evaluation between each mode is carried out. Finally, the prototype experimental results verify the function realization and switching stability of multimode and provide a design method to integrate and perform multimode for quadruped robots with deployable characteristics.
基金supports from following sources:National Key R&D Program of China(grant No.2021YFB2801500)National Natural Science Foundation of China(grant No.62375126,No.62105149 and No.62334001)+1 种基金Natural Science Foundation of Jiangsu Province(grant No.BK20210288)Opening Foundation of Key Laboratory of Laser&Infrared System(Shandong University),Minister of Education Key Lab of Modern Optical Technologies of Education Ministry of China,Soochow University State Key Laboratory of Advanced Optical Communication Systems and Networks,China Specially-appointed Professor Fund of Jiangsu.
文摘Despite the pressing demand for integrated spectrometers,a solution that deliver high-performance while being practically operated is still missing.Furthermore,current integrated spectrometers lack reconfigurability in their performance,which is highly desirable for dynamic working scenarios.This study presents a viable solution by demonstrating a userfriendly,reconfigurable spectrometer on silicon.At the core of this innovative spectrometer is a programmable photonic circuit capable of exhibiting diverse spectral responses,which can be significantly adjusted using on-chip phase shifters.The distinguishing feature of our spectrometer lies in its inverse design approach,facilitating effortless control and efficient manipulation of the programmable circuit.By eliminating the need for intricate configuration,our design reduces power consumption and mitigates control complexity.Additionally,our reconfigurable spectrometer offers two distinct operating conditions.In the Ultra-High-Performance mode,it is activated by multiple phase-shifters and achieves exceptional spectral resolution in the picometer scale while maintaining broad bandwidth.On the other hand,the Ease-of-Use mode further simplifies the control logic and reduces power consumption by actuating a single-phase shifter.Although this mode provides a slightly degraded spectral resolution of approximately 0.3 nm,it prioritizes ease of use and is wellsuited for applications where ultra-fine spectral reconstruction is not a primary requirement.
基金supported by the National Natural Science Foundation of China(Nos.82272504 and 82072456)the National Key R&D Program of China(No.2018YFB1105100)+4 种基金the Department of Science and Technology of Jilin Province,China(Nos.20200404202YY,20200403086SF,20210101321JC,20210204104YY,20200201453JC,20220204119YY,202201ZYTS131,202201ZYTS129,20220401084YY,202201ZYTS505,and YDZJ202301ZYTS076)the Department of Finance of Jilin Province,China(No.2020SCZT037)the Jilin Provincial Development and Reform Commission,China(Nos.2018C010 and 2022C043-5)the Interdisciplinary Integration and Cultivation Project of Jilin University(No.JLUXKJC2020307)the Central University Basic Scientific Research Fund(No.2023-JCXK-04).
文摘Bone screws are devices used to fix implants or bones to bones.However,conventional screws are mechanically fixed with thread and often face long-term failure due to poor osseointegration.To improve osseointegration,screws are evolving from solid and smooth to porous and rough.Additive manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and rough.This paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw breakage.Next,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing osseointegration.At the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore shape.In addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi structure.At the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated screws.Simultaneously,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated screws.AM osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength.
基金Project supported by the National Key Research and Development Program of China(Grant No.2021YFB2012600)the Science and Technology Plan Project of State Administration of Market Regulation,China(Grant No.2021MK039)。
文摘An integrated quantum probe for magnetic field imaging is proposed,where the nitrogen–vacancy(NV)center fixed at the fiber tip is located on the periphery of flexible ring resonator.Using flexible polyimide(PI)as the substrate medium,we design a circular microstrip antenna,which can achieve a bandwidth of 140 MHz at Zeeman splitting frequency of 2.87 GHz,specifically suitable for NV center experiments.Subsequently,this antenna is seamlessly fixed at a three-dimensional-printed cylindrical support,allowing the optical fiber tip to extend out of a dedicated aperture.To mitigate errors originating from processing,precise tuning within a narrow range can be achieved by adjusting the conformal amplitude.Finally,we image the microwave magnetic field around the integrated probe with high resolution,and determine the suitable area for placing the fiber tip(SAP).
基金The Chongqing University of Engineering for 2024 Construction Project Landscape for Comprehensive Project Library:Riverfront Space Renewal Project of Diaoyuzui Peninsula,Dadukou,Chongqing(Project No.2024-JZ-XMK054-XM083)。
文摘To enhance our talent cultivation model through“school-enterprise cooperation and industry-teaching fusion”,we aim to improve the“4321”Industry-Education Integration System.This includes actively promoting the use of case banks and project banks in teaching to develop students’practical engineering skills through hands-on application of professional knowledge.Additionally,landscape design courses emphasize practical learning experiences to implement the fundamental goal of“cultivating morality”.Guided by enhancing students’practical skills,we ensure alignment with course objectives and professional training requirements,emphasizing the seamless integration of theory and practice.
文摘Integrated sensing and communication(ISAC) is considered an effective technique to solve spectrum congestion in the future. In this paper, we consider a hybrid reconfigurable intelligent surface(RIS)-assisted downlink ISAC system that simultaneously serves multiple single-antenna communication users and senses multiple targets. Hybrid RIS differs from fully passive RIS in that it is composed of both active and passive elements, with the active elements having the effect of amplifying the signal in addition to phase-shifting. We maximize the achievable sum rate of communication users by collaboratively improving the beamforming matrix at the dual function base station(DFBS) and the phase-shifting matrix of the hybrid RIS, subject to the transmit power constraint at the DFBS, the signal-to-interference-plus-noise-ratio(SINR) constraint of the radar echo signal and the RIS constraint are satisfied at the same time. The builtin RIS-assisted ISAC design problem model is significantly non-convex due to the fractional objective function of this optimization problem and the coupling of the optimization variables in the objective function and constraints. As a result, we provide an effective alternating optimization approach based on fractional programming(FP) with block coordinate descent(BCD)to solve the optimization variables. Results from simulations show that the hybrid RIS-assisted ISAC system outperforms the other benchmark solutions.
基金supported by NIH-NIA (1F31AG057155-01A1)University of Minnesota Doctoral Dissertation Fellowship (to JL)
文摘Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have revealed that astrocytes exhibit two distinct states of intracellular calcium activity:(1)graded subcellular localized clusters with independently active microdomains,likely influenced by nearby synaptic events,and(2)whole-cell astrocyte calcium surges,believed to result from the coordinated activation of multiple synapses.Notably,astrocyte calcium responses are not solely graded;instead,a spatial threshold of intracellular calcium activity can be overcome to elicit an astrocyte calcium surge.Together these calcium responses,in turn,initiate downstream signaling pathways capable of modifying synaptic communication and overall network activity.In summary,astrocytes can function as integrators of local synaptic events,actively contributing to information processing within the brain.
基金Supported by National Natural Science Foundation of China,No.82174461Hospital Capability Enhancement Project of Xiyuan Hospital,CACMS,No.XYZX0201-22Technology Innovation Project of China Academy of Chinese Medical Sciences,No.CI2021A01811.
文摘BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.
文摘According to the operational characteristics of the logistics networks for the third party logistics supplier (3PLS), the forward and reverse logistics networks together for 3PLS under the uncertain environment are designed. First, a fuzzy model is proposed by taking multiple customers, multiple commodities, capacitated facility location and integrated logistics facility layout into account. In the model, the fuzzy customer demands and transportation rates are illustrated by triangular fuzzy numbers. Secondly, the fuzzy model is converted into a crisp model by applying fuzzy chance constrained theory and possibility theory, and one hybrid genetic algorithm is designed for the crisp model. Finally, two different examples are designed to illustrate that the model and solution discussed are valid.
文摘A wideband monolithic optoelectronic integrated receiver with a high-speed photo-detector,completely compatible with standard CMOS processes,is designed and implemented in 0.6μm standard CMOS technology.The experimental results demonstrate that its performance approaches applicable requirements,where the photo-detector achieves a -3dB frequency of 1.11GHz,and the receiver achieves a 3dB bandwidth of 733MHz and a sensitivity of -9dBm for λ=850nm at BER=10-12.
文摘Natural environment and historical humanities are the two elements constituting regional features.The construction of urban park should search design language from regional features.The author,taking Dongshan Park in Qianxi County,Hebei Province as an example,discussed how to search local natural environment features,reasonably exploit cultural resources and integrate regional features from the establishment of planning theme to the expression of designing details.
文摘This paper deals with the research of the GPS/INS integrated navigation system applying Extended Kalman Filter, which involves integrated principles, scheme and technology of combining with real INS and GPS receiver data. Emphases are placed on the modeling of system errors and implementation of the integrated system. Both loose and tightly coupled GPS/INS integrated in schemes are analyzed. On the basis of our experience accumulated in the research of GPS/INS for many years, the GPS/INS integrated navigation developing system is developed. It can be put into efficient and economic use in the study and design of integrated navigation system. It plays an important role in the aeronautical and astronautical fields in China. This system is not only a computer aided design software but also a semi physical simulation system by obtaining real INS and GPS receiver data. So the key software unit of the developing system could be conveniently transferred into practical engineering software in actual hardware integrated system. The application of this system shows that the design ideas and integrated scheme of this development system are successful, and can achieve good navigation result.
文摘The concurrent subspace design (CSD) framework has been used to conduct a preliminary design optimization of an electric powered, unmanned air vehicle (EPUAV) operating at a low Reynolds number. A multidisciplinary system analysis that includes aerodynamics, weights, propulsion, performance and stability and control has been developed for this class of vehicles. The CSD framework employs artificial neural network based response surfaces to provide approximations to the design space. The EPUAV system includes 25 continuous and 4 discrete design variables. The CSD framework was able to identify feasible designs with significant weight reductions relative to any previously considered (i.e. initial database) designs. This was accomplished with a limited number of system analyses. The results also demonstrate the nature of this design framework adaptive to changes in design requirements.
文摘Taking a microwave product as an example, a system of integrated assembly structure design is presented. Getting design constraints from the upstream design section through product data management(PDM), the system generates the assembly scheme using the case? based method, then assigns the design requirements into each component of the assembly. The detail design for each component can be performed under these design constraints. In order to practise concurrent design, the system sends the final design result to the upstream section and downstream section through PDM to achieve information sharing and integration.
文摘A behavioral model of the photodiode is presented.The model describes the relationship between photocurrent and incident optical power,and it also illustrates the impact of the reverse bias to the variation of the junction capacitance.According to this model,the photodiode and a CMOS receiver circuit are simulated and designed simultaneously under a universal circuit simulation environment.
基金supported by the National Natural Science Foundation of China(6123101761671352)
文摘Orthogonal frequency division multiplexing (OFDM) waveform enables radar and communication functions simultaneously, which encounters low angle resolution and poor data rate for traditional single input single output (SISO) systems. To solve these problems, an integrated radar and communication system (IRCS) with multiple input multiple output (MIMO) OFDM waveform is proposed. The different limitations of radar and communication in designing such a system are investigated. Then, an optimization problem is devised to obtain suitable system parameters, including the number of subcarriers, subcarrier spacing, number of symbols, pulse repetition frequency (PRF) and length of cyclic prefix (CP). Finally, to satisfy the requirements of both radar and communication, the IRCS parameters are derived in three typical cases. Several numerical results are presented to illustrate the demands of radar and communication, inconsistent or consistent, for the IRCS parameters and the superiority of the proposed system.
文摘This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing. Problems can be found and settled during designing, w hich will increase designing efficiency and one-time success rate and realize o ptimum designing for products.