A new method for the synthesis of 1-methylimidazolium trifluoroacetate ([Hmi]Tfa), a protic ionic liquid (PIL), under ultrasonic irradiation has been developed. In addition, the product [Hmi]Tfa was successfully emplo...A new method for the synthesis of 1-methylimidazolium trifluoroacetate ([Hmi]Tfa), a protic ionic liquid (PIL), under ultrasonic irradiation has been developed. In addition, the product [Hmi]Tfa was successfully employed as solvent and catalyst in Biginelli reaction to prepare 3,4-dihydropyrimidinones (DHPMs) in high yield under mild reaction conditions.展开更多
4-Aryl-3, 4-dihydropyrimidinones were synthesized using microwave-assisted,solvent-free protocol of the Biginelli reaction. The simple method provides the title compounds in78%―95% yields by the reaction of aromatic ...4-Aryl-3, 4-dihydropyrimidinones were synthesized using microwave-assisted,solvent-free protocol of the Biginelli reaction. The simple method provides the title compounds in78%―95% yields by the reaction of aromatic aldehydes with ethyl acetoac-etate and urea/thiourea inthe presence of a catalytic amount of cone. HCl. Lewis acids, such as ZnCl_2, SnCl_2, FeCl_3·6H_2O,and CuCl_2·2H_2O, were also found to be efficient catalysts for the synthesis ofdihydropyrimidinones.展开更多
文摘A new method for the synthesis of 1-methylimidazolium trifluoroacetate ([Hmi]Tfa), a protic ionic liquid (PIL), under ultrasonic irradiation has been developed. In addition, the product [Hmi]Tfa was successfully employed as solvent and catalyst in Biginelli reaction to prepare 3,4-dihydropyrimidinones (DHPMs) in high yield under mild reaction conditions.
文摘4-Aryl-3, 4-dihydropyrimidinones were synthesized using microwave-assisted,solvent-free protocol of the Biginelli reaction. The simple method provides the title compounds in78%―95% yields by the reaction of aromatic aldehydes with ethyl acetoac-etate and urea/thiourea inthe presence of a catalytic amount of cone. HCl. Lewis acids, such as ZnCl_2, SnCl_2, FeCl_3·6H_2O,and CuCl_2·2H_2O, were also found to be efficient catalysts for the synthesis ofdihydropyrimidinones.
