Objective To study the application of neuroelectrophysiological monitoring for interventional therapy of intracranial aneurysms. Methods 22 patients with intracranial aneurysm underwent neuroelectrophysiological monit...Objective To study the application of neuroelectrophysiological monitoring for interventional therapy of intracranial aneurysms. Methods 22 patients with intracranial aneurysm underwent neuroelectrophysiological monitoring during interventional therapy. Somatosensory evoked potential( SSEP) ,brainstem展开更多
Hemodynamic parameters play an important role in aneurysm formation and growth. However, it is difficult to directly observe a rapidly growing de novo aneurysm in a patient. To investigate possible associations betwee...Hemodynamic parameters play an important role in aneurysm formation and growth. However, it is difficult to directly observe a rapidly growing de novo aneurysm in a patient. To investigate possible associations between hemodynamic parameters and the formation and growth of intracranial aneurysms, the present study constructed a computational model of a case with an internal carotid artery aneurysm and an anterior communicating artery aneurysm, based on the CT angiography findings of a patient. To simulate the formation of the anterior communicating artery aneurysm and the growth of the internal carotid artery aneurysm, we then constructed a model that virtually removed the anterior communicating artery aneurysm, and a further two models that also progressively decreased the size of the internal carotid artery aneurysm. Computational simulations of the fluid dynamics of the four models were performed under pulsatile flow conditions, and wall shear stress was compared among the different models. In the three aneurysm growth models, increasing size of the aneurysm was associated with an increased area of low wall shear stress, a significant decrease in wall shear stress at the dome of the aneurysm, and a significant change in the wall shear stress of the parent artery. The wall shear stress of the anterior communicating artery remained low, and was significantly lower than the wall shear stress at the bifurcation of the internal carotid artery or the bifurcation of the middle cerebral artery. After formation of the anterior communicating artery aneurysm, the wall shear stress at the dome of the internal carotid artery aneurysm increased significantly, and the wall shear stress in the upstream arteries also changed significantly. These findings indicate that low wall shear stress may be associated with the initiation and growth of aneurysms, and that aneurysm formation and growth may influence hemodynamic parameters in the local and adjacent arteries.展开更多
Objective:To investigate the advantages and effects of pipeline embolization device(PED)or Willis stent,in treating traumatic pseudoaneurysms.Traumatic pseudo intracranial aneurysms(TPIA)can be caused by either direct...Objective:To investigate the advantages and effects of pipeline embolization device(PED)or Willis stent,in treating traumatic pseudoaneurysms.Traumatic pseudo intracranial aneurysms(TPIA)can be caused by either direct trauma or iatrogenic injuries,usually caused by direct arterial wall injury or shear due to acceleration.We describe a series of patients with TPIA who received a PED or Willis stent.Materials and methods:Retrospective analysis was performed on nine patients with TPIA admitted to the southern hospital of Southern Medical University from December 2017 to June 2019,of whom four were treated with PED and five were implanted with six Willis covered stents.The occlusive rate and complication in the two kinds of stents were compared by postoperative follow-up and modified rankin score(MRS).Results:After the implantation of PED,four patients showed an immediate stagnation of blood flow or a decreased filling in aneurysms,three out of four patients exhibited complete occlusion,and the remaining patient had nearly complete occlusion.Four out of five cases of Willis stent implantation were associated with immediate complete occlusion of aneurysms,and the modified rankin score of these patients ranged from 0 to 1.One patient died of unassociated complications.Conclusion:For different types of TPIA in the internal carotid artery(ICA),PED and Willis stents provide significant advantages in treatment,with fewer postoperative complications and prognosis well.展开更多
Prompt diagnosis and therapy of aneurysms are critical for patients with nontraumatic subarachnoid hemorrhage (SAH).The aim of our study was to assess the clinical usefulness of multislice computed tomography angiog...Prompt diagnosis and therapy of aneurysms are critical for patients with nontraumatic subarachnoid hemorrhage (SAH).The aim of our study was to assess the clinical usefulness of multislice computed tomography angiography (CTA) in the surgical and endovascular treatment of intracranial aneurysms.A total of 195 cases with 206 intracranial aneurysms underwent CTA.Fifty (24%) aneurysms underwent surgical clipping while 156 (76%) aneurysms underwent endovascular coiling.In the five missed aneurysms at digital substraction angiography and the nine aneurysms with mass intracerebral hematomas,surgical treatment was successfully performed based on 16-slice CTA alone,and the other 36 aneurysms were clipped on the main basis of the CTA.The intraoperative findings correlated well with the CTA findings and all aneurysms were clipped successfully.Sixteen-slice CTA image information has been shown to determine the choice of aneurysm therapy and assist the surgical and endovascular treatment of intracranial aneurysms.展开更多
Objective:This study aimed to evaluate the clinical and angiographic outcomes of aneurysms that were completely or near-completely embolized and ascertain whether complete embolization is important in the stent-assist...Objective:This study aimed to evaluate the clinical and angiographic outcomes of aneurysms that were completely or near-completely embolized and ascertain whether complete embolization is important in the stent-assisted coiling(SAC)of intracranial aneurysms.Methods:This retrospective study enrolled 390 patients(417 aneurysms).Among them,complete(100%)or nearcomplete(>90%)angiographic obliteration of the aneurysms on immediate angiography was accomplished.Baseline characteristics,complications,angiography follow-up results,and clinical outcomes were analyzed.Results:Cumulative adverse events occurred in 30 patients(7.7%),including thromboembolic complications in 17(4.4%),intraoperative rupture in 10(2.6%),and others in 3(0.8%).Statistical analyses revealed an increased intraprocedural rupture rate in the initial completely occluded aneurysms(5.6%compared with 1.0%).The incidence of cumulative adverse events was higher in patients with completely occluded aneurysms(11.1%)than in those with near-completely occluded aneurysms(5.5%).Angiography follow-up was available for 173 aneurysms.Aneurysm occlusion status at follow-up was correlated with stent placement(p?0.000,odds ratio?5.847),size(p?0.000,odds ratio?6.446 for tiny aneurysms;and p?0.001,odds ratio?5.616 for small aneurysms),and initial aneurysm occlusion status(p?0.001,odds ratio?3.436).Complete occlusion at followup was seen in 82.6%of the initial complete occlusion group versus 63.0%of the initial near-complete occlusion group.The incidence of complete occlusion at follow-up was higher in the initial completely occluded aneurysms with SAC(100%)than in the initial completely occluded aneurysms with non-SAC(65.2%).Conclusions:Initial complete treatment may lead to higher complication rates and good clinical outcomes at follow-up.Stent placement may enhance progressive aneurysm occlusion.Initial complete occlusion with SAC can provide durable closure at follow-up.展开更多
Subaracoid hemorrhage caused by intracranial aneurysms is characterized by high morbidity and mortality.There is no definite conclusion regarding the mechanism of formation,development,and rupture of intracranial aneu...Subaracoid hemorrhage caused by intracranial aneurysms is characterized by high morbidity and mortality.There is no definite conclusion regarding the mechanism of formation,development,and rupture of intracranial aneurysms.It is generally believed to be related to congenital hereditary connective tissue diseases and acquired hemodynamic factors,vascular inflammation,and oral pathogens.In addition,gender,age,hypertension,and psychological status are also important factors.Relevant studies show a significantly lower quality of life in patients with intracranial aneurysms,and psychological factors should be studied in more depth.Neurological complications are considered an important factor in the decrease in quality of life.In conclusion,the formation,development,and rupture of intracranial aneurysms should result from a combination of congenital and acquired factors.展开更多
Introduction: The management of intracranial aneurysms in sub-Saharan Africa is essentially surgical. In this retrospective study, the authors report their experience in surgical management of intracranial aneurysm in...Introduction: The management of intracranial aneurysms in sub-Saharan Africa is essentially surgical. In this retrospective study, the authors report their experience in surgical management of intracranial aneurysm in Côte d’Ivoire. Methods: We carried out a retrospective study on patients operated for a ruptured or unruptured intracranial aneurysm between January 1st, 2012 and December 31st, 2018. Data on epidemiological characteristics of patients and aneurysms, treatments and patient outcomes were analyzed. Results: One hundred twenty eight aneurysms were operated. Sixty-six percent of the patients were female. According to the World Federation of Neurosurgical Societies (WFNS) scale, 58, 5% of patients were in grade I. Fisher scale showed 29% of Fisher 2 and 49% of Fisher 4. The aneurysms were mainly located on the internal carotid artery in 38% and anterior complex in 36%. The average size of aneurysms was 6.5 mm. In 81.4% the size of the aneurysms was less than 10 mm. Most aneurysms (90%) were treated at late stage. According to the modified Rankin Scale, 92 patients (83%) had good outcome, 7 patients (6%) had poor outcome, and the mortality rate was 11%. Conclusions: This study shows encouraging results if we refer to the overall postoperative results. However, there is a sub-diagnosis and low treatment rate of ruptured intracranial aneurysms. The improvement of intracranial aneurysms management requires improving the standard of health in the country.展开更多
Background:Giant intracranial aneurysms(GIAs)are challenges for surgical treatment.Risk factors of postoperative stroke remain unclear.This study aims to investigate the predictors of postoperative stroke in GIAs and ...Background:Giant intracranial aneurysms(GIAs)are challenges for surgical treatment.Risk factors of postoperative stroke remain unclear.This study aims to investigate the predictors of postoperative stroke in GIAs and the impact of stroke on outcomes.Methods:We performed a retrospective medical record review of patients with GIAs who received microsurgery at our institution between 2011 and 2018.Multivariate logistic regression analyses were carried out to identify risk factors for postoperative stroke.The clinical and angiographic outcomes were compared between patients with and without stroke.Results:A total of 97 patients were included in this study.Surgical modalities included direct aneurysm neck clipping in 85 patients(87.7%),trapping with the bypass in 8(8.2%),proximal artery ligation in 1(1%),and bypass alone in 3(3.1%).Postoperative stroke was found in 26 patients(26.8%).Independent factors that affect postoperative stroke were recurrent aneurysm(OR,10.982;95%CI,1.976-61.045;P=0.006)and size≥3.5 cm(OR,3.420;95%CI,1.133-10.327;P=0.029).Combined perioperative mortality and morbidity was 26.8%.Follow-up was achieved from 89 patients(91.8%),with a mean follow-up period of 39 months(range 19 to 94 months).Good outcomes were observed in 75 patients(84.3%)and poor outcomes were observed in 14 patients(15.7%).Conclusions:Postoperative stroke was significantly associated with clinical outcome.Favorable outcomes can be achieved in most patients with GIAs after appropriate microsurgical modality.Recurrent aneurysm and size≥3.5 cm are risk factors of postoperative stroke.展开更多
Background:This study analyzed the safety and efficacy of Enterprise 2 stent-assisted coil embolization for wide-necked intracranial aneurysms by examining stent-vessel apposition,operative complications,embolization ...Background:This study analyzed the safety and efficacy of Enterprise 2 stent-assisted coil embolization for wide-necked intracranial aneurysms by examining stent-vessel apposition,operative complications,embolization outcomes,and clinical outcomes.Methods:We retrospectively reviewed the medical records of patients with wide-necked intracranial aneurysms who underwent Enterprise 2 stent-assisted coiling in our hospital from November 2018 to October 2019.Intraoperative VasoCT was performed immediately after stent release in a continuous cohort of patients to observe stent-vessel apposition.Patient demographic,clinical,and imaging data were recorded and analyzed.Results:A total of 106 wide-necked aneurysms in 106 patients were treated.Stent release was successful in all patients.Twenty-one patients were enrolled consecutively for VasoCT scanning,and incomplete stent apposition was observed in 5(23.8%).Perioperative complications occurred in 10 patients(9.4%):cerebral infarction in 6,intraoperative coil prolapse in 1,puncture site pseudoaneurysm in 1,deep vein thrombosis at multiple sites in 1,and transient brainstem mass effect in 1.Among the 95 aneurysms with angiographic follow-up,embolization was satisfactory(Raymond-Roy classifications I and II)in 89(93.7%).Hyperlipidemia was an independent risk factor for incomplete aneurysm occlusion.At the last clinical follow-up,seven patients had a poor clinical outcome(modified Rankin Scale score≥3).Independent risk factors for poor outcomes were preoperative subarachnoid hemorrhage at presentation and cerebral infarction.Conclusion:Enterprise 2 stent-assisted coiling for treatment of wide-necked intracranial aneurysms showed good safety and efficacy;however,incomplete stent apposition can still occur in vessels with a large curvature.Preoperative subarachnoid hemorrhage at presentation and cerebral infarction are the main reasons for poor clinical outcomes after stent-assisted coil embolization.展开更多
The exact shape of intracranial aneurysms is critical in medical diagnosis and surgical planning.While voxel-based deep learning frameworks have been proposed for this segmentation task,their performance remains limit...The exact shape of intracranial aneurysms is critical in medical diagnosis and surgical planning.While voxel-based deep learning frameworks have been proposed for this segmentation task,their performance remains limited.In this study,we offer a two-step surface-based deep learning pipeline that achieves significantly better results.Our proposed model takes a surface model of an entire set of principal brain arteries containing aneurysms as input and returns aneurysm surfaces as output.A user first generates a surface model by manually specifying multiple thresholds for time-of-flight magnetic resonance angiography images.The system then samples small surface fragments from the entire set of brain arteries and classifies the surface fragments according to whether aneurysms are present using a point-based deep learning network(PointNet++).Finally,the system applies surface segmentation(SO-Net)to surface fragments containing aneurysms.We conduct a direct comparison of the segmentation performance of our proposed surface-based framework and an existing voxel-based method by counting voxels:our framework achieves a much higher Dice similarity(72%)than the prior approach(46%).展开更多
BACKGROUND Lobulated intracranial aneurysm is a special type of aneurysm with at least one additional cyst in the neck or body of the aneurysm.Lobulated intracranial aneurysm is a complex aneurysm with complex morphol...BACKGROUND Lobulated intracranial aneurysm is a special type of aneurysm with at least one additional cyst in the neck or body of the aneurysm.Lobulated intracranial aneurysm is a complex aneurysm with complex morphology and structure and weak tumor wall,which is an independent risk factor for rupture and hemorrhage.Lobular aneurysms located in the anterior communicating artery complex account for 36.9%of all intracranial lobular aneurysms.Due to its special anatomical structure,both craniotomy and endovascular treatment are more difficult.Compared with single-capsule aneurysms,craniotomy for lobular intracranial aneurysms has a higher risk and complication rate.AIM To investigate the efficacy and safety of endovascular treatment for ruptured lobulated anterior communicating artery aneurysm(ACoAA).METHODS Patients with ruptured lobulated ACoAA received endovascular treatment in Sanming First Hospital Affiliated to Fujian Medical University from June 2020 to June 2022 were retrospectively included.Their demographic,clinical and imaging characteristics,endovascular treatment methods and follow-up results were collected.RESULTS A total of 24 patients with ruptured lobulated ACoAA were included,including 9 males(37.5%)and 15 females(62.5%).Their age was 56.2±8.9 years old(range 39-74).The time from rupture to endovascular treatment was 10.9±12.5 h.The maximum diameter of the aneurysms was 5.1±1.0 mm and neck width were 3.0±0.7 mm.Nineteen patients(79.2%)were double-lobed and 5(20.8%)were multilobed.Fisher's grade:Grade 2 in 16 cases(66.7%),grade 3 in 6 cases(25%),and grade 4 in 2 cases(8.3%).Hunt-Hess grade:Grade 0-2 in 5 cases(20.8%),grade 3-5 in 19 cases(79.2%).Glasgow Coma Scale score:9-12 in 14 cases(58.3%),13-15 in 10 cases(41.7%).Immediately postprocedural Raymond-Roy grade:grade 1 in 23 cases(95.8%),grade 2 in 1 case(4.2%).Raymond-Roy grade in imaging follow-up for 2 wk to 3 months:grade 1 in 23 cases(95.8%),grade 2 in 1 case(4.2%).Followup for 2 to 12 months showed that 21 patients(87.5%)had good functional outcomes(modified Rankin Scale score≤2),and there were no deaths.CONCLUSION Endovascular treatment is a safe and effective treatment for ruptured lobulated AcoAA.展开更多
BACKGROUND Patients with giant intracranial aneurysms(GIAs)are at a high risk of rupture,morbidity,and mortality even after surgical or endovascular treatment.We described a case of a spontaneously occluded GIA second...BACKGROUND Patients with giant intracranial aneurysms(GIAs)are at a high risk of rupture,morbidity,and mortality even after surgical or endovascular treatment.We described a case of a spontaneously occluded GIA secondary to gradual growth of the GIA,continuously progressed aneurysmal thrombosis,complete aneurysmal calcification and complete occlusion of the parent artery-the right internal carotid artery(RICA).CASE SUMMARY A 72-year-old female patient complained of sudden pain in her right eye upon admission to our hospital.She had been diagnosed with a GIA[30 mm(axial)×38 mm(coronal)×28 mm(sagittal)]containing an aneurysmal thrombus located in the cavernous sinus segment of RICA diagnosed by magnetic resonance imaging(MRI),enhanced MRI,and magnetic resonance angiography more than 14 years ago.Later,with slow growth of the cavernous carotid GIA,aneurysmal thrombosis progressed continuously,spontaneous occlusion of the RICA,complete aneurysmal calcification,and occlusion of the GIA occurred gradually.She had no history of subarachnoid hemorrhage but missed the chance for endovascular therapy at an early stage.As a result,she was left with severe permanent sequelae from the injuries to the right cranial nerves Ⅱ,Ⅲ,Ⅳ,V1/V2,and Ⅴ.CONCLUSION The risk of rupture of the cavernous carotid GIAs was relatively low and possibly further be reduced by the stasis flow and spontaneous occlusion of the parent artery internal carotid artery(ICA)induced by the mass effect of the cavernous carotid GIAs and the extremely rare aneurysmal calcification.However,nowadays,it is advisable to recommend early endovascular treatment for the cavernous carotid GIAs to prevent injuries to the surrounding intracranial nerves and occlusion of the ICA,mainly caused by the mass effect of the cavernous carotid GIAs.展开更多
In this study, we extracted total RNA from 15 intracranial aneurysms and 17 superficial temporal artery samples, then performed genome-wide expression profiling using the Affymetrix U133 Plus 2.0 GeneChip. Genes that ...In this study, we extracted total RNA from 15 intracranial aneurysms and 17 superficial temporal artery samples, then performed genome-wide expression profiling using the Affymetrix U133 Plus 2.0 GeneChip. Genes that were differentially expressed between intracranial aneurysms and arterial samples were identified using significance analysis for microarrays, and the expression patterns of three randomly-selected genes were verified by real-time polymerase chain reaction analysis. We identified 3 736 differentially-expressed genes out of the 47 000 assayed transcripts. A total of 179 genes showed a 〉10-fold change in expression between the aneurysms and the arterial samples. Genes involved in the proliferation, migration, and apoptosis of vascular muscle cells, atherosclerosis, extracellular matrix disruption, and inflammatory reactions were associated with the formation of intracranial aneurysms. There were no significant differences in gene expression profile between unruptured and ruptured aneurysms.展开更多
Rupture of a cerebral aneurysm (abnormal swelling of blood vessel in the brain) will cause subarachnoid hemorrhage, and will result in an alarming rate of mortality and morbidity. A joint computational-experimental ...Rupture of a cerebral aneurysm (abnormal swelling of blood vessel in the brain) will cause subarachnoid hemorrhage, and will result in an alarming rate of mortality and morbidity. A joint computational-experimental study is conducted to assess the importance of the aspect ratio in the dynamics of blood flow. The aspect ratio is defined here to be the ratio of the height of the aneurysm to the linear dimension of the neck. Idealized models of such aneurysms located near a bifurcation point were investigated. Numerical simulations for hemodynamic properties like shear stress and flow rate were performed. The computational results were verified experimentally with specially fabricated phantoms, blood mimicking fluid and Doppler ultrasound imaging. Excellent agreements were obtained. Two features are highlighted, providing information in the intensely debated link between rupture risk and geometric factors. On increasing the aspect ratios, firstly, a jet impinging on the distal part of the neck can be observed, and secondly, a region of positive shear stress gradient can be found there. Furthermore, computational analyses for four patient-specific models were conducted to correlate with the results of idealized models and to provide further clinical insight.展开更多
Background:Rebleeding can cause a catastrophic outcome after aneurysmal subarachnoid hemorrhage.A clinical+morphology nomogram was promoted in our previous study to assist in discriminating the rupture intracranial an...Background:Rebleeding can cause a catastrophic outcome after aneurysmal subarachnoid hemorrhage.A clinical+morphology nomogram was promoted in our previous study to assist in discriminating the rupture intracranial aneurysms(RIAs)with a high risk of rebleeding.The aim of this study was to validate the predictive accuracy of this nomogram model.Method:The patients with RIAs in two medical centers from December 2020 to September 2021 were retrospectively reviewed,whose clinical and morphological parameters were collected.The Cox regression model was employed to identify the risk factors related to rebleeding after their admission.The predicting accuracy of clinical+morphological nomogram,ELAPSS score and PHASES score was compared based on the area under the curves(AUCs).Results:One hundred thirty-eight patients with RIAs were finally included in this study,20 of whom suffering from rebleeding after admission.Hypertension(hazard ratio(HR),2.54;a confidence interval of 95%(CI),1.01-6.40;P=0.047),bifurcation(HR,3.88;95%CI,1.29-11.66;P=0.016),and AR(HR,2.68;95%CI,1.63-4.41;P<0.001)were demonstrated through Cox regression analysis as the independent risk factors for rebleeding after admission.The clinical+morphological nomogram had the highest predicting accuracy(AUC,0.939,P<0.01),followed by the bifurcation(AUC,0.735,P=0.001),AR(AUC,0.666,P=0.018),and ELAPSS score(AUC,0.682,P=0.009).Hypertension(AUC,0.693,P=0.080)or PHASES score(AUC,0.577,P=0.244)could not be used to predict the risk of rebleeding after admission.The calibration curve for the probability of rebleeding showed a good agreement between the prediction through clinical+morphological nomogram and actual observation.Conclusion:Hypertension,bifurcation site,and AR were independent risk factors related to the rebleeding of RIAs after admission.The clinical+morphological nomogram could help doctors to identify the high-risk RIAs with a high predictive accuracy.展开更多
Background:The purpose of this study was to use the modified Delphi method to identify the influencing factors of health-related quality of life(HRQoL)in patients with unruptured intracranial aneurysms(UIAs)after endo...Background:The purpose of this study was to use the modified Delphi method to identify the influencing factors of health-related quality of life(HRQoL)in patients with unruptured intracranial aneurysms(UIAs)after endovascular treatment.Methods:A modified Delphi method to obtain expert consensus on the content of potential influencing factors of HRQoL in patients with UIAs treated by endovascular intervention was employed.The research team consists of three neuroradiologists and one epidemiologist from Xuanwu Hospital of Capital Medical University.They randomly selected 21 well-known experts in cerebrovascular disease diagnosis and treatment as participating experts.The importance of the indicator is based on the 5-Likert scale.The standard deviation(SD),coefficient of variation(CV),mean(x),and minimum and maximum scores of each indicator were calculated.The consistency was described by Kendall coefficient of concordance with a p value<0.05 indicating that the expert consistency was high.Result:Twenty-one and 18 questionnaires were responded in 2 rounds,with effective response rates of 85.7%and 100.0%,respectively.The average authoritative coefficient(Cr)of all 21 experts was 0.88,familiarity with the indicators(Cs)was 0.82,and the judgment basis of the indicators(Ca)was 0.94.Eventually,the x values of arterial puncture hematoma,hyperlipidemia,gender,marital status,and hospitalization for other diseases were lower than 3.5;CV for marital status and gender was higher than 0.35.The Kendall coefficient of concordance in the first round was 0.19(p<0.001),and the second round was 0.15(p<0.001).Conclusion:In this study,the factors affecting the recovery of HRQoL after endovascular treatment in patients with UIAs were analyzed by the modified Delphi method,which provided a valuable evidence for the clinical management and daily life guidance for UIAs patients.展开更多
The central nervous system is an immunologically active environment where several components of the immune and inflammatory response interact among them and with the constituents of nervous tissue and vasculature in a...The central nervous system is an immunologically active environment where several components of the immune and inflammatory response interact among them and with the constituents of nervous tissue and vasculature in a critically orchestrated manner,influencing physiologic and pathologic processes.In particular,inflammation takes a central role in the pathogenesis of intracranial aneurysms(IAs).The common pathway for aneurysm formation involves endothelial dysfunction and injury,a mounting inflammatory response,vascular smooth muscle cells(VSMCs)phenotypic modulation,extracellular matrix remodeling,and subsequent cell death and vessel wall degeneration.We conducted a literature review(1980-2014)by Medline and EMBASE databases using the searching terms“IA”and“cerebral aneurysm”and further search was performed to link the search terms with the following key words:inflammation,hemodynamic(s),remodeling,macrophages,neutrophils,lymphocytes,complement,VSMCs,mast cells,cytokines,and inflammatory biomarkers.The aim of this review was to summarize the most recent and pertinent evidences regarding the articulated processes of aneurysms formation,growth,and rupture.Knowledge of these processes may guide the diagnosis and treatment of these vascular malformations,the most common cause of subarachnoid hemorrhage,which prognosis remains dismal.展开更多
Background:The aim of this study was to comprehensively evaluate the risk factors of periprocedural ischemic stroke associated with endovascular treatment of intracranial aneurysms using a real-world database.Methods:...Background:The aim of this study was to comprehensively evaluate the risk factors of periprocedural ischemic stroke associated with endovascular treatment of intracranial aneurysms using a real-world database.Methods:From August 2016 to March 2017,167 patients were enrolled.Univariate analysis and multivariate logistic regression analysis were used to examine the risk factors for periprocedural ischemic stroke.Results:Among the 167 cases,periprocedural ischemic stroke occurred in 20 cases(11.98%).After univariate analysis,the ischemic group had a higher proportion of large(≥10 mm)aneurysms than the control group(45.0%vs.23.1%,p=0.036).The incidence of periprocedural ischemic stroke was higher in cases treated by flow diverter(21.6%)or stent-assisted coiling(11.8%)than in cases treated by coiling only(2.7%),and the differences were statistically significant(p=0.043).After multivariate logistic regression analysis,treatment modality was the independent risk factor for periprocedural ischemic stroke.Compared with the coiling-only procedure,flow diverter therapy was associated with a significantly higher rate of periprocedural ischemic stroke(OR 9.931;95%CI 1.174-84.038;p=0.035).Conclusions:Aneurysm size and treatment modality were associated with periprocedural ischemic stroke.Larger aneurysms were associated with increased risk of periprocedural ischemic stroke.Flow diverter therapy was associated with significantly more periprocedural ischemic stroke than the coiling procedure alone.展开更多
Background:The purpose of this analysis is to evaluate the current evidence with regard to the effectiveness and safety between coiling and clipping in patients with ruptured intracranial aneurysms(RIAs).Methods:We pe...Background:The purpose of this analysis is to evaluate the current evidence with regard to the effectiveness and safety between coiling and clipping in patients with ruptured intracranial aneurysms(RIAs).Methods:We performed a meta-analysis that compared clipping with coiling between July 2000 and September 2021.PubMed,EMBASE,and the Cochrane Library were searched for related articles systematically.And the treatment efficacy and postoperative complications were analyzed.Results:We identified three randomized controlled trials and thirty-seven observational studies involving 60,875 patients with ruptured cerebral aneurysms.The summary results showed that coiling was related a better quality of life(mRS0-2;OR=1.327;CI=1.093-1.612;p<0.05),a higher risk of mortality(OR=1.116;CI=1.054-1.180;p<0.05),higher rate of rebleeding(RR=1.410;CI=1.092-1.822;p<0.05),lower incidence of vasospasm(OR=0.787;CI=0.649-0.954;p<0.05),higher risk of hydrocephalous(RR=1.143;CI=1.043-1.252;p<0.05),lower risk of cerebral infarction(RR=0.669;CI=0.596-0.751;p<0.05),lower risk of neuro deficits(RR=0.720;CI=0.582-0.892;p<0.05),and a lower rate of complete occlusion(OR=0.495;CI=0.280-0.876;p<0.05).Conclusion:Coiling was significantly associated with a better life quality(mRS0-2),a lower incidence of postoperative complications,and a higher rate of mortality,rebleeding,hydrocephalous,and a lower rate of complete occlusion than clipping.展开更多
文摘Objective To study the application of neuroelectrophysiological monitoring for interventional therapy of intracranial aneurysms. Methods 22 patients with intracranial aneurysm underwent neuroelectrophysiological monitoring during interventional therapy. Somatosensory evoked potential( SSEP) ,brainstem
基金supported by the National Natural Science Foundation of China, No. 81171109
文摘Hemodynamic parameters play an important role in aneurysm formation and growth. However, it is difficult to directly observe a rapidly growing de novo aneurysm in a patient. To investigate possible associations between hemodynamic parameters and the formation and growth of intracranial aneurysms, the present study constructed a computational model of a case with an internal carotid artery aneurysm and an anterior communicating artery aneurysm, based on the CT angiography findings of a patient. To simulate the formation of the anterior communicating artery aneurysm and the growth of the internal carotid artery aneurysm, we then constructed a model that virtually removed the anterior communicating artery aneurysm, and a further two models that also progressively decreased the size of the internal carotid artery aneurysm. Computational simulations of the fluid dynamics of the four models were performed under pulsatile flow conditions, and wall shear stress was compared among the different models. In the three aneurysm growth models, increasing size of the aneurysm was associated with an increased area of low wall shear stress, a significant decrease in wall shear stress at the dome of the aneurysm, and a significant change in the wall shear stress of the parent artery. The wall shear stress of the anterior communicating artery remained low, and was significantly lower than the wall shear stress at the bifurcation of the internal carotid artery or the bifurcation of the middle cerebral artery. After formation of the anterior communicating artery aneurysm, the wall shear stress at the dome of the internal carotid artery aneurysm increased significantly, and the wall shear stress in the upstream arteries also changed significantly. These findings indicate that low wall shear stress may be associated with the initiation and growth of aneurysms, and that aneurysm formation and growth may influence hemodynamic parameters in the local and adjacent arteries.
文摘Objective:To investigate the advantages and effects of pipeline embolization device(PED)or Willis stent,in treating traumatic pseudoaneurysms.Traumatic pseudo intracranial aneurysms(TPIA)can be caused by either direct trauma or iatrogenic injuries,usually caused by direct arterial wall injury or shear due to acceleration.We describe a series of patients with TPIA who received a PED or Willis stent.Materials and methods:Retrospective analysis was performed on nine patients with TPIA admitted to the southern hospital of Southern Medical University from December 2017 to June 2019,of whom four were treated with PED and five were implanted with six Willis covered stents.The occlusive rate and complication in the two kinds of stents were compared by postoperative follow-up and modified rankin score(MRS).Results:After the implantation of PED,four patients showed an immediate stagnation of blood flow or a decreased filling in aneurysms,three out of four patients exhibited complete occlusion,and the remaining patient had nearly complete occlusion.Four out of five cases of Willis stent implantation were associated with immediate complete occlusion of aneurysms,and the modified rankin score of these patients ranged from 0 to 1.One patient died of unassociated complications.Conclusion:For different types of TPIA in the internal carotid artery(ICA),PED and Willis stents provide significant advantages in treatment,with fewer postoperative complications and prognosis well.
基金supported by grant of Changzhou science and technology projects of social development (No. CS2007203)
文摘Prompt diagnosis and therapy of aneurysms are critical for patients with nontraumatic subarachnoid hemorrhage (SAH).The aim of our study was to assess the clinical usefulness of multislice computed tomography angiography (CTA) in the surgical and endovascular treatment of intracranial aneurysms.A total of 195 cases with 206 intracranial aneurysms underwent CTA.Fifty (24%) aneurysms underwent surgical clipping while 156 (76%) aneurysms underwent endovascular coiling.In the five missed aneurysms at digital substraction angiography and the nine aneurysms with mass intracerebral hematomas,surgical treatment was successfully performed based on 16-slice CTA alone,and the other 36 aneurysms were clipped on the main basis of the CTA.The intraoperative findings correlated well with the CTA findings and all aneurysms were clipped successfully.Sixteen-slice CTA image information has been shown to determine the choice of aneurysm therapy and assist the surgical and endovascular treatment of intracranial aneurysms.
文摘Objective:This study aimed to evaluate the clinical and angiographic outcomes of aneurysms that were completely or near-completely embolized and ascertain whether complete embolization is important in the stent-assisted coiling(SAC)of intracranial aneurysms.Methods:This retrospective study enrolled 390 patients(417 aneurysms).Among them,complete(100%)or nearcomplete(>90%)angiographic obliteration of the aneurysms on immediate angiography was accomplished.Baseline characteristics,complications,angiography follow-up results,and clinical outcomes were analyzed.Results:Cumulative adverse events occurred in 30 patients(7.7%),including thromboembolic complications in 17(4.4%),intraoperative rupture in 10(2.6%),and others in 3(0.8%).Statistical analyses revealed an increased intraprocedural rupture rate in the initial completely occluded aneurysms(5.6%compared with 1.0%).The incidence of cumulative adverse events was higher in patients with completely occluded aneurysms(11.1%)than in those with near-completely occluded aneurysms(5.5%).Angiography follow-up was available for 173 aneurysms.Aneurysm occlusion status at follow-up was correlated with stent placement(p?0.000,odds ratio?5.847),size(p?0.000,odds ratio?6.446 for tiny aneurysms;and p?0.001,odds ratio?5.616 for small aneurysms),and initial aneurysm occlusion status(p?0.001,odds ratio?3.436).Complete occlusion at followup was seen in 82.6%of the initial complete occlusion group versus 63.0%of the initial near-complete occlusion group.The incidence of complete occlusion at follow-up was higher in the initial completely occluded aneurysms with SAC(100%)than in the initial completely occluded aneurysms with non-SAC(65.2%).Conclusions:Initial complete treatment may lead to higher complication rates and good clinical outcomes at follow-up.Stent placement may enhance progressive aneurysm occlusion.Initial complete occlusion with SAC can provide durable closure at follow-up.
文摘Subaracoid hemorrhage caused by intracranial aneurysms is characterized by high morbidity and mortality.There is no definite conclusion regarding the mechanism of formation,development,and rupture of intracranial aneurysms.It is generally believed to be related to congenital hereditary connective tissue diseases and acquired hemodynamic factors,vascular inflammation,and oral pathogens.In addition,gender,age,hypertension,and psychological status are also important factors.Relevant studies show a significantly lower quality of life in patients with intracranial aneurysms,and psychological factors should be studied in more depth.Neurological complications are considered an important factor in the decrease in quality of life.In conclusion,the formation,development,and rupture of intracranial aneurysms should result from a combination of congenital and acquired factors.
文摘Introduction: The management of intracranial aneurysms in sub-Saharan Africa is essentially surgical. In this retrospective study, the authors report their experience in surgical management of intracranial aneurysm in Côte d’Ivoire. Methods: We carried out a retrospective study on patients operated for a ruptured or unruptured intracranial aneurysm between January 1st, 2012 and December 31st, 2018. Data on epidemiological characteristics of patients and aneurysms, treatments and patient outcomes were analyzed. Results: One hundred twenty eight aneurysms were operated. Sixty-six percent of the patients were female. According to the World Federation of Neurosurgical Societies (WFNS) scale, 58, 5% of patients were in grade I. Fisher scale showed 29% of Fisher 2 and 49% of Fisher 4. The aneurysms were mainly located on the internal carotid artery in 38% and anterior complex in 36%. The average size of aneurysms was 6.5 mm. In 81.4% the size of the aneurysms was less than 10 mm. Most aneurysms (90%) were treated at late stage. According to the modified Rankin Scale, 92 patients (83%) had good outcome, 7 patients (6%) had poor outcome, and the mortality rate was 11%. Conclusions: This study shows encouraging results if we refer to the overall postoperative results. However, there is a sub-diagnosis and low treatment rate of ruptured intracranial aneurysms. The improvement of intracranial aneurysms management requires improving the standard of health in the country.
基金supported by National Natural Science Foundation of China(81771234)Beijing Natural Science Foundation of China(7204253)Beijing Municipal Administration of Hospitals Incubating Program,Beijing,China(Grant No.:pX2020023)
文摘Background:Giant intracranial aneurysms(GIAs)are challenges for surgical treatment.Risk factors of postoperative stroke remain unclear.This study aims to investigate the predictors of postoperative stroke in GIAs and the impact of stroke on outcomes.Methods:We performed a retrospective medical record review of patients with GIAs who received microsurgery at our institution between 2011 and 2018.Multivariate logistic regression analyses were carried out to identify risk factors for postoperative stroke.The clinical and angiographic outcomes were compared between patients with and without stroke.Results:A total of 97 patients were included in this study.Surgical modalities included direct aneurysm neck clipping in 85 patients(87.7%),trapping with the bypass in 8(8.2%),proximal artery ligation in 1(1%),and bypass alone in 3(3.1%).Postoperative stroke was found in 26 patients(26.8%).Independent factors that affect postoperative stroke were recurrent aneurysm(OR,10.982;95%CI,1.976-61.045;P=0.006)and size≥3.5 cm(OR,3.420;95%CI,1.133-10.327;P=0.029).Combined perioperative mortality and morbidity was 26.8%.Follow-up was achieved from 89 patients(91.8%),with a mean follow-up period of 39 months(range 19 to 94 months).Good outcomes were observed in 75 patients(84.3%)and poor outcomes were observed in 14 patients(15.7%).Conclusions:Postoperative stroke was significantly associated with clinical outcome.Favorable outcomes can be achieved in most patients with GIAs after appropriate microsurgical modality.Recurrent aneurysm and size≥3.5 cm are risk factors of postoperative stroke.
文摘Background:This study analyzed the safety and efficacy of Enterprise 2 stent-assisted coil embolization for wide-necked intracranial aneurysms by examining stent-vessel apposition,operative complications,embolization outcomes,and clinical outcomes.Methods:We retrospectively reviewed the medical records of patients with wide-necked intracranial aneurysms who underwent Enterprise 2 stent-assisted coiling in our hospital from November 2018 to October 2019.Intraoperative VasoCT was performed immediately after stent release in a continuous cohort of patients to observe stent-vessel apposition.Patient demographic,clinical,and imaging data were recorded and analyzed.Results:A total of 106 wide-necked aneurysms in 106 patients were treated.Stent release was successful in all patients.Twenty-one patients were enrolled consecutively for VasoCT scanning,and incomplete stent apposition was observed in 5(23.8%).Perioperative complications occurred in 10 patients(9.4%):cerebral infarction in 6,intraoperative coil prolapse in 1,puncture site pseudoaneurysm in 1,deep vein thrombosis at multiple sites in 1,and transient brainstem mass effect in 1.Among the 95 aneurysms with angiographic follow-up,embolization was satisfactory(Raymond-Roy classifications I and II)in 89(93.7%).Hyperlipidemia was an independent risk factor for incomplete aneurysm occlusion.At the last clinical follow-up,seven patients had a poor clinical outcome(modified Rankin Scale score≥3).Independent risk factors for poor outcomes were preoperative subarachnoid hemorrhage at presentation and cerebral infarction.Conclusion:Enterprise 2 stent-assisted coiling for treatment of wide-necked intracranial aneurysms showed good safety and efficacy;however,incomplete stent apposition can still occur in vessels with a large curvature.Preoperative subarachnoid hemorrhage at presentation and cerebral infarction are the main reasons for poor clinical outcomes after stent-assisted coil embolization.
基金This research was supported by AMED under Grant No.JP18he1602001.
文摘The exact shape of intracranial aneurysms is critical in medical diagnosis and surgical planning.While voxel-based deep learning frameworks have been proposed for this segmentation task,their performance remains limited.In this study,we offer a two-step surface-based deep learning pipeline that achieves significantly better results.Our proposed model takes a surface model of an entire set of principal brain arteries containing aneurysms as input and returns aneurysm surfaces as output.A user first generates a surface model by manually specifying multiple thresholds for time-of-flight magnetic resonance angiography images.The system then samples small surface fragments from the entire set of brain arteries and classifies the surface fragments according to whether aneurysms are present using a point-based deep learning network(PointNet++).Finally,the system applies surface segmentation(SO-Net)to surface fragments containing aneurysms.We conduct a direct comparison of the segmentation performance of our proposed surface-based framework and an existing voxel-based method by counting voxels:our framework achieves a much higher Dice similarity(72%)than the prior approach(46%).
基金Supported by Fujian Province Health Young and Middle-aged Backbone Personnel Training Project,No.2021GGB022Fujian Medical University Sailing Fund,No.2019QH1262.
文摘BACKGROUND Lobulated intracranial aneurysm is a special type of aneurysm with at least one additional cyst in the neck or body of the aneurysm.Lobulated intracranial aneurysm is a complex aneurysm with complex morphology and structure and weak tumor wall,which is an independent risk factor for rupture and hemorrhage.Lobular aneurysms located in the anterior communicating artery complex account for 36.9%of all intracranial lobular aneurysms.Due to its special anatomical structure,both craniotomy and endovascular treatment are more difficult.Compared with single-capsule aneurysms,craniotomy for lobular intracranial aneurysms has a higher risk and complication rate.AIM To investigate the efficacy and safety of endovascular treatment for ruptured lobulated anterior communicating artery aneurysm(ACoAA).METHODS Patients with ruptured lobulated ACoAA received endovascular treatment in Sanming First Hospital Affiliated to Fujian Medical University from June 2020 to June 2022 were retrospectively included.Their demographic,clinical and imaging characteristics,endovascular treatment methods and follow-up results were collected.RESULTS A total of 24 patients with ruptured lobulated ACoAA were included,including 9 males(37.5%)and 15 females(62.5%).Their age was 56.2±8.9 years old(range 39-74).The time from rupture to endovascular treatment was 10.9±12.5 h.The maximum diameter of the aneurysms was 5.1±1.0 mm and neck width were 3.0±0.7 mm.Nineteen patients(79.2%)were double-lobed and 5(20.8%)were multilobed.Fisher's grade:Grade 2 in 16 cases(66.7%),grade 3 in 6 cases(25%),and grade 4 in 2 cases(8.3%).Hunt-Hess grade:Grade 0-2 in 5 cases(20.8%),grade 3-5 in 19 cases(79.2%).Glasgow Coma Scale score:9-12 in 14 cases(58.3%),13-15 in 10 cases(41.7%).Immediately postprocedural Raymond-Roy grade:grade 1 in 23 cases(95.8%),grade 2 in 1 case(4.2%).Raymond-Roy grade in imaging follow-up for 2 wk to 3 months:grade 1 in 23 cases(95.8%),grade 2 in 1 case(4.2%).Followup for 2 to 12 months showed that 21 patients(87.5%)had good functional outcomes(modified Rankin Scale score≤2),and there were no deaths.CONCLUSION Endovascular treatment is a safe and effective treatment for ruptured lobulated AcoAA.
基金Supported by The Fong Shu Fook Tong and Fong Yun Wah Foundations,No.14X30127.
文摘BACKGROUND Patients with giant intracranial aneurysms(GIAs)are at a high risk of rupture,morbidity,and mortality even after surgical or endovascular treatment.We described a case of a spontaneously occluded GIA secondary to gradual growth of the GIA,continuously progressed aneurysmal thrombosis,complete aneurysmal calcification and complete occlusion of the parent artery-the right internal carotid artery(RICA).CASE SUMMARY A 72-year-old female patient complained of sudden pain in her right eye upon admission to our hospital.She had been diagnosed with a GIA[30 mm(axial)×38 mm(coronal)×28 mm(sagittal)]containing an aneurysmal thrombus located in the cavernous sinus segment of RICA diagnosed by magnetic resonance imaging(MRI),enhanced MRI,and magnetic resonance angiography more than 14 years ago.Later,with slow growth of the cavernous carotid GIA,aneurysmal thrombosis progressed continuously,spontaneous occlusion of the RICA,complete aneurysmal calcification,and occlusion of the GIA occurred gradually.She had no history of subarachnoid hemorrhage but missed the chance for endovascular therapy at an early stage.As a result,she was left with severe permanent sequelae from the injuries to the right cranial nerves Ⅱ,Ⅲ,Ⅳ,V1/V2,and Ⅴ.CONCLUSION The risk of rupture of the cavernous carotid GIAs was relatively low and possibly further be reduced by the stasis flow and spontaneous occlusion of the parent artery internal carotid artery(ICA)induced by the mass effect of the cavernous carotid GIAs and the extremely rare aneurysmal calcification.However,nowadays,it is advisable to recommend early endovascular treatment for the cavernous carotid GIAs to prevent injuries to the surrounding intracranial nerves and occlusion of the ICA,mainly caused by the mass effect of the cavernous carotid GIAs.
基金supported by a grant from the National Natural Science Foundation of China(30830101/H0928)
文摘In this study, we extracted total RNA from 15 intracranial aneurysms and 17 superficial temporal artery samples, then performed genome-wide expression profiling using the Affymetrix U133 Plus 2.0 GeneChip. Genes that were differentially expressed between intracranial aneurysms and arterial samples were identified using significance analysis for microarrays, and the expression patterns of three randomly-selected genes were verified by real-time polymerase chain reaction analysis. We identified 3 736 differentially-expressed genes out of the 47 000 assayed transcripts. A total of 179 genes showed a 〉10-fold change in expression between the aneurysms and the arterial samples. Genes involved in the proliferation, migration, and apoptosis of vascular muscle cells, atherosclerosis, extracellular matrix disruption, and inflammatory reactions were associated with the formation of intracranial aneurysms. There were no significant differences in gene expression profile between unruptured and ruptured aneurysms.
基金Partial financial support has been provided by the Seed Funding Program for Basic Research of The University of Hong Kong,funding program from the Research Grants Council(Grant No.GRF 785113)Innovation and Technology Support Program through contracts ITS/011/13 and ITS/150/15 of the Government of the Hong Kong Special Administrati-ve Region
文摘Rupture of a cerebral aneurysm (abnormal swelling of blood vessel in the brain) will cause subarachnoid hemorrhage, and will result in an alarming rate of mortality and morbidity. A joint computational-experimental study is conducted to assess the importance of the aspect ratio in the dynamics of blood flow. The aspect ratio is defined here to be the ratio of the height of the aneurysm to the linear dimension of the neck. Idealized models of such aneurysms located near a bifurcation point were investigated. Numerical simulations for hemodynamic properties like shear stress and flow rate were performed. The computational results were verified experimentally with specially fabricated phantoms, blood mimicking fluid and Doppler ultrasound imaging. Excellent agreements were obtained. Two features are highlighted, providing information in the intensely debated link between rupture risk and geometric factors. On increasing the aspect ratios, firstly, a jet impinging on the distal part of the neck can be observed, and secondly, a region of positive shear stress gradient can be found there. Furthermore, computational analyses for four patient-specific models were conducted to correlate with the results of idealized models and to provide further clinical insight.
基金the projects of National Natural Science Foundation of China(Grant Nos.82071296,81471210,and 81671129)"Major special projects in the 13th five-year plan"(Grant No.2016YFC1301800)+1 种基金"Major special projects in the 14th five-year plan"(Grant No.2021YFC2501100)The sponsors had no role in the design or conduct of this research.
文摘Background:Rebleeding can cause a catastrophic outcome after aneurysmal subarachnoid hemorrhage.A clinical+morphology nomogram was promoted in our previous study to assist in discriminating the rupture intracranial aneurysms(RIAs)with a high risk of rebleeding.The aim of this study was to validate the predictive accuracy of this nomogram model.Method:The patients with RIAs in two medical centers from December 2020 to September 2021 were retrospectively reviewed,whose clinical and morphological parameters were collected.The Cox regression model was employed to identify the risk factors related to rebleeding after their admission.The predicting accuracy of clinical+morphological nomogram,ELAPSS score and PHASES score was compared based on the area under the curves(AUCs).Results:One hundred thirty-eight patients with RIAs were finally included in this study,20 of whom suffering from rebleeding after admission.Hypertension(hazard ratio(HR),2.54;a confidence interval of 95%(CI),1.01-6.40;P=0.047),bifurcation(HR,3.88;95%CI,1.29-11.66;P=0.016),and AR(HR,2.68;95%CI,1.63-4.41;P<0.001)were demonstrated through Cox regression analysis as the independent risk factors for rebleeding after admission.The clinical+morphological nomogram had the highest predicting accuracy(AUC,0.939,P<0.01),followed by the bifurcation(AUC,0.735,P=0.001),AR(AUC,0.666,P=0.018),and ELAPSS score(AUC,0.682,P=0.009).Hypertension(AUC,0.693,P=0.080)or PHASES score(AUC,0.577,P=0.244)could not be used to predict the risk of rebleeding after admission.The calibration curve for the probability of rebleeding showed a good agreement between the prediction through clinical+morphological nomogram and actual observation.Conclusion:Hypertension,bifurcation site,and AR were independent risk factors related to the rebleeding of RIAs after admission.The clinical+morphological nomogram could help doctors to identify the high-risk RIAs with a high predictive accuracy.
基金This work was supported by the National Key R&D program of China with grant 2016YFC1300800the Beijing Municipal Administration of Hospitals’Ascent Plan with grant DFL20180801
文摘Background:The purpose of this study was to use the modified Delphi method to identify the influencing factors of health-related quality of life(HRQoL)in patients with unruptured intracranial aneurysms(UIAs)after endovascular treatment.Methods:A modified Delphi method to obtain expert consensus on the content of potential influencing factors of HRQoL in patients with UIAs treated by endovascular intervention was employed.The research team consists of three neuroradiologists and one epidemiologist from Xuanwu Hospital of Capital Medical University.They randomly selected 21 well-known experts in cerebrovascular disease diagnosis and treatment as participating experts.The importance of the indicator is based on the 5-Likert scale.The standard deviation(SD),coefficient of variation(CV),mean(x),and minimum and maximum scores of each indicator were calculated.The consistency was described by Kendall coefficient of concordance with a p value<0.05 indicating that the expert consistency was high.Result:Twenty-one and 18 questionnaires were responded in 2 rounds,with effective response rates of 85.7%and 100.0%,respectively.The average authoritative coefficient(Cr)of all 21 experts was 0.88,familiarity with the indicators(Cs)was 0.82,and the judgment basis of the indicators(Ca)was 0.94.Eventually,the x values of arterial puncture hematoma,hyperlipidemia,gender,marital status,and hospitalization for other diseases were lower than 3.5;CV for marital status and gender was higher than 0.35.The Kendall coefficient of concordance in the first round was 0.19(p<0.001),and the second round was 0.15(p<0.001).Conclusion:In this study,the factors affecting the recovery of HRQoL after endovascular treatment in patients with UIAs were analyzed by the modified Delphi method,which provided a valuable evidence for the clinical management and daily life guidance for UIAs patients.
文摘The central nervous system is an immunologically active environment where several components of the immune and inflammatory response interact among them and with the constituents of nervous tissue and vasculature in a critically orchestrated manner,influencing physiologic and pathologic processes.In particular,inflammation takes a central role in the pathogenesis of intracranial aneurysms(IAs).The common pathway for aneurysm formation involves endothelial dysfunction and injury,a mounting inflammatory response,vascular smooth muscle cells(VSMCs)phenotypic modulation,extracellular matrix remodeling,and subsequent cell death and vessel wall degeneration.We conducted a literature review(1980-2014)by Medline and EMBASE databases using the searching terms“IA”and“cerebral aneurysm”and further search was performed to link the search terms with the following key words:inflammation,hemodynamic(s),remodeling,macrophages,neutrophils,lymphocytes,complement,VSMCs,mast cells,cytokines,and inflammatory biomarkers.The aim of this review was to summarize the most recent and pertinent evidences regarding the articulated processes of aneurysms formation,growth,and rupture.Knowledge of these processes may guide the diagnosis and treatment of these vascular malformations,the most common cause of subarachnoid hemorrhage,which prognosis remains dismal.
基金National Key Research and Development Plan of China(grant number:2016YFC1300800)National Natural Science Foundation of China(grant numbers:8207071595,81801156,81801158 and 81671139)+1 种基金Special Research Project for Capital Health Development(grant number:2018-4-1077)Beijing Hospitals Authority Youth Programme(code:QML20190503)。
文摘Background:The aim of this study was to comprehensively evaluate the risk factors of periprocedural ischemic stroke associated with endovascular treatment of intracranial aneurysms using a real-world database.Methods:From August 2016 to March 2017,167 patients were enrolled.Univariate analysis and multivariate logistic regression analysis were used to examine the risk factors for periprocedural ischemic stroke.Results:Among the 167 cases,periprocedural ischemic stroke occurred in 20 cases(11.98%).After univariate analysis,the ischemic group had a higher proportion of large(≥10 mm)aneurysms than the control group(45.0%vs.23.1%,p=0.036).The incidence of periprocedural ischemic stroke was higher in cases treated by flow diverter(21.6%)or stent-assisted coiling(11.8%)than in cases treated by coiling only(2.7%),and the differences were statistically significant(p=0.043).After multivariate logistic regression analysis,treatment modality was the independent risk factor for periprocedural ischemic stroke.Compared with the coiling-only procedure,flow diverter therapy was associated with a significantly higher rate of periprocedural ischemic stroke(OR 9.931;95%CI 1.174-84.038;p=0.035).Conclusions:Aneurysm size and treatment modality were associated with periprocedural ischemic stroke.Larger aneurysms were associated with increased risk of periprocedural ischemic stroke.Flow diverter therapy was associated with significantly more periprocedural ischemic stroke than the coiling procedure alone.
文摘Background:The purpose of this analysis is to evaluate the current evidence with regard to the effectiveness and safety between coiling and clipping in patients with ruptured intracranial aneurysms(RIAs).Methods:We performed a meta-analysis that compared clipping with coiling between July 2000 and September 2021.PubMed,EMBASE,and the Cochrane Library were searched for related articles systematically.And the treatment efficacy and postoperative complications were analyzed.Results:We identified three randomized controlled trials and thirty-seven observational studies involving 60,875 patients with ruptured cerebral aneurysms.The summary results showed that coiling was related a better quality of life(mRS0-2;OR=1.327;CI=1.093-1.612;p<0.05),a higher risk of mortality(OR=1.116;CI=1.054-1.180;p<0.05),higher rate of rebleeding(RR=1.410;CI=1.092-1.822;p<0.05),lower incidence of vasospasm(OR=0.787;CI=0.649-0.954;p<0.05),higher risk of hydrocephalous(RR=1.143;CI=1.043-1.252;p<0.05),lower risk of cerebral infarction(RR=0.669;CI=0.596-0.751;p<0.05),lower risk of neuro deficits(RR=0.720;CI=0.582-0.892;p<0.05),and a lower rate of complete occlusion(OR=0.495;CI=0.280-0.876;p<0.05).Conclusion:Coiling was significantly associated with a better life quality(mRS0-2),a lower incidence of postoperative complications,and a higher rate of mortality,rebleeding,hydrocephalous,and a lower rate of complete occlusion than clipping.