Diabetes is an age-related disease,most of which is type 2 diabetes,and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes.Recent studies have revealed that autophagy plays an ...Diabetes is an age-related disease,most of which is type 2 diabetes,and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes.Recent studies have revealed that autophagy plays an important role in maintaining the structure and func-tion of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress.In this review,we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus,which is the so-called double-edged sword,analysed its possible mechanism,and identifed possible research hot spots.展开更多
基金This work was supported by grants from the National Nat-ural Science Foundation of China(grant number 81370885)Research Institute performance incentive and guidance project of Chongqing Science and Technology Bureau(grant number cstc2019jxjl130006)+1 种基金General program of Natural Science Foundation of Chongqing Science and Technology Bureau(grant number cstc2019jcyj-msxm0827)2019 Merck Diabetes Research Fund(grant number g-x-2019-056).
文摘Diabetes is an age-related disease,most of which is type 2 diabetes,and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes.Recent studies have revealed that autophagy plays an important role in maintaining the structure and func-tion of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress.In this review,we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus,which is the so-called double-edged sword,analysed its possible mechanism,and identifed possible research hot spots.
