In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the ...In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the potential to positively influence mental health by providing monitoring,insights,and inter-ventions.However,they also come with challenges that need to be addressed.Understanding the primary purpose for which individuals use these smart tech-nologies is essential to tailoring them to specific mental health needs and prefe-rences.展开更多
BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohor...BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.展开更多
Via database technology, a perfect lightning protection integrated service work platform is established, thereby realizing paperless data management of routine business.
The space-air-ground integrated network(SAGIN) is regarded as the key approach to realize global coverage in future network and it reaches broad access for various services. Being the new paradigm of service, immersiv...The space-air-ground integrated network(SAGIN) is regarded as the key approach to realize global coverage in future network and it reaches broad access for various services. Being the new paradigm of service, immersive media(IM) has attracted users’ attention for its virtualization, but it poses challenges to network performance, e.g. bandwidth, rate, latency. However, the SAGIN has limitations in supporting IM services, such as 4 K/8 K video, virtual reality, and interactive games. In this paper, a novel service customized SAGIN architecture for IM applications(SAG-IM) is proposed, which achieves content interactive and real-time communication among terminal users. State-of-the-art research is investigated in detail to facilitate the combination of SAGIN and service customized technology, which provides endto-end differentiated services for users. Besides, the functional components of SAG-IM contain the infrastructure layer, perception layer, intelligence layer, and application layer, reaching the capabilities of intelligent management of the network. Moreover, to provide IM content with ultra-high-definition and high frame rate for the optimal user experience, the promising key technologies on intelligent routing and delivery are discussed. The performance evaluation shows the superiority of SAG-IM in supporting IM service.Finally, the prospects in practical application are high-lighted.展开更多
An integrated energy service company in an industrial park or commercial building is responsible for managing all energy sources in their local region, including electricity, water, gas, heating, and cooling. To reduc...An integrated energy service company in an industrial park or commercial building is responsible for managing all energy sources in their local region, including electricity, water, gas, heating, and cooling. To reduce energy wastage and increase energy utilization, it is necessary to perform efficiency analyses and diagnoses on integrated energy systems(IESs). However, the integrated energy data necessary for energy efficiency analyses and diagnoses come from a wide variety of instruments, each of which uses different transmission protocols and data formats. This makes it challenging to handle energy-flow data in a unified manner. Thus, we have constructed a unified model for diagnosing energy usage abnormalities in IESs. Using this model, the data are divided into working days and non-working days, and benchmark values are calculated after the data have been weighted to enable unified analysis of several types of energy data. The energy-flow data may then be observed, managed, and compared in all aspects to monitor sudden changes in energy usage and energy wastage. The abnormal data identified and selected by the unified model are then subjected to big-data analysis using technical management tools, enabling the detection of user problems such as abnormalities pertaining to acquisition device, metering, and energy usage. This model facilitates accurate metering of energy data and improves energy efficiency. The study has significant implications in terms of fulfilling the energy saving.展开更多
Using enterprise GIS platform, spatial databases and modern information technology, building geo-spatial information service platform of digital mine which has the features of the data exchange service, enterprise GIS...Using enterprise GIS platform, spatial databases and modern information technology, building geo-spatial information service platform of digital mine which has the features of the data exchange service, enterprise GIS services, directory services, logging services, is key technology and application infrastructure for digital mine. Based on the support of geospatial information service platform of digital mine, the professional GIS application service adapter can be developed and the application supports related to mining application system can be realized. Using high-resolution satellite remote sensing data, the mine functional partition map and geographic grids can be divided, and the geographic grid parts, status and events of important features of the surface object were investigated and defined. The system architecture and technical characteristics of integrated spatial information service platform were analyzed firstly, which guarantee service ability of digital mine. The methods and applications of functional partition map for integrated management service platform were discussed which are the services scheme of digital mine. The application results indicated that digital mine upgrades and enhances the capability and range of mine surveying and mapping, and is of great significance for guarantee of efficient, green and intensive exploitation of mine.展开更多
The Service-based Architecture(SBA) is one of the key innovations of 5G architecture that leverage modularized, self-contained and independent services to provide flexible and cloud-native 5G network. In this paper, S...The Service-based Architecture(SBA) is one of the key innovations of 5G architecture that leverage modularized, self-contained and independent services to provide flexible and cloud-native 5G network. In this paper, SBA for Space-Air-Ground Integrated Network(SAGIN) is investigated to enable the 5G integration deployment. This paper proposes a novel Holistic Service-based Architecture(H-SBA)for SAGIN of 5G-Advanced and beyond, i.e., 6G. The H-SBA introduces the concept of end-to-end servicebased architecture design. The "Network Function Service", introduced in 5G SBA, is extended from Control Plane to User Plane, from core network to access network. Based on H-SBA, the new generation of protocol design is proposed, which proposes to use IETF QUIC and SRv6 to substitute 5G HTTP/2.0 and GTP-U. Testing results show that new protocols can achieve low latency and high throughput, making them promising candidate for H-SBA.展开更多
This methodological investigation deals with measurement and valuation of ecological service functions for urban green space. Social, economic and ecological dimensions for such types of function were analyzed and a ...This methodological investigation deals with measurement and valuation of ecological service functions for urban green space. Social, economic and ecological dimensions for such types of function were analyzed and a concept “integrated ecological service functions” (IESF) was put forward for evaluation. Based upon this conceptual approach, an index system for measuring IESF for urban green space was established. With a methodological integration of fuzzy mathematics, decision making analysis and Delphi method, an AHP fuzzy evaluation techniques for IESF for urban green space, called AFIFUG method, was developed. Such a method has been directly applied to the land use strategic planning of Tianjin out ring green belt(TOGB), and its analysis results have been successfully put into operation.展开更多
There is growing interest in the integrated sensing and communication(ISAC)to extend the 5G+/6G network capabilities by introducing sensing capability.While the solutions for mono-static or bi-static ISAC have shown f...There is growing interest in the integrated sensing and communication(ISAC)to extend the 5G+/6G network capabilities by introducing sensing capability.While the solutions for mono-static or bi-static ISAC have shown feasibility and benefits based on existing 5G physical layer design,whether and how to coordinate multiple ISAC devices to better exert networking performance are rarely discussed.3 rd Partnership Project(3GPP)has initiated the ISAC use cases study,and the follow-up studies for network architecture could be anticipated.In this article,we focus on gNB-based sensing mode and propose ISAC functional framework with given of highlevel service procedures to enable cellular based ISAC services.In the proposed ISAC framework,three types of network functions for sensing service as Sensing Function(SF),lightweight-Edge Sensing Function(ESF)and full-version-ESF are designed with interaction with network nodes to fulfill the latency requirements of ISAC use cases.Finally,with simulation evaluations and hardware testbed results,we further verify the performance benefit and feasibility to enable ISAC in 5G for the gNB-based sensing mode with new design on SF and related signaling protocols.展开更多
With the gradual intensification of aging in China,the issue of elderly care has become the primary issue that needs to be urgently solved in society.The construction of a reasonable and scientific integrated medical ...With the gradual intensification of aging in China,the issue of elderly care has become the primary issue that needs to be urgently solved in society.The construction of a reasonable and scientific integrated medical and care service system can not only efficiently allocate medical resources and services,but also better meet the needs of the elderly.Due to the involvement of multiple disciplines such as architecture,sociology,psychology,and behavioral science in the construction of the system,as well as the restriction of various objective factors such as medical capacity,spatial scale,and operating costs,the government and elderly care institutions have always been unable to find the best solution for how to scientifically and reasonably construct an integrated medical and care service system.This paper is based on Anshan City,Liaoning Province,which has prominent aging issues and distinct characteristics of the elderly population.Through extensive field research in elderly care institutions,and face-to-face communication with personnel from relevant government departments such as the Municipal Commission on Aging,the Civil Affairs Bureau,the Health Commission,the Medical Insurance Bureau,and the Human Resources and Social Security Bureau,it truly understands the problems that arise in the construction of the urban integrated medical and care service system.From three aspects:urban situation,institutional situation and the needs of the elderly,it is proposed to establish a clear departmental linkage mechanism with clear rights and responsibilities,a policy guarantee mechanism tailored to local conditions,a multi-measure operation mechanism,a technology first intelligent response mechanism,a warm and efficient service mechanism for the people,an overall layout mechanism,an evaluation and supervision mechanism for full process control,and a talent supply mechanism of external introduction and internal training.It aims to provide reference for the construction of an integrated medical and care service system in similar cities.展开更多
Globally, there are approximately 36.7 million people living with HIV. Integration of HIV treatment with primary care services improves effectiveness, efficiency and equity in service delivery. The study sought to est...Globally, there are approximately 36.7 million people living with HIV. Integration of HIV treatment with primary care services improves effectiveness, efficiency and equity in service delivery. The study sought to establish service delivery factors that influenced utilization of integrated HIV and primary health care services in Embu Teaching and Referral hospital. A descriptive cross-sectional survey design was used to collect data at a specific period and point of time from a sample of 302 seropositive clients who were selected using simple random method. Data collection tool was structured and semi-structured questionnaire. The tool was reliable at Cronbach’s alpha of 0.817. SPSS version 23 was used to analyze the data. A binary logistic regression model was used to predict the relationship between service delivery and utilization of integrated services. Results: Majority of the respondents (59.6%) were aged over 35 years with majority being female (58.9%) and the married were 57.6% of the total sample. On service delivery factors, majority (94.7%) felt that their health status had improved. Action taken when clients developed side effects, 78.8% reported that the drugs were changed. Action taken following drug side effects significantly affected utilization, χ2 = 1.305, p = 0.001, df = 1. The findings showed that waiting time significantly influenced utilization, χ2 = 9.284, df = 1, p = 0.002. Source of information on self care also significantly influenced utilization, χ2 = 10.689, df = 1, p = 0.001. Kind of treatment at the facility also significantly influenced utilization, χ2 = 5.713, p = 0.048. Conclusion: significant factors that influenced utilization of integrated services were source of health care information, secondly waiting time was another factor which influenced utilization. Majority of the respondents were satisfied with duration of time they take before they were served;they reported to take utmost 1 hour to be attended to and action taken by health care provider following side effects was another factor that influenced the utilization.展开更多
With the constructions of "intelligence city", intelligent life quietly came to the people. As the "cell" of the city, the construction of intelligence community arises. Resident service system and e-government ap...With the constructions of "intelligence city", intelligent life quietly came to the people. As the "cell" of the city, the construction of intelligence community arises. Resident service system and e-government application system have been used in the traditional information community, but these systems are independent of each other, lack of interconnectedness, which results in the phenomenon of information isolated island. Intelligence community integrated information service platform can integrate information service resources and provide residents with efficient and convenient life. From the meaning, operation mode, we can design the cooperative, open and extensible system architecture.展开更多
Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electroni...Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics.展开更多
Because of no strict expression of calculating call blocking probability (CBP) in the solution procedure of virtual-path bandwidth allocation problem, the process of calculating bandwidth through CBP and traffic loa...Because of no strict expression of calculating call blocking probability (CBP) in the solution procedure of virtual-path bandwidth allocation problem, the process of calculating bandwidth through CBP and traffic load adopts the iteration algorithm in common, which is an inverse process of calculating CBP through traffic load and bandwidth. It limits computing speed by a long way because of including recursion. An approximate algorithm of bandwidth is presented. We compare the performance of this algorithm with that of another classical algorithm and conclude that the former makes a great increase in speed with little error about 2 %.展开更多
This paper takes the public services in the grassroots community of Dongguan as the object of study and studies the integrated construction of the public service platform in grassroots communities with the thinking pr...This paper takes the public services in the grassroots community of Dongguan as the object of study and studies the integrated construction of the public service platform in grassroots communities with the thinking principle of resources integration so as to set up a service platform integrating electronization, informatization and networking, ensure the convenience of public services and provide high-quality community public services for the community residents.展开更多
Studying the spatiotemporal variations in ecosystem services and their interrelationships on the Loess Plateau against the background of the gully control and land consolidation(GCLC)project has significant implicatio...Studying the spatiotemporal variations in ecosystem services and their interrelationships on the Loess Plateau against the background of the gully control and land consolidation(GCLC)project has significant implications for ecological protection and quality development of the Yellow River Basin.Therefore,in this study,we took Yan'an City,Shaanxi Province of China,as the study area,selected four typical ecosystem services,including soil conservation service,water yield service,carbon storage service,and habitat quality service,and quantitatively evaluated the spatiotemporal variation characteristics and trade-offs and synergies of ecosystem services from 2010 to 2018 using the Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)model.We also analysed the relationship between the GCLC project and regional ecosystem service changes in various regions(including 1 city,2 districts,and 10 counties)of Yan'an City and proposed a coordinated development strategy between the GCLC project and the ecological environment.The results showed that,from 2010 to 2018,soil conservation service decreased by 7.76%,while the other three ecosystem services changed relatively little,with water yield service increasing by 0.56% and carbon storage service and habitat quality service decreasing by 0.16% and 0.14%,respectively.The ecological environment of Yan'an City developed in a balanced way between 2010 and 2018,and the four ecosystem services showed synergistic relationships,among which the synergistic relationships between soil conservation service and water yield service and between carbon storage service and habitat quality service were significant.The GCLC project had a negative impact on the ecosystem services of Yan'an City,and the impact on carbon storage service was more significant.This study provides a theoretical basis for the scientific evaluation of the ecological benefits of the GCLC project and the realization of a win-win situation between food security and ecological security.展开更多
The Aging Tsunami as it is often quoted to describe the worrying situations of rapidly aging in China has not met with detail planning in facilities upgrade and careful consideration in service models. Broad brushed c...The Aging Tsunami as it is often quoted to describe the worrying situations of rapidly aging in China has not met with detail planning in facilities upgrade and careful consideration in service models. Broad brushed central policies categorizes services into home care, community care and institutional care and set policy goals at 90-6-4, representing the percentage of older people in receiving respective care. This leaves local officials helpless on how these ideals can be actualized. Some cities have inclined to build huge older people homes and pour resources into institutional care, forgetting the need for older people to be connected with the society. This paper reviews the historical developments of older people services in Hong Kong and recommends an integrative model of social work services connecting institutional, community and home care into a seamless network. The city of Zhuhai will be presented as a perfect experimental city on how its existing facilities can be converted and developed according to the model. Survey on the situations of the 16 public older people homes will be used to illustrate the potentials of an integrative model.展开更多
Ecosystem services(ESs)refer to the continuous provisioning of ecosystem goods and services that benefit human beings.Over recent decades,rapid urbanization has exerted significant pressure on coastal ecosystems,resul...Ecosystem services(ESs)refer to the continuous provisioning of ecosystem goods and services that benefit human beings.Over recent decades,rapid urbanization has exerted significant pressure on coastal ecosystems,resulting in biodiversity and habitat loss,environmental pollution,and the depletion of natural resources.In response to these environmental challenges,the Sustainable Development Goals(SDGs)were proposed.Given the pressing need to address these issues,understanding the changes in ESs under the SDGs is crucial for formulating specific ecological strategies.In this study,we first analyzed land use and cover change in the Zhejiang coasts of China during 2000–2020.Then,we investigated the spatiotemporal configuration of ESs by integrating carbon storage(CS),soil retention(SR),habitat quality(HQ)and water yield(WY)using the Integrated Valuation of Ecosystem Services and Tradeoffs(InVEST)model.The driving mechanisms of ESs,which varied by space and time,were also explored using the Geo-detector method.The results revealed that,over the past two decades:1)the Zhejiang coasts have experienced a significant increase of 2783.72 km^(2) in built-up land areas and a continuous decrease in farmland areas due to rapid urbanization;2)owing to higher precipitation,extensive vegetation cover,and reduced anthropogenic disturbances,forests emerge as a crucial land use type for maintaining ecosystem services such as HQ,CS,WY,and SR;3)ESs have generally declined across the entire Zhejiang coasts,with a significant decrease observed in the northern areas and an increase in the southern areas spatially;4)the expansion of built-up land areas emerged as the primary factor affecting ecosystem services,while the vegetation factor has been increasingly significant and is expected to become predominant in the near future.Our study provides insights of understanding of ecosystem service theory and emphasizing the importance of preserving biodiversity for long-term sustainable development,and valuable scientific references to support the ecological management decision-making for local governments.展开更多
The identification of dominant driving factors for different ecosystem services(ESs)is crucial for ecological conservation and sustainable development.However,the spatial heterogeneity of the dominant driving factors ...The identification of dominant driving factors for different ecosystem services(ESs)is crucial for ecological conservation and sustainable development.However,the spatial heterogeneity of the dominant driving factors affecting various ESs has not been adequately elucidated,particularly in ecologically fragile regions.This study employed the integrated valuation of ESs and trade-offs(InVEST)model to evaluate four ESs,namely,water yield(WY),soil conservation(SC),habitat quality(HQ),and carbon storage(CS),and then to identify the dominant driving factors of spatiotemporal differentiation of ES and further to characterize the spatial heterogeneity characteristics of the dominant driving factors in the eco-fragile areas of the upper Yellow River,China from 2000 to 2020.The results demonstrated that WY exhibited northeast-high and northwest-low patterns in the upper Yellow River region,while high values of SC and CS were distributed in central forested areas and a high value of HQ was distributed in vast grassland areas.The CS,WY,and SC exhibited decreasing trends over time.The most critical factors affecting WY,SC,HQ,and CS were the actual evapotranspiration,precipitation,slope,and normalized difference vegetation index,respectively.In addition,the effects of different factors on various ESs exhibited spatial heterogeneity.These results could provide spatial decision support for eco-protection and rehabilitation in ecologically fragile areas.展开更多
Nature reserves play a significant role in providing ecosystem services and are key sites for biodiversity conservation.The Tianchi Bogda Peak Natural Reserve(TBPNR),located in Xinjiang Uygur Autonomous Region,China,i...Nature reserves play a significant role in providing ecosystem services and are key sites for biodiversity conservation.The Tianchi Bogda Peak Natural Reserve(TBPNR),located in Xinjiang Uygur Autonomous Region,China,is an important ecological barrier area in the temperate arid zone.The evaluation of its important ecosystem services is of great significance to improve the management level and ecological protection efficiency of the reserve.In the present study,we assessed the spatiotemporal variations of four ecosystem services(including net primary productivity(NPP),water yield,soil conservation,and habitat quality)in the TBPNR from 2000 to 2020 based on the environmental and social data using the Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)model.In addition,the coldspot and hotspot areas of ecosystem services were identified by hotspot analysis,and the trade-off and synergistic relationships between ecosystem services were analyzed using factor analysis in a geographic detector.During the study period,NPP and soil conservation values in the reserve increased by 48.20%and 25.56%,respectively;conversely,water yield decreased by 16.56%,and there was no significant change in habitat quality.Spatially,both NPP and habitat quality values were higher in the northern part and lower in the southern part,whereas water yield showed an opposite trend.Correlation analysis revealed that NPP showed a synergistic relationship with habitat quality and soil conservation,and exhibited a trade-off relationship with water yield.Water yield and habitat quality also had a trade-off relationship.NPP and habitat quality were affected by annual average temperature and Normalized Difference Vegetation Index(NDVI),respectively,while water yield and soil conservation were more affected by digital elevation model(DEM).Therefore,attention should be paid to the spatial distribution and dynamics of trade-off and synergistic relationships between ecosystem services in future ecological management.The findings of the present study provide a reference that could facilitate the sustainable utilization of ecosystem services in the typical fragile areas of Northwest China.展开更多
文摘In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the potential to positively influence mental health by providing monitoring,insights,and inter-ventions.However,they also come with challenges that need to be addressed.Understanding the primary purpose for which individuals use these smart tech-nologies is essential to tailoring them to specific mental health needs and prefe-rences.
基金Supported by National Natural Science Foundation of China,No.82174461Hospital Capability Enhancement Project of Xiyuan Hospital,CACMS,No.XYZX0201-22Technology Innovation Project of China Academy of Chinese Medical Sciences,No.CI2021A01811.
文摘BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.
文摘Via database technology, a perfect lightning protection integrated service work platform is established, thereby realizing paperless data management of routine business.
基金supported by the National Key Research and Development Program of China (No.2019YFB1803103)in part by the BUPT Excellent Ph.D. Students Foundation (No.CX2021113)。
文摘The space-air-ground integrated network(SAGIN) is regarded as the key approach to realize global coverage in future network and it reaches broad access for various services. Being the new paradigm of service, immersive media(IM) has attracted users’ attention for its virtualization, but it poses challenges to network performance, e.g. bandwidth, rate, latency. However, the SAGIN has limitations in supporting IM services, such as 4 K/8 K video, virtual reality, and interactive games. In this paper, a novel service customized SAGIN architecture for IM applications(SAG-IM) is proposed, which achieves content interactive and real-time communication among terminal users. State-of-the-art research is investigated in detail to facilitate the combination of SAGIN and service customized technology, which provides endto-end differentiated services for users. Besides, the functional components of SAG-IM contain the infrastructure layer, perception layer, intelligence layer, and application layer, reaching the capabilities of intelligent management of the network. Moreover, to provide IM content with ultra-high-definition and high frame rate for the optimal user experience, the promising key technologies on intelligent routing and delivery are discussed. The performance evaluation shows the superiority of SAG-IM in supporting IM service.Finally, the prospects in practical application are high-lighted.
基金supported by National Key Research and Development Program of China (No.2017YFB903304)the State Grid Science and Technology Program (Hybrid Simnlation Key Technology for Integrated Energy System and Platform Construction)
文摘An integrated energy service company in an industrial park or commercial building is responsible for managing all energy sources in their local region, including electricity, water, gas, heating, and cooling. To reduce energy wastage and increase energy utilization, it is necessary to perform efficiency analyses and diagnoses on integrated energy systems(IESs). However, the integrated energy data necessary for energy efficiency analyses and diagnoses come from a wide variety of instruments, each of which uses different transmission protocols and data formats. This makes it challenging to handle energy-flow data in a unified manner. Thus, we have constructed a unified model for diagnosing energy usage abnormalities in IESs. Using this model, the data are divided into working days and non-working days, and benchmark values are calculated after the data have been weighted to enable unified analysis of several types of energy data. The energy-flow data may then be observed, managed, and compared in all aspects to monitor sudden changes in energy usage and energy wastage. The abnormal data identified and selected by the unified model are then subjected to big-data analysis using technical management tools, enabling the detection of user problems such as abnormalities pertaining to acquisition device, metering, and energy usage. This model facilitates accurate metering of energy data and improves energy efficiency. The study has significant implications in terms of fulfilling the energy saving.
基金Project(40771175)supported by the National Natural Science Foundation of China
文摘Using enterprise GIS platform, spatial databases and modern information technology, building geo-spatial information service platform of digital mine which has the features of the data exchange service, enterprise GIS services, directory services, logging services, is key technology and application infrastructure for digital mine. Based on the support of geospatial information service platform of digital mine, the professional GIS application service adapter can be developed and the application supports related to mining application system can be realized. Using high-resolution satellite remote sensing data, the mine functional partition map and geographic grids can be divided, and the geographic grid parts, status and events of important features of the surface object were investigated and defined. The system architecture and technical characteristics of integrated spatial information service platform were analyzed firstly, which guarantee service ability of digital mine. The methods and applications of functional partition map for integrated management service platform were discussed which are the services scheme of digital mine. The application results indicated that digital mine upgrades and enhances the capability and range of mine surveying and mapping, and is of great significance for guarantee of efficient, green and intensive exploitation of mine.
基金funded by Tsinghua University-China Mobile Communications Group Co., Ltd. Joint Institute。
文摘The Service-based Architecture(SBA) is one of the key innovations of 5G architecture that leverage modularized, self-contained and independent services to provide flexible and cloud-native 5G network. In this paper, SBA for Space-Air-Ground Integrated Network(SAGIN) is investigated to enable the 5G integration deployment. This paper proposes a novel Holistic Service-based Architecture(H-SBA)for SAGIN of 5G-Advanced and beyond, i.e., 6G. The H-SBA introduces the concept of end-to-end servicebased architecture design. The "Network Function Service", introduced in 5G SBA, is extended from Control Plane to User Plane, from core network to access network. Based on H-SBA, the new generation of protocol design is proposed, which proposes to use IETF QUIC and SRv6 to substitute 5G HTTP/2.0 and GTP-U. Testing results show that new protocols can achieve low latency and high throughput, making them promising candidate for H-SBA.
文摘This methodological investigation deals with measurement and valuation of ecological service functions for urban green space. Social, economic and ecological dimensions for such types of function were analyzed and a concept “integrated ecological service functions” (IESF) was put forward for evaluation. Based upon this conceptual approach, an index system for measuring IESF for urban green space was established. With a methodological integration of fuzzy mathematics, decision making analysis and Delphi method, an AHP fuzzy evaluation techniques for IESF for urban green space, called AFIFUG method, was developed. Such a method has been directly applied to the land use strategic planning of Tianjin out ring green belt(TOGB), and its analysis results have been successfully put into operation.
文摘There is growing interest in the integrated sensing and communication(ISAC)to extend the 5G+/6G network capabilities by introducing sensing capability.While the solutions for mono-static or bi-static ISAC have shown feasibility and benefits based on existing 5G physical layer design,whether and how to coordinate multiple ISAC devices to better exert networking performance are rarely discussed.3 rd Partnership Project(3GPP)has initiated the ISAC use cases study,and the follow-up studies for network architecture could be anticipated.In this article,we focus on gNB-based sensing mode and propose ISAC functional framework with given of highlevel service procedures to enable cellular based ISAC services.In the proposed ISAC framework,three types of network functions for sensing service as Sensing Function(SF),lightweight-Edge Sensing Function(ESF)and full-version-ESF are designed with interaction with network nodes to fulfill the latency requirements of ISAC use cases.Finally,with simulation evaluations and hardware testbed results,we further verify the performance benefit and feasibility to enable ISAC in 5G for the gNB-based sensing mode with new design on SF and related signaling protocols.
基金the 2021 General Project of Liaoning Department of Education(LJKR0125)the 2021 General Project of National Natural Science Foundation of China(52178011)+1 种基金the 2021 Liaoning Provincial Social Science Planning Fund Project(L21BRK003)the 2023 Research Topic on the Economic and Social Development of Liaoning Province(2023lslybkt-076).
文摘With the gradual intensification of aging in China,the issue of elderly care has become the primary issue that needs to be urgently solved in society.The construction of a reasonable and scientific integrated medical and care service system can not only efficiently allocate medical resources and services,but also better meet the needs of the elderly.Due to the involvement of multiple disciplines such as architecture,sociology,psychology,and behavioral science in the construction of the system,as well as the restriction of various objective factors such as medical capacity,spatial scale,and operating costs,the government and elderly care institutions have always been unable to find the best solution for how to scientifically and reasonably construct an integrated medical and care service system.This paper is based on Anshan City,Liaoning Province,which has prominent aging issues and distinct characteristics of the elderly population.Through extensive field research in elderly care institutions,and face-to-face communication with personnel from relevant government departments such as the Municipal Commission on Aging,the Civil Affairs Bureau,the Health Commission,the Medical Insurance Bureau,and the Human Resources and Social Security Bureau,it truly understands the problems that arise in the construction of the urban integrated medical and care service system.From three aspects:urban situation,institutional situation and the needs of the elderly,it is proposed to establish a clear departmental linkage mechanism with clear rights and responsibilities,a policy guarantee mechanism tailored to local conditions,a multi-measure operation mechanism,a technology first intelligent response mechanism,a warm and efficient service mechanism for the people,an overall layout mechanism,an evaluation and supervision mechanism for full process control,and a talent supply mechanism of external introduction and internal training.It aims to provide reference for the construction of an integrated medical and care service system in similar cities.
文摘Globally, there are approximately 36.7 million people living with HIV. Integration of HIV treatment with primary care services improves effectiveness, efficiency and equity in service delivery. The study sought to establish service delivery factors that influenced utilization of integrated HIV and primary health care services in Embu Teaching and Referral hospital. A descriptive cross-sectional survey design was used to collect data at a specific period and point of time from a sample of 302 seropositive clients who were selected using simple random method. Data collection tool was structured and semi-structured questionnaire. The tool was reliable at Cronbach’s alpha of 0.817. SPSS version 23 was used to analyze the data. A binary logistic regression model was used to predict the relationship between service delivery and utilization of integrated services. Results: Majority of the respondents (59.6%) were aged over 35 years with majority being female (58.9%) and the married were 57.6% of the total sample. On service delivery factors, majority (94.7%) felt that their health status had improved. Action taken when clients developed side effects, 78.8% reported that the drugs were changed. Action taken following drug side effects significantly affected utilization, χ2 = 1.305, p = 0.001, df = 1. The findings showed that waiting time significantly influenced utilization, χ2 = 9.284, df = 1, p = 0.002. Source of information on self care also significantly influenced utilization, χ2 = 10.689, df = 1, p = 0.001. Kind of treatment at the facility also significantly influenced utilization, χ2 = 5.713, p = 0.048. Conclusion: significant factors that influenced utilization of integrated services were source of health care information, secondly waiting time was another factor which influenced utilization. Majority of the respondents were satisfied with duration of time they take before they were served;they reported to take utmost 1 hour to be attended to and action taken by health care provider following side effects was another factor that influenced the utilization.
文摘With the constructions of "intelligence city", intelligent life quietly came to the people. As the "cell" of the city, the construction of intelligence community arises. Resident service system and e-government application system have been used in the traditional information community, but these systems are independent of each other, lack of interconnectedness, which results in the phenomenon of information isolated island. Intelligence community integrated information service platform can integrate information service resources and provide residents with efficient and convenient life. From the meaning, operation mode, we can design the cooperative, open and extensible system architecture.
基金This work is financially supported by the National Natural Science Foundation of China(52303036)the Natural Science Foundation of Guangxi Province(2020GXNSFAA297028)+4 种基金the Guangxi Science and Technology Base and Talent Special Project(GUIKE AD23026179)the International Science&Technology Cooperation Project of Chengdu(2021-GH03-00009-HZ)the Program of Innovative Research Team for Young Scientists of Sichuan Province(22CXTD0019)the Natural Science Foundation of Sichuan Province(2023NSFSC0986)the Opening Project of State Key Laboratory of Polymer Materials Engineering(Sichuan University)(Sklpme2023-3-18).
文摘Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics.
基金This project was supported by National Natural Science Foundation of China (69972015) Guangdong Provincial NationalScience Foundation (31391) .
文摘Because of no strict expression of calculating call blocking probability (CBP) in the solution procedure of virtual-path bandwidth allocation problem, the process of calculating bandwidth through CBP and traffic load adopts the iteration algorithm in common, which is an inverse process of calculating CBP through traffic load and bandwidth. It limits computing speed by a long way because of including recursion. An approximate algorithm of bandwidth is presented. We compare the performance of this algorithm with that of another classical algorithm and conclude that the former makes a great increase in speed with little error about 2 %.
文摘This paper takes the public services in the grassroots community of Dongguan as the object of study and studies the integrated construction of the public service platform in grassroots communities with the thinking principle of resources integration so as to set up a service platform integrating electronization, informatization and networking, ensure the convenience of public services and provide high-quality community public services for the community residents.
基金supported by the Innovation Capability Support Program of Shaanxi Province,China(2023-CX-RKX-102)the Key Research and Development Program of Shaanxi Province,China(2022FP-34)+1 种基金the Open Foundation of the Key Laboratory of Natural Resource Coupling Process and Effects(2023KFKTB008)the Open Fund of Shaanxi Key Laboratory of Land Consolidation,China(300102352502).
文摘Studying the spatiotemporal variations in ecosystem services and their interrelationships on the Loess Plateau against the background of the gully control and land consolidation(GCLC)project has significant implications for ecological protection and quality development of the Yellow River Basin.Therefore,in this study,we took Yan'an City,Shaanxi Province of China,as the study area,selected four typical ecosystem services,including soil conservation service,water yield service,carbon storage service,and habitat quality service,and quantitatively evaluated the spatiotemporal variation characteristics and trade-offs and synergies of ecosystem services from 2010 to 2018 using the Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)model.We also analysed the relationship between the GCLC project and regional ecosystem service changes in various regions(including 1 city,2 districts,and 10 counties)of Yan'an City and proposed a coordinated development strategy between the GCLC project and the ecological environment.The results showed that,from 2010 to 2018,soil conservation service decreased by 7.76%,while the other three ecosystem services changed relatively little,with water yield service increasing by 0.56% and carbon storage service and habitat quality service decreasing by 0.16% and 0.14%,respectively.The ecological environment of Yan'an City developed in a balanced way between 2010 and 2018,and the four ecosystem services showed synergistic relationships,among which the synergistic relationships between soil conservation service and water yield service and between carbon storage service and habitat quality service were significant.The GCLC project had a negative impact on the ecosystem services of Yan'an City,and the impact on carbon storage service was more significant.This study provides a theoretical basis for the scientific evaluation of the ecological benefits of the GCLC project and the realization of a win-win situation between food security and ecological security.
文摘The Aging Tsunami as it is often quoted to describe the worrying situations of rapidly aging in China has not met with detail planning in facilities upgrade and careful consideration in service models. Broad brushed central policies categorizes services into home care, community care and institutional care and set policy goals at 90-6-4, representing the percentage of older people in receiving respective care. This leaves local officials helpless on how these ideals can be actualized. Some cities have inclined to build huge older people homes and pour resources into institutional care, forgetting the need for older people to be connected with the society. This paper reviews the historical developments of older people services in Hong Kong and recommends an integrative model of social work services connecting institutional, community and home care into a seamless network. The city of Zhuhai will be presented as a perfect experimental city on how its existing facilities can be converted and developed according to the model. Survey on the situations of the 16 public older people homes will be used to illustrate the potentials of an integrative model.
基金Under the auspices of the National Natural Science Fundation (No.41901121,42276234)Open Funding of Zhejiang Collaborative Innovation Center for Land and Marine Spatial Utilization and Governance Research (No.LHGTXT-2024-004)+1 种基金Science and Technology Major Project of Ningbo (No.2022Z181)Key Laboratory of Coastal Zone Exploitation and Protection,Ministry of Natural Resources (No.2023CZEPK04)。
文摘Ecosystem services(ESs)refer to the continuous provisioning of ecosystem goods and services that benefit human beings.Over recent decades,rapid urbanization has exerted significant pressure on coastal ecosystems,resulting in biodiversity and habitat loss,environmental pollution,and the depletion of natural resources.In response to these environmental challenges,the Sustainable Development Goals(SDGs)were proposed.Given the pressing need to address these issues,understanding the changes in ESs under the SDGs is crucial for formulating specific ecological strategies.In this study,we first analyzed land use and cover change in the Zhejiang coasts of China during 2000–2020.Then,we investigated the spatiotemporal configuration of ESs by integrating carbon storage(CS),soil retention(SR),habitat quality(HQ)and water yield(WY)using the Integrated Valuation of Ecosystem Services and Tradeoffs(InVEST)model.The driving mechanisms of ESs,which varied by space and time,were also explored using the Geo-detector method.The results revealed that,over the past two decades:1)the Zhejiang coasts have experienced a significant increase of 2783.72 km^(2) in built-up land areas and a continuous decrease in farmland areas due to rapid urbanization;2)owing to higher precipitation,extensive vegetation cover,and reduced anthropogenic disturbances,forests emerge as a crucial land use type for maintaining ecosystem services such as HQ,CS,WY,and SR;3)ESs have generally declined across the entire Zhejiang coasts,with a significant decrease observed in the northern areas and an increase in the southern areas spatially;4)the expansion of built-up land areas emerged as the primary factor affecting ecosystem services,while the vegetation factor has been increasingly significant and is expected to become predominant in the near future.Our study provides insights of understanding of ecosystem service theory and emphasizing the importance of preserving biodiversity for long-term sustainable development,and valuable scientific references to support the ecological management decision-making for local governments.
基金Under the auspices of National Natural Science Foundation of China (No.41977402,41977194)。
文摘The identification of dominant driving factors for different ecosystem services(ESs)is crucial for ecological conservation and sustainable development.However,the spatial heterogeneity of the dominant driving factors affecting various ESs has not been adequately elucidated,particularly in ecologically fragile regions.This study employed the integrated valuation of ESs and trade-offs(InVEST)model to evaluate four ESs,namely,water yield(WY),soil conservation(SC),habitat quality(HQ),and carbon storage(CS),and then to identify the dominant driving factors of spatiotemporal differentiation of ES and further to characterize the spatial heterogeneity characteristics of the dominant driving factors in the eco-fragile areas of the upper Yellow River,China from 2000 to 2020.The results demonstrated that WY exhibited northeast-high and northwest-low patterns in the upper Yellow River region,while high values of SC and CS were distributed in central forested areas and a high value of HQ was distributed in vast grassland areas.The CS,WY,and SC exhibited decreasing trends over time.The most critical factors affecting WY,SC,HQ,and CS were the actual evapotranspiration,precipitation,slope,and normalized difference vegetation index,respectively.In addition,the effects of different factors on various ESs exhibited spatial heterogeneity.These results could provide spatial decision support for eco-protection and rehabilitation in ecologically fragile areas.
基金This research was funded by the Key Laboratory for Sustainable Development of Xinjiang's Historical and Cultural Tourism,Xinjiang University,China(LY2022-06)the Tianchi Talent Project.
文摘Nature reserves play a significant role in providing ecosystem services and are key sites for biodiversity conservation.The Tianchi Bogda Peak Natural Reserve(TBPNR),located in Xinjiang Uygur Autonomous Region,China,is an important ecological barrier area in the temperate arid zone.The evaluation of its important ecosystem services is of great significance to improve the management level and ecological protection efficiency of the reserve.In the present study,we assessed the spatiotemporal variations of four ecosystem services(including net primary productivity(NPP),water yield,soil conservation,and habitat quality)in the TBPNR from 2000 to 2020 based on the environmental and social data using the Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)model.In addition,the coldspot and hotspot areas of ecosystem services were identified by hotspot analysis,and the trade-off and synergistic relationships between ecosystem services were analyzed using factor analysis in a geographic detector.During the study period,NPP and soil conservation values in the reserve increased by 48.20%and 25.56%,respectively;conversely,water yield decreased by 16.56%,and there was no significant change in habitat quality.Spatially,both NPP and habitat quality values were higher in the northern part and lower in the southern part,whereas water yield showed an opposite trend.Correlation analysis revealed that NPP showed a synergistic relationship with habitat quality and soil conservation,and exhibited a trade-off relationship with water yield.Water yield and habitat quality also had a trade-off relationship.NPP and habitat quality were affected by annual average temperature and Normalized Difference Vegetation Index(NDVI),respectively,while water yield and soil conservation were more affected by digital elevation model(DEM).Therefore,attention should be paid to the spatial distribution and dynamics of trade-off and synergistic relationships between ecosystem services in future ecological management.The findings of the present study provide a reference that could facilitate the sustainable utilization of ecosystem services in the typical fragile areas of Northwest China.