Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psorias...Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psoriasis and depression, and they show the relationships of reciprocal causation and mutual promotion. Psoriasis with depression is more harmful than simple psoriasis, and its prognosis is worse, which brings a huge burden to the family and society and is worthy of clinical attention. Based on the pathogenic factors of western medicine and pathogenesis of traditional Chinese medicine in psoriasis with depression, the paper summarized and elaborated the research progress on the mechanism of traditional Chinese medicine in the treatment of psoriasis with depression, in order to provide new ideas for clinical treatment.展开更多
Geochemical differentiation of soils has a series of consequences on plant and places pressure on the ecological environment.The quantitative evaluation of element migration in the Earth’s critical zone is a challeng...Geochemical differentiation of soils has a series of consequences on plant and places pressure on the ecological environment.The quantitative evaluation of element migration in the Earth’s critical zone is a challenging task.In this study,two demonstration study areas of Scutellaria baicalensis Georgi were selected,and multiple chemical weathering indexes,chemical loss fraction,mass migration coefficients and biological enrichment coefficient method were used to assess the ecological and geochemical suitability.The results show that for the element of Fe,Zn,Se,Cu,Co,Ni,Mo and Ge,the degree of weathering and soil maturation,were greater in the rhyolitic tuff area than in the Plagioclase gneiss area.In both research sites,the heavy metal level of samples in Scutellaria baicalensis Georgi did not exceed the standard limits.The plagioclase gneiss region’s surface soil environment was more alkaline,and the content of soil organic matter was lower,resulting in a higher bioenrichment intensity of Ge,Co,Cu,and Se elements in Scutellaria baicalensis Georgi than in the rhyolite-tuff area.The elements of Cd,Nb,Mo,Pb and As are considerably enriched in the soil of the plagioclase gneiss area but lost by leaching in the soil of the rhyolite tuff area,which is connected to the interplay of elemental abundance and human impact in the parent materials.This study provides a good example of how to assess growth suitability of Chinese medicinal materials in the Earth’s critical zone.展开更多
针对中文汽车领域实体抽取任务中对嵌套实体、长实体识别效果差的问题,提出一种实体类别增强的嵌套实体抽取(ECE-NER)模型。首先,基于特征融合编码,提高模型对领域实体边界的感知能力;然后,尾词识别模块利用多层感知机得到实体尾词集合...针对中文汽车领域实体抽取任务中对嵌套实体、长实体识别效果差的问题,提出一种实体类别增强的嵌套实体抽取(ECE-NER)模型。首先,基于特征融合编码,提高模型对领域实体边界的感知能力;然后,尾词识别模块利用多层感知机得到实体尾词集合;最后,前向边界识别模块基于义原构造的实体类别特征和自注意力机制得到实体类别增强的候选尾词表征,融合领域实体类别特征,利用双仿射编码器计算特定尾词和实体类型的实体跨度概率,从而确定命名实体。在某汽车企业生产线故障数据集、汽车工业故障抽取评测数据集CCL2022和中文医学文本数据集CHIP2020上进行模型验证。实验结果表明,所提模型在前两个数据集上的实体识别F1值比序列标注模型(BERT+BiLSTM+CRF)、基于跨度的实体抽取模型(PURE(Princeton University Relation Extraction)、SpERT(Span-based Entity and Relation Transformer))分别提高了4.1、1.8、1.6个百分点和9.0、5.4、7.3个百分点;在第一个数据集和第三个数据集中嵌套实体识别F1值与PURE、SpERT模型相比提高了13.3、8.3个百分点和21.7、9.3个百分点,验证了所提模型在嵌套实体识别上的有效性。展开更多
In this study, rabbit models of optic nerve injury were reproduced by the clamp method. After modeling, rabbit models were given one injection of 50 ng recombinant human ciliary neurotrophic factor into the vitreous b...In this study, rabbit models of optic nerve injury were reproduced by the clamp method. After modeling, rabbit models were given one injection of 50 ng recombinant human ciliary neurotrophic factor into the vitreous body and/or intragastric injection of 4 g/kg compound light granules containing Radix Angelicae Sinensis and Raidix Paeoniae Alba at 4 days after modeling, once per day for 30 consecutive days. After administration, the animals were sacrificed and the intraorbital optic nerve was harvested. Hematoxylin-eosin staining revealed that the injured optic nerve was thinner and optic nerve fibers were irregular. After treatment with recombinant human ciliary neurotrophic factor, the arrangement of optic nerve fibers was disordered but they were not markedly thinner. After treatment with compound light granules, the arrangement of optic nerve fibers was slightly disordered and their structure was intact. After combined treatment with recombinant human ciliary neurotrophic factor and compound light granules, the arrangement of optic nerve fibers was slightly disordered and the degree of injury was less than after either treatment alone. Results of tensile mechanical testing of the optic nerve showed that the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly lower than the normal optic nerve. After treatment with recombinant human ciliary neurotrophic factor and/or compound light granules, the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly increased, especially after the combined treatment. These experimental findings indicate that compound light granules and ciliary neurotrophic factor can alleviate optic nerve injury at the histological and biochemical levels, and the combined treatment is more effective than either treatment alone.展开更多
基金National Natural Science Foundation of China(No.81973846)Heilongjiang Province Traditional Chinese Medicine Research Fund Projec(No.t ZHY2022-132)。
文摘Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psoriasis and depression, and they show the relationships of reciprocal causation and mutual promotion. Psoriasis with depression is more harmful than simple psoriasis, and its prognosis is worse, which brings a huge burden to the family and society and is worthy of clinical attention. Based on the pathogenic factors of western medicine and pathogenesis of traditional Chinese medicine in psoriasis with depression, the paper summarized and elaborated the research progress on the mechanism of traditional Chinese medicine in the treatment of psoriasis with depression, in order to provide new ideas for clinical treatment.
基金funded by the China Geological Survey,grant number DD20190822。
文摘Geochemical differentiation of soils has a series of consequences on plant and places pressure on the ecological environment.The quantitative evaluation of element migration in the Earth’s critical zone is a challenging task.In this study,two demonstration study areas of Scutellaria baicalensis Georgi were selected,and multiple chemical weathering indexes,chemical loss fraction,mass migration coefficients and biological enrichment coefficient method were used to assess the ecological and geochemical suitability.The results show that for the element of Fe,Zn,Se,Cu,Co,Ni,Mo and Ge,the degree of weathering and soil maturation,were greater in the rhyolitic tuff area than in the Plagioclase gneiss area.In both research sites,the heavy metal level of samples in Scutellaria baicalensis Georgi did not exceed the standard limits.The plagioclase gneiss region’s surface soil environment was more alkaline,and the content of soil organic matter was lower,resulting in a higher bioenrichment intensity of Ge,Co,Cu,and Se elements in Scutellaria baicalensis Georgi than in the rhyolite-tuff area.The elements of Cd,Nb,Mo,Pb and As are considerably enriched in the soil of the plagioclase gneiss area but lost by leaching in the soil of the rhyolite tuff area,which is connected to the interplay of elemental abundance and human impact in the parent materials.This study provides a good example of how to assess growth suitability of Chinese medicinal materials in the Earth’s critical zone.
文摘针对中文汽车领域实体抽取任务中对嵌套实体、长实体识别效果差的问题,提出一种实体类别增强的嵌套实体抽取(ECE-NER)模型。首先,基于特征融合编码,提高模型对领域实体边界的感知能力;然后,尾词识别模块利用多层感知机得到实体尾词集合;最后,前向边界识别模块基于义原构造的实体类别特征和自注意力机制得到实体类别增强的候选尾词表征,融合领域实体类别特征,利用双仿射编码器计算特定尾词和实体类型的实体跨度概率,从而确定命名实体。在某汽车企业生产线故障数据集、汽车工业故障抽取评测数据集CCL2022和中文医学文本数据集CHIP2020上进行模型验证。实验结果表明,所提模型在前两个数据集上的实体识别F1值比序列标注模型(BERT+BiLSTM+CRF)、基于跨度的实体抽取模型(PURE(Princeton University Relation Extraction)、SpERT(Span-based Entity and Relation Transformer))分别提高了4.1、1.8、1.6个百分点和9.0、5.4、7.3个百分点;在第一个数据集和第三个数据集中嵌套实体识别F1值与PURE、SpERT模型相比提高了13.3、8.3个百分点和21.7、9.3个百分点,验证了所提模型在嵌套实体识别上的有效性。
文摘In this study, rabbit models of optic nerve injury were reproduced by the clamp method. After modeling, rabbit models were given one injection of 50 ng recombinant human ciliary neurotrophic factor into the vitreous body and/or intragastric injection of 4 g/kg compound light granules containing Radix Angelicae Sinensis and Raidix Paeoniae Alba at 4 days after modeling, once per day for 30 consecutive days. After administration, the animals were sacrificed and the intraorbital optic nerve was harvested. Hematoxylin-eosin staining revealed that the injured optic nerve was thinner and optic nerve fibers were irregular. After treatment with recombinant human ciliary neurotrophic factor, the arrangement of optic nerve fibers was disordered but they were not markedly thinner. After treatment with compound light granules, the arrangement of optic nerve fibers was slightly disordered and their structure was intact. After combined treatment with recombinant human ciliary neurotrophic factor and compound light granules, the arrangement of optic nerve fibers was slightly disordered and the degree of injury was less than after either treatment alone. Results of tensile mechanical testing of the optic nerve showed that the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly lower than the normal optic nerve. After treatment with recombinant human ciliary neurotrophic factor and/or compound light granules, the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly increased, especially after the combined treatment. These experimental findings indicate that compound light granules and ciliary neurotrophic factor can alleviate optic nerve injury at the histological and biochemical levels, and the combined treatment is more effective than either treatment alone.
