Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistoche...Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X2 and P2X3 receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X2 and P2X3 receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X2 and P2X3 receptor expression in dorsal root ganglia.展开更多
Irritable bowel syndrome(IBS)is a common refractory disease.Chinese medicine(CM)has remarkable efficacy and advantages on the treatment of IBS.This review summarized the articles focusing on the treatment of IBS with ...Irritable bowel syndrome(IBS)is a common refractory disease.Chinese medicine(CM)has remarkable efficacy and advantages on the treatment of IBS.This review summarized the articles focusing on the treatment of IBS with CM to sum up the latest treatment methods for IBS and the underlying mechanisms.Literature analysis showed that prescriptions,acupuncture,and moxibustion are the primary methods of CM treatment for IBS.The potential mechanisms center on the regulation of the enteric nervous system,the alleviation of visceral hypersensitivity,the stability of intestinal flora,and the regulation of the immune system.展开更多
基金funded by the National Natural Science Foundation of China,No.30973783the Shanghai Municipal Scientific Committee Project,No.11ZR1434300the Key Subject Program of State Administration of Traditional Chinese Medicine
文摘Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X2 and P2X3 receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X2 and P2X3 receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X2 and P2X3 receptor expression in dorsal root ganglia.
基金Supported by National Science and Technology Innovation Major New Drug Creation Project(No.2018Zx09721001-008)Southwest Characteristic Traditional Chinese Medicine Resource and Gene Innovation Platform,Central Guidance Local Special Project(No.2020ZYD058)。
文摘Irritable bowel syndrome(IBS)is a common refractory disease.Chinese medicine(CM)has remarkable efficacy and advantages on the treatment of IBS.This review summarized the articles focusing on the treatment of IBS with CM to sum up the latest treatment methods for IBS and the underlying mechanisms.Literature analysis showed that prescriptions,acupuncture,and moxibustion are the primary methods of CM treatment for IBS.The potential mechanisms center on the regulation of the enteric nervous system,the alleviation of visceral hypersensitivity,the stability of intestinal flora,and the regulation of the immune system.