期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Positive association of RhoC gene overexpression with tumour invasion and lymphatic metastasis in gastric carcinoma 被引量:48
1
作者 WANGZhen-ning XUHui-mian +3 位作者 JIANGLi ZHOUXin LUChong ZHANGXue 《Chinese Medical Journal》 SCIE CAS CSCD 2005年第6期502-504,共3页
Worldwide estimates establish gastric carcinoma as the second most frequent cause of cancer deaths. Tumour invasion and metastasis is the biggest impediment to gastric carcinoma cure. Active migration of tumour cells ... Worldwide estimates establish gastric carcinoma as the second most frequent cause of cancer deaths. Tumour invasion and metastasis is the biggest impediment to gastric carcinoma cure. Active migration of tumour cells is now considered as the pivotal step in cancer invasion and metastasis. RhoC is a member of the Ras-superfamily of small guanosine triphosphatases that can regulate many cellular functions, especially cytoskeletal organization and cell locomotion. Overexpressing RhoC in vitro in the poorly metastatic cell line from human melanoma may induce a highly metastatic phenotype.~1 The recent development of laser capture microdissection (LCM) affords the opportunity to further evaluate the role RhoC plays in the invasion and metastasis of gastric carcinoma cells in their native tissue environment. 展开更多
关键词 gastric carcinoma · invasion · metastasis · RhoC gene
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部