Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive im...Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s health.To find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were exhibited.Based on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of FEJ.Transcriptome data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by PCR.The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and transcriptome.The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.展开更多
Jiao Xun’s concept of the succession of literary genres according to each generation’s strengths clearly establishes the interrelationship between historical time and literary genres.Jiao Xun’s idea of the transfor...Jiao Xun’s concept of the succession of literary genres according to each generation’s strengths clearly establishes the interrelationship between historical time and literary genres.Jiao Xun’s idea of the transformation of literary styles differs from the prevailing notion at that time,which advocated prioritizing poetry and prose that conveyed aspirations and ideals while considering other literary genres such as ci(a form of lyric poetry),qu(drama),and novels as inferior.Instead,Jiao Xun advocated using the“nature”and“events”of objects as criteria and awakened a more traditional“poetic teaching tradition”characterized by metaphorical expression and emotional resonance,which aligned with the concept of literature conveying aspirations and ideals.This enabled the standard of“nature”to transcend the boundaries of literary genres,establishing new criteria for the hierarchy of genres and encapsulating Jiao Xun’s intention to summon emerging literary genres that were in harmony with the“present”.展开更多
基金supported by the National Key R&D Program of China(2018YFC1707300)the Taishan Industrial Experts Program(tscx202211148).
文摘Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s health.To find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were exhibited.Based on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of FEJ.Transcriptome data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by PCR.The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and transcriptome.The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.
文摘Jiao Xun’s concept of the succession of literary genres according to each generation’s strengths clearly establishes the interrelationship between historical time and literary genres.Jiao Xun’s idea of the transformation of literary styles differs from the prevailing notion at that time,which advocated prioritizing poetry and prose that conveyed aspirations and ideals while considering other literary genres such as ci(a form of lyric poetry),qu(drama),and novels as inferior.Instead,Jiao Xun advocated using the“nature”and“events”of objects as criteria and awakened a more traditional“poetic teaching tradition”characterized by metaphorical expression and emotional resonance,which aligned with the concept of literature conveying aspirations and ideals.This enabled the standard of“nature”to transcend the boundaries of literary genres,establishing new criteria for the hierarchy of genres and encapsulating Jiao Xun’s intention to summon emerging literary genres that were in harmony with the“present”.
