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Association between intercellular adhesion molecule-1 to depression and blood-brain barrier penetration in cerebellar vascular disease
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作者 Ju-Luo Chen Rui Wang +2 位作者 Pei-Qi Ma You-Meng Wang Qi-Qiang Tang 《World Journal of Psychiatry》 SCIE 2024年第11期1661-1670,共10页
BACKGROUND Cerebral small vessel disease(CSVD)is a prevalent cerebrovascular disease in clinical practice that is often associated with macrovascular disease.A clear understanding of the underlying causes of CSVD rema... BACKGROUND Cerebral small vessel disease(CSVD)is a prevalent cerebrovascular disease in clinical practice that is often associated with macrovascular disease.A clear understanding of the underlying causes of CSVD remains elusive.AIM To explore the association between intercellular adhesion molecule-1(ICAM-1)and blood-brain barrier(BBB)penetration in CSVD.METHODS This study included patients admitted to Fuyang People’s Hospital and Fuyang Community(Anhui,China)between December 2021 and March 2022.The study population comprised 142 patients,including 80 in the CSVD group and 62 in the control group.Depression was present in 53 out of 80 patients with CSVD.Multisequence magnetic resonance imaging(MRI)and dynamic contrast-enhanced MRI were applied in patients to determine the brain volume,cortical thickness,and cortical area of each brain region.Moreover,neuropsychological tests including the Hamilton depression scale,mini-mental state examination,and Montreal cognitive assessment basic scores were performed.RESULTS The multivariable analysis showed that age[P=0.011;odds ratio(OR)=0.930,95%confidence interval(CI):0.880-0.983]and ICAM-1 levels(P=0.023;OR=1.007,95%CI:1.001-1.013)were associated with CSVD.Two regions of interest(ROIs;ROI3 and ROI4)in the white matter showed significant(both P<0.001;95%CI:0.419-0.837 and 0.366-0.878)differences between the two groups,whereas only ROI1 in the gray matter showed signi-ficant difference(P=0.046;95%CI:0.007-0.680)between the two groups.ICAM-1 was significantly correlated(all P<0.05)with cortical thickness in multiple brain regions in the CSVD group.CONCLUSION This study revealed that ICAM-1 levels were independently associated with CSVD.ICAM-1 may be associated with cortical thickness in the brain,predominantly in the white matter,and a significant increase in BBB permeability,proposing the involvement of ICAM-1 in BBB destruction. 展开更多
关键词 Cerebral small vessel disease Intercellular adhesion molecule-1 Blood-brain barrier penetration Cortical thickness White matter
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EFFECTS OF ELECTROACUPUNCTURE ON EXPRESSION OF INTERCELLULAR ADHESION MOLECULE-1 IN THE RAT OF LOCAL CEREBRAL ISCHEMIA-REPERFUSION 被引量:2
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作者 孔立红 毛庆菊 陈邦国 《World Journal of Acupuncture-Moxibustion》 2007年第1期31-36,共6页
Objective To investigate effects of electroacupuncture (EA) on expression of intercellular adhesion molecule-1 (ICAM-1) in the rat of local cerebral ischemia-reperfusion. Methods Eighty SD rats were randomly divid... Objective To investigate effects of electroacupuncture (EA) on expression of intercellular adhesion molecule-1 (ICAM-1) in the rat of local cerebral ischemia-reperfusion. Methods Eighty SD rats were randomly divided into a normal control group, a sham operation group, a model group and an EA treatment group, 20 rats in each group. The thread-obstruction method was used for preparation of ischemia-reperfusion model. Zea-Longa rating criteria were used for evaluation of nervous function disorder; Immunohistochemical SABC method was used for detection of ICAM-1 expression in the microvascular endothelial cell of the ischemic brain region, and ELISA method for the soluble ICAM-1 (slCAM-1) content in peripheral blood. Re. suits After cerebral ischemia-reperfusion, both ICAM-1 expression level in the microvascular endethelium cell of the ischemic brain region and slCAM-1 content in the peripheral blood significantly increased in the model group as compared with the normal group and the sham operation group (P〈0.01); After EA treatment, the ICAM-1 expression level in the microvascular endothelial cell of the ischemic brain region and slCAM-1 content in the peripheral blood were significantly down-regulated in the EA treatment group as com- pared with the model group (P〈 0.05). Conclusion After cerebral ischemia-reperfusion, the microvascular endothelial cell of the ischemic brain region releases ICAM-1, which induces inflammatory injury of cerebral tissues; EA treatment can decease the expression of ICAM-1, so as to prevent the brain from the injury. 展开更多
关键词 Electroacupuncture Cerebral ischemia and reperfusion Intercellularadhesion molecule-1 (I-CAM-1 Soluble intercellular adhesion molecule-1 (slCAM-1)
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Soluble intercellular adhesion molecule-1,D-lactate and diamine oxidase in patients with inflammatory bowel disease 被引量:23
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作者 Wei-Bing Song Yong-Hui Lv +6 位作者 Zhen-Shu Zhang Ya-Nan Li Li-Ping Xiao Xin-Pei Yu Yuan-Yuan Wang Hong-Li Ji Li Ma 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第31期3916-3919,共4页
AIM: To study the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1), plasma D-lactate and diamine oxidase (DAO) in patients with inflammatory bowel disease (IBD), and the potential clinical si... AIM: To study the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1), plasma D-lactate and diamine oxidase (DAO) in patients with inflammatory bowel disease (IBD), and the potential clinical significance. METHODS: Sixty-nine patients with IBD and 30 healthy controls were included in this study. The concentration of sICAM-1 was detected with enzyme-linked immunosorbent assay, the level of D-lactate and DAO was measured by spectroscopic analysis, and the number of white blood cells (WBC) was determined by routine procedure. RESULTS: The levels of sICAM-I, DAO, and WBC in IBD patients were significantly higher than those in the control group (P 〈 0,01), sICAM-I in IBD patients was found to be closely related to the levels of DAO and D-lactate (212.94 ± 69.89 vs 6.35 ± 2.35, P = 0.000), DAO 212.94 ± 69.89 vs 8.65 ± 3.54, P = 0.000) and WBC (212.94 ± 69.89 vs 7.40 ± 2.61, P = 0.000), but no significant difference was observed between patients with ulcerative colitis and patients with Crohn's disease. The post-treatment levels of sICAM-I, D-lactate and WBC were significantly lower than before treatment (sICAM-I 206.57 ± 79.21 vs 146.21 ± 64.43, P = 0.000), (D-lactate 1.46 ± 0.94 vs 0.52± 0.32, P = 0.000) and (WBC 7.24 ± 0.2.33 vs 5.21 ± 3.21, P = 0.000). CONCLUSION: sICAM-1, D-lactate and DAO are closely related to the specific conditions of IBD, and thus could be used as a major diagnostic index. 展开更多
关键词 Inflammatory bowel diseases Intercellular adhesion molecule-1 D-LACTATE Diamine oxidase
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Up-regulation of intestinal nuclear factor kappa B and intercellular adhesion molecule-1 following traumatic brain injury in rats 被引量:16
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作者 Chun-HuaHang Ji-XinShi +2 位作者 Jie-ShouLi Wei-QinLi Hong-XiaYin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第8期1149-1154,共6页
AIM: Nuclear factor kappa B (NF-κB) regulates a large number of genes involved in the inflammatory response to critical illnesses, but it is not known if and how NF-KB is activated and intercellular adhesion molecule... AIM: Nuclear factor kappa B (NF-κB) regulates a large number of genes involved in the inflammatory response to critical illnesses, but it is not known if and how NF-KB is activated and intercellular adhesion molecule-1 (ICAM-1) expressed in the gut following traumatic brain injury (TBI). The aim of current study was to investigate the temporal pattern of intestinal NF-κB activation and ICAM-1 expression following TBI. METHODS: Male Wistar rats were randomly divided into six groups (6 rats in each group) including controls with sham operation and TBI groups at hours 3, 12, 24, and 72, and on d 7. Parietal brain contusion was adopted using weight-dropping method. All rats were decapitated at corresponding time point and mid-jejunum samples were taken. NF-KB binding activity in jejunal tissue was measured using EMSA. Immunohistochemistry was used for detection of ICAM-1 expression in jejunal samples. RESULTS: There was a very low NF-κB binding activity and little ICAM-1 expression in the gut of control rats after sham surgery. NF-KB binding activity in jejunum significantly increased by 160% at 3 h following TBI (P<0.05 vs control), peaked at 72 h (500% increase) and remained elevated on d 7 post-injury by 390% increase. Compared to controls, ICAM-1 was significantly up-regulated on the endothelia of microvessels in villous interstitium and lamina propria by 24 h following TBI and maximally expressed at 72 h post-injury (P<0.001). The endothelial ICAM-1 immunoreactivity in jejunal mucosa still remained strong on d 7 post-injury. The peak of NF-κB activation and endothelial ICAM-1 expression coincided in time with the period during which secondary mucosal injury of the gut was also at their culmination following TBI. CONCLUSION: TBI could induce an immediate and persistent up-regulation of NF-κB activity and subsequent up-regulation of ICAM-1 expression in the intestine. Inflammatory response mediated by increased NF-κB activation and ICAM-1 expression may play an important role in the pathogenesis of acute gut mucosal injury following TBI. 展开更多
关键词 Traumatic brain injury INTESTINE Nuclear factor kappa B Intercellular adhesion molecule-1 Inflammatory response
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The Value of the Soluable Intercellular Adhesion Molecule-1 Levels in Matermal Serum for Determination of Occult Chorioamnionitis in Premature Rupture of Membranes 被引量:6
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作者 邹丽 张会军 +1 位作者 祝建芳 朱剑文 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2004年第2期154-157,共4页
To compare the diagnostic value of soluble intercellular adhesion molecule 1 (sICAM-1) with that of c-reactive protein (CRP) for detecting chorioamnionitis (CAM) in serum of women with premature rupture of membranes (... To compare the diagnostic value of soluble intercellular adhesion molecule 1 (sICAM-1) with that of c-reactive protein (CRP) for detecting chorioamnionitis (CAM) in serum of women with premature rupture of membranes (PROM), 55 pregnant women with PROM, including 18 pregnant women with preterm premature rupture of membranes (PPROM) and 20 normal pregnant women at term (TPROM) were studied. Maternal serum were measured by Sandwish enzyme-linked immunoabsorbent assay (ELISA) for sICAM. CAM was histologically confirmed after delivery. The results revealed that (1) maternal serum levels of sICAM-1 and CRP were significantly higher in women with PROM than those without it; (2) maternal serum levels of sICAM-1 and CRP were significantly higher in women with CAM than those without it; (3) serum levels of sICAM-1 in PPROM women were similar to those in TPROM women, whereas serum levels of CRP in PPROM women were significantly higher than those in TPROM women; (4) the sensitivity, specificity, positive predictive value, negative predictive value, Kappa index and area under receiver operating characteristic (ROC) curve of maternal serum sICAM-1 (cutoff 104.7 ng/ml) and CRP(cutoff 1.03 mg/dl) for diagnosing CAM were 100 %, 91.2 %, 87.5 %, 100 %, 0.20, 0.995 and 81.0 %, 73.5 %, 65.4 %, 86.2 %, 0.13, 0.811, respectively; (5) among the mild histological CAM group, severe histological CAM group and clinical CAM group, the difference in maternal serum levels of sICAM-1 were significantly (P<0.001), with the order of concentration from high level to low level corresponding to the severity of CAM. It is concluded that maternal serum level of ICAM-1 is superior to that of CRP as biomarker for diagnosing intraamniotic infection in pregnant women with PROM. 展开更多
关键词 intercellular adhesion molecule-1 chorioamninitis diagnosis
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Effects of TCMP-1 on the changes of platelet endothelial cell adhesion molecule-1 expression in acute edematous pancreatitis 被引量:4
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作者 Hong-Kai Gao, Zong-Guang Zhou, Tao He, You-Qin Chen, Fang-Hai Han and Cun Wang Chengdu, ChinaDepartment of General Surgery & Division of Diges- tive Surgery, West China Hospital, Sichuan University, Chengdu 610041 , China 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2004年第2期311-315,共5页
BACKGROUND: Traditional Chinese medicine is a potent agent in the management of clinical and experimental acute pancreatitis (AP), but the molecular mechanism of its the- rapeutic action is unclear. Numerous experimen... BACKGROUND: Traditional Chinese medicine is a potent agent in the management of clinical and experimental acute pancreatitis (AP), but the molecular mechanism of its the- rapeutic action is unclear. Numerous experimental and clinical studies have shown that platelet endothelial cell ad- hesion molecule-1 (PECAM-1) is pivotal to leukocyte re- cruitment, which results in microcirculatory injury during inflammation, but its role in acute pancreatitis is poorly un- derstood. We investigated the effects of a compound of tra- ditional Chinese medicine pancreatitis-1 (TCMP-1) on the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in acute edematous pancreatitis (AEP). METHODS: The model of acute pancreatitis was estab- lished by subcutaneous injection of caerulein, and TCMP-1 treated groups were given TCMP-1 by catheterization from mouth to stomach (20 ml/kg) immediately after first time subcutaneous injection of caerulein. The changes of expres- sion of PECAM-1 on leukocytes from the blood of the splenic vein and inferior vena cava were determined by flow cytometry. RESULTS: In the AEP group, expression of PECAM-1 on PMNs was not significantly different between pancreatic microcirculation and systemic circulation at AEP2h and AEP4h time point. Then from AEP4h time point to AEP8h time point, expression of PECAM-1 was up-regulated in systemic circulation while it was down-regulated in pancre- atic microcirculation and was significantly different be- tween pancreatic microcirculation and systemic circulation at AEP8h time point (P<0.05). In the TCMP-1 treated group, compared with the AEP group, expression of PE-CAM-1 on PMNs decreased in different levels between pan- creatic microcirculation and systemic circulation and was of significant difference at AEP8h time point (P <0.05). CONCLUSION: Inhibition of PECAM-1 expression on PMNs may prevent PMNs from transmigration through the endo- thelium and may be one of the treatment mechanisms of TCMP-1 decoction on AEP. 展开更多
关键词 acute pancreatitis platelet endothelial cell adhesion molecule-1 Chinese medicine
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Differences in platelet endothelial cell adhesion molecule-1 expression between peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous pancreatitis 被引量:2
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作者 Hong-KaiGao Zong-GuangZhou +5 位作者 Fang-HaiHan You-QinChert Wen-WeiYan TaoHe CunWang ZhaoWang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第5期661-664,共4页
AIM: To investigate the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation and pancreatic microcirculation in cerulein-induce... AIM: To investigate the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous pancreatitis (AEP).METHODS: Fifty Wistar rats were randomly divided into control group (n=10) and AEP group (n=40). A model of AEP was established by subcutaneous injection of cerulein 5.5 and 7.5 μg/kg at 0 and 1 h after the beginning of experiment respectively. PECAM-1 expression on PMNs from splenic vein and inferior vena cava was determined by RT-PCR at mRNA level and determined by flow cytometry at protein level.RESULTS: In experimental rats, an increased PECAM-1mRNA expression was seen from 4 to 8 h of AEP in peripheral circulation (0.77±0.25%, 0.76±0.28%, 0.89±0.30%,1.00±0.21% ), while in pancreatic microcirculation,expression decreased from 2 h and reached the lowest level at 6 h of AEP (0.78±0.29%, 0.75±0.26%, 0.62±0.28%,0.66±0.20%). There were significant differences at 8-h time point of AEP between peripheral circulation and pancreatic microcirculation (1.00±0.21% vs0.66±0.20%, P<0.05).Meanwhile,the difference at protein level was also found.CONCLUSION: A reverse expression of PECAM-1 on PMNs was found between peripheral circulation and pancreatic microcirculation, suggesting that inhibition of PECAM-1expression may improve the pathological change of AEP. 展开更多
关键词 Pancreatitis Platelet endothelial cell adhesion molecule-1 Microcirculation CERULEIN
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The relationship between platelet endothelial cell adhesion molecule-1 and paraquat-induced lung injury in rabbits 被引量:7
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作者 Jing Shi Chun-lin Hu +2 位作者 Yu-feng Gao Xiao-xing Liao Hope Xu 《World Journal of Emergency Medicine》 CAS 2012年第1期60-64,共5页
BACKGROUND:Platelet endothelial cell adhesion molecule-1(PECAM-1),also known as CD31,is mainly distributed in vascular endothelial cells.Studies have shown that PECAM-1 is a very significant indicator of angiogenesis,... BACKGROUND:Platelet endothelial cell adhesion molecule-1(PECAM-1),also known as CD31,is mainly distributed in vascular endothelial cells.Studies have shown that PECAM-1 is a very significant indicator of angiogenesis,and has been used as an indicator for vascular endothelial cells.The present study aimed to explore the relationship between the expression of PECAM-1 and the degree of acute lung injury(ALI) and fibrosis in paraquat(PQ) induced lung injury in rabbits.METHODS:Thirty-six adult New Zealand rabbits were randomly divided into three groups(12rabbits in each group) according to PQ dosage:8 mg/kg(group A),16 mg/kg(group B),and 32 mg/kg(group C).After PQ infusion,the rabbits were monitored for 7 days and then euthanized.The lungs were removed for histological evaluation.Masson staining was used to determine the degree of lung fibrosis(LF),and semi-quantitative immune-histochemistry analysis to determine the expression of PECAM-1.Pearson's product-moment correlation analysis was performed to evaluate the relationship between the expression of PECAM-1 and the extent of lung injuries expressed by ALI score and degree of LF.RESULTS:Rabbits in the three groups showed apparent poisoning.The rabbits survived longer in group A than in groups B and C(6.47±0.99 days vs.6.09±1.04 days vs.4.77±2.04 days)(P<0.05).ALI score was lower in group A than in groups B and C(8.33±1.03 vs.9.83±1.17 vs.11.50±1.38)(P<0.05),and there was statistically significant difference between group B and group C(P=0.03).LF was slighter in group A than in groups B and C(31.09%±2.05%vs.34.37%±1.62%vs.36.54%±0.44%)(P<0.05),and there was statistically significant difference between group B and group C(P=0.026).The PEACAM-1 expression was higher in group A than in groups B and C(20.31%±0.70%vs.19.34%±0.68%vs.18.37%±0.46%)(P<0.05),and there was statistically significant difference between group B and group C(P=0.017).Pearson's correlation analysis showed that the expression of PECAM-1 was negatively correlated to both ALI score(Coe=-0.732,P=0.001)and degree of LF(Coe=-0.779,P<0.001).CONCLUSIONS:The PECAM-1 expression significantly decreases in New Zealand rabbits after PQ poisoning,and the decrease is dose-dependent.The PECAM-1 expression is negatively correlated with ALI score and LF,showing a significant role in the development of lung injuries induced by PQ. 展开更多
关键词 Platelet endothelial cell adhesion molecule-1 PARAQUAT Acute lung injury Lung fibrosis
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Mild hypothermia effects on intercellular adhesion molecule-1 and serum interleukin-6 expression in brain tissues of a rat focal ischemia model 被引量:1
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作者 Shengqi Fu Lei Yang +2 位作者 Shuling Zhang Shilong Sun Xingai Mao 《Neural Regeneration Research》 SCIE CAS CSCD 2008年第10期1124-1127,共4页
BACKGROUND: Previous studies have confirmed the neuroprotective effect of mild hypothermia on ischemic brain injury. OBJECTIVE: To investigate the effects of mild hypothermia on intercellular adhesion molecule-1 exp... BACKGROUND: Previous studies have confirmed the neuroprotective effect of mild hypothermia on ischemic brain injury. OBJECTIVE: To investigate the effects of mild hypothermia on intercellular adhesion molecule-1 expression and serum interleukin-6 levels in ischemic brain tissues of focal brain ischemia rats, and to explore the neuroprotective effects of mild hypothermia on ischemic brain injury. DESIGN, TIME AND SETTING: A randomized, controlled, neurobiological experiment was performed at the Central Laboratory, First Affiliated Hospital, Xinxiang Medical College, China from February to July 2006. MATERIALS: Thirty healthy, adult, Sprague Dawley rats were used to establish middle cerebral artery occlusion models using the suture method, The immunohistochemistry (streptavidin-biotin-peroxidase complex method) kit was purchased from Boster, China. Interleukin-6 radioimmunoassay was supplied by Institute of Radioimmunity, Technology Development Center, General Hospital of Chinese PLA. METHODS: The rats were equally and randomly assigned into mild hypothermia and control groups, and middle cerebral artery occlusion models were established. The rectal temperature was maintained at (37 ±0.5)℃ in the control group. In the mild hypothermia group, the rectal temperature was maintained at (33±1)℃. MAIN OUTCOME MEASURES: At 12 hours after model establishment, the ischemic brain hemispheres were coronally sliced at the level of the optic chiasm. The number of intercellular adhesion molecule-1-positive vessels per high-power field was observed with an optical microscope. Serum interleukin-6 levels were measured by radioimmunoassay. RESULTS: Compared with the control group, intercellular adhesion molecule-1 and serum interleukin-6 expressions were significantly decreased in ischemic brain tissues of the mild hypothermia group (P 〈 0.01). CONCLUSION: Mild hypothermia exhibits a neuroprotective effect by reducing serum interleukin-6 and intercellular adhesion molecule-1 expression following cerebral ischemia. 展开更多
关键词 cerebral ischemia intercellular adhesion molecule-1 INTERLEUKIN-6 mild hypothermia
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Association of G+1688A Polymorphism of Platelet Endothelial Cell Adhesion Molecule-1 Gene with Myocardial Infarction in the Chinese Han Population 被引量:1
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作者 杨颖 程龙献 +3 位作者 Ripen Nsenga 何美安 常智堂 邬堂春 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2007年第5期520-523,共4页
In order to investigate the association of G+1688A (Ser563Asn) polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene with myocardial infarction (MI) in the Chinese Han population, the G+... In order to investigate the association of G+1688A (Ser563Asn) polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene with myocardial infarction (MI) in the Chinese Han population, the G+1688A polymorphism in PECAM-1 gene was detected by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) method among 502 subjects, including 218 patients with MI and 284 controls. The results showed that there was significant difference in AA frequencies of genotype G+1688A polymorphism between case and control groups (39% vs 24%, P〈0.001). A similar trend was observed on the allele frequencies (A/G: 62% vs 49%, P〈0.001). Among the subjects with high serum total cholesterol level or high systolic blood pressure level, the variant AA genotype was associated with high risk of MI (adjusted OR, 2.13; 95% CI, 1.08 -4.41 and adjusted OR, 2.53; 95%CI, 1.63-3.63). The single nucleotide polymorphism (SNP) at position +1688 in the exon 8 of PECAM-1 gene was associated with MI and the allele A might be a risk factor for MI in the Chinese Han population. 展开更多
关键词 platelet endothelial adhesion molecule-1 single nucleotide polymorphism myocardial infarction polymerase chain reaction-restriction fragment-length polymorphism
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Expression of Intercellular Adhesion Molecule-1 in Immune Response of Inner Ear
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作者 龚树生 曾新力 +1 位作者 严臻 汪吉宝 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1998年第4期208-211,共4页
To understand the role of intercellular adhesion molecule-1 (ICAM-1) in immune response of the inner ear, inner ear immune response was induced in rats by inoculation of keyhole limpet hemocyanine (KLH) into the scala... To understand the role of intercellular adhesion molecule-1 (ICAM-1) in immune response of the inner ear, inner ear immune response was induced in rats by inoculation of keyhole limpet hemocyanine (KLH) into the scala tympani of the animals who had been systemically sensitized. The expression of ICAM-1 in the inner ear was immunohistochemically examined. ICAM-1 was found in the epithelium of the spiral modiolar vein (SMV) with its collecting venules (CVs) as early as 6 h after challenge. Expression of ICAM-1 was observed on the epithelium of the endolymphatic sac (ES) and perisaccular region at 12 h. The intensity of ICAM-1 staining reached its peak within 24 - 48 h in these sites of the inner ear. By day 28, most specimens were devoid of appreciable staining for ICAM-1. Our study demonstrates that adhesion molecules play an important role in extravasation of inflammatory cells from the systemic circulation in the process of inner ear immune response. It also shows that cytokines that control expression of adhesion molecules may be released by cells outside ES, besides those cells in the ES. 展开更多
关键词 LABYRINTH AUTOIMMUNITY intercellular adhesion molecule-1 en-dolymphatic sac
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Changes of soluble intercellular adhesion molecule-1 in the serum from patients with acute cerebral infarction
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作者 周华东 陈曼娥 颜建华 《Journal of Medical Colleges of PLA(China)》 CAS 1997年第4期328-330,共3页
objective: To observe the changes of soluble intercellular adhesion molecule-1(sICAM-1) in the serum of patients with acute cerebral infarctlon (ACI) and their clinical significance. Methods: The concen-tration of sIC... objective: To observe the changes of soluble intercellular adhesion molecule-1(sICAM-1) in the serum of patients with acute cerebral infarctlon (ACI) and their clinical significance. Methods: The concen-tration of sICAM-1 in the serum of 91 patients with ACI was determined with ELISA and then the results were compared wlth those of 43 patients with cerebral hemorrhage and 30 healthy individuals. Results: In the 24th hour after infarction. the concentration of sICAMu-1 in the serum was significantly higher in patients with ACI than in patients with cerebral hemorrhage and normal controls (P< 0. 01). In the patients with ACI, the concentration exhibited an decreasing tendency in the period from the 24th hour to the 14th day andwas correlated with the focal size of cerebral infarction. During the first 14 days after infarction, the concen-tration was significantly higher in the patients with the complication of infection than in those without. Con-clusion: sICAM-1 is closely correlated with clinical manifestation of ACI. 展开更多
关键词 CEREBRAL INFARCTION SOLUBLE INTERCELLULAR adhesion molecule-1 (sicam-1)
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The effects of coxsackievirus B3 infection on induction of ICAM-1 in cardiac myocytes and on Iymphocyte-myocyte adhesion
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作者 沈茜 徐雨莲 +1 位作者 林伟 吴红 《Journal of Medical Colleges of PLA(China)》 CAS 1999年第3期205-208,共4页
objective:To observe the effects of coxsackievirus B3(CoxB3) infection on-induction of intercellu lar adhesion molecule-1 (ICAM-1) in cardiac myocytes and on lymphocyte-myocyte adhesion. Metkods: ICAM 1 expression on ... objective:To observe the effects of coxsackievirus B3(CoxB3) infection on-induction of intercellu lar adhesion molecule-1 (ICAM-1) in cardiac myocytes and on lymphocyte-myocyte adhesion. Metkods: ICAM 1 expression on cultured neonatal rat cardiac myocytes infected by CoxB3 was determined through enzyme linked immunosorbent assay (ELISA) analysis. Lymphocyte-myocyte adhesion was observed with adherence assay and monoclonal antibodies to adhesion molecule inhibition. Results:ICAM-1 expression on cardiac my ocytes was markedly induced after exposure to CoxB3 100 or 200 TCID50/ml infectious dose for 24~48 h (P<0. 05). Adhesion of rat activated lymphocytes to myocytes was stimulated by CoxB3 infection,and the effects of CoxB3 infection on adherence was significantly inhibited by anti-lymphocyte function antigen-1 (LFA-12)monoclonal antibodies (inhibition rate 40. 6% and 26. 45 % respectively). Couclusion:CoxB3 infec tion promotes lymphocyte-myocyte adhesion through inducing ICAAM-1 expression on cardiac myocytes. 展开更多
关键词 coxsackievirus B INTERCELLULAR adhesion molecule-1 LYMPHOCYTE
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Relationship of plasma homocysteine, soluble intercellular adhesion molecule-1, high mobility group box 1 protein with carotid intima-media thickness in elderly patients with type 2 diabetes mellitus
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作者 Zhijie Cai Jun Xue +4 位作者 Xiaohui Ma Peifeng Chen Biao Ge Yuying Zhang Zhihui Dong 《Discussion of Clinical Cases》 2022年第1期9-12,共4页
Objective:To explore the relationship of plasma homocysteine(Hcy),soluble intercellular adhesion molecule-1(sICAM-1)and high mobility group box 1 protein(HMGB1)with carotid intima-media thickness(c-IMT)in elderly pati... Objective:To explore the relationship of plasma homocysteine(Hcy),soluble intercellular adhesion molecule-1(sICAM-1)and high mobility group box 1 protein(HMGB1)with carotid intima-media thickness(c-IMT)in elderly patients with type 2 diabetes mellitus.Methods:A total of 100 elderly patients who were diagnosed as type 2 diabetes mellitus in Baogang Hospital of Inner Mongolia from June 2017 to May 2020 were chosen as research objects.According to c-IMT,they were divided into the normal group(n=35),the mild to moderate group(n=41)and the severe group(n=24).The expression levels of plasma Hcy,sICAM-1 and HMGB1 were compared between groups respectively.Pearson’s correlation coefficient was used to analyze the relationship of plasma Hcy,sICAM-1,HMGB1 with c-IMT.Results:The comparison in plasma Hcy,sICAM-1,HMGB1 and c-IMT among the three groups of patients was of statistical significance(p<.05).The results of correlation analysis showed that the expression levels of plasma Hcy,sICAM-1 and HMGB1 were positively correlated with c-IMT in elderly patients with type 2 diabetes mellitus(r=.627,.598,.614;p<.05).Conclusions:The expression levels of plasma Hcy,sICAM-1 and HMGB1 are abnormally increased in elderly patients with type 2 diabetes mellitus,and related to c-IMT,which can provide a strong evidence for clinical diagnosis and treatment by detecting their levels in clinical practice. 展开更多
关键词 Type 2 diabetes mellitus Carotid intima-media thickness HOMOCYSTEINE Soluble intercellular adhesion molecule-1 High mobility group box 1 protein
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Serum inter-cellular adhesion molecule 1 is an early marker of diagnosis and prediction of severe acute pancreatitis 被引量:8
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作者 Hai-Hang Zhu Lin-Lin Jiang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第20期2554-2560,共7页
AIM:To determine if serum inter-cellular adhesion molecule 1(ICAM-1)is an early marker of the diagnosis and prediction of severe acute pancreatitis(SAP) within 24 h of onset of pain,and to compare the sensitivity,spec... AIM:To determine if serum inter-cellular adhesion molecule 1(ICAM-1)is an early marker of the diagnosis and prediction of severe acute pancreatitis(SAP) within 24 h of onset of pain,and to compare the sensitivity,specificity and prognostic value of this test with those of acute physiology and chronic health evaluation(APACHE)Ⅱscore and interleukin-6(IL-6). METHODS:Patients with acute pancreatitis(AP)were divided into two groups according to the Ranson's criteria:mild acute pancreatitis(MAP)group and SAP group.Serum ICAM-1,APACHEⅡand IL-6 levels were detected in all the patients.The sensitivity,specificity and prognostic value of the ICAM-1,APACHEⅡscore and IL-6 were evaluated. RESULTS:The ICAM-1 level in 36 patients with SAP within 24 h of onset of pain was increased and was significantly higher than that in the 50 patients with MAP and the 15 healthy volunteers(P<0.01).The ICAM-1 level(25 ng/mL)was chosen as the optimum cutoff to distinguish SAP from MAP,and the sensitivity,specificity,positive predictive value,negative predictive value(NPV),positive likelihood ratio and negative likelihood ratio were 61.11%,71.42%,0.6111,0.7142, 2.1382 and 0.5445,respectively.The area under the curve demonstrated that the prognostic accuracy of ICAM-1(0.712)was similar to the APACHE-Ⅱscoring system(0.770)and superior to IL-6(0.508)in distinguishing SAP from MAP. CONCLUSION:ICAM-1 test is a simple,rapid and reliable method in clinical practice.It is an early marker of diagnosis and prediction of SAP within the first 24 h after onset of pain or on admission.As it has a relatively low NPV and does not allow it to be a stand-alone test for the diagnosis of AP,other conventional diagnostic tests are required. 展开更多
关键词 Intercellular adhesion molecule-1 Severe acute pancreatitis Early prediction
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Monocyte chemotactic protein-1 and soluble adhesion molecules as possible prognostic markers of the efficacy of antiviral treatment in chronic hepatitis C 被引量:1
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作者 AnatolPanasiuk DanutaProkopowicz BozenaPanasiuk 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第24期3639-3642,共4页
AIM:To explain the role of Monocyte chemotactic protein-1 (MCP-1) and soluble adhesion molecules in chronic hepatitis C during the treatment of interferon alpha (IFNα) 2 b and ribavirin (RBV). METHODS:Concentrations ... AIM:To explain the role of Monocyte chemotactic protein-1 (MCP-1) and soluble adhesion molecules in chronic hepatitis C during the treatment of interferon alpha (IFNα) 2 b and ribavirin (RBV). METHODS:Concentrations of MCP-1,soluble adhesion molecules intercellular adhesion molecule-1 (sICAM-1),sP- selectin,interleukin (IL) 6,and IL10 in serum were estimated in the group of 40 patients with chronic hepatitis C treated with IFNalpha2 b and RBV in 0,16,32,48 wk of the therapy, RESULTS:In chronic hepatitis C,before and during the treatment,the serum levels of MCP-1 and sP-selectin in responders were similar to those of healthy subjects.In non- responders (NR),MCP-1 increased in the course of IFNc^+RBV treatment,differences were statistically significant as compared to responders.MCP-1 correlated statistically with the activity of periportal inflammation (r=0.35,P<0.05) but not with staging of liver fibrosis,sICAM-1 positively correlated with inflammatory activity and fibrosis in NR.sP-selectin did not correlate with histological findings in the liver.The MCP-1 correlated with the soluble form of sP-selectin concentrations (r= 6,P<0.001) and with IL-10 level in NR (r=0.4,P<0.05).There was no correlation observed between the concentration of MCP-1 and sICAM-1,IL-6 during the treatment. CONCLUSION:MCP-1 concentration may be a prognostic marker of the efficacy of IFN+RBV therapy in patients with chronic hepatitis C. 展开更多
关键词 Adult Antiviral Agents DOSAGE Biological Markers Female Hepatitis C Chronic Humans Intercellular adhesion molecule-1 INTERLEUKIN-10 INTERLEUKIN-6 Male Middle Aged Monocyte Chemoattractant Protein-1 P-SELECTIN Prognosis SOLUBILITY
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急性白血病患者中ICAM-1和VCAM-1的表达及意义 被引量:7
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作者 王永韧 陆化 +5 位作者 刘澎 张建富 仇海荣 吴雨洁 杨慧 李建勇 《江苏医药》 CAS CSCD 北大核心 2007年第8期765-767,共3页
目的探讨细胞间黏附分子1(ICAM-1)和血管细胞间黏附分子1(VCAM-1)在急性白血病(AL)中的表达及临床意义。方法39例初诊AL患者,其中27例经治疗后达完全缓解(CR)。采用逆转录-PCR法检测AL骨髓单个核细胞ICAM-1和VCAM-1的 mRNA表达水平。对... 目的探讨细胞间黏附分子1(ICAM-1)和血管细胞间黏附分子1(VCAM-1)在急性白血病(AL)中的表达及临床意义。方法39例初诊AL患者,其中27例经治疗后达完全缓解(CR)。采用逆转录-PCR法检测AL骨髓单个核细胞ICAM-1和VCAM-1的 mRNA表达水平。对照组12例均为骨髓像正常的门诊患者。结果ICAM-1和VCAM-1水平在初诊AL者明显高于CR组及对照组(P<0.01),且CR组和对照组之间无显著差异(P>0.05);高白细胞(WBC>100×109/L)组和死亡组的ICAM-1和VCAM-1水平明显增高(P<0.05)。髓外浸润组仅ICAM-1高于非髓外浸润组(P<0.01);非淋巴细胞AL(ANLL)具有良好核型者ICAM-1水平低于其他患者(P<0.05)。结论AL表达ICAM-1和VCAM-1明显增高,其检测对疗效及预后判断有重要意义。 展开更多
关键词 细胞间黏附分子1 血管细胞间黏附分子1 急性白血病
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重复正加速度暴露对大鼠心肌血管内皮超微结构和ICAM-1表达的影响 被引量:14
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作者 张政 詹皓 +2 位作者 陆江阳 辛益妹 李彤 《中国应用生理学杂志》 CAS CSCD 北大核心 2002年第3期245-248,共4页
目的 :观察重复正加速度 (+Gz)暴露对大鼠心肌血管内皮细胞超微结构的影响及其暴露后细胞间粘附分子 1(ICAM 1)表达的变化情况 ,进一步探讨高 +Gz暴露致心肌损伤的机理。方法 :30只雄性Wistar大鼠随机分成 3组 (n =10 ) ,其中对照组不受... 目的 :观察重复正加速度 (+Gz)暴露对大鼠心肌血管内皮细胞超微结构的影响及其暴露后细胞间粘附分子 1(ICAM 1)表达的变化情况 ,进一步探讨高 +Gz暴露致心肌损伤的机理。方法 :30只雄性Wistar大鼠随机分成 3组 (n =10 ) ,其中对照组不受 +Gz作用 ;正加速度组分为 +1Gz组 :受 +1Gz作用 ,+10Gz组 :重复 +10Gz暴露 (+10Gz 30s,5counts/d ,3d/w ,3w)。于末次 +Gz作用后次日同时处死大鼠 ,速取左室心肌 ,常规透射电镜制样、观察。另取左室心肌制成石蜡切片 ,行免疫组化检测。结果 :重复 +10Gz作用后 ,心肌间质弥漫水肿 ,小血管内皮细胞肿胀 ,吞饮泡增多 ,血管内皮细胞ICAM 1含量也明显增加 (P <0 .0 5 ) ,而 +1Gz组心肌血管内皮结构及其I CAM 1含量与对照组之间无明显差别。结论 :重复 +Gz暴露后 ,大鼠心肌血管内皮细胞可出现明显损伤 ,其I CAM 1表达增多 ,提示粘附分子诱导的炎症反应参与了高 展开更多
关键词 重复正加速度暴露 大鼠 心肌血管内皮 超微结构 icam-1 表达 心脏 细胞间粘附分子-1 免疫组织化学
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缺氧缺血性脑病新生儿血清TNF-α和sICAM-1变化及其临床意义 被引量:13
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作者 柴斌英 王海英 华亚军 《临床儿科杂志》 CAS CSCD 北大核心 2010年第3期231-232,243,共3页
目的观察新生儿缺氧缺血性脑病(HIE)患儿血清肿瘤坏死因子-α(TNF-α)和可溶性细胞间黏附分子-1(sICAM-1)的水平变化,探讨其在HIE中的作用。方法应用酶联免疫吸附法(ELISA)检测58例HIE患儿血清TNF-α和sICAM-1的水平,其中中重度28例,轻... 目的观察新生儿缺氧缺血性脑病(HIE)患儿血清肿瘤坏死因子-α(TNF-α)和可溶性细胞间黏附分子-1(sICAM-1)的水平变化,探讨其在HIE中的作用。方法应用酶联免疫吸附法(ELISA)检测58例HIE患儿血清TNF-α和sICAM-1的水平,其中中重度28例,轻度30例,并与20例正常新生儿对照,采用方差分析进行统计学分析。结果中重度及轻度HIE患儿血清TNF-α和sICAM-1水平均高于正常对照组,差异有统计学意义(P均<0.05);中重度HIE患儿与轻度HIE组比较,差异有统计学意义(P<0.05)。结论TNF-α和sICAM-1可能通过缺氧缺血后的免疫功能改变、炎症反应参与HIE患儿的病理过程,血清TNF-α和sICAM-1水平可作为HIE严重程度和预后判断的早期分子生物学指标。 展开更多
关键词 缺氧缺血性脑病 肿瘤坏死因子-Α 可溶性细胞间黏附分子-1
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厄贝沙坦对实验性糖尿病大鼠肾脏保护作用及对ICAM-1与VCAM-1表达的影响 被引量:7
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作者 李佃淳 闻海霞 +1 位作者 丛艳 于垂恭 《微循环学杂志》 2009年第1期13-16,F0003,共5页
目的:从影响细胞间粘附分子-1(ICAM-1)和血管细胞粘附分子-1(VCAM-1)表达的角度,探讨厄贝沙坦对实验性糖尿病大鼠肾脏的保护作用及其可能机制。方法:Wistar大鼠24只,随机分为对照组、模型组、药物组,每组8只。链脲佐菌素(STZ)诱导糖尿... 目的:从影响细胞间粘附分子-1(ICAM-1)和血管细胞粘附分子-1(VCAM-1)表达的角度,探讨厄贝沙坦对实验性糖尿病大鼠肾脏的保护作用及其可能机制。方法:Wistar大鼠24只,随机分为对照组、模型组、药物组,每组8只。链脲佐菌素(STZ)诱导糖尿病大鼠模型,药物组大鼠每日给予厄贝沙坦150mg/kg灌胃,持续8周。8周后抽血测空腹血糖(FBG)、糖化血红蛋白(HbA1c)、尿素氮(BUN)、肌酐(Scr);测定24h尿微量白蛋白(mAlb),计算尿白蛋白排泄率(UAER)。处死Wistar大鼠,取其肾脏,计算肾脏肥大指数,用免疫组化方法检测ICAM-1,蛋白质印迹法(Westernblot)检测VCAM-1蛋白表达水平。结果:模型组和药物组的FBG、HbA1c、BUN、Scr均高于对照组,上述指标在模型组与药物组之间无统计学差异。模型组UAER高于对照组,而药物组则低于模型组。药物组ICAM-1与VCAM-1蛋白表达量低于模型组。结论:厄贝沙坦对实验性糖尿病大鼠的肾脏有保护作用,其机制可能是通过抑制ICAM-1与VCAM-1在肾脏的表达来实现的。 展开更多
关键词 实验性糖尿病大鼠 VCAM-1 icam-1 肾脏保护作用 厄贝沙坦 肾小管-间质纤维化 血管细胞粘附分子 细胞间粘附分子
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