An interval Pade-type approximation is introduced and then Routh-Pade-type method (IRPTM) is presented to model reduction in interval systems. The denominator in reduced model is obtained from the stable Routh table...An interval Pade-type approximation is introduced and then Routh-Pade-type method (IRPTM) is presented to model reduction in interval systems. The denominator in reduced model is obtained from the stable Routh table, and its numerator is constructed by the interval Pade-type definition. Compared to the existing Routh-Pade method, IRPTM does not need to solve linear interval equations theoretical analysis shows that IRPTM has example is given to illustrate our method. Hence, we do not have to compute smaller computational cost than that interval division in the process. Moreover, of Routh-Pade method. A typical numerical展开更多
Sufficient conditions for the quadratic D-stability and further robust D-stability of interval systems are presented in this paper. This robust D-stability condition is based on a parameter-dependent Lyapunov function...Sufficient conditions for the quadratic D-stability and further robust D-stability of interval systems are presented in this paper. This robust D-stability condition is based on a parameter-dependent Lyapunov function obtained from the feasibility of a set of linear matrix inequalities (LMIs) defined at a series of partial-vertex-based interval matrices other than the total vertex matrices as in previous results. The results contain the usual quadratic and robust stability of continuous-time and discrete-time interval systems as particular cases. The illustrative example shows that this method is effective and less conservative for checking the quadratic and robust D-stability of interval systems.展开更多
A special type of asymptotic (exponential) stability, namely componentwise asymptotic (exponential) stability for the continuous-time interval system is investigated. A set-valued map that represents the constraint of...A special type of asymptotic (exponential) stability, namely componentwise asymptotic (exponential) stability for the continuous-time interval system is investigated. A set-valued map that represents the constraint of the state of the system is defined. And, by applying the viability theory of differential equation, sufficient and necessary conditions for the componentwise asymptotical (exponential) stability of this kind of systems are given.展开更多
By using power mapping(s =v^m),stability analysis of fractional order polynomials was simplified to the stability analysis of expanded degree integer order polynomials in the first Riemann sheet.However,more investiga...By using power mapping(s =v^m),stability analysis of fractional order polynomials was simplified to the stability analysis of expanded degree integer order polynomials in the first Riemann sheet.However,more investigation is needed for revealing properties of power mapping and demonstration of conformity of Hurwitz stability under power mapping of fractional order characteristic polynomials.Contributions of this study have two folds: Firstly,this paper demonstrates conservation of root argument and magnitude relations under power mapping of characteristic polynomials and thus substantiates validity of Hurwitz stability under power mapping of fractional order characteristic polynomials.This also ensures implications of edge theorem for fractional order interval systems.Secondly,in control engineering point of view,numerical robust stability analysis approaches based on the consideration of minimum argument roots of edge and vertex polynomials are presented.For the computer-aided design of fractional order interval control systems,the minimum argument root principle is applied for a finite set of edge and vertex polynomials,which are sampled from parametric uncertainty box.Several illustrative examples are presented to discuss effectiveness of these approaches.展开更多
The robust stability analysis for discrete large-scale uncertain systems with multiple time delays is addressed in this paper. We establish a method for selecting properly a positive definite matrix Q to derive a very...The robust stability analysis for discrete large-scale uncertain systems with multiple time delays is addressed in this paper. We establish a method for selecting properly a positive definite matrix Q to derive a very simple upper solution bound of the discrete algebraic Lyapunov equation (DALE). Then, using the Lyapunov equation approach method with this upper bound, several sufficient conditions are presented to guarantee the robust stability of the overall systems. Comparisons between the proposed results with a previous one are also given.展开更多
Addressing the insufficiency in down-regulation leeway within integrated energy systems stemming from the erratic and volatile nature of wind and solar renewable energy generation,this study focuses on formulating a c...Addressing the insufficiency in down-regulation leeway within integrated energy systems stemming from the erratic and volatile nature of wind and solar renewable energy generation,this study focuses on formulating a coordinated strategy involving the carbon capture unit of the integrated energy system and the resources on the load storage side.A scheduling model is devised that takes into account the confidence interval associated with renewable energy generation,with the overarching goal of optimizing the system for low-carbon operation.To begin with,an in-depth analysis is conducted on the temporal energy-shifting attributes and the low-carbon modulation mechanisms exhibited by the source-side carbon capture power plant within the context of integrated and adaptable operational paradigms.Drawing from this analysis,a model is devised to represent the adjustable resources on the charge-storage side,predicated on the principles of electro-thermal coupling within the energy system.Subsequently,the dissimilarities in the confidence intervals of renewable energy generation are considered,leading to the proposition of a flexible upper threshold for the confidence interval.Building on this,a low-carbon dispatch model is established for the integrated energy system,factoring in the margin allowed by the adjustable resources.In the final phase,a simulation is performed on a regional electric heating integrated energy system.This simulation seeks to assess the impact of source-load-storage coordination on the system’s low-carbon operation across various scenarios of reduction margin reserves.The findings underscore that the proactive scheduling model incorporating confidence interval considerations for reduction margin reserves effectively mitigates the uncertainties tied to renewable energy generation.Through harmonized orchestration of source,load,and storage elements,it expands the utilization scope for renewable energy,safeguards the economic efficiency of system operations under low-carbon emission conditions,and empirically validates the soundness and efficacy of the proposed approach.展开更多
The robust stability study of the classic Smith predictor-based control system for uncertain fractional-order plants with interval time delays and interval coefficients is the emphasis of this work.Interval uncertaint...The robust stability study of the classic Smith predictor-based control system for uncertain fractional-order plants with interval time delays and interval coefficients is the emphasis of this work.Interval uncertainties are a type of parametric uncertainties that cannot be avoided when modeling real-world plants.Also,in the considered Smith predictor control structure it is supposed that the controller is a fractional-order proportional integral derivative(FOPID)controller.To the best of the authors'knowledge,no method has been developed until now to analyze the robust stability of a Smith predictor based fractional-order control system in the presence of the simultaneous uncertainties in gain,time-constants,and time delay.The three primary contributions of this study are as follows:ⅰ)a set of necessary and sufficient conditions is constructed using a graphical method to examine the robust stability of a Smith predictor-based fractionalorder control system—the proposed method explicitly determines whether or not the FOPID controller can robustly stabilize the Smith predictor-based fractional-order control system;ⅱ)an auxiliary function as a robust stability testing function is presented to reduce the computational complexity of the robust stability analysis;andⅲ)two auxiliary functions are proposed to achieve the control requirements on the disturbance rejection and the noise reduction.Finally,four numerical examples and an experimental verification are presented in this study to demonstrate the efficacy and significance of the suggested technique.展开更多
Aiming at the fact that the rotor winding inter-turn weak faults can hardly be detected due to the strong electromagnetic coupling effect in the excitation system,an interval observer based on current residual is desi...Aiming at the fact that the rotor winding inter-turn weak faults can hardly be detected due to the strong electromagnetic coupling effect in the excitation system,an interval observer based on current residual is designed.Firstly,the mechanism of the inter-turn short circuit of the rotor winding in the excitation system is modeled under the premise of stable working conditions,and electromagnetic decoupling and system simplification are carried out through Park Transform.An interval observer is designed based on the current residual in the two-phase coordinate system,and the sensitive and stable conditions of the observer is preset.The fault diagnosis process based on the interval observer is formulated,and the observer gain matrix is convexly optimized by linear matrix inequality.The numerical simulation and experimental results show that the inter-turn short circuit weak fault is hardly detected directly through the current signal,but the fault is quickly and accurately diagnosed through the residual internal observer.Compared with the traditional fault diagnosis method based on excitation current,the diagnosis speed and accuracy are greatly improved,and the probability of misdiagnosis also decreases.This method provides a theoretical basis for weak fault identification of excitation systems,and is of great significance for the operation and maintenance of excitation systems.展开更多
BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic syndrome characterized by insulin resistance and hyperglycemia that may lead to endothelial dysfunction,reduced functional capacity and exercise intolera...BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic syndrome characterized by insulin resistance and hyperglycemia that may lead to endothelial dysfunction,reduced functional capacity and exercise intolerance.Regular aerobic exercise has been promoted as the most beneficial non-pharmacological treatment of cardiovascular diseases.High intensity interval training(HIIT)seems to be superior than moderate-intensity continuous training(MICT)in cardiovascular diseases by improving brachial artery flow-mediated dilation(FMD)and cardiorespiratory fitness to a greater extent.However,the beneficial effects of HIIT in patients with T2DM still remain under investigation and number of studies is limited.AIM To evaluate the effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in patients with T2DM.METHODS We performed a search on PubMed,PEDro and CINAHL databases,selecting papers published between December 2012 and December 2022 and identified published randomized controlled trials(RCTs)in the English language that included community or outpatient exercise training programs in patients with T2DM.RCTs were assessed for methodological rigor and risk of bias via the Physiotherapy Evidence Database(PEDro).The primary outcome was peak VO_(2 ) and the secondary outcome was endothelial function assessed either by FMD or other indices of microcirculation.RESULTS Twelve studies were included in our systematic review.The 12 RCTs resulted in 661 participants in total.HIIT was performed in 310 patients(46.8%),MICT to 271 and the rest 80 belonged to the control group.Peak VO_(2 ) increased in 10 out of 12 studies after HIIT.Ten studies compared HIIT with other exercise regimens(MICT or strength endurance)and 4 of them demonstrated additional beneficial effects of HIIT over MICT or other exercise regimens.Moreover,4 studies explored the effects of HIIT on endothelial function and FMD in T2DM patients.In 2 of them,HIIT further improved endothelial function compared to MICT and/or the control group while in the rest 2 studies no differences between HIIT and MICT were observed.CONCLUSION Regular aerobic exercise training has beneficial effects on cardiorespiratory fitness and endothelial function in T2DM patients.HIIT may be superior by improving these parameters to a greater extent than MICT.展开更多
BACKGROUND Corrected QT(QTc)interval is prolonged in patients with liver cirrhosis and has been proposed to correlate with the severity of the disease.However,the effects of sex,age,severity,and etiology of cirrhosis ...BACKGROUND Corrected QT(QTc)interval is prolonged in patients with liver cirrhosis and has been proposed to correlate with the severity of the disease.However,the effects of sex,age,severity,and etiology of cirrhosis on QTc have not been elucidated.At the same time,the role of treatment,acute illness,and liver transplantation(Tx)remains largely unknown.AIM To determine the mean QTc in patients with cirrhosis,assess whether QTc is prolonged in patients with cirrhosis,and investigate whether QTc is affected by factors such as sex,age,severity,etiology,treatment,acute illness,and liver Tx.METHODS In the present systematic review and meta-analysis,the searching protocol“{[QTc]OR[QT interval]OR[QT-interval]OR[Q-T syndrome]}AND{[cirrhosis]OR[Child-Pugh]OR[MELD]}”was applied in PubMed,EMBASE,and Google Scholar databases to identify studies that reported QTc in patients with cirrhosis and published after 1998.Seventy-three studies were considered eligible.Data concerning first author,year of publication,type of study,method used,sample size,mean age,female ratio,alcoholic etiology of cirrhosis ratio,Child-Pugh A/B/C ratio,mean model for end-stage liver disease(MELD)score,treatment withβ-blockers,episode of acute gastrointestinal bleeding,formula for QT correction,mean pulse rate,QTc in patients with cirrhosis and controls,and QTc according to etiology of cirrhosis,sex,Child-Pugh stage,MELD score,and liver Tx status(pre-Tx/post-Tx)were retrieved.The Newcastle-Ottawa quality assessment scale appraised the quality of the eligible studies.Effect estimates,expressed as proportions or standardized mean differences,were combined using the randomeffects,generic inverse variance method of DerSimonian and Laird.Subgroup,sensitivity analysis,and meta-regressions were applied to assess heterogeneity.RESULTS QTc combined mean in patients with cirrhosis was 444.8 ms[95%confidence interval(CI):440.4-449.2;P<0.001 when compared with the upper normal limit of 440 ms],presenting high heterogeneity(I2=97.5%;95%CI:97.2%-97.8%);both Egger’s and Begg’s tests showed non-significance.QTc was elongated in patients with cirrhosis compared with controls(P<0.001).QTc was longer in patients with Child-Pugh C cirrhosis when compared with Child-Pugh B and A(P<0.001);Child-Pugh B patients presented longer QTc when compared with Child-Pugh A patients(P=0.003).The MELD score was higher in patients with cirrhosis with QTc>440 ms when compared with QTc≤440 ms(P<0.001).No correlation of QTc with age(P=0.693),sex(P=0.753),or etiology(P=0.418)was detected.β-blockers shortened QTc(P<0.001).QTc was prolonged during acute gastrointestinal bleeding(P=0.020).Tx tended to improve QTc(P<0.001).No other sources of QTc heterogeneity were revealed.CONCLUSION QTc is prolonged in cirrhosis independently of sex,age,and etiology but is correlated with severity and affected byβ-blockers and acute gastrointestinal bleeding.QTc is improved after liver Tx.展开更多
This research article is based on a study of optimal frequency to the repairable system due to the failure finding interval to maximize as well as minimize the availability of some components devices. We studied toget...This research article is based on a study of optimal frequency to the repairable system due to the failure finding interval to maximize as well as minimize the availability of some components devices. We studied together maintenance and corrective actions that carried out item of failure and periodic failure finding designed to check whether a system is still working. The model is proved as well as useful application in detecting the problem related to finding failure tasks of different scheme devices by maximization. The model formulated and the numerical application to the relevant mathematical model have been discussed to demonstrate the article quality. Therefore based on probability analytic development, the optimal maintenance policy is then obtained as solution of an optimization problem in which the maintenance cost rate is the objective function and the risk of corrective maintenance is the constraint function. Finally, the solution to the optimal device in the considered development model has been well adjusted due to derivation to the experimental observation rather than theory which will be taken into consideration in the next applied practical design research related and the system device provided that, the proactive device agreed with using the exponential distribution to the survive distribution function which can not be considered as valid.展开更多
This work focuses on the effect of the interval between two shocks on the ejecta formation from the grooved aluminum(Al_(1100))surface by using smoothed particle hydrodynamics numerical simulation.Two unsupported shoc...This work focuses on the effect of the interval between two shocks on the ejecta formation from the grooved aluminum(Al_(1100))surface by using smoothed particle hydrodynamics numerical simulation.Two unsupported shocks are obtained by the plate-impact between sample and two flyers at interval,with a peak pressure of approximately 30 GPa for each shock.When the shock interval varies from 2.11 to 7.67 times the groove depth,the bubble velocity reduces to a constant,and the micro jetting factor R_(J) from spike to bubble exhibits a non-monotonic change that decreases initially and then increases.At a shock interval of 3.6 times the groove depth,micro jetting factor R_(J) from spike to bubble reaches its minimum value of approximately 0.6.While,the micro jetting factor R_(F) from spike to free surface decreases linearly at first,and stabilizes around 0.25 once the shock interval surpasses 4.18 times the groove depth.When the shock interval is less than 4.18 times the groove depth,the unloading wave generated by the breakout of the first shock wave is superimpose with the unloading part of the second shock wave to form a large tensile area.展开更多
2D profile lines play a critical role in cost-effectively evaluating rock joint properties and shear strength.However,the interval(DIL)between these lines significantly impacts roughness and shear strength assessments...2D profile lines play a critical role in cost-effectively evaluating rock joint properties and shear strength.However,the interval(DIL)between these lines significantly impacts roughness and shear strength assessments.A detailed study of 45 joint samples using four statistical measures across 500 different DIL values identified a clear line interval effect with two stages:stable and fluctuation-discrete.Further statistical analysis showed a linear relationship between the error bounds of four parameters,shear strength evaluation,and their corresponding maximum DIL values,where the gradient k of this linear relationship was influenced by the basic friction angle and normal stress.Accounting for these factors,lower-limit linear models were employed to determine the optimal DIL values that met error tolerances(1%–10%)for all metrics and shear strength.The study also explored the consistent size effect on joints regardless of DIL changes,revealing three types of size effects based on morphological heterogeneity.Notably,larger joints required generally higher DIL to maintain the predefined error limits,suggesting an increased interval for large joint analyses.Consequently,this research provides a basis for determining the optimal DIL,improving accuracy in 2D profile line assessments of joint characteristics.展开更多
Interval model updating(IMU)methods have been widely used in uncertain model updating due to their low requirements for sample data.However,the surrogate model in IMU methods mostly adopts the one-time construction me...Interval model updating(IMU)methods have been widely used in uncertain model updating due to their low requirements for sample data.However,the surrogate model in IMU methods mostly adopts the one-time construction method.This makes the accuracy of the surrogate model highly dependent on the experience of users and affects the accuracy of IMU methods.Therefore,an improved IMU method via the adaptive Kriging models is proposed.This method transforms the objective function of the IMU problem into two deterministic global optimization problems about the upper bound and the interval diameter through universal grey numbers.These optimization problems are addressed through the adaptive Kriging models and the particle swarm optimization(PSO)method to quantify the uncertain parameters,and the IMU is accomplished.During the construction of these adaptive Kriging models,the sample space is gridded according to sensitivity information.Local sampling is then performed in key subspaces based on the maximum mean square error(MMSE)criterion.The interval division coefficient and random sampling coefficient are adaptively adjusted without human interference until the model meets accuracy requirements.The effectiveness of the proposed method is demonstrated by a numerical example of a three-degree-of-freedom mass-spring system and an experimental example of a butted cylindrical shell.The results show that the updated results of the interval model are in good agreement with the experimental results.展开更多
Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives ...Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.展开更多
Theα-universal triple I(α-UTI)method is a recognized scheme in the field of fuzzy reasoning,whichwas proposed by our research group previously.The robustness of fuzzy reasoning determines the quality of reasoning al...Theα-universal triple I(α-UTI)method is a recognized scheme in the field of fuzzy reasoning,whichwas proposed by our research group previously.The robustness of fuzzy reasoning determines the quality of reasoning algorithms to a large extent,which is quantified by calculating the disparity between the output of fuzzy reasoning with interference and the output without interference.Therefore,in this study,the interval robustness(embodied as the interval stability)of theα-UTI method is explored in the interval-valued fuzzy environment.To begin with,the stability of theα-UTI method is explored for the case of an individual rule,and the upper and lower bounds of its results are estimated,using four kinds of unified interval implications(including the R-interval implication,the S-interval implication,the QL-interval implication and the interval t-norm implication).Through analysis,it is found that theα-UTI method exhibits good interval stability for an individual rule.Moreover,the stability of theα-UTI method is revealed in the case of multiple rules,and the upper and lower bounds of its outcomes are estimated.The results show that theα-UTI method is stable for multiple rules when four kinds of unified interval implications are used,respectively.Lastly,theα-UTI reasoning chain method is presented,which contains a chain structure with multiple layers.The corresponding solutions and their interval perturbations are investigated.It is found that theα-UTI reasoning chain method is stable in the case of chain reasoning.Two application examples in affective computing are given to verify the stability of theα-UTImethod.In summary,through theoretical proof and example verification,it is found that theα-UTImethod has good interval robustness with four kinds of unified interval implications aiming at the situations of an individual rule,multi-rule and reasoning chain.展开更多
In this paper, the methods of decomposition of large-scale system and Liapunov function are used in studying the existence of stationary oscillation of periodic interval system, some new results are obtained.
In this paper, we consider the problem of robust stability for a class of linear systems with interval time-varying delay under nonlinear perturbations using Lyapunov-Krasovskii (LK) functional approach. By partitio...In this paper, we consider the problem of robust stability for a class of linear systems with interval time-varying delay under nonlinear perturbations using Lyapunov-Krasovskii (LK) functional approach. By partitioning the delay-interval into two segments of equal length, and evaluating the time-derivative of a candidate LK functional in each segment of the delay-interval, a less conservative delay-dependent stability criterion is developed to compute the maximum allowable bound for the delay-range within which the system under consideration remains asymptotically stable. In addition to the delay-bi-segmentation analysis procedure, the reduction in conservatism of the proposed delay-dependent stability criterion over recently reported results is also attributed to the fact that the time-derivative of the LK functional is bounded tightly using a newly proposed bounding condition without neglecting any useful terms in the delay-dependent stability analysis. The analysis, subsequently, yields a stable condition in convex linear matrix inequality (LMI) framework that can be solved non-conservatively at boundary conditions using standard numerical packages. Furthermore, as the number of decision variables involved in the proposed stability criterion is less, the criterion is computationally more effective. The effectiveness of the proposed stability criterion is validated through some standard numerical examples.展开更多
Since the great 1303 Hongtong, Shanxi, earthquake of magnitude 8, 700 years have elapsed. To analyze the long-term seismic potential, this paper divides the Taiyuan-Linfen portion of the Shanxi graben system into 5 se...Since the great 1303 Hongtong, Shanxi, earthquake of magnitude 8, 700 years have elapsed. To analyze the long-term seismic potential, this paper divides the Taiyuan-Linfen portion of the Shanxi graben system into 5 seismogenic segments. Based on data of historical earthquakes and GPS observation, the authors estimate mean seismic-moment rates and average recurrence intervals of strong earthquakes for the individual segments, and fur-ther analyze relative levels of current stress cumulation on the segments based on mapping b-values along the gra-ben system by using the network seismic data for the recent over 30 years. The main result shows that the Linfen basin segment has an estimated mean seismic-moment rate of 2.211016 Nm/a to 3.031016 Nm/a, and its average recurrence interval for M=7.5 earthquake is estimated to be between 1 560 and 2 140 years. For the Ling-shi-Hongtong segment, the estimated average recurrence interval for M=8 earthquakes is between 4 300 and 5 100 years, equivalent to having a mean moment-rate of 2.581016 Nm/a to 3.101016 Nm/a. The contour map of b-values shows that the two segments of Lingshi-Hongtong and Linfen basin have been being at low or relatively low stress levels, reflecting that since the 1303 M=8 and the 1695 M=7.5 earthquake ruptures, the fault-planes strengths of the both segments have not been resumed yet. And the other two segments, the Houma and the Jiexiu-Fenyang, have relatively high stress levels, and have been already identified as potential risky segments for the coming earthquakes from the analysis combining with the estimated average recurrence intervals of earth-quakes on the both segments.展开更多
AIM To examine the impact of liver cirrhosis on QT interval and cardiac autonomic neuropathy(CAN). METHODS A total of 51 patients with cirrhosis and 51 controls were examined. Standard 12-lead electrocardiogram record...AIM To examine the impact of liver cirrhosis on QT interval and cardiac autonomic neuropathy(CAN). METHODS A total of 51 patients with cirrhosis and 51 controls were examined. Standard 12-lead electrocardiogram recordings were obtained and QT as well as corrected QT interval(QTc) and their dispersions(dQT, dQTc) were measured and calculated using a computer-based program. The diagnosis of CAN was based upon the battery of the tests proposed by Ewing and Clarke and the consensus statements of the American Diabetes Association. CAN was diagnosed when two out of the four classical Ewing tests were abnormal. RESULTS QT, QTc and their dispersions were significantly longer(P < 0.01) in patients with cirrhosis than in controls. No significant differences in QT interval were found among the subgroups according to the etiology of cirrhosis. Multivariate regression analysis after controlling for age, gender and duration of cirrhosis demonstrated significant association between QT and presence of diabetes mellitus [standardized regression coefficient(beta) = 0.45, P = 0.02] and treatment with diuretics(beta = 0.55, P = 0.03), but not with the Child-Pugh score(P = 0.54). Prevalence of CAN was common(54.9%) among patients with cirrhosis and its severity was associated with the Child-Pugh score(r = 0.33, P = 0.02). Moreover, patients with decompensated cirrhosis had more severe CAN that those with compensated cirrhosis(P = 0.03). No significant association was found between severity of CAN and QT interval duration.CONCLUSION Patients with cirrhosis have QT prolongation. Treatment with diuretics is associated with longer QT. CAN is common in patients with cirrhosis and its severity is associated with severity of the disease.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant No.10271074)the Shanghai Leading Academic Discipline Project (Grant No.J50101)
文摘An interval Pade-type approximation is introduced and then Routh-Pade-type method (IRPTM) is presented to model reduction in interval systems. The denominator in reduced model is obtained from the stable Routh table, and its numerator is constructed by the interval Pade-type definition. Compared to the existing Routh-Pade method, IRPTM does not need to solve linear interval equations theoretical analysis shows that IRPTM has example is given to illustrate our method. Hence, we do not have to compute smaller computational cost than that interval division in the process. Moreover, of Routh-Pade method. A typical numerical
基金This work was supported by the National Natural Science Foundation of China(No.60421002).
文摘Sufficient conditions for the quadratic D-stability and further robust D-stability of interval systems are presented in this paper. This robust D-stability condition is based on a parameter-dependent Lyapunov function obtained from the feasibility of a set of linear matrix inequalities (LMIs) defined at a series of partial-vertex-based interval matrices other than the total vertex matrices as in previous results. The results contain the usual quadratic and robust stability of continuous-time and discrete-time interval systems as particular cases. The illustrative example shows that this method is effective and less conservative for checking the quadratic and robust D-stability of interval systems.
基金This project was supported by the National Natural Science Foundation of China (7017004).
文摘A special type of asymptotic (exponential) stability, namely componentwise asymptotic (exponential) stability for the continuous-time interval system is investigated. A set-valued map that represents the constraint of the state of the system is defined. And, by applying the viability theory of differential equation, sufficient and necessary conditions for the componentwise asymptotical (exponential) stability of this kind of systems are given.
文摘By using power mapping(s =v^m),stability analysis of fractional order polynomials was simplified to the stability analysis of expanded degree integer order polynomials in the first Riemann sheet.However,more investigation is needed for revealing properties of power mapping and demonstration of conformity of Hurwitz stability under power mapping of fractional order characteristic polynomials.Contributions of this study have two folds: Firstly,this paper demonstrates conservation of root argument and magnitude relations under power mapping of characteristic polynomials and thus substantiates validity of Hurwitz stability under power mapping of fractional order characteristic polynomials.This also ensures implications of edge theorem for fractional order interval systems.Secondly,in control engineering point of view,numerical robust stability analysis approaches based on the consideration of minimum argument roots of edge and vertex polynomials are presented.For the computer-aided design of fractional order interval control systems,the minimum argument root principle is applied for a finite set of edge and vertex polynomials,which are sampled from parametric uncertainty box.Several illustrative examples are presented to discuss effectiveness of these approaches.
文摘The robust stability analysis for discrete large-scale uncertain systems with multiple time delays is addressed in this paper. We establish a method for selecting properly a positive definite matrix Q to derive a very simple upper solution bound of the discrete algebraic Lyapunov equation (DALE). Then, using the Lyapunov equation approach method with this upper bound, several sufficient conditions are presented to guarantee the robust stability of the overall systems. Comparisons between the proposed results with a previous one are also given.
基金supported by the Science and Technology Project of State Grid Inner Mongolia East Power Co.,Ltd.:Research on Carbon Flow Apportionment and Assessment Methods for Distributed Energy under Dual Carbon Targets(52664K220004).
文摘Addressing the insufficiency in down-regulation leeway within integrated energy systems stemming from the erratic and volatile nature of wind and solar renewable energy generation,this study focuses on formulating a coordinated strategy involving the carbon capture unit of the integrated energy system and the resources on the load storage side.A scheduling model is devised that takes into account the confidence interval associated with renewable energy generation,with the overarching goal of optimizing the system for low-carbon operation.To begin with,an in-depth analysis is conducted on the temporal energy-shifting attributes and the low-carbon modulation mechanisms exhibited by the source-side carbon capture power plant within the context of integrated and adaptable operational paradigms.Drawing from this analysis,a model is devised to represent the adjustable resources on the charge-storage side,predicated on the principles of electro-thermal coupling within the energy system.Subsequently,the dissimilarities in the confidence intervals of renewable energy generation are considered,leading to the proposition of a flexible upper threshold for the confidence interval.Building on this,a low-carbon dispatch model is established for the integrated energy system,factoring in the margin allowed by the adjustable resources.In the final phase,a simulation is performed on a regional electric heating integrated energy system.This simulation seeks to assess the impact of source-load-storage coordination on the system’s low-carbon operation across various scenarios of reduction margin reserves.The findings underscore that the proactive scheduling model incorporating confidence interval considerations for reduction margin reserves effectively mitigates the uncertainties tied to renewable energy generation.Through harmonized orchestration of source,load,and storage elements,it expands the utilization scope for renewable energy,safeguards the economic efficiency of system operations under low-carbon emission conditions,and empirically validates the soundness and efficacy of the proposed approach.
基金supported by the Estonian Research Council(PRG658)。
文摘The robust stability study of the classic Smith predictor-based control system for uncertain fractional-order plants with interval time delays and interval coefficients is the emphasis of this work.Interval uncertainties are a type of parametric uncertainties that cannot be avoided when modeling real-world plants.Also,in the considered Smith predictor control structure it is supposed that the controller is a fractional-order proportional integral derivative(FOPID)controller.To the best of the authors'knowledge,no method has been developed until now to analyze the robust stability of a Smith predictor based fractional-order control system in the presence of the simultaneous uncertainties in gain,time-constants,and time delay.The three primary contributions of this study are as follows:ⅰ)a set of necessary and sufficient conditions is constructed using a graphical method to examine the robust stability of a Smith predictor-based fractionalorder control system—the proposed method explicitly determines whether or not the FOPID controller can robustly stabilize the Smith predictor-based fractional-order control system;ⅱ)an auxiliary function as a robust stability testing function is presented to reduce the computational complexity of the robust stability analysis;andⅲ)two auxiliary functions are proposed to achieve the control requirements on the disturbance rejection and the noise reduction.Finally,four numerical examples and an experimental verification are presented in this study to demonstrate the efficacy and significance of the suggested technique.
基金supports from National Science Foundation of China(Grant No.51777121).
文摘Aiming at the fact that the rotor winding inter-turn weak faults can hardly be detected due to the strong electromagnetic coupling effect in the excitation system,an interval observer based on current residual is designed.Firstly,the mechanism of the inter-turn short circuit of the rotor winding in the excitation system is modeled under the premise of stable working conditions,and electromagnetic decoupling and system simplification are carried out through Park Transform.An interval observer is designed based on the current residual in the two-phase coordinate system,and the sensitive and stable conditions of the observer is preset.The fault diagnosis process based on the interval observer is formulated,and the observer gain matrix is convexly optimized by linear matrix inequality.The numerical simulation and experimental results show that the inter-turn short circuit weak fault is hardly detected directly through the current signal,but the fault is quickly and accurately diagnosed through the residual internal observer.Compared with the traditional fault diagnosis method based on excitation current,the diagnosis speed and accuracy are greatly improved,and the probability of misdiagnosis also decreases.This method provides a theoretical basis for weak fault identification of excitation systems,and is of great significance for the operation and maintenance of excitation systems.
文摘BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic syndrome characterized by insulin resistance and hyperglycemia that may lead to endothelial dysfunction,reduced functional capacity and exercise intolerance.Regular aerobic exercise has been promoted as the most beneficial non-pharmacological treatment of cardiovascular diseases.High intensity interval training(HIIT)seems to be superior than moderate-intensity continuous training(MICT)in cardiovascular diseases by improving brachial artery flow-mediated dilation(FMD)and cardiorespiratory fitness to a greater extent.However,the beneficial effects of HIIT in patients with T2DM still remain under investigation and number of studies is limited.AIM To evaluate the effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in patients with T2DM.METHODS We performed a search on PubMed,PEDro and CINAHL databases,selecting papers published between December 2012 and December 2022 and identified published randomized controlled trials(RCTs)in the English language that included community or outpatient exercise training programs in patients with T2DM.RCTs were assessed for methodological rigor and risk of bias via the Physiotherapy Evidence Database(PEDro).The primary outcome was peak VO_(2 ) and the secondary outcome was endothelial function assessed either by FMD or other indices of microcirculation.RESULTS Twelve studies were included in our systematic review.The 12 RCTs resulted in 661 participants in total.HIIT was performed in 310 patients(46.8%),MICT to 271 and the rest 80 belonged to the control group.Peak VO_(2 ) increased in 10 out of 12 studies after HIIT.Ten studies compared HIIT with other exercise regimens(MICT or strength endurance)and 4 of them demonstrated additional beneficial effects of HIIT over MICT or other exercise regimens.Moreover,4 studies explored the effects of HIIT on endothelial function and FMD in T2DM patients.In 2 of them,HIIT further improved endothelial function compared to MICT and/or the control group while in the rest 2 studies no differences between HIIT and MICT were observed.CONCLUSION Regular aerobic exercise training has beneficial effects on cardiorespiratory fitness and endothelial function in T2DM patients.HIIT may be superior by improving these parameters to a greater extent than MICT.
文摘BACKGROUND Corrected QT(QTc)interval is prolonged in patients with liver cirrhosis and has been proposed to correlate with the severity of the disease.However,the effects of sex,age,severity,and etiology of cirrhosis on QTc have not been elucidated.At the same time,the role of treatment,acute illness,and liver transplantation(Tx)remains largely unknown.AIM To determine the mean QTc in patients with cirrhosis,assess whether QTc is prolonged in patients with cirrhosis,and investigate whether QTc is affected by factors such as sex,age,severity,etiology,treatment,acute illness,and liver Tx.METHODS In the present systematic review and meta-analysis,the searching protocol“{[QTc]OR[QT interval]OR[QT-interval]OR[Q-T syndrome]}AND{[cirrhosis]OR[Child-Pugh]OR[MELD]}”was applied in PubMed,EMBASE,and Google Scholar databases to identify studies that reported QTc in patients with cirrhosis and published after 1998.Seventy-three studies were considered eligible.Data concerning first author,year of publication,type of study,method used,sample size,mean age,female ratio,alcoholic etiology of cirrhosis ratio,Child-Pugh A/B/C ratio,mean model for end-stage liver disease(MELD)score,treatment withβ-blockers,episode of acute gastrointestinal bleeding,formula for QT correction,mean pulse rate,QTc in patients with cirrhosis and controls,and QTc according to etiology of cirrhosis,sex,Child-Pugh stage,MELD score,and liver Tx status(pre-Tx/post-Tx)were retrieved.The Newcastle-Ottawa quality assessment scale appraised the quality of the eligible studies.Effect estimates,expressed as proportions or standardized mean differences,were combined using the randomeffects,generic inverse variance method of DerSimonian and Laird.Subgroup,sensitivity analysis,and meta-regressions were applied to assess heterogeneity.RESULTS QTc combined mean in patients with cirrhosis was 444.8 ms[95%confidence interval(CI):440.4-449.2;P<0.001 when compared with the upper normal limit of 440 ms],presenting high heterogeneity(I2=97.5%;95%CI:97.2%-97.8%);both Egger’s and Begg’s tests showed non-significance.QTc was elongated in patients with cirrhosis compared with controls(P<0.001).QTc was longer in patients with Child-Pugh C cirrhosis when compared with Child-Pugh B and A(P<0.001);Child-Pugh B patients presented longer QTc when compared with Child-Pugh A patients(P=0.003).The MELD score was higher in patients with cirrhosis with QTc>440 ms when compared with QTc≤440 ms(P<0.001).No correlation of QTc with age(P=0.693),sex(P=0.753),or etiology(P=0.418)was detected.β-blockers shortened QTc(P<0.001).QTc was prolonged during acute gastrointestinal bleeding(P=0.020).Tx tended to improve QTc(P<0.001).No other sources of QTc heterogeneity were revealed.CONCLUSION QTc is prolonged in cirrhosis independently of sex,age,and etiology but is correlated with severity and affected byβ-blockers and acute gastrointestinal bleeding.QTc is improved after liver Tx.
文摘This research article is based on a study of optimal frequency to the repairable system due to the failure finding interval to maximize as well as minimize the availability of some components devices. We studied together maintenance and corrective actions that carried out item of failure and periodic failure finding designed to check whether a system is still working. The model is proved as well as useful application in detecting the problem related to finding failure tasks of different scheme devices by maximization. The model formulated and the numerical application to the relevant mathematical model have been discussed to demonstrate the article quality. Therefore based on probability analytic development, the optimal maintenance policy is then obtained as solution of an optimization problem in which the maintenance cost rate is the objective function and the risk of corrective maintenance is the constraint function. Finally, the solution to the optimal device in the considered development model has been well adjusted due to derivation to the experimental observation rather than theory which will be taken into consideration in the next applied practical design research related and the system device provided that, the proactive device agreed with using the exponential distribution to the survive distribution function which can not be considered as valid.
基金supported by the Doctoral Research Launch Foundation of Liaoning Province(Grant No.2022-BS-185),Chinathe Science Challenge Project(Grant No.TZ2016001),China+2 种基金the National Natural Science Foundation of China(Grant Nos.11972092,12172056,12002049),Chinathe key Laboratory of Computational Physics(Gant No.HX02021-24)720-24)Shenyang Ligong University Talent Introduction Support Fund,China。
文摘This work focuses on the effect of the interval between two shocks on the ejecta formation from the grooved aluminum(Al_(1100))surface by using smoothed particle hydrodynamics numerical simulation.Two unsupported shocks are obtained by the plate-impact between sample and two flyers at interval,with a peak pressure of approximately 30 GPa for each shock.When the shock interval varies from 2.11 to 7.67 times the groove depth,the bubble velocity reduces to a constant,and the micro jetting factor R_(J) from spike to bubble exhibits a non-monotonic change that decreases initially and then increases.At a shock interval of 3.6 times the groove depth,micro jetting factor R_(J) from spike to bubble reaches its minimum value of approximately 0.6.While,the micro jetting factor R_(F) from spike to free surface decreases linearly at first,and stabilizes around 0.25 once the shock interval surpasses 4.18 times the groove depth.When the shock interval is less than 4.18 times the groove depth,the unloading wave generated by the breakout of the first shock wave is superimpose with the unloading part of the second shock wave to form a large tensile area.
基金the National Natural Science Foundation of China(Nos.42002275 and 52325905)the Natural Science Foundation of Zhejiang Province(No.LQ24D020012)+2 种基金the Open Research Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering(No.SKLGME023007)Open Fund of Badong National Observation and Research Station of Geohazards(No.BNORSG202308)the Shaoxing Science and Technology Plan Project(No.2022A13003).
文摘2D profile lines play a critical role in cost-effectively evaluating rock joint properties and shear strength.However,the interval(DIL)between these lines significantly impacts roughness and shear strength assessments.A detailed study of 45 joint samples using four statistical measures across 500 different DIL values identified a clear line interval effect with two stages:stable and fluctuation-discrete.Further statistical analysis showed a linear relationship between the error bounds of four parameters,shear strength evaluation,and their corresponding maximum DIL values,where the gradient k of this linear relationship was influenced by the basic friction angle and normal stress.Accounting for these factors,lower-limit linear models were employed to determine the optimal DIL values that met error tolerances(1%–10%)for all metrics and shear strength.The study also explored the consistent size effect on joints regardless of DIL changes,revealing three types of size effects based on morphological heterogeneity.Notably,larger joints required generally higher DIL to maintain the predefined error limits,suggesting an increased interval for large joint analyses.Consequently,this research provides a basis for determining the optimal DIL,improving accuracy in 2D profile line assessments of joint characteristics.
基金Project supported by the National Natural Science Foundation of China(Nos.12272211,12072181,12121002)。
文摘Interval model updating(IMU)methods have been widely used in uncertain model updating due to their low requirements for sample data.However,the surrogate model in IMU methods mostly adopts the one-time construction method.This makes the accuracy of the surrogate model highly dependent on the experience of users and affects the accuracy of IMU methods.Therefore,an improved IMU method via the adaptive Kriging models is proposed.This method transforms the objective function of the IMU problem into two deterministic global optimization problems about the upper bound and the interval diameter through universal grey numbers.These optimization problems are addressed through the adaptive Kriging models and the particle swarm optimization(PSO)method to quantify the uncertain parameters,and the IMU is accomplished.During the construction of these adaptive Kriging models,the sample space is gridded according to sensitivity information.Local sampling is then performed in key subspaces based on the maximum mean square error(MMSE)criterion.The interval division coefficient and random sampling coefficient are adaptively adjusted without human interference until the model meets accuracy requirements.The effectiveness of the proposed method is demonstrated by a numerical example of a three-degree-of-freedom mass-spring system and an experimental example of a butted cylindrical shell.The results show that the updated results of the interval model are in good agreement with the experimental results.
基金supported by the National Natural Science Foundation of China,Nos.82071426,81873784Clinical Cohort Construction Program of Peking University Third Hospital,No.BYSYDL2019002(all to DF)。
文摘Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.
基金the National Natural Science Foundation of China under Grants 62176083,62176084,61877016,and 61976078the Key Research and Development Program of Anhui Province under Grant 202004d07020004the Natural Science Foundation of Anhui Province under Grant 2108085MF203.
文摘Theα-universal triple I(α-UTI)method is a recognized scheme in the field of fuzzy reasoning,whichwas proposed by our research group previously.The robustness of fuzzy reasoning determines the quality of reasoning algorithms to a large extent,which is quantified by calculating the disparity between the output of fuzzy reasoning with interference and the output without interference.Therefore,in this study,the interval robustness(embodied as the interval stability)of theα-UTI method is explored in the interval-valued fuzzy environment.To begin with,the stability of theα-UTI method is explored for the case of an individual rule,and the upper and lower bounds of its results are estimated,using four kinds of unified interval implications(including the R-interval implication,the S-interval implication,the QL-interval implication and the interval t-norm implication).Through analysis,it is found that theα-UTI method exhibits good interval stability for an individual rule.Moreover,the stability of theα-UTI method is revealed in the case of multiple rules,and the upper and lower bounds of its outcomes are estimated.The results show that theα-UTI method is stable for multiple rules when four kinds of unified interval implications are used,respectively.Lastly,theα-UTI reasoning chain method is presented,which contains a chain structure with multiple layers.The corresponding solutions and their interval perturbations are investigated.It is found that theα-UTI reasoning chain method is stable in the case of chain reasoning.Two application examples in affective computing are given to verify the stability of theα-UTImethod.In summary,through theoretical proof and example verification,it is found that theα-UTImethod has good interval robustness with four kinds of unified interval implications aiming at the situations of an individual rule,multi-rule and reasoning chain.
基金'Project supported by the Natural Science Foundation of Henan Province (No.0211010900) Natural Science Foundation of Shandong Institute of Business and Technology.
文摘In this paper, the methods of decomposition of large-scale system and Liapunov function are used in studying the existence of stationary oscillation of periodic interval system, some new results are obtained.
文摘In this paper, we consider the problem of robust stability for a class of linear systems with interval time-varying delay under nonlinear perturbations using Lyapunov-Krasovskii (LK) functional approach. By partitioning the delay-interval into two segments of equal length, and evaluating the time-derivative of a candidate LK functional in each segment of the delay-interval, a less conservative delay-dependent stability criterion is developed to compute the maximum allowable bound for the delay-range within which the system under consideration remains asymptotically stable. In addition to the delay-bi-segmentation analysis procedure, the reduction in conservatism of the proposed delay-dependent stability criterion over recently reported results is also attributed to the fact that the time-derivative of the LK functional is bounded tightly using a newly proposed bounding condition without neglecting any useful terms in the delay-dependent stability analysis. The analysis, subsequently, yields a stable condition in convex linear matrix inequality (LMI) framework that can be solved non-conservatively at boundary conditions using standard numerical packages. Furthermore, as the number of decision variables involved in the proposed stability criterion is less, the criterion is computationally more effective. The effectiveness of the proposed stability criterion is validated through some standard numerical examples.
文摘Since the great 1303 Hongtong, Shanxi, earthquake of magnitude 8, 700 years have elapsed. To analyze the long-term seismic potential, this paper divides the Taiyuan-Linfen portion of the Shanxi graben system into 5 seismogenic segments. Based on data of historical earthquakes and GPS observation, the authors estimate mean seismic-moment rates and average recurrence intervals of strong earthquakes for the individual segments, and fur-ther analyze relative levels of current stress cumulation on the segments based on mapping b-values along the gra-ben system by using the network seismic data for the recent over 30 years. The main result shows that the Linfen basin segment has an estimated mean seismic-moment rate of 2.211016 Nm/a to 3.031016 Nm/a, and its average recurrence interval for M=7.5 earthquake is estimated to be between 1 560 and 2 140 years. For the Ling-shi-Hongtong segment, the estimated average recurrence interval for M=8 earthquakes is between 4 300 and 5 100 years, equivalent to having a mean moment-rate of 2.581016 Nm/a to 3.101016 Nm/a. The contour map of b-values shows that the two segments of Lingshi-Hongtong and Linfen basin have been being at low or relatively low stress levels, reflecting that since the 1303 M=8 and the 1695 M=7.5 earthquake ruptures, the fault-planes strengths of the both segments have not been resumed yet. And the other two segments, the Houma and the Jiexiu-Fenyang, have relatively high stress levels, and have been already identified as potential risky segments for the coming earthquakes from the analysis combining with the estimated average recurrence intervals of earth-quakes on the both segments.
文摘AIM To examine the impact of liver cirrhosis on QT interval and cardiac autonomic neuropathy(CAN). METHODS A total of 51 patients with cirrhosis and 51 controls were examined. Standard 12-lead electrocardiogram recordings were obtained and QT as well as corrected QT interval(QTc) and their dispersions(dQT, dQTc) were measured and calculated using a computer-based program. The diagnosis of CAN was based upon the battery of the tests proposed by Ewing and Clarke and the consensus statements of the American Diabetes Association. CAN was diagnosed when two out of the four classical Ewing tests were abnormal. RESULTS QT, QTc and their dispersions were significantly longer(P < 0.01) in patients with cirrhosis than in controls. No significant differences in QT interval were found among the subgroups according to the etiology of cirrhosis. Multivariate regression analysis after controlling for age, gender and duration of cirrhosis demonstrated significant association between QT and presence of diabetes mellitus [standardized regression coefficient(beta) = 0.45, P = 0.02] and treatment with diuretics(beta = 0.55, P = 0.03), but not with the Child-Pugh score(P = 0.54). Prevalence of CAN was common(54.9%) among patients with cirrhosis and its severity was associated with the Child-Pugh score(r = 0.33, P = 0.02). Moreover, patients with decompensated cirrhosis had more severe CAN that those with compensated cirrhosis(P = 0.03). No significant association was found between severity of CAN and QT interval duration.CONCLUSION Patients with cirrhosis have QT prolongation. Treatment with diuretics is associated with longer QT. CAN is common in patients with cirrhosis and its severity is associated with severity of the disease.