Data-driven modeling on anisotropic mechanical behavior of brain tissue with internal pressure

Brain tissue is one of the softest parts of the human body,composed of white matter and grey matter.The mechanical behavior of the brain tissue plays an essential role in regulating brain morphology and brain function.Besides,traumatic brain injury(TBI)and various brain diseases are also greatly influenced by the brain's mechanical properties.Whether white matter or grey matter,brain tissue contains multiscale structures composed of neurons,glial cells,fibers,blood vessels,etc.,each with different mechanical properties.As such,brain tissue exhibits complex mechanical behavior,usually with strong nonlinearity,heterogeneity,and directional dependence.Building a constitutive law for multiscale brain tissue using traditional function-based approaches can be very challenging.Instead,this paper proposes a data-driven approach to establish the desired mechanical model of brain tissue.We focus on blood vessels with internal pressure embedded in a white or grey matter matrix material to demonstrate our approach.The matrix is described by an isotropic or anisotropic nonlinear elastic model.A representative unit cell(RUC)with blood vessels is built,which is used to generate the stress-strain data under different internal blood pressure and various proportional displacement loading paths.The generated stress-strain data is then used to train a mechanical law using artificial neural networks to predict the macroscopic mechanical response of brain tissue under different internal pressures.Finally,the trained material model is implemented into finite element software to predict the mechanical behavior of a whole brain under intracranial pressure and distributed body forces.Compared with a direct numerical simulation that employs a reference material model,our proposed approach greatly reduces the computational cost and improves modeling efficiency.The predictions made by our trained model demonstrate sufficient accuracy.Specifically,we find that the level of internal blood pressure can greatly influence stress distribution and determine the possible related damage behaviors.

The scaling laws of cabin structures subjected to internal blast loading:Experimental and numerical studies

This paper presents a combination of experimental and numerical investigations on the dynamic response of scaling cabin structures under internal blast loading.The purpose of this study is to modify the similar relationship between the scaled-down model and the prototype of the cabin structures under internal blast loading.According to the Hopkinson’s scaling law,three sets of cabin structure models with different scaling factors combined with different explosive masses were designed for the experimental study.The dynamic deformation process of the models was recorded by a three-dimensional digital imaging correlation(DIC)method and a 3D scanning technology was used to reconstruct the deformation modes of the specimen.In addition,a finite element model was developed for the modification of the scaling law.The experimental results showed that the final deflection-to-thickness ratio was increased with the increase of the model size despite of the similar trend of their deformation processes.The reason for this inconsistency was discussed based on the traditional scaling law and a modified formula considering of the effects of size and strain-rate was provided.

Triangular temporal-distribution law for disintegrating internal solitons over a step

Internal solitary waves have been found to disintegrate into a series of solitons over variablebathymetry, with important applications for offshore engineering. Considering realisticbackground stratification in the South China Sea, internal solitary waves propagating over a stepare studied here. By assuming disintegrated solitons propagate independently, a theoreticalmodel, namely a triangular temporal-distribution law based on the Korteweg–de Vries theory, isproposed to describe the fission process of internal solitary waves undergoing disintegration. Aparameter is then introduced to quantify the accuracy of the theoretical model. The resultsindicate that the triangular law predicts the fission process better for a longer travelling distanceand a larger amplitude of internal solitary waves.

“私国际法”和“International Private Law”考证

国际私法学科的中英文名称是一个有争议的问题,中文名称"私国际法"和英文名称"International Private Law"就是两例。将"Private International Law"直译为中文"私国际法",违反了术语系统性和一致性的特点,也不符合英汉两种语言之间的句法结构和篇章结构的差异。将德文"Internationalen Privatrechts"直译为英文"International Private Law",违反了术语国际性和一致性的特点。所以,该学科的英文名称应为"Private International Law",也应中译为"国际私法";同时,取消中文名称"私国际法"和英文名称"International Private Law"。

On the Definition of State Variables for an Internal State Variable Constitutive Model Describing Metal Deformation

The quest for an internal state variable constitutive model describing metal deformation is reviewed. First, analogy is drawn between a deformation model and the Ideal Gas Law. The use of strain as a variable in deformation models is discussed, and whether strain serves as an internal state variable is considered. A simple experiment that demonstrated path dependence in copper is described. The importance of defining appropriate internal state variables for a constitutive law relates to the ability to accurately model temperature and strain-rate dependencies in deformation simulations.

Building a Community with a Shared Future for Mankind: International Law-based Principles and Approaches

Building a community with a shared future for mankind is an important guiding principle for China to address foreign affairs in this new era, and its profound connotations echo the spirit of international law. In the context of globalization, the ever-increasing common interests of the international community lay a material basis for building a community with a shared future for mankind. The doctrine of international community orientation, which is based on sovereignty and at the same time transcends sovereignty, forms an ideological basis for building a community with a shared future. Realizing international socialism and striking a balance between formalism and substantial justice is a moral prerequisite for building a community with a shared future. To reduce existing legal obstacles to international communications, the laws of all countries and regions exhibit a tendency towards legal assimilation, which is expected to be a domestic law approach to the building of a community with a shared future for mankind. The establishment of international legal systems and the development of international organizations have vigorously promoted and maintained world peace yet failed to bring about perpetual peace. International law should attach more importance to the facilitation of human inner peace so as to realize perpetual peace. This is a new international law-based approach to the building of a community with a shared future for mankind. China's peaceful rise, which is based on traditional Chinese culture and the basic principles of international law, is China's special contribution to this great cause.

On the Eve of the Enforcement of the Arbitration Law——An interview with Xu Dayou, vice-chairman of China Council for the Promotion of International Trade and of the China International Economic and Trade Arbitration Commission

The Arbitration Law of the People’s Republic of China will go into effect on September 1, 1995, which has become the focus of world attention. This is an important law promulgated by China for handling economic disputes. All the parties concerned are making intense preparations for the successful enforcement of the Law. As the first nongovernmental organisation engaged in arbitration affairs, the China Council

AN INVESTIGATION ON INTERNAL THERMAL FLOW OF NON-NEWTONIAN FLUID

In the present paper an unsteady thermal flow of non-Newtonian fluid is investigated which is of the flow into axisymmetric mould cavity. In the second part an unsteady thermal flow of upper-convected Maxwell fluid is studied. For the flow into mould cavity the constitutive equation of power-law fluid is used as a Theological model of polymer fluid. The apparent viscosity is considered as a function of shear rate and temperature. A characteristic viscosity is introduced in order to avoid the nonlinearity due to the temperature dependence of the apparent viscosity. As the viscosity of the fluid is relatively high the flow of the thermal fluid can be considered as a flow of fully developed velocity field. However, the temperature field of the fluid flow is considered as an unsteady one. The governing equations are constitutive equation, momentum equation of steady flow and energy conservation equation of non-steady form. The present system of equations has been solved numerically by the splitting difference method. The numerical results show that the splitting difference method is suitable for the 2D problem of non-Newtonian fluid. The present application of the splitting diffference method is at first developed by us for non-Newtonian case. For the unsteady flow in the tube the finite difference scheme is given which leads to a tridiagonal system of equations.

Self-organized Criticality Model for Ocean Internal Waves

在这篇论文，我们在场为海洋的一个简单春天块模型内部波浪基于自我组织的 criticality (SOC ) 。在模型的水块的摆动在频率领域与 2 的一个代表显示幂定律行为，它在实际海洋和 Munk 深海洋类似于水流和海水温度系列内部波浪模型 [Geophysical 液体动力学 2 ( 1972 ) 225 ；J。Geophys。物件。80 (1975 ) 291 ] 。到到在模型的 SOC 行为的春天系数的驱动力的比率的影响也被讨论。

The Application of International Law with Regard to Cyber War in Terms of the Tallinn Manual 2.0

The study of international law and regulation of cyber war in the Tallinn Manual 2.0 is questionable with regard to attribution, the use of force, the exercise of the right of self-defense, the application of the principle of distinction, and even the definition of‘cyber war'. The application of contemporary law of war to cyberspace, including the militarization of cyberspace itself, should be reviewed judiciously. The construction of a cyberspace community with a shared future may be a better way out.

ASEAN Commitment to Sustainable Development in the Regional International Environmental Law Perspective

The World Commission on Environment and Development in its report entitled“Our Common Future”has put forward the idea of sustainable development which is also an important part of the development of regional environmental law in Southeast Asia.In 1985 ASEAN Agreement on the Nature and Natural Resources has put sustainable development for the first time in ASEAN’s treaty.Sustainable development continues to grow through the 1987 Jakarta Resolution on Sustainable Development agreed upon by the leaders of ASEAN.This research will look at the importance of sustainable development as part of the regional environmental international law concept and how it has grown in ASEAN today.The purpose of this research is to know the various international agreements both soft law and hard law that puts sustainable development as an important element.The results show that sustainable development has become an integral part of the regional international environmental legal system in ASEAN.A provisional conclusion shows that ASEAN’s commitment to sustainable development has greatly improved the success of implementing environmental policies at the ASEAN level.

Human Rights Education in the Perspective of International Human Rights Law

In a statement issued on the 2004 World Human Rights Day, Ms. Louse Arbour, United Nations High Commissioner for Human Rights, described human rights education as a strategy for attainment of ＂human rights for all,＂ as a basic means for developing a universal culture of human rights, as an instrument for promoting equality and involvement of the people in decision-making under democratic mechanisms, and as an investment to prevent infringements upon human fights and to ward off conflicts of violence. It should be noted that so much importance attached by UN human rights organ to human rights education epitomizes the empowering characters of human rights education and the functions it performs in the global human rights system.

One Belt And One Road Policy from the Perspective of International Law

"One Belt And One Road" is a major initiative put forward by China in the new historical period in accordance with the new development and changes in the international and domestic situation, and has been praised internationally. This paper makes an in-depth analysis of One Belt And One Road from the perspective of international law. Starting from the relationship between international law and One Belt And One Road, it explores the purpose, approach and existing realistic dilemma of One Belt And One Road from the perspective of international law, in order to put forward some useful insights for the rapid promotion of One Belt And One Road in China.

Interpretation of the Concept of the Right to Internet Access from the Perspective of International Law

The advent of the internet era breeds a new concept, namely, the right to internet access. Many countries and international organizations, as well as individuals, are advocating or have already embodied it as a basic human right, thus enhancing the issues of whether it should be incorporated into the macro system of international human rights. By analyzing the facts, this article points out that the international concept of the right to internet access should be distinguished from its domestic concept, for there are no legal sources about the right to internet access for guidance as with some treaties in the current international law, despite its close relationship with some existing rights such as the freedom of speech, press and assembly, or the right of equality, or the right to development. And there is still a long time before the legal value and related responsibilities as well as the boundaries about the right to internet access becomes a consensus in the international society. Even though there is quite a possibility, this right hasn’t been embodied as part of international human rights, and thus hasn’t made a legal concept in international human right law.

Modernization of International Humanitarian Law——The Origins and Evolution of the 1977 Additional Protocols to the 1949 Geneva Conventions

Regional wars and internal armed conflicts after the conclusion of the 1949 geneva conventions have presented new challenges to traditional international humanitarian law? To address those challenges, the international community concluded two additional protocols in 1977 to the 1949 geneva conventions? Those two protocols have unified the Hague Rules and the geneva Rules in the realm of traditional laws on wars, improved the protection of civilians,expanded the concept of armed conflicts and combatants, and developed special treaties applicable to non-international armed conflicts,reaffirming and developing the principles and rules of international humanitarian law worldwide, and promoting its modernization?

International Comparative Study on Education Laws of the Persons with Disabilities: An Observation on Regulations on the Education of Persons with Disabilities

The issue of education for people with disabilities has become of increasing concern. How can we effectively guarantee the basic right to education for persons with disabilities? Will the revised Regulation on Education for Persons with Disabilities meet their needs? This article takes the Regulation on Education for Persons with Disabilities as the core and compares it with the related special educational laws of the United States, Britain and Japan. The following conclusions were drawn from this study: In terms of educational concept, the three countries follow the concept of inclusive education, and pursue equity and educational justice. They not only pay attention to inclusive education but also focus on improving the quality of education for students with disabilities. All three countries focus on accommodating children with special needs, but each implements its programs in a different way. These practices can be used as reference for the development of a special needs education law in China.

Norms of International Law on Environmental Protection in Wartime: Application and Improvement

The enormous environmental damage caused by war makes it necessary for international law to balance the reality of military necessity with the need to ensure the survival of human beings and other life forms. International law provides a large number of norms for environmental protection in wartime, constituting a legal order including general and special norms of wartime law and wartime environmental protection obligations of international law in peacetime. It explicitly prohibits unreasonable environmental damage caused by military needs in wartime. Contrary to the cognition that there is no international norm to protect the environment in wartime,the key reason that causes the effect of environmental protection in wartime is not as good as expected lies in the different degrees of defects in the application of these complex norms. It is a more important and practical path choice to renew the general principles of wartime environmental protection, expand the scope of application of wartime laws and special environmental norms, strengthen the wartime application of international law in peacetime, and give full play to the maximum effectiveness of the existing normative system than to expect the new convention to accomplish the whole task at one stroke.

China Academy of Arbitration Law First Publishes China International Commercial Arbitration Annual Report

At the regular news press held by China Council for the Promotion of International Trade(CCPIT) held on September 22,China Academy of Arbitration Law officially published China International Commercial Arbitration Annual Report (2014).This is the first report released

The Development of International Human Rights Law and the Chinese Contribution to the Global Human Rights Cause

Prior to World War II,human rights were mainly considered to be matters that came under the domestic jurisdiction of each state.The United Nations Charter,adopted in 1945,includes human rights provisions.The adoption of the Universal Declaration of Human Rights in 1948 that marked the initial formation of international human rights law.Today,the world has formed a relatively comprehensive system of international human rights law and mechanisms.Since the founding of the People’s Republic of China,and in particular after she introduced reform and opening-up policy in 1978,the Chinese government has actively participated in international human rights causes.To date,the Chinese government has ratified 26 human rights conventions and fulfilled the obligations required by these.China has put forward and continually enriched human rights theory of socialism with Chinese characteristics,emphasizing the importance of state sovereignty in safeguarding human rights and the resolution of human rights controversies through dialogue,thereby contributing to the global human rights cause.

General covariant conservative angular momentum as internal charges

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