AIM:The current study was to determine the serum/pLasma levels of VEGF,IL-6,malondialdehyde (MDA),nitric oxide (NO),PCT and CRP in gastric carcinoma and correlation with the stages of the disease and accompanying infe...AIM:The current study was to determine the serum/pLasma levels of VEGF,IL-6,malondialdehyde (MDA),nitric oxide (NO),PCT and CRP in gastric carcinoma and correlation with the stages of the disease and accompanying infection. METHODS:We examined the levels of serum VEGF,IL-6, PCT,CRP and plasma MDA,NO in 42 preoperative gastric cancer patients and 23 healthy subjects.There were infection anamneses that had no definite origin in 19 cancer patients. RESULTS:The VEGF levels (mean±SD; pg/mL) were 478.05±178.29 and 473.85±131.24 in gastric cancer patients with and without infection,respectively,and these values were not significantly different (P>0.05).The levels of VEGF, CRP,PCT,It-6,MDA and NO in cancer patients were significantly higher than those in healthy controls and the levels of CRP,PCT,It-6,MDA and NO were statistically increased in infection group when compared with non- infection group (P<0.001). CONCLUSION:Although serum VEGF concentrations were increased in gastric cancer,this increase might not be related to infection.CRP,PCT,IL-6,MDA and NO have obvious drawbacks in the diagnosis of infections in cancer patients. These markers may not help to identify infections in the primary evaluation of cancer patients and hence to avoid unnecessary antibiotic treatments as well as hospitalization. According to the results of this study,IL-6,MDA,NO and especially VEGF can be used as useful parameters to diagnose and grade gastric cancer.展开更多
Objective:To investigate the protective effect of sinomenine stellate ganglion block(SGB)on chronic myocardial ischemia and its related mechanism.Methods:SD male and female rats(180~200g)were randomly divided into fou...Objective:To investigate the protective effect of sinomenine stellate ganglion block(SGB)on chronic myocardial ischemia and its related mechanism.Methods:SD male and female rats(180~200g)were randomly divided into four groups:blank group,model group,lidocaine group,lidocaine+sinomenine group.The rats in blank group were fed with normal standard diet without modeling,and the other rats were fed with high-fat diet.After 8 weeks of feeding,the rats in high-fat diet group were significantly different from those in blank control group.Then they were randomly divided into 3 groups,10 rats in model group were injected with 0.9%NaCl into right stellate ganglion(RSG)After 2 weeks of continuous injection,pituitrin injection was continuously injected into sublingual vein of rats for 3 days,once every 24 hours;lidocaine group rats were injected with 0.24 mL 1%lidocaine injection in RSG,the rest was the same as model group;lidocaine+sinomenine group rats were injected with 0.24 mL 1%lidocaine injection+0.095 mL sinomenine hydrochloride+2.9 mL 0.8 mL 0.8 mL in RSG,the rest was the same as model group.At the end of the eighth week of the experiment,the rats in the high-fat diet feeding group and the standard ordinary diet feeding group were given the medicine after there was significant difference in blood lipid;before the third injection of pituitrin,the ECG changes of the rats in each group were observed;the general situation of the rats before and after the administration was observed;after the experiment,the blood of the rats in each group was taken from the abdominal aorta,and the serum oxidative stress indexes,such as total superoxide dismutase(SOD)and malondialdehyde,were detected(MDA,IL-6 and cTnI were measured.Results:compared with the blank group,the ECG of the model group changed significantly(P<0.01),the cTnI value increased significantly(P<0.01),indicating that the rat myocardial ischemia model was successfully established;compared with the model group,the SOD level of lidocaine group and lidocaine+sinomenine group increased significantly(P<0.05,P<0.01),the MDA level decreased significantly(P<0.05,P<0.01),IL-6 decreased significantly(P<0.05,P<0.01)05,P<0.01).Conclusion:sinomenine SGB has protective effect on rats with chronic myocardial ischemia,which is related to anti oxidative stress and inhibition of inflammatory reaction.展开更多
目的探讨益肾通络解毒汤对气阴两虚兼毒瘀互结型糖尿病肾病的临床疗效及对氧化应激的影响。方法选取2018年1月—2019年6月医院收治的120例气阴两虚兼毒瘀互结型糖尿病肾病患者,随后依据患者就诊顺序将其分为观察组及对照组各60例,两组...目的探讨益肾通络解毒汤对气阴两虚兼毒瘀互结型糖尿病肾病的临床疗效及对氧化应激的影响。方法选取2018年1月—2019年6月医院收治的120例气阴两虚兼毒瘀互结型糖尿病肾病患者,随后依据患者就诊顺序将其分为观察组及对照组各60例,两组均予以口服降糖药、皮注胰岛素、运动疗法、饮食控制等基础治疗,在基础治疗上对照组加以尿毒清颗粒治疗,观察组予以益肾通络解毒汤治疗,比较治疗前后两组肾脏功能指标[肾小球滤过率(eGFR)、血肌酐(SCr)、24 h尿蛋白排泄率(24 h UAER)]、炎症指标[白细胞介素-6(IL-6)、超敏C反应蛋白(hsCRP)]、氧化应激指标[8-羟基脱氧鸟嘌呤(8-OHdG)、晚期糖基化终产物(AGEs)、丙二醛(MDA)、活性氧(ROS)、超氧化物歧化酶(SOD)、晚期氧化蛋白产物(AOPP)]变化情况,并比较两组病人的临床疗效。结果两组治疗疗程结束后,观察组肾功能、炎症反应及氧化应激水平各项指标均明显优于对照组(P<0.05)。观察组总有效率为90.00%,对照组总有效率为70.00%,观察组优于对照组(P<0.05)。结论益肾通络解毒汤治疗气阴两虚兼毒瘀互结型糖尿病肾病患者疗效确切,能有效改善患者的肾功能,其机制可能与其抑制炎症反应及抗氧化应激相关。展开更多
文摘AIM:The current study was to determine the serum/pLasma levels of VEGF,IL-6,malondialdehyde (MDA),nitric oxide (NO),PCT and CRP in gastric carcinoma and correlation with the stages of the disease and accompanying infection. METHODS:We examined the levels of serum VEGF,IL-6, PCT,CRP and plasma MDA,NO in 42 preoperative gastric cancer patients and 23 healthy subjects.There were infection anamneses that had no definite origin in 19 cancer patients. RESULTS:The VEGF levels (mean±SD; pg/mL) were 478.05±178.29 and 473.85±131.24 in gastric cancer patients with and without infection,respectively,and these values were not significantly different (P>0.05).The levels of VEGF, CRP,PCT,It-6,MDA and NO in cancer patients were significantly higher than those in healthy controls and the levels of CRP,PCT,It-6,MDA and NO were statistically increased in infection group when compared with non- infection group (P<0.001). CONCLUSION:Although serum VEGF concentrations were increased in gastric cancer,this increase might not be related to infection.CRP,PCT,IL-6,MDA and NO have obvious drawbacks in the diagnosis of infections in cancer patients. These markers may not help to identify infections in the primary evaluation of cancer patients and hence to avoid unnecessary antibiotic treatments as well as hospitalization. According to the results of this study,IL-6,MDA,NO and especially VEGF can be used as useful parameters to diagnose and grade gastric cancer.
基金National Administration of traditional Chinese medicine base project(No.jdzx2012144,jdzx2015253)Shaanxi provincial major disease TCM innovation plan:chest obstruction(coronary heart disease)+1 种基金Shaanxi Provincial Administration of traditional Chinese medicine scientific research project(No.15-scjh015,15-lc016,lcpt089,15-scjh016)discipline innovation team of the Second Affiliated Hospital of Shaanxi University of Chinese medicine(No.2020xktd-b03)。
文摘Objective:To investigate the protective effect of sinomenine stellate ganglion block(SGB)on chronic myocardial ischemia and its related mechanism.Methods:SD male and female rats(180~200g)were randomly divided into four groups:blank group,model group,lidocaine group,lidocaine+sinomenine group.The rats in blank group were fed with normal standard diet without modeling,and the other rats were fed with high-fat diet.After 8 weeks of feeding,the rats in high-fat diet group were significantly different from those in blank control group.Then they were randomly divided into 3 groups,10 rats in model group were injected with 0.9%NaCl into right stellate ganglion(RSG)After 2 weeks of continuous injection,pituitrin injection was continuously injected into sublingual vein of rats for 3 days,once every 24 hours;lidocaine group rats were injected with 0.24 mL 1%lidocaine injection in RSG,the rest was the same as model group;lidocaine+sinomenine group rats were injected with 0.24 mL 1%lidocaine injection+0.095 mL sinomenine hydrochloride+2.9 mL 0.8 mL 0.8 mL in RSG,the rest was the same as model group.At the end of the eighth week of the experiment,the rats in the high-fat diet feeding group and the standard ordinary diet feeding group were given the medicine after there was significant difference in blood lipid;before the third injection of pituitrin,the ECG changes of the rats in each group were observed;the general situation of the rats before and after the administration was observed;after the experiment,the blood of the rats in each group was taken from the abdominal aorta,and the serum oxidative stress indexes,such as total superoxide dismutase(SOD)and malondialdehyde,were detected(MDA,IL-6 and cTnI were measured.Results:compared with the blank group,the ECG of the model group changed significantly(P<0.01),the cTnI value increased significantly(P<0.01),indicating that the rat myocardial ischemia model was successfully established;compared with the model group,the SOD level of lidocaine group and lidocaine+sinomenine group increased significantly(P<0.05,P<0.01),the MDA level decreased significantly(P<0.05,P<0.01),IL-6 decreased significantly(P<0.05,P<0.01)05,P<0.01).Conclusion:sinomenine SGB has protective effect on rats with chronic myocardial ischemia,which is related to anti oxidative stress and inhibition of inflammatory reaction.
文摘目的探讨益肾通络解毒汤对气阴两虚兼毒瘀互结型糖尿病肾病的临床疗效及对氧化应激的影响。方法选取2018年1月—2019年6月医院收治的120例气阴两虚兼毒瘀互结型糖尿病肾病患者,随后依据患者就诊顺序将其分为观察组及对照组各60例,两组均予以口服降糖药、皮注胰岛素、运动疗法、饮食控制等基础治疗,在基础治疗上对照组加以尿毒清颗粒治疗,观察组予以益肾通络解毒汤治疗,比较治疗前后两组肾脏功能指标[肾小球滤过率(eGFR)、血肌酐(SCr)、24 h尿蛋白排泄率(24 h UAER)]、炎症指标[白细胞介素-6(IL-6)、超敏C反应蛋白(hsCRP)]、氧化应激指标[8-羟基脱氧鸟嘌呤(8-OHdG)、晚期糖基化终产物(AGEs)、丙二醛(MDA)、活性氧(ROS)、超氧化物歧化酶(SOD)、晚期氧化蛋白产物(AOPP)]变化情况,并比较两组病人的临床疗效。结果两组治疗疗程结束后,观察组肾功能、炎症反应及氧化应激水平各项指标均明显优于对照组(P<0.05)。观察组总有效率为90.00%,对照组总有效率为70.00%,观察组优于对照组(P<0.05)。结论益肾通络解毒汤治疗气阴两虚兼毒瘀互结型糖尿病肾病患者疗效确切,能有效改善患者的肾功能,其机制可能与其抑制炎症反应及抗氧化应激相关。
