AIM： TO observe the therapeutic effects of new traditional Chinese medicine （TClVl） therapy on coagulation disorder and accompanying intractable jaundice in HBV-related liver cirrhosis patients. METHODS： Using str...AIM： TO observe the therapeutic effects of new traditional Chinese medicine （TClVl） therapy on coagulation disorder and accompanying intractable jaundice in HBV-related liver cirrhosis patients. METHODS： Using stratified random sampling according to fibrinogen （Fib） levels, 145 liver cirrhosis patients due to hepatitis B complicated by coagulation disorder were treated. Of them, 70 in research group were treated with TCM by ＂nourishing yin, cooling blood and invigorating blood circulation＂ and Western medicine, 75 in control group were treated with conventional Western medicine. The indexes of liver function, coagulation function and bleeding events were observed and compared. RESULTS： The prothrombin time （PT） was shorter and the fibrinogen （Fib） level was higher in the research group than in the control group （Fib = 1.6-2.0 g/L, 1.1-1.5 g/L, and ≤ 1.0 g/L）. The total bilirubin （TBIL） level was significantly lower in the research group than in the control group, except for the subgroup of FIB ≤ 1.0 g/L. CONCLUSION： TCM therapy can improve coagulation fuction and decrease TBIL.展开更多
对近10年来有关中医辨治胃癌前病变(precancerous lesions of gastric cancer,PLGC)的研究进行综述。PLGC是指在慢性萎缩性胃炎基础上出现的胃黏膜肠上皮化生和异型增生,作为慢性萎缩性胃炎与胃癌的中间阶段,PLGC的病程较缓慢。中医辨治...对近10年来有关中医辨治胃癌前病变(precancerous lesions of gastric cancer,PLGC)的研究进行综述。PLGC是指在慢性萎缩性胃炎基础上出现的胃黏膜肠上皮化生和异型增生,作为慢性萎缩性胃炎与胃癌的中间阶段,PLGC的病程较缓慢。中医辨治PLGC具有一定的优势。PLGC主要可分为脾胃虚弱证、脾胃湿热证、肝胃气滞证、胃络瘀阻证、胃阴不足证5种证型。胃镜技术的普及促进了胃病微观辨证的发展,微观辨证与宏观辨证的结合为PLGC的中医辨证论治提供了更加丰富的理论支持。PLGC根本病机为脾胃虚弱,脾胃气机不畅,兼有湿热、瘀毒、痰湿等病理因素蕴结,日久胃阴亏耗。中药治疗PLGC的临床研究开展较多,治疗主要采用以益气健脾为主,兼以疏肝活血、化湿消瘀、化瘀解毒、养阴益胃,从而防止PLGC向胃癌进一步发展。针灸治疗胃癌前病变的研究开展较少。今后需开展更多严格且规范的多中心、大样本的临床随机对照试验,深入研究针灸治疗胃癌前病变机制,以期为中医辨治PLGC提供更多高级别的循证依据。展开更多
目的:观察养阴益气活血法对干燥综合征(Sjogren′ssyndrom e,SS)N O D小鼠颌下腺组织及其唾液分泌功能的影响,初步探讨其对干燥综合征的治疗作用及其机制。方法:将48只8周龄N O D小鼠随机分为6组,同时选Balb/C小鼠8只做为正常对照组(正...目的:观察养阴益气活血法对干燥综合征(Sjogren′ssyndrom e,SS)N O D小鼠颌下腺组织及其唾液分泌功能的影响,初步探讨其对干燥综合征的治疗作用及其机制。方法:将48只8周龄N O D小鼠随机分为6组,同时选Balb/C小鼠8只做为正常对照组(正常组)。实验期间记录每只小鼠平均每日饮水量,每2周测定唾液分泌量,实验8周后股动脉取血,处死小鼠,解剖摘取颌下腺、脾脏,计算颌下腺和脾脏指数,光镜下观察颌下腺病理变化。结果:模型小鼠颌下腺淋巴细胞浸润评分明显高于正常组(P<0.05),各给药组小鼠病理形态和评分明显改善,且中西药组优于其他组(P<0.05)。至第6周末,各给药组小鼠每日饮水量逐渐减少,低于模型组(P<0.05),而唾液分泌量逐渐增加,且高于模型组(P<0.05)。中药高剂量组、中西药组小鼠每日饮水量明显低于其他给药组(P<0.05)。实验第8周结束后,各给药组小鼠唾液分泌量均高于模型组和同组第2周末(P<0.05);高剂量组、中西药组唾液分泌量高于羟氯喹组、中剂量组、低剂量组(P<0.05)。正常组小鼠脾脏指数低于其他各组(P<0.05),高剂量组、中西药组低于模型组(P<0.05)。模型组颌下腺指数低于正常组(P<0.05),中药低剂量组、羟氯喹组低于正常组(P<0.05);而中西药组均高于模型组、低剂量组和羟氯喹组(P<0.05)。结论:养阴益气活血煎剂能减少干燥综合征N O D小鼠饮水量,增加小鼠唾液分泌量,调节颌下腺和脾脏指数,减轻颌下腺组织病理损害;养阴益气活血煎剂对SS小鼠有治疗作用,且高剂量组效果显著。展开更多
基金Science and Technology Agency of Guangdong Province,NO.2008B030301041
文摘AIM： TO observe the therapeutic effects of new traditional Chinese medicine （TClVl） therapy on coagulation disorder and accompanying intractable jaundice in HBV-related liver cirrhosis patients. METHODS： Using stratified random sampling according to fibrinogen （Fib） levels, 145 liver cirrhosis patients due to hepatitis B complicated by coagulation disorder were treated. Of them, 70 in research group were treated with TCM by ＂nourishing yin, cooling blood and invigorating blood circulation＂ and Western medicine, 75 in control group were treated with conventional Western medicine. The indexes of liver function, coagulation function and bleeding events were observed and compared. RESULTS： The prothrombin time （PT） was shorter and the fibrinogen （Fib） level was higher in the research group than in the control group （Fib = 1.6-2.0 g/L, 1.1-1.5 g/L, and ≤ 1.0 g/L）. The total bilirubin （TBIL） level was significantly lower in the research group than in the control group, except for the subgroup of FIB ≤ 1.0 g/L. CONCLUSION： TCM therapy can improve coagulation fuction and decrease TBIL.
文摘对近10年来有关中医辨治胃癌前病变(precancerous lesions of gastric cancer,PLGC)的研究进行综述。PLGC是指在慢性萎缩性胃炎基础上出现的胃黏膜肠上皮化生和异型增生,作为慢性萎缩性胃炎与胃癌的中间阶段,PLGC的病程较缓慢。中医辨治PLGC具有一定的优势。PLGC主要可分为脾胃虚弱证、脾胃湿热证、肝胃气滞证、胃络瘀阻证、胃阴不足证5种证型。胃镜技术的普及促进了胃病微观辨证的发展,微观辨证与宏观辨证的结合为PLGC的中医辨证论治提供了更加丰富的理论支持。PLGC根本病机为脾胃虚弱,脾胃气机不畅,兼有湿热、瘀毒、痰湿等病理因素蕴结,日久胃阴亏耗。中药治疗PLGC的临床研究开展较多,治疗主要采用以益气健脾为主,兼以疏肝活血、化湿消瘀、化瘀解毒、养阴益胃,从而防止PLGC向胃癌进一步发展。针灸治疗胃癌前病变的研究开展较少。今后需开展更多严格且规范的多中心、大样本的临床随机对照试验,深入研究针灸治疗胃癌前病变机制,以期为中医辨治PLGC提供更多高级别的循证依据。
文摘目的:观察养阴益气活血法对干燥综合征(Sjogren′ssyndrom e,SS)N O D小鼠颌下腺组织及其唾液分泌功能的影响,初步探讨其对干燥综合征的治疗作用及其机制。方法:将48只8周龄N O D小鼠随机分为6组,同时选Balb/C小鼠8只做为正常对照组(正常组)。实验期间记录每只小鼠平均每日饮水量,每2周测定唾液分泌量,实验8周后股动脉取血,处死小鼠,解剖摘取颌下腺、脾脏,计算颌下腺和脾脏指数,光镜下观察颌下腺病理变化。结果:模型小鼠颌下腺淋巴细胞浸润评分明显高于正常组(P<0.05),各给药组小鼠病理形态和评分明显改善,且中西药组优于其他组(P<0.05)。至第6周末,各给药组小鼠每日饮水量逐渐减少,低于模型组(P<0.05),而唾液分泌量逐渐增加,且高于模型组(P<0.05)。中药高剂量组、中西药组小鼠每日饮水量明显低于其他给药组(P<0.05)。实验第8周结束后,各给药组小鼠唾液分泌量均高于模型组和同组第2周末(P<0.05);高剂量组、中西药组唾液分泌量高于羟氯喹组、中剂量组、低剂量组(P<0.05)。正常组小鼠脾脏指数低于其他各组(P<0.05),高剂量组、中西药组低于模型组(P<0.05)。模型组颌下腺指数低于正常组(P<0.05),中药低剂量组、羟氯喹组低于正常组(P<0.05);而中西药组均高于模型组、低剂量组和羟氯喹组(P<0.05)。结论:养阴益气活血煎剂能减少干燥综合征N O D小鼠饮水量,增加小鼠唾液分泌量,调节颌下腺和脾脏指数,减轻颌下腺组织病理损害;养阴益气活血煎剂对SS小鼠有治疗作用,且高剂量组效果显著。
