Development of Prolonged Release Microspheres of Metformin Hydrochloride Using Ion Exchange Resins

Aim To prepare the prolonged-released microspheres of mefformin hydrochloride. Methods Ion-exchange resin-drug mefformin hydrochloride complexes were prepared as core materials, and followed by coating using ethylcellulose （EC） by the emulsion solvent diffusion technique. The release rate of mefformin from the microcapsules was highly dependent on the encapsulating formulation, thus being used as an index for formulation screening. Orthogonal experiments were performed to optimize the coating formulation. Results The final chosen formulation for coating of mefformin microcapsules were as follows： （ 1 ） the ratio of EC （20cps） to EC （45cps） was 50：50; （2） the ratio of plasticizer to coating materials was 20% ;and （3） the ratio of resin-mefformin complexes to coating materials was 5 ： 1. Conclusion The prolonged release microspheres of mefformin hydrochloride were successfully prepared.

A Novel Process Using Ion Exchange Resins for the Coproduction of Ethyl and Butyl Acetates

Before proposing an innovative process for the coproduction of ethyl and butyl acetates, the individual syntheses of ethyl acetate and butyl acetate by two different routes were first studied. These syntheses involved the reaction of ethanol or n-butanol with acetic acid or acetic anhydride in the presence of ion exchange resins: Amberlyst 15, Amberlyst 16, Amberlyst 36 and Dowex 50WX8. Kinetic and thermodynamic studies were performed with all resins. The lowest activation energy (Ea) value was obtained with Dowex 50WX8, which was identified as the best-performing resin, able to be reused at least in four runs without regeneration. The presence of water-azeotropes during the synthesis of ethyl acetate makes its purification difficult. A new strategy was adopted here, involving the use of ethanol and acetic anhydride as the starting material. In order to minimize acetic acid as co-product of this reaction, a novel two-step process for the coproduction of ethyl and butyl acetates was developed. The first step involves the production of ethyl acetate and its purification. Butyl acetate was produced in the second step: n-butanol was added to the mixture of acetic acid and the resin remaining after the first-step distillation. This process yields ethyl acetate and butyl acetate at high purity and shows an environmental benefit over the independent syntheses by green metrics calculation and life cycle assessment.

Kinetic Study of Esterification of Lactic Acid with Isobutanol and n-Butanol Catalyzed by Ion-exchange Resins

The esterification reactions of lactic acid with isobutanol and n-butanol have been studied in the presence of acid ion-exchange resin Weblyst D009. The influences of catalyst loading, stirrer speed, catalyst particle size, initial reactant molar ratio and temperature on the reaction rate have been examined. Experimental kinetic data were correlated by using the pseudo-homogeneous, Langnluir-Hinshelwood and Eley-Rideal models. Nonideality of the liquid phase was taken into account by using activities instead of molar fractions. The activity coefficients were calculated according to the group contribution method UNIFAC. Provided that the nonideality of the liquid is taken into account, the esterification kinetics of lactic acid with isobutanol and n-butanol catalyzed by the acid ion-exchange resin can be described using all threemodels with reasonable errors.

Taste masking of ciprofloxacin by ion-exchange resin and sustain release at gastric-intestinal through interpenetrating polymer network

The aim of the study was to taste mask ciprofloxacin(CP)by using ion-exchange resins(IERs)followed by sustain release of CP by forming interpenetrating polymer network(IPN).IERs based on the copolymerization of acrylic acid with different cross linking agents were synthesised.Drug-resin complexes(DRCs)with three different ratios of drug to IERs(1:1,1:2,1:4)were prepared&evaluated for taste masking by following in vivo and in vitro methods.Human volunteers graded ADC 1:4,acrylic acid-divinyl benzene(ADC-3)resin as tasteless.Characterization studies such as FTIR,SEM,DSC,P-XRD differentiated ADC 1:4,from physical mixture(PM 1:4)and confirmed the formation of complex.In vitro drug release of ADC 1:4 showed complete release of CP within 60 min at simulated gastric fluid(SGF)i.e.pH 1.2.IPN beads were prepared with ADC 1:4 by using sodium alginate(AL)and sodium alginate-chitosan(AL-CS)for sustain release of CP at SGF pH and followed by simulated intestinal fluid(SIF i.e.pH 7.4).FTIR spectra confirmed the formation of IPN beads.The release of CP was sustain at SGF pH(<20%)whereas in SIF media it was more(>75%).The kinetic model of IPN beads showed the release of CP was non-Fickian diffusion type.

Direct extraction of Mo(VI) from acidic leach solution of molybdenite ore by ion exchange resin:Batch and column adsorption studies

The adsorption behavior of ion exchange resin D301 in the extraction of hexavalent molybdenum from high acidic leach solution was investigated. SEM, EDS and Raman spectra analyses were applied to studying the adsorption capacity, reaction kinetics and possible adsorption mechanism in detail. Results showed that the adsorption capacity of D301 resin for molybdenum from high acidic leach solution was up to 463.63 mg/g. Results of the kinetic analysis indicated that the adsorption process was controlled by the particle diffusion with the activation energy 25.47 k J/mol（0.9-1.2 mm） and 20.38 k J/mol（0.6-0.9 mm）. Furthermore, the molybdenum loaded on the resin could be eluted by using 2 mol/L ammonia hydroxide solution. Besides, dynamic continuous column experiments verified direct extraction of molybdenum from acidic leach solutions by ion exchange resin D301 and the upstream flow improved dynamic continuous absorption.

Study on the influence of humic acid of different molecular weight on basic ion exchange resin's adsorption capacity

In this paper, humic acid （HA） was ultra-filtered into different molecular weight sections and was characterized by multielement analysis, UV254/TOC, FT-IR and three-dimensional fluorescence spectrometric. Since humic acids of different molecular weights have different hydrophilic and molecular size, the maximum adsorption capacity of basic ion exchange resins appears on the humic acid whose molecular weight ranges from 6000 to 10,000 Da.

Combination of chlorine and magnetic ion exchange resin for drinking water treatment of algae

The effectiveness of a magnetic ion exchange resin （MIEX） for the treatment of Hongze Lake water in China was evaluated, The kinetics of natural organic matter （NOM） removal at various MIEX doses and contact time, multiple-loading experiments, impacts of MIEX prior to coagulation on coagulant demands and the effectiveness of combination of MIEX, pre-chlorination and coagulation were investigated. Kinetic experimental results show that more than 80% UV254 and 67% dissolved organic carbon （DOC） from raw water can be removed by the use of MIEX alone. 94% sulfate, 69% nitrate and 98% bromide removals are obtained after the first use of MIEX in multiple-loading experiments. It is suggested that MIEX can be loaded up to 1 250 bed volume （BV, volume ratio of tested water to resin） or more without saturation when regarding organics removal as a target. MIEX can remove organics to a greater extend than coagulation and lower the coagulant demand when combining with coagulation. Chlorination experimental results show that MIEX can remove 57% chlorine demand and 77% trihalomethane formation potential （THMFP） for raw water. Pre-chlorination followed by MIEX and coagulation can give additional organic and THMFP removals. The results suggest that MIEX provides a new method to solve thc problem algae reproduction.

Optimizing the Synthesis of Ethyl tert-Butyl Ether in Continuous Catalytic Distillation Column Using New Ion Exchange Resin Catalyst

Liquid phase synthesis of one of the important fuel oxygenate, ethyl tert-butyl ether （ETBE）, from etha-nol and tert-butyl alcohol （TBA） has been studied in catalytic distillation column （CDC） using ion exchange resin catalyst CT-145H. A packed CDC of 1.2 m height and 50 mm diameter with indigenously developed reactive sec-tion packing was used to generate experimental data. Effect of different key variables on product purity in distillate, was investigated to find the optimum operating conditions for ETBE synthesis. The optimum conditions for 0.2 kg·s-1 of ethanol feed were found：reboiler duty of 375 W, molar feed ratio of 1︰1.3 of reactants, and reflux ratio of 7. Concentration profiles for each component along each column section at optimum conditions were also drawn. Neither output nor input multiplicity was observed at experimental conditions.

A new configuration of membrane stack for retrieval of nickel absorbed in resins

A new configuration integrated ion exchange effect with both electro-migration and electrochemical reaction in a single cell was developed to effectively retrieve metal ions from simulated wastewater using ion exchange resins without additive chemicals. By simply assembling cation exchange resins and anion exchange resins separated by homogeneous membranes, we found that the system will always be acidic in the concentrate compartment so that ion exchange resins could be in-situ regenerated without hydroxide precipitation. Such a realizable design will be really suitable for wastewater purification.

17α-Ethinylestradiol removal from water by magnetic ion exchange resin

Magnetic ion exchange(MIEX) resins have received considerable attention in drinking water treatment due to their fast and efficient removal of dissolved organic carbon(DOC). Two types of mechanisms, i.e., ion exchange,reversible and irreversible adsorption, may occur during pollutants removal by MIEX. This work examined the removal mechanism of 17α-Ethinylestradiol(EE2) by MIEX. As one of typical estrogen micro-pollutants,EE2 existed as neutral molecule in natural water, and its charge density was close to zero [(0.00000219 ±0.00000015) meq·(μg EE2)^(-1)] based on the potentiometric titration method. However, the removal of EE2 by MIEX was much higher than that of other micro-pollutants previously reported. Multi-cycle adsorptionregeneration experiments and ion exchange stoichiometry analysis were conducted to elucidate the removal mechanism of EE2 by MIEX resin. The results suggested that the main removal mechanism of EE2 by MIEX was ion exchange instead of reversible micro-pore adsorption. The experimental analysis based on Donnan theory indicated that the internal micro-environment of resin beads was alkaline, in the alkaline environment EE2 would be ionized into negatively charged groups. As a result, ion exchange reaction occurred inside the pore of MIEX resin, and the removal process of EE2 by MIEX was dominated by the ion exchange reaction.

ELECTRIC REGENERATION METHOD OF IONEXCHANGE RESIN IN THE MIXED BED

In this paper the self-regeneration process of the mixed resins consisting of cationand anion ion exchangers in the electrolialyser of the packed bed is analyzed and anelectric regeneration method is put forward to supply the desalinated water by mixedbed The electric regeneration technology is a new one used for regeneration of theexhausted ion exchangers in the mixed bed instead of the traditional regeneratingprocess by using acid and abc liquor Electric energy is consumed to regenerat theion exchangers loaded by salts from water treatment without any chemicals- acid alkali. The advantage of the electric regeneration process edibited convenientoperation, no discharge any waste, and therefore no Polluted to the recehang waterbode and the environmental ground

Determination of Sc by Ion-exchanger Colorimetry

Ion exchanger colorimetry for scandium in the form of ternary color system “Sc(Ⅲ) CPA pc Ac” was developed. The influences of types and grain sizes of resin, adsorption modes and the acidity on the determination were studied systematically, and the optimum operating conditions and the allowable amounts of foreign ions were determined. In comparison with the ordinary solution colorimetry, both of the sensitivity and the selectivity of this ion exchanger colorimetry are improved obviously. The preliminary uses of this method to the determination of Sc(Ⅲ) in two synthetic samples were satisfied.

Cleaning the Ion Exchange Resin Sorption of Uranium from Silicic Acid Solution ＂Ayanat＂

The authors discovered a new way to clean the ion exchange resin sorption of uranium from silicic acid used solution ＂Ayanat＂. The method reduces the costs of regeneration of ion exchange resin and its reuse in the sorption of uranium.

Adsorption of Copper from an Ammonia-Thiosulfate Media Using DOWEX 550A Ion Exchange Resin

The study of copper adsorption onto ion exchange resins of anionic type is part of the gold recovery from ammonia-thiosulfate solutions, where copper is the main impurity of the system because it acts as a catalyst of gold dissolution reaction. A study is made of the adsorption and desorption of copper in the form of the complex in an ammonia-thiosulfate media on an ion exchange resin, DOWEX 550A, classified as a strong base, which in its inner structure has a quaternary amine functional group. In the studied pH range copper adsorption increased with increasing pH, while the presence of thiosulfate decreased it, the same as the ammonia content, due to the greater presence of cuprotetramine, . Elution of the copper complexes from the resin was more efficient with sulfite than with perchlorate.

Reaction kinetics for the heterogeneously resin-catalyzed and homogeneously self-catalyzed esterification of thioglycolic acid with 2-ethyl-1-hexanol

Producing 2-ethyl-1-hexyl thioglycolate(ETE)via esterification reaction with thioglycolic acid(TGA)aqueous solution as raw material by reactive-separation coupling technology is a promising process intensification method.To choose suitable reactive-separation coupling strategy,the kinetic studies of the esterification of TGA with 2-ethyl-1-hexanol(EHL)were carried out in a batch system.The commercial ion exchange resin was employed as an eco-friendly catalyst.The effects of temperature,catalyst concentration and molar ratio were determined.It was interesting to observe that the equilibrium conversion of TGA increased with the increase of catalyst mass fraction due to the adsorption of product water onto resin surface.The activity-based pseudo-homogeneous(PH),Eley-Rideal(ER)and Langmuir-Hinshelwood-Ho ugen-Watson(LHHW)models were used to fit the kinetics data of the resin-catalyzed reaction.The models of ER and LHHW performed better than the PH model.The kinetics of the TGA-self-catalyzed reaction was also determined.An activity-based homogeneous kinetics model could well describe this self-catalyzed reaction.These results would be meaningful to the selection and design of an appropriate reactionseparation strategy for the production of ETE,to realize the process intensification.

Research Progress on the Separation of Alkaloids from Chinese Medicines by Column Chromatography

Alkaloids have a variety of bioactivities and great development value in the fields of pharmaceuticals, cosmetics and health food. Column chromatography is a common method for preparing alkaloids. In this paper, the research status of the separation and purification of alkaloids from Chinese medicines by column chromatography is reviewed, and the factors that influence the refining of alkaloids via a macroporous adsorption resin, ion exchange resin and silica gel are summarized. The thermodynamic and kinetic modeling methods for the static adsorption of adsorbents are also reviewed in this paper. It is suggested that the modeling method of the column chromatography process be deeply studied to establish a more stringent quality control method for sampling liquid and to strengthen the online detection of the chromatography process to improve the refining effect of alkaloids.

STUDY ON THE SEPARATION OF PENTOSE AND HEXOSE FROM GLUCOSE YEAST WATER

D-ribose is a unique, 5-carbon sugar that occurs naturally in all living cells. D-ribose has been used as a staring material for preparation of some certain medicines or just as a new nutraceutical that helps the body naturally restore its energy level. The fermentative processes are the best for their relatively simple series of production steps and relatively cheap starting materials. However, because of the many impurities in glucose yeast water and its dark color, pretreatment and purification must be done to the fluid before D-ribose can be separated. In this paper, separation and purification of D-ribose was carried out using cation exchange resins, of which Ca2+ exchange resin had the best effect. The optimal condition for adsorption is a flow velocity of 0.5BV/h at adsorption temperature of 25℃. The optimal condition for desorption is a flow velocity of 0.5 BV/h at desorption temperature of 80℃.

Development and Research of Non⁃Stirring Conveying Device for Waste Resin in Nuclear Power Plant

Blockage in the storage and transportation of waste resin is a difficult problem in the radioactive waste treatment process of nuclear power plants.In this study,in order to solve the problems of unstable resin transport concentration and easy blockage of conveying equipment and pipelines in nuclear power plants in China,a set of non⁃stirring conveying devices is developed,and theoretical calculations,simulation analysis and experimental verification are carried out.By transporting resin using the no stirring conveying device developed in this paper,it is not only to eliminate the risk of blockage and ensure the safety of transportation,but also to adjust the concentration of conveying resin to change the transport efficiency according to the operating conditions.The effective bearing rate of waste resin storage tank can be improved,so that the comprehensive performance of waste resin storage and transportation in nuclear power plants can be greatly improved.

Solidification of Spent Ion Exchange Resin Using ASC Cement

Ion exchange resins (IERs) have been widely used in nuclear facilities. However, the spent radioactive IERs result in major quantities of low and intermediate level radioactive wastes. This article describes a laboratory experimental study on solidification processing of IERs using a new type of cement named ASC cement. The strength of the cementation matrix is in the range of 1820 MPa (28 d); the loading of the spent IER in the cement-resin matrix is over 45% and leaching rates of 137Cs, 90Sr and 60Co are 7.92×10 -5, 5.7×10 -6, and 1.19×10 -8 cm/d. The results show that ASC cement can be a preferable cementation material for immobilization of radioactive spent IER.

Preparation and quality assessment of high-purity ginseng total saponins by ion exchange resin combined with macroporous adsorption resin separation

AIM： To prepare high-purity ginseng total saponins from a water decoction of Chinese ginseng root.METHOD： Total saponins were efficiently purified by dynamic anion-cation exchange following the removal of hydrophilic impurities by macroporous resin D101. For quality control, ultrahigh-performance liquid chromatography with a charged aerosol detector （CAD） was applied to quantify marker components. The total saponin content was estimated by a colorimetric method using a vanillin-vitriol system and CAD response. RESULTS： D201, which consisted of a cross-linked polystyrene matrix and -]N＋（CI-13）3 functional groups, was the best of the four anion exchange resins tested. However, no significant difference in cation exchange ability was observed between D001 （strong acid） and D 113 （weak acid）, although they have different functional groups and matrices. After purification in combination with D101, D201, and D 113, the estimated contents of total saponins were 107% and 90% according to the colorimetric method and CAD response, respectively. The total amount of representative ginsenosides Re, Rd, Rgl, and compound K was approximately 22% based on ultrahigh-performance liquid chromatography-CAD quantitative analysis. CONCLUSION： These findings suggest that an ion exchange resin, combined with macroporous adsorption resin separation, is a promising and feasible purification procedure for neutral natural polar components.