As the complexity of autonomous vehicles(AVs)continues to increase and artificial intelligence algorithms are becoming increasingly ubiquitous,a novel safety concern known as the safety of the intended functionality(S...As the complexity of autonomous vehicles(AVs)continues to increase and artificial intelligence algorithms are becoming increasingly ubiquitous,a novel safety concern known as the safety of the intended functionality(SOTIF)has emerged,presenting significant challenges to the widespread deployment of AVs.SOTIF focuses on issues arising from the functional insufficiencies of the AVs’intended functionality or its implementation,apart from conventional safety considerations.From the systems engineering standpoint,this study offers a comprehensive exploration of the SOTIF landscape by reviewing academic research,practical activities,challenges,and perspectives across the development,verification,validation,and operation phases.Academic research encompasses system-level SOTIF studies and algorithm-related SOTIF issues and solutions.Moreover,it encapsulates practical SOTIF activities undertaken by corporations,government entities,and academic institutions spanning international and Chinese contexts,focusing on the overarching methodologies and practices in different phases.Finally,the paper presents future challenges and outlook pertaining to the development,verification,validation,and operation phases,motivating stakeholders to address the remaining obstacles and challenges.展开更多
The method of extracting and describing the intended behavior of software precisely has become one of the key points in the fields of software behavior's dynamic and trusted authentication. In this paper, the author ...The method of extracting and describing the intended behavior of software precisely has become one of the key points in the fields of software behavior's dynamic and trusted authentication. In this paper, the author proposes a specified measure of extracting SIBDS (software intended behaviors describing sets) statically from the binary executable using the software's API functions invoking, and also introduces the definition of the structure used to store the SIBDS in detail. Experimental results demonstrate that the extracting method and the storage structure definition offers three strong properties: (i) it can describe the software's intended behavior accurately; (ii) it demands a small storage expense; (iii) it provides strong capability to defend against mimicry attack.展开更多
This study aimed to investigate various regimens of antihypertensive agents for different groups of patients and the outcomes in the real world. We retrospectively collected 974 prescriptions for hypertension from thr...This study aimed to investigate various regimens of antihypertensive agents for different groups of patients and the outcomes in the real world. We retrospectively collected 974 prescriptions for hypertension from three hospitals in Beijing, along with medical records of 219 hypertensive patients from one of the hospitals to study the regimens and their effects on patients. The antihypertensive regimens were classified by different combinations of subclasses of antihypertensive agents. Nearly all prescriptions can be classified into 11 different antihypertensive regimens, and most of them are combination therapy. Grade III hypertension patients significantly (P〈0.001) tend to be treated with regimens containing calcium channel blocker (CCB) and RAAS inhibitors, angiotensin II receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI). β-Blockers are more likely to be combined with CCB than with other categories of antihypertensive agents. Hydrochlorothiazide is less widely used than recommended.展开更多
Intelligent and connected vehicles(ICVs)are confronted with critically complex traffic scenarios and safety challenges that have attracted increasing attention from academia and industry.The intelligent safety of ICVs...Intelligent and connected vehicles(ICVs)are confronted with critically complex traffic scenarios and safety challenges that have attracted increasing attention from academia and industry.The intelligent safety of ICVs involves several technologies and requires the common efforts of researchers and engineers,including the safety of the intended functionality(SOTIF),the safety of artificial intelligence,the intricacies of cybersecurity,and ethical dilemmas.Ensuring the intelligent safety of ICVs presents substantial chal-lenges in both research and commercialization,particularly SOTIF,which refers to the absence of unreasonable risk owing to hazards resulting from functional insufficiencies of the intended functiona-lity or reasonably foreseeable misuse by person.Because of the limited scene coverage ability of training samples and the practical application conditions without boundary restrictions,it is very dif-ficult to find the functional insufficiency of the intended function-ality and overcome it under dynamic unknown scenarios,which is also the source of SOTIF.展开更多
The recent Conference of the Parties of the United Nations Framework Convention on Climate Change has resulted in the submission of the Intended Nationally Determined Contributions (INDCs) of 190 countries. This study...The recent Conference of the Parties of the United Nations Framework Convention on Climate Change has resulted in the submission of the Intended Nationally Determined Contributions (INDCs) of 190 countries. This study aims to provide an analysis of the ambitiousness and fairness of the mitigation components of the INDCs submitted by various parties. We use a unified framework to assess 23 INDCs that cover 50 countries, including European Union (EU)-28 countries as parties to the Convention, which represent 87.45% of the global greenhouse gas emissions in 2012. First, we transform initial INDC files into reported reduction targets. Second, we create four schemes and six scenarios to determine the required reduction effort, which considers each nation's reduction responsibility, capacity, and potential, thereby reflecting their historical and current development status. Finally, we combine the reported reduction target and the required reduction effort to assess INDCs. Evaluation results of the 23 emitters indicate that 2 emitters (i.e., EU and Brazil) are rated as "sufficient," 7 emitters (e.g., China, the United States, and Canada) are rated as "moderate," and 14 emitters (e.g., India, Russia, and Japan) are rated as "insufficient." Most pledges exhibit a considerable distance from representing a fair contribution.展开更多
1.Misinformation,disinformation,and malinformation(MDM)about depression This editorial article aims to address the hidden dangers of self-diagnosed depression,especially among young people,which has been exacerbated b...1.Misinformation,disinformation,and malinformation(MDM)about depression This editorial article aims to address the hidden dangers of self-diagnosed depression,especially among young people,which has been exacerbated by massive media coverage of depression risks during the COVID-19 pandemic.While misinformation and disinformation both refer to the distribution of inaccurate information,misinformation is not intended to cause harm while disinformation is.Meanwhile,malinformation is true information that is intended to cause harm.For example,it is common for companies to spread both disinformation and malinformation about depression to promote the sales of their products,such as books and therapies.展开更多
My childhood and adolescence1were a joyous outpouring2 of energy,a ceaseless3 quest for expression,skill,and experience.School was only a background to the supreme delight of lessons in music,dance,and dramatics,and t...My childhood and adolescence1were a joyous outpouring2 of energy,a ceaseless3 quest for expression,skill,and experience.School was only a background to the supreme delight of lessons in music,dance,and dramatics,and the thrill of sojourns4 in the country,theaters,and concerts.And books,展开更多
The dictum of Hippocrates“Let thy food be thy medicine and medicine be thy food”is potentially both more accurate and more dangerous than ever before.This dictum can only be realistically applied if all foods are kn...The dictum of Hippocrates“Let thy food be thy medicine and medicine be thy food”is potentially both more accurate and more dangerous than ever before.This dictum can only be realistically applied if all foods are known to be safe.Nowadays foods are being produced,which are processed in a variety of ways with ingredients sourced from many different countries and processed in a variety of ways.This processing may include the addition of supplements which are intended to improve health and of adulterants which are potentially harmful.Additionally,foods may be contaminated with pesticides and other materials encountered during production and processing.Thus there is a need to identify“unsafe”foods.The question may be better put as:Which foods are safe?展开更多
Research indicates that high levels of sedentary behavior(sitting or lying with low energy expenditure) are adversely associated with health. A key factor in improving our understanding of the impact of sedentary beha...Research indicates that high levels of sedentary behavior(sitting or lying with low energy expenditure) are adversely associated with health. A key factor in improving our understanding of the impact of sedentary behavior(and patterns of sedentary time accumulation) on health is the use of objective measurement tools that collect date and time-stamped activity information. One such tool is the activP AL monitor. This thigh-worn device uses accelerometer-derived information about thigh position to determine the start and end of each period spent sitting/lying, standing, and stepping, as well as stepping speed, step counts, and postural transitions. The activP AL is increasingly being used within field-based research for its ability to measure sitting/lying via posture. We summarise key issues to consider when using the activP AL in physical activity and sedentary behavior field-based research with adult populations. It is intended that the findings and discussion points be informative for researchers who are currently using activP AL monitors or are intending to use them. Pre-data collection decisions, monitor preparation and distribution, data collection considerations, and manual and automated data processing possibilities are presented using examples from current literature and experiences from 2 research groups from the UK and Australia.展开更多
During the Fifth International Conference onEnvironmental Mutagens which was held in Cleveland,Ohio,USA on July 10-15,1989,the idea of organizing anInternational Symposium on Environmental Mutagenesisand Carcinogenesi...During the Fifth International Conference onEnvironmental Mutagens which was held in Cleveland,Ohio,USA on July 10-15,1989,the idea of organizing anInternational Symposium on Environmental Mutagenesisand Carcinogenesis in China was conceived.The ChineseEnvironmental Mutagen Society and the Institute of Genet-ics of Fudan University accepted the responsibility.展开更多
In English,especially in oral English,there are a large number of verb+particle combinations for us to account for.Among these combinations,many are idiomatic ones,of which the meanings cannot be easily figured out by...In English,especially in oral English,there are a large number of verb+particle combinations for us to account for.Among these combinations,many are idiomatic ones,of which the meanings cannot be easily figured out by simply adding the literal meaning of the verb to that of the particle.Therefore,even quite advanced EFL(English as a Foreign Language)learners get confused from time to time when trying to catch what such combinations are intended to mean.Studied from either the semantic or the syntactic point of view,such combinations show certain linguistic features which are quite different from the assumptions of the EFL learners and therefore worth our efforts to analyze.This paper is supposed to offer a tentative analysis of such combinations,in hope of enhancing EFL learners’mastery of them,practically as well as theoretically.展开更多
The Acta Seismologica Sinica (ASS) is a comprehensive journal concerned with the study of scientific problems of seismology published by the Seismological Society of China. Its Editor-in-Chief is Academician CHEN Yun-...The Acta Seismologica Sinica (ASS) is a comprehensive journal concerned with the study of scientific problems of seismology published by the Seismological Society of China. Its Editor-in-Chief is Academician CHEN Yun-tai of the展开更多
基金supported by the National Science Foundation of China Project(52072215,U1964203,52242213,and 52221005)National Key Research and Development(R&D)Program of China(2022YFB2503003)State Key Laboratory of Intelligent Green Vehicle and Mobility。
文摘As the complexity of autonomous vehicles(AVs)continues to increase and artificial intelligence algorithms are becoming increasingly ubiquitous,a novel safety concern known as the safety of the intended functionality(SOTIF)has emerged,presenting significant challenges to the widespread deployment of AVs.SOTIF focuses on issues arising from the functional insufficiencies of the AVs’intended functionality or its implementation,apart from conventional safety considerations.From the systems engineering standpoint,this study offers a comprehensive exploration of the SOTIF landscape by reviewing academic research,practical activities,challenges,and perspectives across the development,verification,validation,and operation phases.Academic research encompasses system-level SOTIF studies and algorithm-related SOTIF issues and solutions.Moreover,it encapsulates practical SOTIF activities undertaken by corporations,government entities,and academic institutions spanning international and Chinese contexts,focusing on the overarching methodologies and practices in different phases.Finally,the paper presents future challenges and outlook pertaining to the development,verification,validation,and operation phases,motivating stakeholders to address the remaining obstacles and challenges.
基金the National Natural Science Foundation of China (60673071, 60743003, 90718005, 90718006)the National High Technology Research and Development Program of China (863 Program) (2006AA01Z442, 2007AA01Z411)
文摘The method of extracting and describing the intended behavior of software precisely has become one of the key points in the fields of software behavior's dynamic and trusted authentication. In this paper, the author proposes a specified measure of extracting SIBDS (software intended behaviors describing sets) statically from the binary executable using the software's API functions invoking, and also introduces the definition of the structure used to store the SIBDS in detail. Experimental results demonstrate that the extracting method and the storage structure definition offers three strong properties: (i) it can describe the software's intended behavior accurately; (ii) it demands a small storage expense; (iii) it provides strong capability to defend against mimicry attack.
文摘This study aimed to investigate various regimens of antihypertensive agents for different groups of patients and the outcomes in the real world. We retrospectively collected 974 prescriptions for hypertension from three hospitals in Beijing, along with medical records of 219 hypertensive patients from one of the hospitals to study the regimens and their effects on patients. The antihypertensive regimens were classified by different combinations of subclasses of antihypertensive agents. Nearly all prescriptions can be classified into 11 different antihypertensive regimens, and most of them are combination therapy. Grade III hypertension patients significantly (P〈0.001) tend to be treated with regimens containing calcium channel blocker (CCB) and RAAS inhibitors, angiotensin II receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI). β-Blockers are more likely to be combined with CCB than with other categories of antihypertensive agents. Hydrochlorothiazide is less widely used than recommended.
文摘Intelligent and connected vehicles(ICVs)are confronted with critically complex traffic scenarios and safety challenges that have attracted increasing attention from academia and industry.The intelligent safety of ICVs involves several technologies and requires the common efforts of researchers and engineers,including the safety of the intended functionality(SOTIF),the safety of artificial intelligence,the intricacies of cybersecurity,and ethical dilemmas.Ensuring the intelligent safety of ICVs presents substantial chal-lenges in both research and commercialization,particularly SOTIF,which refers to the absence of unreasonable risk owing to hazards resulting from functional insufficiencies of the intended functiona-lity or reasonably foreseeable misuse by person.Because of the limited scene coverage ability of training samples and the practical application conditions without boundary restrictions,it is very dif-ficult to find the functional insufficiency of the intended function-ality and overcome it under dynamic unknown scenarios,which is also the source of SOTIF.
文摘The recent Conference of the Parties of the United Nations Framework Convention on Climate Change has resulted in the submission of the Intended Nationally Determined Contributions (INDCs) of 190 countries. This study aims to provide an analysis of the ambitiousness and fairness of the mitigation components of the INDCs submitted by various parties. We use a unified framework to assess 23 INDCs that cover 50 countries, including European Union (EU)-28 countries as parties to the Convention, which represent 87.45% of the global greenhouse gas emissions in 2012. First, we transform initial INDC files into reported reduction targets. Second, we create four schemes and six scenarios to determine the required reduction effort, which considers each nation's reduction responsibility, capacity, and potential, thereby reflecting their historical and current development status. Finally, we combine the reported reduction target and the required reduction effort to assess INDCs. Evaluation results of the 23 emitters indicate that 2 emitters (i.e., EU and Brazil) are rated as "sufficient," 7 emitters (e.g., China, the United States, and Canada) are rated as "moderate," and 14 emitters (e.g., India, Russia, and Japan) are rated as "insufficient." Most pledges exhibit a considerable distance from representing a fair contribution.
文摘1.Misinformation,disinformation,and malinformation(MDM)about depression This editorial article aims to address the hidden dangers of self-diagnosed depression,especially among young people,which has been exacerbated by massive media coverage of depression risks during the COVID-19 pandemic.While misinformation and disinformation both refer to the distribution of inaccurate information,misinformation is not intended to cause harm while disinformation is.Meanwhile,malinformation is true information that is intended to cause harm.For example,it is common for companies to spread both disinformation and malinformation about depression to promote the sales of their products,such as books and therapies.
文摘My childhood and adolescence1were a joyous outpouring2 of energy,a ceaseless3 quest for expression,skill,and experience.School was only a background to the supreme delight of lessons in music,dance,and dramatics,and the thrill of sojourns4 in the country,theaters,and concerts.And books,
文摘The dictum of Hippocrates“Let thy food be thy medicine and medicine be thy food”is potentially both more accurate and more dangerous than ever before.This dictum can only be realistically applied if all foods are known to be safe.Nowadays foods are being produced,which are processed in a variety of ways with ingredients sourced from many different countries and processed in a variety of ways.This processing may include the addition of supplements which are intended to improve health and of adulterants which are potentially harmful.Additionally,foods may be contaminated with pesticides and other materials encountered during production and processing.Thus there is a need to identify“unsafe”foods.The question may be better put as:Which foods are safe?
基金supported by the National Institute for Health Researsch (NIHR) DietLifestyle & Physical Activity Biomedical Research Unit based at University Hospitals of Leicester and Loughborough University+5 种基金the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care-East Midlands (NIHR CLAHRC- EM)the Leicester Clinical Trials Unitsupported by a National Health and Medical Research Council (NHMRC) Centre for Research Excellence Grant on Sitting Time and Chronic Disease Prevention-Measurement, Mechanisms and Interventions (APP1057608)supported by a Heart Foundation Postdoctoral (PH 12B 7054)NHMRC Career Development (#1086029) Fellowshipsupported by an Australian Research Council Future Fellowship (FTE 100100918)
文摘Research indicates that high levels of sedentary behavior(sitting or lying with low energy expenditure) are adversely associated with health. A key factor in improving our understanding of the impact of sedentary behavior(and patterns of sedentary time accumulation) on health is the use of objective measurement tools that collect date and time-stamped activity information. One such tool is the activP AL monitor. This thigh-worn device uses accelerometer-derived information about thigh position to determine the start and end of each period spent sitting/lying, standing, and stepping, as well as stepping speed, step counts, and postural transitions. The activP AL is increasingly being used within field-based research for its ability to measure sitting/lying via posture. We summarise key issues to consider when using the activP AL in physical activity and sedentary behavior field-based research with adult populations. It is intended that the findings and discussion points be informative for researchers who are currently using activP AL monitors or are intending to use them. Pre-data collection decisions, monitor preparation and distribution, data collection considerations, and manual and automated data processing possibilities are presented using examples from current literature and experiences from 2 research groups from the UK and Australia.
文摘During the Fifth International Conference onEnvironmental Mutagens which was held in Cleveland,Ohio,USA on July 10-15,1989,the idea of organizing anInternational Symposium on Environmental Mutagenesisand Carcinogenesis in China was conceived.The ChineseEnvironmental Mutagen Society and the Institute of Genet-ics of Fudan University accepted the responsibility.
文摘In English,especially in oral English,there are a large number of verb+particle combinations for us to account for.Among these combinations,many are idiomatic ones,of which the meanings cannot be easily figured out by simply adding the literal meaning of the verb to that of the particle.Therefore,even quite advanced EFL(English as a Foreign Language)learners get confused from time to time when trying to catch what such combinations are intended to mean.Studied from either the semantic or the syntactic point of view,such combinations show certain linguistic features which are quite different from the assumptions of the EFL learners and therefore worth our efforts to analyze.This paper is supposed to offer a tentative analysis of such combinations,in hope of enhancing EFL learners’mastery of them,practically as well as theoretically.
文摘The Acta Seismologica Sinica (ASS) is a comprehensive journal concerned with the study of scientific problems of seismology published by the Seismological Society of China. Its Editor-in-Chief is Academician CHEN Yun-tai of the