Objective: To compare the pharmacokinetics of the routine intraperitonealchemotherapy (RIP) and continuous washing intraperitoneal chemotherapy (CWIP) of cisplatin(CDDP) in 38 patients with ovarian cancer. Methods: Th...Objective: To compare the pharmacokinetics of the routine intraperitonealchemotherapy (RIP) and continuous washing intraperitoneal chemotherapy (CWIP) of cisplatin(CDDP) in 38 patients with ovarian cancer. Methods: The patients had a performance status ofⅡ -Ⅳ on the FIGO scale.38 patients were randomized into CWIP group (16 patients) and RIP group(22 patients). CDDP was used as intraperitoneal chemotherapy (IP) with 70mg/m2. In 72h, thesamples from serum, ascites and urine were collected respectively and their platinum density weredetermined with electrochemistry polarographic analysis. On the third day and one month after IP,liver and kidney function and blood routine were examined. Results: The maximum concentration(Cmax) of plasma in CWIP and RIP groups were 3.84μg/ml and 1.27μg/ml respectively;the Cmaxof ascites were 7.04μg/ml and 4.43μg/ml respectively in the two groups. The area under the plas-ma concentration-time curve(AUC) in CWIP and RIP groups were 1067.77μg. h/ml and 191.72μg.h/ml respectively,and 1299.02μg. h/ml and 584.43μg. h/ml in ascites,their statistics dif-ference were significant ( P ＜ 0.05). Conclusion: CWIP is better than the RIP in the pharmacoki-netics, while its side-effects is not increased. The new methods may be used on the patients.展开更多
目的:分析恶性腹腔积液疾病特点、治疗需求,评价持续热灌注腹腔化疗结合体外高频热疗治疗的优势。方法:选择2018年3月~2019年5月本院诊治的80例恶性腹腔积液疾病患者,伦理委员会批准同意,按照入院先后顺序分组治疗。对照组患者采取持续...目的:分析恶性腹腔积液疾病特点、治疗需求,评价持续热灌注腹腔化疗结合体外高频热疗治疗的优势。方法:选择2018年3月~2019年5月本院诊治的80例恶性腹腔积液疾病患者,伦理委员会批准同意,按照入院先后顺序分组治疗。对照组患者采取持续热灌注腹腔化疗治疗,观察组患者采取持续热灌注腹腔化疗结合体外高频热疗治疗。比较2组患者治疗情况,包括治疗效果、生存率以及生存质量。结果:组间临床治疗效果情况比较,观察组患者临床总有效率95.00%明显高于对照组(P<0.05);组间随访6个月、1年患者生存率情况比较,观察组患者随访生存率均明显高于对照组(P<0.05);采用欧洲癌症研究与治疗组织生活质量测定量表(european organzation for research and treatment of cancer quality of life-C30,EORTC QLQ-C30)评估恶性腹腔积液患者生活质量,观察组评分(88.80±6.60)分高于对照组(P<0.05)。结论:与单纯持续热灌注腹腔化疗治疗比较,结合体外高频热疗治疗恶性腹腔积液效果更为理想,提升了患者的生存率与生活质量,是有效的治疗方案。展开更多
文摘Objective: To compare the pharmacokinetics of the routine intraperitonealchemotherapy (RIP) and continuous washing intraperitoneal chemotherapy (CWIP) of cisplatin(CDDP) in 38 patients with ovarian cancer. Methods: The patients had a performance status ofⅡ -Ⅳ on the FIGO scale.38 patients were randomized into CWIP group (16 patients) and RIP group(22 patients). CDDP was used as intraperitoneal chemotherapy (IP) with 70mg/m2. In 72h, thesamples from serum, ascites and urine were collected respectively and their platinum density weredetermined with electrochemistry polarographic analysis. On the third day and one month after IP,liver and kidney function and blood routine were examined. Results: The maximum concentration(Cmax) of plasma in CWIP and RIP groups were 3.84μg/ml and 1.27μg/ml respectively;the Cmaxof ascites were 7.04μg/ml and 4.43μg/ml respectively in the two groups. The area under the plas-ma concentration-time curve(AUC) in CWIP and RIP groups were 1067.77μg. h/ml and 191.72μg.h/ml respectively,and 1299.02μg. h/ml and 584.43μg. h/ml in ascites,their statistics dif-ference were significant ( P ＜ 0.05). Conclusion: CWIP is better than the RIP in the pharmacoki-netics, while its side-effects is not increased. The new methods may be used on the patients.
文摘目的:分析恶性腹腔积液疾病特点、治疗需求,评价持续热灌注腹腔化疗结合体外高频热疗治疗的优势。方法:选择2018年3月~2019年5月本院诊治的80例恶性腹腔积液疾病患者,伦理委员会批准同意,按照入院先后顺序分组治疗。对照组患者采取持续热灌注腹腔化疗治疗,观察组患者采取持续热灌注腹腔化疗结合体外高频热疗治疗。比较2组患者治疗情况,包括治疗效果、生存率以及生存质量。结果:组间临床治疗效果情况比较,观察组患者临床总有效率95.00%明显高于对照组(P<0.05);组间随访6个月、1年患者生存率情况比较,观察组患者随访生存率均明显高于对照组(P<0.05);采用欧洲癌症研究与治疗组织生活质量测定量表(european organzation for research and treatment of cancer quality of life-C30,EORTC QLQ-C30)评估恶性腹腔积液患者生活质量,观察组评分(88.80±6.60)分高于对照组(P<0.05)。结论:与单纯持续热灌注腹腔化疗治疗比较,结合体外高频热疗治疗恶性腹腔积液效果更为理想,提升了患者的生存率与生活质量,是有效的治疗方案。
