Objective:The inter-α-trypsin inhibitor heavy chain 4(ITIH4)protein is involved in the development of tumors.However,the relationship between ITIH4 and ovarian cancer(OC)has not been extensively examined.This study a...Objective:The inter-α-trypsin inhibitor heavy chain 4(ITIH4)protein is involved in the development of tumors.However,the relationship between ITIH4 and ovarian cancer(OC)has not been extensively examined.This study aimed to explore the effect of ITIH4 on OC and to identify its underlying mechanism.Methods:Expressions of ITIH4 in OC tissues and cells were determined using quantitative reverse transcription polymerase chain reaction(RT-qPCR)and western blots.The function of ITIH4 in the OC cell line HO8910 pm was tested via ITIH4 knockdown.The cell growth rate was measured using MTT and colony formation assays.Flow cytometry was performed to evaluate cell cycle progression.Cell migration and invasion abilities were observed using the transwell migration assay.Results:ITIH4 was downregulated in OC tissues and cells.ITIH4 knockdown promoted cell growth and cell cycle progression.Consistent with these results,inhibition of ITIH4 in OC cells significantly increased cell migration and invasion abilities.Cox regression analysis suggests that ITIH4 expression alone is not a good predictor of the prognosis of malignant ovarian tumors in patients.Conclusions:ITIH4 inhibits the progression of OC,suggesting that ITIH4 may be a useful biomarker for OC.This study may provide a potential novel target for the treatment of OC.展开更多
Ocean is home town of wind and rain, treasury of resources. To exploit and use ocean will make great contribution to people’s existence and development. China is a great oceanic country with pre cinct sea area of 3,0...Ocean is home town of wind and rain, treasury of resources. To exploit and use ocean will make great contribution to people’s existence and development. China is a great oceanic country with pre cinct sea area of 3,000,000 km2. The eastern coastal region with only 60 km width, 15 % area and 40% of population of China, has created about 60% of GDP and has become the most developed region. But marine disaster in China is frequent and serious. From statistical data, economy loss made by surge, billow, sea ice, tsunami, red tide, oil spill, coast erosion, bay deposit, sea water intrusion, sea level rise, land salinization, sea water pollution, etc. increase quickly. Economy loss per year is one billion in the l980s, 10 billion in the l990s, exceeded 20 billion in 1996, and 30 billion in 1997. About 80% of it happened in the coastal area. So, marine disaster at present has become obstacle of society progress and economy development in coastal area. To mitigate marine disaster has become need for the economy development, also important task of the integrated coastal zone management. In this article, we briefly introduce countermeasures for marine disaster prevention, coastal zone management, and achievements made in the past 50 years, its problems now confronted, and the main countermeasures in the 21St century.展开更多
Layered double hydroxides(LDH)frameworks have shown significant enhancement in stability and reusability,and their tailorable architecture brings new insight into the development of the next generation of hybrid mater...Layered double hydroxides(LDH)frameworks have shown significant enhancement in stability and reusability,and their tailorable architecture brings new insight into the development of the next generation of hybrid materials,which attracted considerable attention in many fields over the years.One of the factors contributing to the widespread applicability of layered double hydroxides is their adaptable composition,which can accommodate a wide spectrum of potential anionic guests.This exceptional property makes the LDH system simple to adjust for various applications.However,most LDH systems are synthesized in situ in an autoclave at high temperatures and pressures that severely restrict the industrial use of such coating systems.In this study,LDH was directly synthesized on a magnesium alloy that had undergone plasma electrolytic oxidation(PEO)treatment in the presence of ethylenediaminetetraacetic acid,thereby avoiding the use of hydrothermal autoclave conditions.This LDH system was compared with a hybrid architecture consisting of organic-inorganic self-assembly.An organic layer was fabricated on top of the LDH film using 4-Aminophenol(Aph)compound,resulting in a smart hierarchical structure that can provide a robust Aph@LDH film with excellent anti-corrosion performance.At the molecular level,the conjugation characteristics and adsorption mechanism of Aph molecule were studied using two levels of theory as follows.First,Localized orbit locator(LOL)-πisosurface,electrostatic potential(ESP)distribution,and average local ionization energy(ALIE)on the molecular surface were used to highlight localization region,reveal the favorable electrophilic and nucleophilic attacks,and clearly explore the type of interactions that occurred around interesting regions.Second,first-principles based on density functional theory(DFT)was applied to study the hybrid mechanism of Aph on LDH system and elucidate their mutual interactions.The experimental and computational analyses suggest that the highπ-electron density and delocalization characteristics of the functional groups and benzene ring in the Aph molecule played a leading role in the synergistic effects arising from the combination of organic and inorganic coatings.This work provides a promising approach to design advanced hybrid materials with exceptional electrochemical performance.展开更多
目的总结血液肿瘤患者PICC相关并发症预防的最佳证据,为临床实践提供参考。方法系统检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、医脉通、美国国立指南库、英国国家卫生与临床优化研究所网站、乔安娜布里格斯研究所...目的总结血液肿瘤患者PICC相关并发症预防的最佳证据,为临床实践提供参考。方法系统检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、医脉通、美国国立指南库、英国国家卫生与临床优化研究所网站、乔安娜布里格斯研究所(JBI)数据库、国际指南协作网、苏格兰校际指南网站、WHO网站、BMJ、Up To Date、Embase、PubMed、Web of Science、Cochrane Library关于血液科肿瘤患者PICC并发症预防的相关文献,检索时间为建库至2022年6月30日,对符合纳入排除标准的文献进行质量评价、证据分级及整合。结果最终纳入11篇文献,其中指南3篇、系统评价3篇、干预性研究2篇、专家共识3篇,总结出包括PICC评估与管理、置管前预防、置管中预防、置管后预防和健康教育5个方面的31条证据。结论本研究总结的血液肿瘤患者PICC相关并发症预防的最佳证据具有良好的科学性和系统性,可为提高患者治疗效果、减轻其经济负担提供循证依据,但应结合临床现况,针对性地运用最佳证据。展开更多
基金supported by Guangxi Scientific Research and Technology Development Project (No. 14124004-1-24)
文摘Objective:The inter-α-trypsin inhibitor heavy chain 4(ITIH4)protein is involved in the development of tumors.However,the relationship between ITIH4 and ovarian cancer(OC)has not been extensively examined.This study aimed to explore the effect of ITIH4 on OC and to identify its underlying mechanism.Methods:Expressions of ITIH4 in OC tissues and cells were determined using quantitative reverse transcription polymerase chain reaction(RT-qPCR)and western blots.The function of ITIH4 in the OC cell line HO8910 pm was tested via ITIH4 knockdown.The cell growth rate was measured using MTT and colony formation assays.Flow cytometry was performed to evaluate cell cycle progression.Cell migration and invasion abilities were observed using the transwell migration assay.Results:ITIH4 was downregulated in OC tissues and cells.ITIH4 knockdown promoted cell growth and cell cycle progression.Consistent with these results,inhibition of ITIH4 in OC cells significantly increased cell migration and invasion abilities.Cox regression analysis suggests that ITIH4 expression alone is not a good predictor of the prognosis of malignant ovarian tumors in patients.Conclusions:ITIH4 inhibits the progression of OC,suggesting that ITIH4 may be a useful biomarker for OC.This study may provide a potential novel target for the treatment of OC.
文摘Ocean is home town of wind and rain, treasury of resources. To exploit and use ocean will make great contribution to people’s existence and development. China is a great oceanic country with pre cinct sea area of 3,000,000 km2. The eastern coastal region with only 60 km width, 15 % area and 40% of population of China, has created about 60% of GDP and has become the most developed region. But marine disaster in China is frequent and serious. From statistical data, economy loss made by surge, billow, sea ice, tsunami, red tide, oil spill, coast erosion, bay deposit, sea water intrusion, sea level rise, land salinization, sea water pollution, etc. increase quickly. Economy loss per year is one billion in the l980s, 10 billion in the l990s, exceeded 20 billion in 1996, and 30 billion in 1997. About 80% of it happened in the coastal area. So, marine disaster at present has become obstacle of society progress and economy development in coastal area. To mitigate marine disaster has become need for the economy development, also important task of the integrated coastal zone management. In this article, we briefly introduce countermeasures for marine disaster prevention, coastal zone management, and achievements made in the past 50 years, its problems now confronted, and the main countermeasures in the 21St century.
基金supported by the Fundamental-Core National Project of the National Research Foundation(NRF)funded by the Ministry of Science and ICT,Republic of Korea(2022R1F1A1072739).
文摘Layered double hydroxides(LDH)frameworks have shown significant enhancement in stability and reusability,and their tailorable architecture brings new insight into the development of the next generation of hybrid materials,which attracted considerable attention in many fields over the years.One of the factors contributing to the widespread applicability of layered double hydroxides is their adaptable composition,which can accommodate a wide spectrum of potential anionic guests.This exceptional property makes the LDH system simple to adjust for various applications.However,most LDH systems are synthesized in situ in an autoclave at high temperatures and pressures that severely restrict the industrial use of such coating systems.In this study,LDH was directly synthesized on a magnesium alloy that had undergone plasma electrolytic oxidation(PEO)treatment in the presence of ethylenediaminetetraacetic acid,thereby avoiding the use of hydrothermal autoclave conditions.This LDH system was compared with a hybrid architecture consisting of organic-inorganic self-assembly.An organic layer was fabricated on top of the LDH film using 4-Aminophenol(Aph)compound,resulting in a smart hierarchical structure that can provide a robust Aph@LDH film with excellent anti-corrosion performance.At the molecular level,the conjugation characteristics and adsorption mechanism of Aph molecule were studied using two levels of theory as follows.First,Localized orbit locator(LOL)-πisosurface,electrostatic potential(ESP)distribution,and average local ionization energy(ALIE)on the molecular surface were used to highlight localization region,reveal the favorable electrophilic and nucleophilic attacks,and clearly explore the type of interactions that occurred around interesting regions.Second,first-principles based on density functional theory(DFT)was applied to study the hybrid mechanism of Aph on LDH system and elucidate their mutual interactions.The experimental and computational analyses suggest that the highπ-electron density and delocalization characteristics of the functional groups and benzene ring in the Aph molecule played a leading role in the synergistic effects arising from the combination of organic and inorganic coatings.This work provides a promising approach to design advanced hybrid materials with exceptional electrochemical performance.
文摘目的总结血液肿瘤患者PICC相关并发症预防的最佳证据,为临床实践提供参考。方法系统检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、医脉通、美国国立指南库、英国国家卫生与临床优化研究所网站、乔安娜布里格斯研究所(JBI)数据库、国际指南协作网、苏格兰校际指南网站、WHO网站、BMJ、Up To Date、Embase、PubMed、Web of Science、Cochrane Library关于血液科肿瘤患者PICC并发症预防的相关文献,检索时间为建库至2022年6月30日,对符合纳入排除标准的文献进行质量评价、证据分级及整合。结果最终纳入11篇文献,其中指南3篇、系统评价3篇、干预性研究2篇、专家共识3篇,总结出包括PICC评估与管理、置管前预防、置管中预防、置管后预防和健康教育5个方面的31条证据。结论本研究总结的血液肿瘤患者PICC相关并发症预防的最佳证据具有良好的科学性和系统性,可为提高患者治疗效果、减轻其经济负担提供循证依据,但应结合临床现况,针对性地运用最佳证据。
