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Integrated analysis of comorbidity, pregnant outcomes, and amniotic fluid cytogenetics of fetuses with persistent left superior vena cava
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作者 Xin Yang Xin-Hui Su +4 位作者 Zhen Zeng Yao Fan Yuan Wu Li-Li Guo Xiao-Yan Xu 《World Journal of Cardiology》 2023年第10期500-507,共8页
BACKGROUND Persistent left superior vena cava(PLSVC)is the most common venous system variant.The clinical characteristics and amniotic fluid cytogenetics of fetuses with PLSVC remain to be further explored.AIM To deve... BACKGROUND Persistent left superior vena cava(PLSVC)is the most common venous system variant.The clinical characteristics and amniotic fluid cytogenetics of fetuses with PLSVC remain to be further explored.AIM To develop reliable prenatal diagnostic recommendations through integrated analysis of the clinical characteristics of fetuses with PLSVC.METHODS Cases of PLSVC diagnosed using prenatal ultrasonography between September 2019 and November 2022 were retrospectively studied.The clinical characteristics of the pregnant women,ultrasonic imaging information,gestational age at diagnosis,pregnancy outcomes,and amniocentesis results were summarized and analyzed using categorical statistics and the chi-square test or Fisher’s exact test.RESULTS Of the 97 cases diagnosed by prenatal ultrasound,49(50.5%)had isolated PLSVC and 48(49.5%)had other structural abnormalities.The differences in pregnancy outcomes and amniocentesis conditions between the two groups were statistically significant(P<0.05).No significant differences were identified between the two groups in terms of advanced maternal age and gestational age(P>0.05).According to the results of the classification statistics,the most common intrac-ardiac abnormality was a ventricular septal defect and the most common extrac-ardiac abnormality was a single umbilical artery.In the subgroup analysis,the concurrent combination of intra-and extracardiac structural abnormalities was a risk factor for adverse pregnancy outcomes(odds ratio>1,P<0.05).Additional-ly,all abnormal cytogenetic findings on amniocentesis were observed in the comorbidity group.One case was diagnosed with 21-trisomy and six cases was diagnosed with chromosome segment duplication.CONCLUSION Examination for other structural abnormalities is strongly recommended when PLSVC is diagnosed.Poorer pregnancy outcomes and increased amniocentesis were observed in PLSVC cases with other structural abnor-malities.Amniotic fluid cytogenetics of fetuses is recommended for PLSVC with other structural abnormalities. 展开更多
关键词 Persistent left superior vena cava Prenatal diagnosis Amniotic fluid cytogenetics Pregnancy outcome integrated analysis COMORBIDITY
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Research on Integrated Analysis Method for Equipment and Tactics Based on Intervention Strategy Discussion
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作者 陈超 张迎新 毛赤龙 《Defence Technology(防务技术)》 SCIE EI CAS 2012年第1期59-64,共6页
As the increase of the complexity of the information warfare,its intervention strategy needs to be designed in an integrated environment.However,the current research always breaks the internal relation between equipme... As the increase of the complexity of the information warfare,its intervention strategy needs to be designed in an integrated environment.However,the current research always breaks the internal relation between equipment and tactics,and it is difficult to meet the requirements of their integrated analysis.In this paper,the research status quo of the integrated analysis about equipment and tactics is discussed first,some shortages of the current methods are summarized then,and an evolvement mechanism of the integrated analysis for equipment and tactics is given finally.Based on these,a framework of integrated analysis is proposed.This method's effectiveness is validated by an example. 展开更多
关键词 system engineering integrated analysis equipment and tactics operation effect
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Identification of metastasis-associated genes in colorectal cancer through an integrated genomic and transcriptomic analysis 被引量:2
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作者 Xiaobo Li Sihua Peng 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第6期623-636,共14页
Objective: Identification of colorectal cancer (CRC) metastasis genes is one of the most important issues in CRC research. For the purpose of mining CRC metastasis-associated genes, an integrated analysis of mJcroa... Objective: Identification of colorectal cancer (CRC) metastasis genes is one of the most important issues in CRC research. For the purpose of mining CRC metastasis-associated genes, an integrated analysis of mJcroarray data was presented, by combined with evidence acquired from comparative genornic hybridization (CGH) data. Methods: Gene expression profile data of CRC samples were obtained at Gene Expression Omnibus (GEO) website. The 15 important chromosomal aberration sites detected by using CGH technology were used for integrated genomic and transcriptomic analysis. Significant Analysis of Microarray (SAM) was used to detect significantly differentially expressed genes across the whole genome. The overlapping genes were selected in their corresponding chromosomal aberration regions, and analyzed by using the Database for Annotation, Visualization and Integrated Discovery (DAVID). Finally, SVM-T-RFE gene selection algorithm was applied to identify ted genes in CRC. Results: A minimum gene set was obtained with the minimum number [14] of genes, and the highest classification accuracy (100%) in both PRI and META datasets. A fraction of selected genes are associated with CRC or its metastasis. Conclusions- Our results demonstrated that integration analysis is an effective strategy for mining cancer- associated genes. 展开更多
关键词 Colorectal cancer metastasis integrated analysis comparative genomic hybridization (CGH) Significant analysis of Microarray (SAM) Database for Annotation Visualization and integrated Discovery(DAVID) SVM-T-RFE gene selection algorithm
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Developing Regional Ecological Networks along the Grand Canal based on an Integrated Analysis Framework 被引量:2
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作者 XU Chuangsheng CHENG Long +2 位作者 SU Jie YIN Haiwei GUO Yiqiang 《Journal of Resources and Ecology》 CSCD 2021年第6期801-813,共13页
As a complex social ecosystem network,the area along the Grand Canal has a prominent contradiction between the demand for economic development and the protection of natural resources,which means that there is an urgen... As a complex social ecosystem network,the area along the Grand Canal has a prominent contradiction between the demand for economic development and the protection of natural resources,which means that there is an urgent need for ecological restoration and environmental protection.Using ArcGIS,Conefor,Linkage Mapper and other software platforms,this paper developed an integrated analysis framework,through loose coupling of the attribute-function-structure index system and a series of methods such as the least cost path,circuit theory and moving window search.Based on the framework,we resolve a series of scientific issues in developing regional ecological networks,such as the selection of ecological sources,the simulation of potential ecological corridors,the assessment of the importance of ecological sources and corridors,and the identification of key ecological nodes.Moreover,an overall conservation pattern of the regional ecological network is constructed.The results show that:1)A total of 88 important ecological sources are identified in the study area.The patches with high centrality values are mainly concentrated in the southern mountainous area and the areas with abundant rivers and lakes.2)A total of 138 important ecological corridors are identified,and they are not evenly distributed.Extremely important corridors mostly appear between important patches,and very important corridors are mainly distributed in the central area.3)Fifteen ecological pinch points are extracted,and they are mainly concentrated in the northern part of the study area and eastern Zhejiang Province.The barriers are mostly concentrated in the southern and northern parts of the study area.4)Combining the demands of ecological protection and socioeconomic development,we propose an overall ecological conservation pattern of"one axis,five sections,multiple cores and multiple nodes"to effectively guide future ecological restoration work.These results can provide a useful reference and spatial guidance for decision makers in terms of ecological restoration and cooperation on cross-regional ecological protection along the Grand Canal. 展开更多
关键词 ecological network integrated analysis framework ecological conservation pattern the Grand Canal
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Prediction of Cancer-Associated piRNA–mRNA and piRNA–lncRNA Interactions by Integrated Analysis of Expression and Sequence Data
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作者 Yajun Liu Junying Zhang +4 位作者 Aimin Li Zhaowen Liu Zhongzhen He Xiguo Yuan Shouheng Tuo 《Tsinghua Science and Technology》 SCIE EI CAS CSCD 2018年第2期115-125,共11页
piwi-interactingRNAs(piRNAs) are valuable biomarkers, but functional studies are still very limited.Recent research shows that piRNA-mediated cleavage acts on Transposable Elements(TEs), messengerRNAs(mRNAs), and long... piwi-interactingRNAs(piRNAs) are valuable biomarkers, but functional studies are still very limited.Recent research shows that piRNA-mediated cleavage acts on Transposable Elements(TEs), messengerRNAs(mRNAs), and long non-codingRNAs(lncRNAs). This study aimed to predict cancer-associated piRNA-mRNA and piRNA-lncRNA interactions as well as piRNA regulatory functions. Four cancer types(BRCA, HNSC, KIRC,and LUAD) were investigated. Interactions were identified by integrated analysis of the expression and sequence data. For the expression analysis, only piRNA–mRNA and piRNA–lncRNA pairs with expression profiles that were significantly inversely correlated were retained to reduce false-positive rates during the prediction. For the sequence analysis, miRanda was used for the target prediction. We identified 198 piRNA–mRNA and 10 piRNA–lncRNA pairs. Unlike mRNA and lncRNA expressions, the piRNA expression was relatively consistent across the cancer types. Furthermore, the identified piRNAs were consistent with previously published cancer biomarkers, such as piRNA-36741, piR-21032, and piRNA-57125. More importantly, predicted piRNA functions were determined by constructing an interaction network, and piRNA targets were placed in gene ontology categories related to the cancer hallmarks "activating invasion and metastasis" and "sustained angiogenesis". 展开更多
关键词 CO-EXPRESSION piRNA-mRNA interaction piRNA-lncRNA interaction integrated analysis target prediction
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Municipal Temperature and Heatwave Predictions as a Tool for Integrated Socio-Environmental Impact Analysis in Brazil
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作者 D.Costa S.Hacon +4 位作者 A.S.P.Siqueira S.L.L.A.Pinheiro K.S.Goncalves A.Oliveira P.Cox 《American Journal of Climate Change》 2015年第4期385-396,共12页
Numerical climate models render data in a gridded format which is often problematic for integrated analysis with other kinds of data in jurisdictional formats. In this paper a joint analysis of municipal Gross Domesti... Numerical climate models render data in a gridded format which is often problematic for integrated analysis with other kinds of data in jurisdictional formats. In this paper a joint analysis of municipal Gross Domestic Product per capita (GDPc) and predicted temperature increase was undertaken in order to estimate different levels of human and economic exposure. This is based on a method of converting model outputs into a country municipal grid which enabled depicting climate predictions from the Eta-Hadgem2-ES Regional Climate Model (RCM) into the municipal level in Brazil. The conversion to country municipality grid was made using a combination of interpolation and buffering techniques in ArcGIS for two emission scenarios (RCP 4.5 and 8.5) and three timeframes (2011-2040, 2041-2070, 2071-2100) for mean temperature increase and number of heatwave days (WSDI). The results were used to support the Third National Communication (TCN) of Brazil to the United Nations Framework Convention on Climate Change (UNFCCC) and show a coherent matching of the gridded output from the original RCM. The joint climate and GDPc analysis show that in the beginning of the century the more severe warming is centred over regions where GDPc is generally higher (Centre-West and Southeast). At the end of the century, critical levels of warming spread north and northeastwards where municipalities have the lowest GDPc levels. In the high emission scenario (RCP 8.5), the strongest warming and the spreading over poorer regions are anticipated to the mid-century. These results are the key to further explore solutions for climate change adaptation based on current resources and prepare in different sectors, for long-term risk management and climate adaptation planning strategies. 展开更多
关键词 Climate Change MUNICIPALITY integrated analysis Spatial Interpolation Climate Impacts Socio-Environmental Impact analysis
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Integrated Process Capability Analysis
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作者 Chen H T Huang M L +1 位作者 Hung Y H Chen K S 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期193-,共1页
Process Capability Analysis (PCA) is a powerful too l to assess the ability of a process for manufacturing product that meets specific ations. The larger process capability index implies the higher process yield, a nd... Process Capability Analysis (PCA) is a powerful too l to assess the ability of a process for manufacturing product that meets specific ations. The larger process capability index implies the higher process yield, a nd the larger process capability index also indicates the lower process expected loss. Chen et al. (2001) has applied indices C pu, C pl, and C pk for evaluating the process capability for a multi-process product wi th smaller-the-better, larger-the-better, and nominal-the-best specificati ons respectively. However, C pk cannot reasonably reflect the process expected loss. In this paper, index C pn is selected to replace C pk. Indices C pu, C pl, and C pn are used to evalu ate the entire process capability for a multi-process product with smaller-the -better, larger-the-better, and nominal-the-best specifications respectivel y. An integrated process capability index for a multi-process product is propo sed. The relationship between process capability index and the process yield is introduced. A multi-process capability analysis chart (MPCAC), reasonably rev ealing the status of process capability for the entire product, is constructed f or practical application. An evaluating procedure of the process capability for the entire product is also provided. 展开更多
关键词 process capability indices integrated capability analysis process yield
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Identification of key pathways and genes from gastric precancerous lesions to gastric cancer by integrated bioinformatics analysis
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作者 Liang-Jun Yang Jing Li +1 位作者 Chi Zhang Yue-Jun Li 《TMR Cancer》 2020年第1期32-43,共12页
Objective:This work aimed to illuminate the potential key genes and pathways in GC tumorigenesis based on bioinfOrmatics analysis.Methods:The differentially expressed genes(DEGs)between GPL tissue samples and GC tissu... Objective:This work aimed to illuminate the potential key genes and pathways in GC tumorigenesis based on bioinfOrmatics analysis.Methods:The differentially expressed genes(DEGs)between GPL tissue samples and GC tissue samples were investigated using the GSE55696 and GSE87666 microarray data from the Gene Expression Omnibus(GEO)database.DEGs were identified by an empirical Bayes method based on the Limma R package.Then,KEGG and GO enrichment analyses of DEGs were performed followed by protein-protein interaction(PPI)network construction.Finally,the overall survival(OS)analysis of key genes was performed by the Kaplan-Meier plotter online tool.Results:A total of 250 DEGs were obtained,of which 216 were up-regulated and 34 were down-regulated.KEGG pathways analysis showed that the up-regulated DEGs were enriched in cytokine-cytokine receptor interaction,chemokine signaling pathway,metabolic pathways,PI3K-Akt signaling pathway,NF-kappa B signaling pathway,and other signaling pathways about cancer,while no down-regulated pathways were enriched.A PPI network of DEGs was constructed with 117 nodes and 660 edges,and 20 genes were selected as hub genes owing to high degrees in the network.According to the Kaplan-Meier analysis,6 out of 20 hub genes including CCR7,FPR1,C3,CXCR5,GNB4,and PPBP with high mRNA expression were associated with poor OS for GC patients.Conclusion:The results of this study provide possible factors for the occurrence of GC,and the identification of the genes and pathways associated with the progression from GPL to GC provides valuable data for investigating the pathogenesis in future studies. 展开更多
关键词 Gastric cancer Gastric precancerous lesions integrated bioinformatics analysis PATHWAYS Key genes Differentially expressed genes
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THE EIGENVALUE SENSITIVITY ANALYSIS AND DESIGN FOR INTEGRATED FLIGHT/PROPULSION CONTROL SYSTEM
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作者 Shen Gongzhang, Chen Zongji and Peng KemaoBeijing University of Aeronautics and Astronautics 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 1990年第4期277-284,共8页
In this paper, sensitivity approaches are taken to analyze and design an integrated flight propulsion control system where the interaction between subsystems direitly affects the stability property and handling perfor... In this paper, sensitivity approaches are taken to analyze and design an integrated flight propulsion control system where the interaction between subsystems direitly affects the stability property and handling performances of the aircraft. The eigenvalue sen sitivity approach is employed to study the effect of coupling parameters on system stability and gain sensitivity approach is used to direct the reduced states feedback suboptimal control system design. Simulation results show that the integrated flight propulsion control system designed by sensitivity approaches is of good performance. 展开更多
关键词 THE EIGENVALUE SENSITIVITY analysis AND DESIGN FOR integrated FLIGHT/PROPULSION CONTROL SYSTEM SIMULATION
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Analysis on Construction Requirements for Integrated Gateway Offices
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作者 Chen Yifang~1 Shou Qingliang~2 Wang Po~1 (1.Shanghai R&D Center of ZTE Corporation,Shanghai 201203,China 2.Nanjing R&D Center of ZTE Corporation,Nanjing 210012,China~) 《ZTE Communications》 2003年第2期19-24,共6页
This article describes the significance of constructing integrated gateway office offices by telecom operators in the new era,as well as the change and improvement of the function requirements of in- tegrated gateway ... This article describes the significance of constructing integrated gateway office offices by telecom operators in the new era,as well as the change and improvement of the function requirements of in- tegrated gateway office offices with the continuous development of cross-network services.It puts forward ZTE's overall solution for the inter-network interworking with regard to the construction of in- tegrated gateway office offices. 展开更多
关键词 for in GSM GATEWAY analysis on Construction Requirements for integrated Gateway Offices ZTE of ISSP CDMA on
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Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ-SCD activation in non-alcoholic fatty liver disease 被引量:1
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作者 Ya-Ling Zhu Lei-Lei Meng +17 位作者 Jin-Hu Ma Xin Yuan Shu-Wen Chen Xin-Rui Yi Xin-Yu Li Yi Wang Yun-Shu Tang Min Xue Mei-Zi Zhu Jin Peng Xue-Jin Lu Jian-Zhen Huang Zi-Chen Song Chong Wu Ke-Zhong Zheng Qing-Qing Dai Fan Huang Hao-Shu Fang 《Zoological Research》 SCIE CSCD 2024年第1期79-94,共16页
Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were establi... Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP deficiency.Notably,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory transcriptome.In total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD rats.Based on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating NAFLD.This study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets. 展开更多
关键词 Non-alcoholic fatty liver disease C/EBPΒ Lipopolysaccharide-binding protein H3K27ac Integrative analysis ENHANCER
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Calibration chain design based on integrating sphere transfer radiometer for SI-traceable on-orbit spectral radiometric calibration and its uncertainty analysis 被引量:1
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作者 赵维宁 方伟 +2 位作者 孙立微 崔立红 王玉鹏 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第9期276-283,共8页
In order to satisfy the requirement of SI-traceable on-orbit absolute radiation calibration transfer with high accuracy for satellite remote sensors,a transfer chain consisting of a fiber coupling monochromator(FBM)... In order to satisfy the requirement of SI-traceable on-orbit absolute radiation calibration transfer with high accuracy for satellite remote sensors,a transfer chain consisting of a fiber coupling monochromator(FBM) and an integrating sphere transfer radiometer(ISTR) was designed in this paper.Depending on the Sun,this chain based on detectors provides precise spectral radiometric calibration and measurement to spectrometers in the reflective solar band(RSB) covering 300–2500 nm with a spectral bandwidth of 0.5–6 nm.It shortens the traditional chain based on lamp source and reduces the calibration uncertainty from 5% to 0.5% by using the cryogenic radiometer in space as a radiometric benchmark and trap detectors as secondary standard.This paper also gives a detailed uncertainty budget with reasonable distribution of each impact factor,including the weak spectral signal measurement with uncertainty of 0.28%.According to the peculiar design and comprehensive uncertainty analysis,it illustrates that the spectral radiance measurement uncertainty of the ISTR system can reach to 0.48%.The result satisfies the requirements of SI-traceable on-orbit calibration and has wider significance for expanding the application of the remote sensing data with high-quality. 展开更多
关键词 SI-traceable calibration on-orbit high-accuracy transfer chain integrating sphere transfer radiometer uncertainty analysis
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Reliability Analysis of Unmanned Aerial Vehicles Flight Control System Based on Reliability Analysis Technologies
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作者 CAI Shuang JIANG Guangjun 《Journal of Donghua University(English Edition)》 EI CAS 2018年第3期264-269,共6页
The unmanned aerial vehicles( UAV) has been becoming more and more important in the aviation industry.Despite the superior performance and advanced technology,major accident of UAV happens frequently due to the impact... The unmanned aerial vehicles( UAV) has been becoming more and more important in the aviation industry.Despite the superior performance and advanced technology,major accident of UAV happens frequently due to the impact of their systems,long distance of remote control and skill of manipulator technology.According to the application of engineering application,failure mode effects and criticality analysis( FMECA),failure reporting analysis and corrective action comprehensive analysis systems( FRACAS)and fault tree analysis( FTA)( 3 F) were combined.And also a set of user-friendly,more time,more efficient and accurate reliability analysis system were explored. 展开更多
关键词 failure mode effect and criticality analysis(FMECA) failure reporting analysis and corrective action comprehensive analysis systems(FRACAS) fault tree analysis(FTA) 3F integrated system analysis
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Numerical Simulation of Installation Process and Uplift Resistance for An Integrated Suction Foundation in Deep Ocean
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作者 李英 杨树耕 于书铭 《China Ocean Engineering》 SCIE EI CSCD 2016年第1期33-46,共14页
A concept design, named integrated suction foundation, is proposed for a tension leg platform(TLP) in deep ocean. The most important improvement in comparing with the traditional one is that a pressure-resistant sto... A concept design, named integrated suction foundation, is proposed for a tension leg platform(TLP) in deep ocean. The most important improvement in comparing with the traditional one is that a pressure-resistant storage module is designed. It utilizes the high hydrostatic pressure in deep ocean to drive water into the module to generate negative pressure for bucket suction. This work aims to further approve the feasibility of the concept design in the aspect of penetration installation and the uplift force in-place. Seepage is generated during suction penetration, and can have both positive and negative effects on penetration process. To study the effect of seepage on the penetration process of the integrated suction foundation, finite element analysis(FEA) is carried out in this work. In particular, an improved methodology to calculate the penetration resistance is proposed for the integrated suction foundation with respect to the reduction factor of penetration resistance. The maximum allowable negative pressure during suction penetration is calculated with the critical hydraulic gradient method through FEA. The simulation results of the penetration process show that the integrated suction foundation can be installed safely. Moreover, the uplift resistance of the integrated suction foundation is calculated and the feasibility of the integrated suction foundation working on-site is verified. In all, the analysis in this work further approves the feasibility of the integrated suction foundation for TLPs in deep ocean applications. 展开更多
关键词 integrated suction foundation penetration resistance TLP finite element analysis deep ocean
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INTEGRATION OF A ZONAL FUNCTION RELATED TO THE LOCAL HARMONIC ANALYSIS ON SPHERES
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作者 Sun Limin (Hangzhou University,China) 《Analysis in Theory and Applications》 1996年第3期93-97,共5页
In studying Local harmonic analysis on the sphere S',R.S.Strichartz introduced certain zonab functionsid(x,y))which satisfy the equation
关键词 INTEGRATION OF A ZONAL FUNCTION RELATED TO THE LOCAL HARMONIC analysis ON SPHERES
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Analysis of Migrant Population's Social Integration in Hangzhou
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作者 XU ZURONG 《The Journal of Human Rights》 2009年第2期27-30,共4页
Since China began implementing reform and opening-up policies, along with a fast development of the national economy and great changes of social life, an increasing number of peasan's have kept flowing into cities an... Since China began implementing reform and opening-up policies, along with a fast development of the national economy and great changes of social life, an increasing number of peasan's have kept flowing into cities and economically more developed regions. Aspiring to improve their life and yearning for a better urban life, they defy the restraint of the household registry system and, in the process of moving from one place to another, ignore economic and psychological costs. As early as in year 2000 China's migrant population reached 140 million, more than 10% of the total population. Since 2000 the migrant poptilation in Zhejiang Province, east China, has kept growing by 20% annually, the second fastest in the country for seven consecutive years. 展开更多
关键词 In analysis of Migrant Population’s Social Integration in Hangzhou
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Integrated interactome and transcriptome analysis reveals key host factors critical for SARS-CoV-2 infection
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作者 Jie Sheng Lili Li +6 位作者 Xueying Lv Meiling Gao Ziyi Chen Zhuo Zhou Jingfeng Wang Aiping Wu Taijiao Jiang 《Virologica Sinica》 SCIE CAS CSCD 2023年第4期508-519,共12页
The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has seriously threatened global public health and caused huge economic losses.Omics studies of SARS-... The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has seriously threatened global public health and caused huge economic losses.Omics studies of SARS-CoV-2 can help understand the interaction between the virus and host,thereby providing a new perspective in guiding the intervention and treatment of the SARS-CoV-2 infection.Since large amount of SARS-CoV-2 omics data have been accumulated in public databases,this study aimed to identify key host factors involved in SARSCoV-2 infection through systematic integration of transcriptome and interactome data.By manually curating published studies,we obtained a comprehensive SARS-CoV-2-human protein-protein interactions(PPIs)network,comprising 3591 human proteins interacting with 31 SARS-CoV-2 viral proteins.Using the RobustRankAggregation method,we identified 123 multiple cell line common genes(CLCGs),of which 115 up-regulated CLCGs showed host enhanced innate immunity and chemotactic response signatures.Combined with network analysis,co-expression and functional enrichment analysis,we discovered four key host factors involved in SARS-CoV-2 infection:IFITM1,SERPINE1,DDX60,and TNFAIP2.Furthermore,SERPINE1 was found to facilitate SARSCoV-2 replication,and can alleviate the endoplasmic reticulum(ER)stress induced by ORF8 protein through interaction with ORF8.Our findings highlight the importance of systematic integration analysis in understanding SARS-CoV-2-human interactions and provide valuable insights for future research on potential therapeutic targets against SARS-CoV-2 infection. 展开更多
关键词 SARS-CoV-2 INTERACTOME TRANSCRIPTOME Integration analysis ER stress
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Predicting stability of integrated circuit test equipment using upper side boundary values of normal distribution
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作者 Zhan Wenfa Hu Xinyi +3 位作者 Zheng Jiangyun Yu Chuxian Cai Xueyuan Zhang Lihua 《The Journal of China Universities of Posts and Telecommunications》 EI CSCD 2024年第2期85-93,共9页
In response to the growing complexity and performance of integrated circuit(IC),there is an urgent need to enhance the testing and stability of IC test equipment.A method was proposed to predict equipment stability us... In response to the growing complexity and performance of integrated circuit(IC),there is an urgent need to enhance the testing and stability of IC test equipment.A method was proposed to predict equipment stability using the upper side boundary value of normal distribution.Initially,the K-means clustering algorithm classifies and analyzes sample data.The accuracy of this boundary value is compared under two common confidence levels to select the optimal threshold.A range is then defined to categorize unqualified test data.Through experimental verification,the method achieves the purpose of measuring the stability of qualitative IC equipment through a deterministic threshold value and judging the stability of the equipment by comparing the number of unqualified data with the threshold value,which realizes the goal of long-term operation monitoring and stability analysis of IC test equipment. 展开更多
关键词 K-means clustering algorithm the upper side boundary of normal distribution THRESHOLD integrated circuit(IC)test equipment stability analysis
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Genome-wide interrogation of transfer RNA-derived small RNAs in a mouse model of traumatic brain injury 被引量:4
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作者 Xiao-Jian Xu Meng-Shi Yang +5 位作者 Bin Zhang Qian-Qian Ge Fei Niu Jin-Qian Dong Yuan Zhuang Bai-Yun Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第2期386-394,共9页
Transfer RNA(t RNA)-derived small RNAs(ts RNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes. Growing evidence indicates that ts RNAs are involved in... Transfer RNA(t RNA)-derived small RNAs(ts RNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes. Growing evidence indicates that ts RNAs are involved in neurological disorders and play a role in the pathogenesis of neurodegenerative disease. However, whether ts RNAs are involved in traumatic brain injury-induced secondary injury remains poorly understood. In this study, a mouse controlled cortical impact model of traumatic brain injury was established, and integrated ts RNA and messenger RNA(m RNA) transcriptome sequencing were used. The results revealed that 103 ts RNAs were differentially expressed in the mouse model of traumatic brain injury at 72 hours, of which 56 ts RNAs were upregulated and 47 ts RNAs were downregulated. Based on micro RNA-like seed matching and Pearson correlation analysis, 57 differentially expressed ts RNA-m RNA interaction pairs were identified, including 29 ts RNAs and 26 m RNAs. Moreover, Gene Ontology annotation of target genes revealed that the significantly enriched terms were primarily associated with inflammation and synaptic function. Collectively, our findings suggest that ts RNAs may be associated with traumatic brain injury-induced secondary brain injury, and are thus a potential therapeutic target for traumatic brain injury. The study was approved by the Beijing Neurosurgical Institute Animal Care and Use Committee(approval No. 20190411) on April 11, 2019. 展开更多
关键词 gene set enrichment analysis INFLAMMATION integrated analysis neurodegenerative disease next-generation sequencing secondary injury synaptic function transfer RNA-derived small RNAs transfer RNAs traumatic brain injury
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Petroleum systems of the Taoudeni Basin,West Africa 被引量:1
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作者 Huang Zhilong Zhao Baoshun Jiang Qingchun Wang Songpo Liu Bo 《Petroleum Science》 SCIE CAS CSCD 2008年第1期24-30,共7页
The Taoudeni Basin is a typical steady intracratonic basin. Based on the distribution of effective source rocks in the Taoudeni Basin, combined with the structure characteristics of the basin and the distribution char... The Taoudeni Basin is a typical steady intracratonic basin. Based on the distribution of effective source rocks in the Taoudeni Basin, combined with the structure characteristics of the basin and the distribution characteristics of reservoir beds, two petroleum systems are recognized in the basin: the infra-Cambrian petroleum system and the Silurian petroleum system. Structural uplift and timing of petroleum generation controlled the timing of petroleum charging and preservation of hydrocarbon accumulations. Maturity, evolution history, and distribution of effective source rocks controlled hydrocarbon richness. The geological key factors and geological processes controlled the type of hydrocarbon accumulations. 展开更多
关键词 Taoudeni Basin source-reservoir-cap rock assemblage petroleum system integrated analysis
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