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Exploration of Therapeutic Measures and Clinical Efficacy for Recurrent Respiratory Infections in Children
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作者 Bei Li Suyi Zhang 《Journal of Clinical and Nursing Research》 2024年第7期60-66,共7页
Objective:To explore the treatment strategies and clinical effects for recurrent respiratory infections in children.Methods:From May 2022 to May 2024,100 pediatric patients with recurrent respiratory infections were s... Objective:To explore the treatment strategies and clinical effects for recurrent respiratory infections in children.Methods:From May 2022 to May 2024,100 pediatric patients with recurrent respiratory infections were selected in this study and evenly divided into two groups.The control group(50 patients)was treated with conventional therapy supplemented with budesonide,while the observation group(50 patients)received pidotimod treatment in addition to the control group’s treatment.Subsequently,the duration of clinical symptom improvement,respiratory function enhancement,serological index changes,reinfection status,and parental satisfaction were compared between the two groups.Results:In terms of clinical symptoms,the observation group showed significantly shorter durations of fever reduction,cough relief,tonsil swelling reduction,and disappearance of fine wet rales compared to the control group(average reduction times were 1.6 days,2.3 days,2.1 days,and 1.9 days,respectively,P<0.05).Regarding respiratory function,the observation group experienced a 12%increase in peak expiratory flow rate variability,a 0.6-liter increase in lung capacity,a 0.7-liter increase in forced lung capacity,and a 0.5-liter increase in forced expiratory volume in the first second after treatment,all significantly higher than the control group(P<0.05).Serological testing revealed that interferon-γand interleukin-2 levels increased by 15%and 18%,respectively,while interferon-α,interleukin-5,and interleukin-4 levels decreased by 10%,12%,and 9%,respectively,in the observation group,showing significant differences compared to the control group(P<0.05).Additionally,the reinfection rate in the observation group(10%)was significantly lower than that in the control group(30%),with an average reduction of two reinfections within one year and a 3.2-day shorter infection control time(P<0.05).In terms of parental satisfaction,the observation group achieved 95%,significantly higher than the 70%in the control group(P<0.05).Conclusion:The addition of pidotimod to conventional therapy for pediatric patients with recurrent respiratory infections can significantly alleviate clinical symptoms,promote the recovery of respiratory function,regulate serological indicators,effectively reduce the risk of reinfection,and improve parental satisfaction.This method deserves widespread clinical application. 展开更多
关键词 PEDIATRICS Respiratory system Recurrent infections BUDESONIDE PIDOTIMOD Clinical efficacy Reinfection rate Parental satisfaction
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Evaluation of the Protective Efficacy of a Fused OmpK/Omp22 Protein Vaccine Candidate against Acinetobacter baumannii Infection in Mice 被引量:5
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作者 GUO San Jun REN Shan XIE Yong En 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2018年第2期155-158,共4页
Acinetobocter baumannfi (A. Baumannii) is an emerging opportunistic pathogen responsible for hospital-acquired infections, and which now constitutes a sufficiently serious threat to public health to necessitate the ... Acinetobocter baumannfi (A. Baumannii) is an emerging opportunistic pathogen responsible for hospital-acquired infections, and which now constitutes a sufficiently serious threat to public health to necessitate the development of an effective vaccine. In this study, a recombinant fused protein named OmpK/Omp22 and two individual proteins OmpK and Omp22 were obtained using recombinant expression and Ni-affinity purification. Groups of BALB/c mice were immunized with these proteins and challenged with a clinically isolated strain of A. boumonnii. The bacterial load in the blood, pathological changes in the lung tissue and survival rates after challenge were evaluated. Mice immunized with OmpK/Omp22 fused protein provided significantly greater protection against A. boumonnfi challenge than those immunized with either of the two proteins individually. The results provide novel clues for future design of vaccines against A. boumonnii. 展开更多
关键词 Evaluation of the Protective efficacy of a Fused OmpK/Omp22 Protein Vaccine Candidate against Acinetobacter baumannii infection in Mice
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Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections 被引量:21
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作者 Dorota Czerucka Patrick Rampall 《World Journal of Gastroenterology》 SCIE CAS 2019年第18期2188-2203,共16页
The yeast Saccharomyces boulardii CNCM I-745 is one of the probiotics recommended for the prevention of antibiotic-associated diarrhea. Studies conducted in vivo and in vitro demonstrated that in the case of infectiou... The yeast Saccharomyces boulardii CNCM I-745 is one of the probiotics recommended for the prevention of antibiotic-associated diarrhea. Studies conducted in vivo and in vitro demonstrated that in the case of infectious diseases there are two potential sites of action of Saccharomyces boulardii CNCM I-745:(1)An action on enteropathogenic microorganisms(adhesion of bacteria and their elimination or an effect on their virulence factors: Toxins, lipopolysaccharide,etc.); and(2) a direct action on the intestinal mucosa(trophic effects, effects on epithelial reconstitution, anti-secretory effects, anti-inflammatory,immunomodulators). Oral administration of Saccharomyces boulardii CNCM I-745 to healthy subjects does not alter their microbiota. However, in the case of diseases associated with the use of antibiotics or chronic diarrhea, Saccharomyces boulardii CNCM I-745 can restore the intestinal microbiota faster. The interaction of Saccharomyces boulardii CNCM I-745 with the innate immune system have been recently demonstrated thus opening up a new therapeutic potential of this yeast in the case of diseases associated with intestinal infections but also other pathologies associated with dysbiosis such as inflammatory diseases. 展开更多
关键词 SACCHAROMYCES boulardii CNCM I-745 PROBIOTICS YEAST intestinal infection Mechanism
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Control Efficacy of Validamycin A·(0.2 Billion Spores/ml) Paenibacillus polymyxa DN-1 3% AS for Rice Sheath Blight
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作者 胡飞 苏卫华 +4 位作者 李昌春 周子燕 胡本进 徐丽娜 郑进国 《Agricultural Science & Technology》 CAS 2016年第11期2615-2618,共4页
With validamycin A.(0.2 billion spores/ml) Paenibacillus polymyxa DN-1 3% AS as the test agent, the effects of different dosage and different application time on the control efficacy for' rich sheath blight were in... With validamycin A.(0.2 billion spores/ml) Paenibacillus polymyxa DN-1 3% AS as the test agent, the effects of different dosage and different application time on the control efficacy for' rich sheath blight were investigated. The results of two- year test showed that when the application amount was in the range of 45-90 g.a.i/ hm^2, the field efficacy of validamycin A-(0.2 billion spores/ml) P. polymyxa DN-1 3% AS in the initial infection stage of rich sheath blight (Le., the diseased plant rate was below 5%) reached 80.38%-89.06%, and that in the peak infection stage (i.e., the diseased plant rate was higher than 10%) reached only 41.12%-53.26%. The field efficacy of validamycin A.(0.2 billion spores/ml) P. polymyxa DN-1 3% AS at the early onset of rich sheath blight was significantly better than that at the onset, so that the application time of validamycin A .(0.2 billion spores/ml) P. polymyxa DN-1 3% AS should be appropriately brought forward in the prevention and control of rice sheath blight. 展开更多
关键词 Validamycin A-(0.2 billion spores/roll P. polymyxa DN-1 3% AS Rice sheath blight Initial infection stage Peak infection stage Control efficacy
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Comparison of the Efficacy of Two Commercial Coccidicidal Compounds on Experimentally Infected Dogs
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作者 Froylan Ibarra-Velarde Yolanda Vera-Montenegro +1 位作者 Nelyda Saldana-Hernandez Pedro Ochoa-Galvan 《Pharmacology & Pharmacy》 2014年第13期1163-1170,共8页
The aim of the present study was to compare the coccidicidal efficacy of two commercial compounds for artificially infected dogs. Eighteen cocccidia-free dogs, male and female aged between 2 and 4 months old, were inf... The aim of the present study was to compare the coccidicidal efficacy of two commercial compounds for artificially infected dogs. Eighteen cocccidia-free dogs, male and female aged between 2 and 4 months old, were infected each with 20,000 Cystoisospora oocists cultured under laboratory conditions. When the poppies showed high counts of oocysts per gramm (OPG) (McMaster method), they were divided into 3 groups (G). G1 was treated with a compound named One&reg (Lab. Bio Zoo) containing 150 mg of toltrazuril/tablet, administered daily/5days dosing 1 tablet per 10 kg b.w. G2 received Giacoccide&reg (Pet’s Pharma) containing 250 mg of sulfadimetoxine and 165 mg of dimetridazole dosing 1 tablet per 10 kg b.w. twice a day for 10 days. G3 served as an untreated control. The puppies were coprologically monitored on Days 0, 3, 5, 10, 15, 20 and 25 to determine the percentage of OPG. Efficacy was measured based on the OPG reduction on treated animals relative to the untreated control. The results indicated an efficacy for compound One of 78.4%, 100%, 100%, 100%, 100% and 100%, for Days 3, 5, 10, 15, 20 and 25, respectively and for Giacoccide 40.6%, 45.5%, 47.4%, 65.9%, 90.4% and 92.7%, for Days 3, 5, 10, 15, 20 and 25, respectively. No statistical difference was observed on the weight of the treated puppies (p < 0.764), but the control group was statistically different to the treated ones (p < 0.014). It was concluded that compound One showed greater efficacy than Giacoccide for the treatment of canine coccidiosis in artificially infected dogs. 展开更多
关键词 efficacy Coccidicides Experimentally Infected Dogs
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GSDMD protects intestinal epithelial cells against bacterial infections through its N-terminal activity affecting intestinal immune homeostasis 被引量:1
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作者 Honghui Li Jie Pu +4 位作者 Dongxue Yang Lu Liu Yingchao Hu Shuo Yang Bingwei Wang 《Journal of Biomedical Research》 CAS CSCD 2024年第6期585-596,共12页
The intestinal mucosal barrier serves as a vital guardian of the gut health,maintaining a delicate equilibrium between gut microbiota and host immune homeostasis.Gasdermin D(GSDMD),a key executioner of pyroptosis down... The intestinal mucosal barrier serves as a vital guardian of the gut health,maintaining a delicate equilibrium between gut microbiota and host immune homeostasis.Gasdermin D(GSDMD),a key executioner of pyroptosis downstream of the inflammasome,has been found to play intricate roles in modulating colitis by influencing intestinal macrophages and regulating mucus secretion from goblet cells.However,the exact nature of the regulatory function of GSDMD in maintaining intestinal immune homeostasis and defending against pathogens remains to be elucidated.In the current study,by using the Citrobacter rodentium infection model,we found that GSDMD played a key role in the defense against intestinal Citrobacter rodentium infection,with high expression levels in intestinal epithelial and lamina propria myeloid cells.Our results showed that GSDMD acted specifically in intestinal epithelial cells to combat the infection,independently of its effects on antimicrobial peptides or mucin secretion.Instead,the resistance was mediated by the N-terminal fragment of GSDMD,highlighting its importance in intestinal immunity.However,the specific mechanism underlying the N-terminal activity of GSDMD in protecting against intestinal bacterial infections requires future investigation. 展开更多
关键词 GSDMD PYROPTOSIS Citrobacter rodentium infection intestinal mucosal barrier
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Efficacy of different antibiotics in treatment of children with respiratory mycoplasma infection 被引量:2
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作者 Mei-Ying Zhang Yan Zhao +3 位作者 Jin-Feng Liu Guo-Ping Liu Rui-Yun Zhang Li-Min Wang 《World Journal of Clinical Cases》 SCIE 2021年第23期6717-6724,共8页
BACKGROUND Respiratory infections in children are common pediatric diseases caused by pathogens that invade the respiratory system.Children are considerably susceptible to Mycoplasma pneumoniae infection.There has bee... BACKGROUND Respiratory infections in children are common pediatric diseases caused by pathogens that invade the respiratory system.Children are considerably susceptible to Mycoplasma pneumoniae infection.There has been widespread clinical attention on treatment strategies for this disease.AIM To analyze the clinical efficacy of different antibiotics in treating pediatric respiratory mycoplasma infections.METHODS We included 106 children with a confirmed diagnosis of respiratory mycoplasma infection who were admitted to our hospital from April 2017 to July 2019 and grouped them using a random number table.Among them,53 children each received clarithromycin or erythromycin.The clinical efficacy of both drugs was evaluated and compared.We performed the multiplex polymerase chain reaction(MP-PCR)test and determined the MP-PCR negative rate in children after the end of the treatment course.We compared the incidence of toxic and side effects,including nausea,diarrhea,and abdominal pain;further,we recorded the length of hospitalization,antipyretic time,and drug costs.Additionally,we evaluated and compared the compliance of the children during treatment.RESULTS The erythromycin group showed a significantly higher total effective rate of clinical treatment than the clarithromycin group.MP-PCR test results showed that the clarithromycin group had a significantly higher MP-PCR negative rate than the erythromycin group.Moreover,children in the clarithromycin group had shorter fever time,shorter hospital stays,and lower drug costs than those in the erythromycin group.The clarithromycin group had a significantly higher overall drug adherence rate than the erythromycin group.The incidence of toxic and side effects was significantly lower in the clarithromycin group than in the erythromycin group(P<0.05).CONCLUSION Our findings indicate that clarithromycin has various advantages over erythromycin,including higher application safety,stronger mycoplasma clearance,and higher medication compliance in children;therefore,it can be actively promoted. 展开更多
关键词 CLARITHROMYCIN ERYTHROMYCIN Mycoplasma respiratory infection CHILDREN Clinical efficacy Drug compliance Toxic side effects
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Evaluation of the Mechanisms Underlying Amino Acid and Microbiota Interactions in Intestinal Infections Using Germ-Free Animals 被引量:2
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作者 Yapeng Yang Peng Bin +5 位作者 Shiyu Tao Guoqiang Zhu Zhifeng Wu Wei Cheng Wenkai Ren Hong Wei 《Infectious Microbes & Diseases》 2021年第2期79-86,共8页
Intestinal infectious diseases refer to the inflammatory changes in the intestinal tract caused by pathogens(including bacteria,viruses,fungi,protozoa,or parasites)or their toxic products.A large number of microorgani... Intestinal infectious diseases refer to the inflammatory changes in the intestinal tract caused by pathogens(including bacteria,viruses,fungi,protozoa,or parasites)or their toxic products.A large number of microorganisms colonize the intestinal tract of healthy people,which together with the intestinal epithelium constitute the biological barrier of the intestinal tract to resist infectious diseases.As an“invisible organ,”the intestinal flora is closely related to human nutrition metabolism and intestinal infections.A variety of intestinal flora participates in the nutritional metabolism of amino acids,and the small molecular substances produced by the amino acid metabolism through the intestinal flora can enhance intestinal immunity and resist bacterial infections.In turn,amino acids can also regulate the composition of the intestinal flora,maintain the steady-state of the intestinal flora,protect the intestinal barrier,and inhibit colonization by pathogenic bacteria.As a model animal with a clear microbial background,germ-free(GF)animals can clarify the mechanisms of interactions between intestinal microbes and amino acid metabolism in intestinal infections by combining genetic engineering technology and multi-omics studies.This article reviews related researches on the involvement of intestinal microbes in host amino acid metabolism and resistance to intestinal infections and discusses the advantages of GF animal models for studying the underlying mechanisms.The GF animal model is helpful to further study the intervention effects of amino acid metabolism of targeted intestinal flora on intestinal infections. 展开更多
关键词 germ-free animal intestinal barrier intestinal flora intestinal immunity intestinal infection metabolism of amino acids
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Clinical efficacy and safety of intravenous itraconazole in patients with invasive fungal infections in emergency intensive care unit 被引量:1
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作者 罗晓 邵宏 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2015年第10期678-682,共5页
This study aimed to analyze the clinical efficacy and safety of itraconazole. We investigated 68 patients with invasive fungal infections(IFI) in emergency intensive care unit(EICU). A retrospective analysis was p... This study aimed to analyze the clinical efficacy and safety of itraconazole. We investigated 68 patients with invasive fungal infections(IFI) in emergency intensive care unit(EICU). A retrospective analysis was performed in patients with IFI who were treated in the authors' institution, a grade III first class hospital in Beijing, China, between Feb. 2013 and Feb. 2015. The age of patients ranged from 35 to 90 years old with the mean age of(75.1±11.1) years old. The study population comprised 36 male and 32 female patients. Total response rate was 60.3%. The response rates in definitive diagnosis, clinical diagnosis and presumed diagnosis were 33.3%, 59.5% and 65.2%, respectively(P〈0.05). The empirical treatment should be provided for patients with presumed diagnosis as earlier as possible. Eleven(16.2%) cases had adverse drug event(ADE) during treatment. The main signs were hepatic functional impairment and hypokalemia of ADE. The clinical efficacy and safety of intravenous itraconazole were precisely assessed. To reduce the adverse drug reaction(ADR), hepatic and renal function and other biochemical criterion should be closely monitored. 展开更多
关键词 ITRACONAZOLE Invasive fungal infections efficacy SAFETY Adverse drug reaction
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Selective intestinal decontamination for the prevention of early bacterial infections after liver transplantation 被引量:8
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作者 Elena Resino Rafael San-Juan Jose Maria Aguado 《World Journal of Gastroenterology》 SCIE CAS 2016年第26期5950-5957,共8页
Bacterial infection in the first month after liver transplantation is a frequent complication that poses a serious risk for liver transplant recipients as contributes substantially to increased length of hospitalizati... Bacterial infection in the first month after liver transplantation is a frequent complication that poses a serious risk for liver transplant recipients as contributes substantially to increased length of hospitalization and hospital costs being a leading cause of death in this period. Most of these infections are caused by gramnegative bacilli, although gram-positive infections, especially Enterococcus sp. constitute an emerging infectious problem. This high rate of early postoperative infections after liver transplant has generated interest in exploring various prophylactic approaches to surmount this problem. One of these approaches is selective intestinal decontamination(SID). SID is a prophylactic strategy that consists of the administration of antimicrobials with limited anaerobicidal activity in order to reduce the burden of aerobic gram-negative bacteria and/or yeast in the intestinal tract and so prevent infections caused by these organisms. The majority of studies carried out to date have found SID to be effective in the reduction of gram-negative infection, but the effect on overall infection is limited due to a higher number of infection episodes by pathogenic enterococci and coagulase-negative staphylococci. However, difficulties in general extrapolation of the favorable results obtained in specific studies together with the potential risk of selection of multirresistant microorganisms has conditioned controversy about the routinely application of these strategies in liver transplant recipients. 展开更多
关键词 Selective intestinal decontamination Liver transplant infection Gram-negative bacterial infection Gram-positive bacterial infection Multirresistant
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Prevalence of intestinal parasitic infections and its relationship with socio-demographics and hygienic habits among male primary schoolchildren in Al-Ahsa,Saudi Arabia 被引量:3
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作者 Hamdan Ibrahim Al-Mohammed Tarek Tawfik Amin +2 位作者 Elsayed Aboulmagd Hatem Refaat Hablus Burhan Omar Zaza 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2010年第11期906-912,共7页
Objective:To investigate the prevalence of different intestinal parasitic infections among male primary schoolchildren in Al-Ahsa,Saudi Arabia,and to explore the possible relative socioeconomic, environmental and beha... Objective:To investigate the prevalence of different intestinal parasitic infections among male primary schoolchildren in Al-Ahsa,Saudi Arabia,and to explore the possible relative socioeconomic, environmental and behavioural sanitary correlates.Methods:A cross-sectional descriptive study was performed.A total of 1 289 male students aged from 7 to 12 years were selected randomly from 20 urban and 12 rural primary schools by multistage sampling method. Data collection was carried out by self administered questionnaire form to the parents/guardians of students and included inquires about socio-demographics,environmental conditions,and behavioural sanitary habits.Stool analysis was carried out to examine the presence of intestinal parasitic infections.Results:Overall prevalence of parasitic infections was 27.2%,more among rural students.Frequently encountered infections included Entamoeba histolytica/dispar(8.2%), Giardia lamblia(6.5%),Entamoeba coli(4.0%) and Enterobius vermicularis(1.6%).Logistic regression revealed that lower maternal educational level and occupational status,low family income,big family size,poor personal hygienic practices and positive history of previous intestinal infections among family members increased the likelihood of infections.Conclusions: Although of low magnitude,intestinal parasitic infections still represent a public health concern among male schoolchildren in Al-Ahsa region.Socio-demographic and poor personal hygienic habits are the main predictors for these infections. 展开更多
关键词 intestinal parasitic infections SCHOOLCHILDREN Epidemiological correlates Hygiene SAUDI ARABIA
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Prevalence of Helicobacter pylori infection and intestinal metaplasia in subjects who had undergone surgery for gastric adenocarcinoma in Northwest Italy 被引量:5
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作者 Giorgio Palestro Rinaldo Pellicano +14 位作者 Gian Ruggero Fronda Guido Valente Marco De Giuli Tito Soldati Agostino Pugliese Stefano Taraglio Mauro Garino Donata Campra Miguel Angel Cutufia Elena Margaria Giancarlo Spinzi Aldo Ferrara Giorgio Marenco Mario Rizzetto Antonio Ponzetto 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第45期7131-7135,共5页
AIM: To investigate the seroprevalence of Helicobacter pylori (Hpylori) infection and its more virulent strains as well as the correlation with the histologic features among patients who had undergone surgery for g... AIM: To investigate the seroprevalence of Helicobacter pylori (Hpylori) infection and its more virulent strains as well as the correlation with the histologic features among patients who had undergone surgery for gastric cancer (GC). METHODS: Samples from 317 (184 males, 133 females, mean age 69±3.4 years) consecutive patientswho had undergone surgery for gastric non-cardia adenocarcinoma were included in the study. Five hundred and fifty-five (294 males, 261 females, mean age 57.3±4.1 years) patients consecutively admitted to the Emergency Care Unit served as control. Histological examination of tumor, lymph nodes and other tissues obtained at the time of surgery represented the diagnostic "gold standard': An enzyme immunosorbent assay was used to detect serum anti-H pylori (IgG) antibodies and Western blotting technique was utilized to search for anti-CagA protein (IgG). RESULTS: Two hundred and sixty-one of three hundred and seventeen (82.3%) GC patients and 314/555 (56.5%) controls were seropositive for anti-H pylori (P〈0.0001; OR, 3.58; 95%CI, 2.53-5.07). Out of the 317 cases, 267 (84.2%) were seropositive for anti-CagA antibody vs 100 out of 555 (18%) controls (P〈0.0001; OR, 24.30; 95%CI, 16.5-35.9). There was no difference between the frequency of H pylori in intestinal type carcinoma (76.2%) and diffuse type cancer (78.8%). Intestinal metaplasia (IM) was more frequent but not significant in the intestinal type cancer (83.4% vs 75.2% in diffuse type and 72.5% in mixed type). Among the patients examined for IM, 39.8% had IM type Ⅰ, 8.3% type Ⅱ and 51.9% type Ⅲ (type IU vs others, P = 0.4). CONCLUSION: This study confirms a high seroprevalence of H pylori infection in patients suffering from gastric adenocarcinoma and provides further evidence that searching for CagA status over H pylori infection might confer additional benefit in identifying populations at greater risk for this tumor. 展开更多
关键词 Hpylori infection Gastric cancer intestinal metaplasia ITALY
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Status of intestinal parasitic infections among rural and urban populations, southwestern Iran 被引量:1
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作者 Molouk Beiromv Esmat Panabad Abdollah Rafiei 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2019年第3期130-136,共7页
Objective: To evaluate the prevalence and risk factors of intestinal parasitic infections in the urban and rural areas of Shushtar County,southwest Iran.Methods: A total of 1 008 fecal samples were analyzed by direct ... Objective: To evaluate the prevalence and risk factors of intestinal parasitic infections in the urban and rural areas of Shushtar County,southwest Iran.Methods: A total of 1 008 fecal samples were analyzed by direct smear examination,formalinether concentration,and Ziehl-Neelsen and trichrome staining; furthermore,PCR was used to distinguish Trichostrongylus and hookworm species based on 28 S rRNA gene.Results: Totally,16.0% cases tested positive,either with a pathogenic or a non-pathogenic parasite. Protozoa were detected in 14.0%,helminths in 1.0%,protozoa and helminth coinfections were detected in 0.3%,and co-infections of two protozoa were detected in 0.7% of cases. The most common protozoa and helminths were Giardia duodenalis(7.7%) and Trichostrongylus spp.(0.5%),respectively. Among five microscopy Trichostrongylus positive cases,Trichostrongylus culbriformis was successfully identified in three isolates by sequencing. In the rural areas,the prevalence of parasitic infection was higher(9.8%) than that in the urban areas(6.2%). A significant association was found between educational level,type of drinking water,animals contact,hand-washing,and clinical symptoms. Conclusions: This study indicates that intestinal parasitic infections remain as a public health priority in Shushtar County. It seems that drinking water and environmental sanitation are the main risk factors of parasitic infections in rural areas. 展开更多
关键词 intestinal PARASITIC infectionS Risk FACTORS Iran
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Helicobacter pylori infection and small intestinal bacterial overgrowth–more than what meets the eye 被引量:4
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作者 Murali Dharan David Wozny 《World Journal of Clinical Cases》 SCIE 2022年第21期7209-7214,共6页
Helicobacter pylori(H.pylori)infection is very common and affects a significant proportion of the world population.In contrast,the prevalence of small intestinal bacterial overgrowth(SIBO)in the general population is ... Helicobacter pylori(H.pylori)infection is very common and affects a significant proportion of the world population.In contrast,the prevalence of small intestinal bacterial overgrowth(SIBO)in the general population is not well understood.There can be coexistence of both disease states in a given patient and their clinical symptoms may also overlap with one and another.There is no clear clinical guidelines for testing for and treating SIBO in patients with H.pylori infection.This review article explores the available evidence on the relationship between H.pylori infection and SIBO,diagnosis and treatment of these entities and also comments on associated non-gastrointestinal conditions. 展开更多
关键词 Helicobacter pylori infection Small intestinal bacterial overgrowth OVERLAP DIAGNOSIS TREATMENT
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Studying host genetic background effects on multimorbidity of intestinal cancer development,type 2 diabetes and obesity in response to oral bacterial infection and high-fat diet using the collaborative cross(CC)lines 被引量:6
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作者 Asal Milhem Hanifa J.Abu Toamih-Atamni +2 位作者 Luna Karkar Yael Houri-Haddad Fuad A.Iraqi 《Animal Models and Experimental Medicine》 CSCD 2021年第1期27-39,共13页
Background:Multimorbidity of intestinal cancer(IC),type 2 diabetes(T2D)and obesity is a complex set of diseases,affected by environmental and genetic risk factors.High-fat diet(HFD)and oral bacterial infection play im... Background:Multimorbidity of intestinal cancer(IC),type 2 diabetes(T2D)and obesity is a complex set of diseases,affected by environmental and genetic risk factors.High-fat diet(HFD)and oral bacterial infection play important roles in the etiology of these diseases through inflammation and various biological mechanisms.Methods:To study the complexity of this multimorbidity,we used the collaborative cross(CC)mouse genetics reference population.We aimed to study the multimorbidity of IC,T2D,and obesity using CC lines,measuring their responses to HFD and oral bacterial infection.The study used 63 mice of both sexes generated from two CC lines(IL557 and IL711).For 12 weeks,experimental mice were maintained on specific dietary regimes combined with co-infection with oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum,while control groups were not infected.Body weight(BW)and results of a intraperitoneal glucose tolerance test(IPGTT)were recorded at the end of 12 weeks,after which length and size of the intestines were assessed for polyp counts.Results:Polyp counts ranged between 2 and 10 per CC line.The combination of HFD and infection significantly reduced(P<.01)the colon polyp size of IL557 females to 2.5 cm 2,compared to the other groups.Comparing BW gain,IL557 males on HFD gained 18 g,while the females gained 10 g under the same conditions and showed the highest area under curve(AUC)values of 40000-45000(min mg/dL)in the IPGTT.Conclusion:The results show that mice from different genetic backgrounds respond differently to a high fat diet and oral infection in terms of polyp development and glucose tolerance,and this effect is gender related. 展开更多
关键词 high-fat diet(42%fat) intestinal cancer MULTIMORBIDITY OBESITY oral bacterial infection type 2 diabetes(T2D)
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Intestinal parasitic infections in suburban government schools,Lak Hok subdistrict,Muang Pathum Thani,Thailand
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作者 Sirima Kitvatanachai Pochong Rhongbutsri 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第9期699-702,共4页
Objective:To provide baseline information of parasitic infections in 3 suburban government schools,Lakhok subdistrict of Muang Pathum Thani,Thailand.Methods:This study was conducted between May-June 2010 using simple ... Objective:To provide baseline information of parasitic infections in 3 suburban government schools,Lakhok subdistrict of Muang Pathum Thani,Thailand.Methods:This study was conducted between May-June 2010 using simple direct smear and modified formalin ether and from a population of 1253 in 3 suburban government schools.Results:Total samples of 202registered and participated.The average of prevalence of infection from 3 schools was 13.9%,there were 13.7%,14.3%and 13.9%in N,S and R school,respectively with no significant difference between schools(P>0.05).The infection rates did not show significant difference between gender(P>0.05).The highest rate of infection was 20.4%in Pathom 2(8 years)students and the lowest was4%in Pathom 1(7 years)with statistically difference between age groups(P<0.05).The highest prevalence of pathogenic protozoa was Giardia lamblin(G.lamblia)which was found in 50%of infected cases,followed by 25%of Entamoeba Inictolytica(E.histolytica)and Blastocystis hominis(B.hominis).The highest prevalence of non-pathogenic protozoa was Endnhmat nano(E.nana)which was found in 88.9%,followed by 11.1%of Entamoeba coli(E.coli).Mixed infections between Blastocwstis hominis(B.hominis)and Endolimax nana(E.nana)were reported at 7.1%.The only helminthic infection found in this study area was hookworm,found in 1 student(3.8%).The formalin ether concentration technique showed a higher efficacy of detection(78%-100%)than the simple direct smear method(0%-50%).Conclusions:Surveillance of protozoan infections may need to be focused on suburban areas. 展开更多
关键词 intestinal PARASITIC infectionS SUBURBAN area Government school
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Epidemiological assessment of intestinal parasitic infections in dogs at animal shelter in Veracruz,Mexico
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作者 Cosme Alvarado-Esquivel Dora Romero-Salas +3 位作者 Mariel Aguilar-Domínguez Anabel Cruz-Romero Nelly Ibarra-Priego dalberto Angel Pérez-de-Len 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2015年第1期34-39,共6页
Objective:To determine the prevalence of infection with intestinal parasites in 101 dogs in an animal shelter in Veracruz.Mexico,and investigate whether any general characteristics of the dogs were associated with inf... Objective:To determine the prevalence of infection with intestinal parasites in 101 dogs in an animal shelter in Veracruz.Mexico,and investigate whether any general characteristics of the dogs were associated with infections.Methods:Parasitologiesl examination of fecal samples from the dogs was performed by means of centrifuge-flotation using Sheather's sucrose and zinc sulfate flotation media.In addition,hematocrit was determined in each canine blood sample.Results:Intestinal parasites were found in 99(98.0%) of the 101 dogs studied.About five different intestinal parasites were identified:Ancylostoma caninum in 89 dogs(88.1%).Giardia canis in 46(45.5%).Unciiuiria stenocephalia in 43(42.6%).Trichuris vulpis in 19(18.8%)and Strongyloides canis in 16(15.8%).Multivariate analysis showed:I) Giardia infection was associated with young age and mixed breed;2) Ancylostoma was associated with young age and no rabies vaccination:and 3) Strongyloides was associated with no rabies vaccination.Unciiuiria and Trichuris infections were not associated with the variables assessed.Conclusions:A high prevalence of intestinal parasites was found in the dogs studied.This suggests that the environment is highly contaminated with intestinal parasites.Preventive and therapeutic measures should be taken against infection with intestinal parasites in dogs in this region. 展开更多
关键词 intestinal parasites infection PREVALENCE SHELTER DOGS Mexico
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Prevalence of Strongyloides stercoralis and other intestinal parasitic infections among mentally retarded residents in central institution of southern Iran
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作者 Azar Shokri Khojasteh Sharifi Sarasiabi +1 位作者 Saeed Hosseini Teshnizi Hamid Mahmoodi 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2012年第2期88-91,共4页
Objective:To determine the prevalence of intestinal parasitic infections among mentally retarded residents of rehabilitation center of Bandar Abbas,Hormozgan province,southern Iran.Methods:A cross-sectional study was ... Objective:To determine the prevalence of intestinal parasitic infections among mentally retarded residents of rehabilitation center of Bandar Abbas,Hormozgan province,southern Iran.Methods:A cross-sectional study was carried out in central rehabilitation institute of Hormozgan province in summer 2010.Fecal samples of all 133 residents(72 males,61 females)aged 3-52,were collected in triplicate.Specimens were examined by direct smear,formalin-ether concentration techniques and stained by permanent Trichrome,Ziehl-Neelsen stains.Statistical analysis was conducted by SPSS 13.5.Results:Intestinal parasitic infections were seen in 48.5%(64 out of 133 subjects:53.4%in males and 46.6%in females).Strongyloides stercoralis with17.3%showed the highest incidence followed by Entamoeba coli(9.8%),Blastocystis hominis(7.5%),Giardia lamblia(2.3%),Endolimax nana(2.3%),Hymenolepis nana(0.8%),Oxyuris vermicularis(0.8%),and Chilomasix mesnili(0.8%).Double infections were found to be as:Strongyloides stercoralis+Giardia lamblia(2.3%),Entamoeba coli+Giardia lamblia(1.5%),Entamoeba coli+Blastocystis hominis(1.5%),Oxyuris vermicularis+Entamoeba coli(0.8%),Strongyloides stercoralis+Entamoeba coli(0.8%),respectively.Conclusions:Our findings reveal that strongyloidiasis is a common disease among mentally retarded population in southern Iran. 展开更多
关键词 intestinal pararsites Mentally retarded Hormozgan Iran STRONGYLOIDES stercoralis STRONGYLOIDIASIS PARASITIC infection Rehabilitation centre
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Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i>Infection
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作者 Tarek El-Banna Ahmed Abd El-Aziz +1 位作者 Nageh EL-Mahdy Yasmine Samy 《Journal of Biosciences and Medicines》 2015年第7期31-53,共23页
There is growing interest in re-evaluation of older antibiotics with the wide spread of pathogen resistance, especially gram negative bacteria, which impair treatment of some infections. In contrast various studies ha... There is growing interest in re-evaluation of older antibiotics with the wide spread of pathogen resistance, especially gram negative bacteria, which impair treatment of some infections. In contrast various studies have reported that some antibiotics have efficacy in clearing resistant bacterial infections. On account of that it was interesting to evaluate the efficacy of erythromycin, chloramphenicol and/or tenoxicam in curing and/or relieving wound infection of highly resistant Escherichia coli and investigate the possible mechanisms beyond their antibacterial activity. This was achieved through evaluating highly resistant E. coli strains in vitro using agar dilution and in vivo rat models of E. coli infected wound and acute inflammation by carrageenin, where possible mechanisms were evaluated through measuring immunological mediators and histopathological examination. This study revealed that in vivo, erythromycin alone or in combination with tenoxicam significantly improved the healing of infected skin wounds with E. coli irresspective of resistancy in vitro. In addition to the improvement of immunological mediators involved in inflammatory reaction, oxidative stress and in cytokines expression as response to the bacterial infection in vivo. On the other hand chloramphenicol neither alone nor in combination with tenoxicam, achieved any significant effect. Tenoxicam didn’t show antimicrobial activity alone nor in combination with tested antibiotics in vitro, but it has shown synergestic activity in combination with tested antibiotics in vivo. Thus we concluded that immunomodulatory activity of erythromycin through anti-inflammatory and antioxidant effects was the possible mechanisms by which this antibiotic had healed infection with resistant E. coli in vivo, despite its resistancy to this antibiotic in vitro. 展开更多
关键词 efficacy ANTIBIOTICS RESISTANT E. coli infection
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Intestinal parasites infection and associated factors among school children in Dagi primary school, Amhara National Regional State, Ethiopia
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作者 Mulat Alamir Worku Awoke Amsalu Feleke 《Health》 2013年第10期1697-1701,共5页
Introduction: Intestinal parasitic infections are among the most common communicable diseases worldwide, particularly in developing countries. Worldwide, about 3.5 billion people are affected, and 450 million are ill ... Introduction: Intestinal parasitic infections are among the most common communicable diseases worldwide, particularly in developing countries. Worldwide, about 3.5 billion people are affected, and 450 million are ill as a result of these infections, among whom, the majority are children. The objective of this study was to assess prevalence of intestinal parasites infection and associated risk factors among school children in Dagi primary school, ANRS, Ethiopia. Methods: Institutional-based cross-sectional study was conducted by involving 399 school children from 24 September to 19 October, 2012. Structured questionnaires were used to identify environmental, socio-demographic and behavioral factors and stool specimens were collected and examined for parasites using direct smear and formal-ether concentration technique. Data analysis was done by using SPSS version 15 statistical soft ware. Results: Eight species of intestinal parasites were identified with an overall prevalence of 77.9%. Students were infected with one or more intestinal parasites and the predominant parasite was hook worm, 94 (23.6%) followed by G. lamblia 91 (22.8%), E. histoltica 86 (21.6%) and Strongyloides 6 (1.5%). The presence of mixed parasitic infection was 106 (34.1%), double and triple infections were 97 (91.5%) and 9 (8.5%) respectively. Intestinal parasitic infection was higher in children whose fathers’ occupational status were farmers, who had unclean finger nails and who did not have the habit of wearing shoes (p parasites infection was an important public health problem among Dagi primary school children. Therefore, the local health office and other governmental and non-governmental organizations need to give attention to this serious problem of intestinal parasitic infection of school children. 展开更多
关键词 intestinal PARASITIC infectionS Amhara NATIONAL REGIONAL STATE Ethiopia
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