New Trends in Japan's“Indo-Pacific”Strategy

Introduced by the late Prime Minister Shinzo Abe and inherited and developed by Fumio Kishida,Japan's“Indo–Pacific”strategy has gradually taken shape.This strategy can be deemed a broad vision,covering a wide range of topics and an extensive network of partners,with a strong trend of pan-securitization.It is a comprehensive inter national st rateg y based on Japan's alliance policy and China containment strategy,following a global,security-oriented approach.Driven by considerations such as maintaining its economic status,realizing its long-cherished dream of becoming a political powerhouse,and containing China,Japan has stepped up its“Indo–Pacific”strategy,which may influence global development,undermine regional maritime security,and impede China's reunification process.Meanwhile,Japan's“Indo–Pacific”strategy faces the triple challenge of a strategic overdraft,the unstable economic foundations,and the weak external support.These constraints may not suffice to reverse the direction of Japan's“Indo–Pacific”strategy in the short term but will limit its effectiveness.

Zero-determinant strategies in iterated multi-strategy games

Self-serving,rational agents sometimes cooperate to their mutual benefit.The two-player iterated prisoner′s dilemma game is a model for including the emergence of cooperation.It is generally believed that there is no simple ultimatum strategy which a player can control the return of the other participants.The zero-determinant strategy in the iterated prisoner′s dilemma dramatically expands our understanding of the classic game by uncovering strategies that provide a unilateral advantage to sentient players pitted against unwitting opponents.However,strategies in the prisoner′s dilemma game are only two strategies.Are there these results for general multi-strategy games?To address this question,the paper develops a theory for zero-determinant strategies for multi-strategy games,with any number of strategies.The analytical results exhibit a similar yet different scenario to the case of two-strategy games.The results are also applied to the Snowdrift game,the Hawk-Dove game and the Chicken game.

大学生信息成瘾行为的触发路径与干预策略:基于S-O-R理论视角

[目的/意义]文章以大学生为研究对象,探究该群体信息成瘾行为的影响机制,为大学生信息成瘾行为的预防和管理提供价值参考。[方法/过程]引入刺激-机体-反应(S-O-R)理论,利用文献梳理总结大学生信息成瘾过程中的外部刺激,深度剖析机体在成瘾过程中产生的认知心理,构建大学生信息成瘾行为理论模型,运用结构方程模型实证分析大学生信息成瘾的触发路径。[结果/结论]研究结果表明,信息过载、间歇性奖励和行为管理会显著正向影响大学生的不确定性回避,进而导致大学生信息成瘾。同时,信息过载也会使大学生产生信息焦虑,信息焦虑显著正向影响大学生信息成瘾行为。面向高等院校、大学生群体和科技企业,提出针对性建议与对策,有助于完善高等院校管理体系,促进学生适应信息化环境,推动高等教育事业更好发展。

Ibrutinib and atrial fibrillation:An in-depth review of clinical implications and management strategies

Ibrutinib,a targeted therapy for B-cell malignancies,has shown remarkable efficacy in treating various hematologic cancers.However,its clinical use has raised concerns regarding cardiovascular complications,notably atrial fibrillation(AF).This comprehensive review critically evaluates the association between ibrutinib and AF by examining incidence,risk factors,mechanistic links,and management strategies.Through an extensive analysis of original research articles,this review elucidates the complex interplay between ibrutinib’s therapeutic benefits and cardiovascular risks.Moreover,it highlights the need for personalized treatment approaches,vigilant monitoring,and interdisciplinary collaboration to optimize patient outcomes and safety in the context of ibrutinib therapy.The review provides a valuable resource for healthcare professionals aiming to navigate the intricacies of ibrutinib’s therapeutic landscape while prioritizing patient well-being.

Entrepreneurial Spirit for China in the New Era and Strategies for Cultivation

What type of entrepreneurial spirit is needed for China’s new era,and how can we unlock its innovation potential?Answers to these questions will unleash vital forces to drive China’s high-quality economic development.After reviewing the theories,dimensions,features,and limitations of the entrepreneurial spirit in the Western context,we concluded that the entrepreneurial spirit in China’s new era,which is characterized by patriotism,innovation,trustworthiness,adherence to the law,fulfillment of social responsibilities,and a global horizon,has overcome the limitations that come with self-interested entrepreneurship in the context of Western economics.This is a major step forward in the development of theories on entrepreneurial spirit.In the development context of the new era,this paper argues that the entrepreneurial spirit should become an important force at the individual level to implement the new development concept,foster the new development paradigm,and promote high-quality development in the new stage.This paper provides answers to the question of what type of entrepreneurial spirit China’s new era requires.Finally,this paper presents basic strategies for cultivating entrepreneurial spirit in the context of China’s new era,emphasizing the importance to promote the healthy growth of young entrepreneurs,ensure their business autonomy,develop a multi-tiered capital market,implement the factor market reforms,improve the business climate,and accelerate the digital transition.

Brand Strategy and Japan's Soft Power

The 21st century is the time of brand strategy showing its position and importance in operation of enterprises.Rapid rise of the brand strategy in operation and management of enterprises has profound social and operation background.The development process of brand strategy also reflects evolution of market economy.A country's cultural influence power depends on its brand equity.An essential task of brand promotion for a county is to narrow the gap between original image and target image,change the past or one-sided image of the public to products of the country,and implement effective communication and propaganda with the aid of related resource system in the country's soft power,and accept new excellent image.Fundamentally,lifting national soft power is to set up distinct and charming national brand or national image.The influence power with culture and communication as core is the direct manifestation of a country's core competitiveness.Brand is an outstanding feature of a country's strength.Brand stretching can promote liftoff of national economy.In expanding international market,famous brands will play a more and more important role.

Japan's State Strategy vs. Anti-Terrorism

The September 11 event upset Japan’s diplomatic agenda and ushered in a strategic restructuring with the focus on anti-terrorism and the top priority given to ties with Washington. Its new diplomacy against terror stresses three aspects: policy towards Washington for ensuring strategic center

New Sino-US Strategic Gambling and China’s Strategy

Since confidence is fading and anxiety is increasing in the US,America’s China policy has become more radical. In the short term, the US has the upper hand and China is in a relatively passive position. In the medium-and long-term, there will be more balance between them. This current strategic gambling between China and the US will be the major issue of international politics in the first half of the 21 st century and the most prominent external challenge China faces. China needs to make strategic adjustments but the gamble may be worthwhile in correcting imbalance in the international order and in the co-evolution of the two countries.

The Indo-Pacific Strategy of the United States from Russia’s Strategic Perspective

The Trump administration of the United States has accelerated the advancement of the‘‘open and free Indo-Pacific’,strategy since 2017.From a geopolitical point of view and in terms of its national interests,Russia has generally been critical of this strategy,believing it has posed certain challenges to its“Pivot to the East”strategy.Meanwhile,Russia is rejoicing for not being the primary target of US containment in the region and has sensed a new opportunity for exercising its Asia-Pacific diplomacy in the context of the Indo-Pacific strategy.Based on this situation,Russia has made a flexible and pragmatic policy response to it.However,Russia will inevitably face many restraints.In the future,Russia will seek to maximize its strategic interests on the basis of adhering to its inherent principles of Asia-Pacific diplomacy.

Research on an International Marketing Strategy for Japanese Rice

This study aims to clarify the factors that form rice prices for different producing areas and brands in Japan, while ascertaining consumers＇ criteria in purchasing rice and their preference for taste in China, in order to establish the method to formulate an overseas marketing strategy for Japanese rice.

Novel therapeutic strategies targeting mitochondria as a gateway in neurodegeneration

In recent years, multiple disciplines have focused on mitochondrial biology and contributed to understanding its relevance towards adult-onset neurodegenerative disorders. These are complex dynamic organelles that have a variety of functions in ensuring cellular health and homeostasis. The plethora of mitochondrial functionalities confers them an intrinsic susceptibility to internal and external stressors(such as mutation accumulation or environmental toxins), particularly so in long-lived postmitotic cells such as neurons. Thus, it is reasonable to postulate an involvement of mitochondria in aging-associated neurological disorders, notably neurodegenerative pathologies including Alzheimer’s disease and Parkinson’s disease. On the other hand, biological effects resulting from neurodegeneration can in turn affect mitochondrial health and function, promoting a feedback loop further contributing to the progression of neuronal dysfunction and cellular death. This review examines state-of-the-art knowledge, focus on current research exploring mitochondrial health as a contributing factor to neuroregeneration, and the development of therapeutic approaches aimed at restoring mitochondrial homeostasis in a pathological setting.

Anderson's Cognitive Theory and Learning Strategy Studies in Second Language Acquisition

Second language acquisition can not be understood without addressing the interaction between language and cognition. Cognitive theory can extend to describe learning strategies as complex cognitive skills. Theoretical developments in Anderson’s production systems cover a broader range of behavior than other theories, including comprehension and production of oral and written texts as well as comprehension, problem solving, and verbal learning.Thus Anderson’s cognitive theory can be served as a rationale for learning strategy studies in second language acquisition.

Zero-determinant strategy:An underway revolution in game theory

Repeated games describe situations where players interact with each other in a dynamic pattern and make decisions ac- cording to outcomes of previous stage games. Very recently, Press and Dyson have revealed a new class of zero-determinant （ZD） strategies for the repeated games, which can enforce a fixed linear relationship between expected payoffs of two play- ers, indicating that a smart player can control her unwitting co-player＇s payoff in a unilateral way [Proc. Acad. Natl. Sci. USA 109, 10409 （2012）]. The theory of ZD strategies provides a novel viewpoint to depict interactions among players, and fundamentally changes the research paradigm of game theory. In this brief survey, we first introduce the mathematical framework of ZD strategies, and review the properties and constrains of two specifications of ZD strategies, called pinning strategies and extortion strategies. Then we review some representative research progresses, including robustness analysis, cooperative ZD strategy analysis, and evolutionary stability analysis. Finally, we discuss some significant extensions to ZD strategies, including the multi-player ZD strategies, and ZD strategies under noise. Challenges in related research fields are also listed.

Management strategies of Barrett's esophagus

Barrett's esophagus is a condition resulting from chronic gastro-esophageal reflux disease with a documented risk of esophageal adenocarcinoma. Current strategies for improved survival in patients with Barrett's adenocarcinoma focus on detection of dysplasia. This can be obtained by screening programs in high-risk cohorts of patients and/or endoscopic biopsy surveillance of patients with known Barrett's esophagus (BE). Several therapies have been developed in attempts to reverse BE and reduce cancer risk. Aggressive medical management of acid reflux, lifestyle modifications, antireflux surgery, and endoscopic treatments have been recommended for many patients with BE. Whether these interventions are cost-effective or reduce mortality from esophageal cancer remains controversial. Current treatment requires combinations of endoscopic mucosal resection techniques to eliminate visible lesions followed by ablation of residual metaplastic tissue. Esophagectomy is currently indicated in multifocal high-grade neoplasia or mucosal Barrett's carcinoma which cannot be managed by endoscopic approach.

Acetylcholinesterase inhibitor modifications: a promising strategy to delay the progression of Alzheimer's disease

Alzheimer＇s disease （AD）, a fatal, progressive, neurodegener- ative disorder, is the most common cause of old-age demen- tia, accounting for 50-75% of dementia patients. Early stages of AD are marked by vocabulary shrinkage, spatial disori- entation, depression, apraxia, and deterioration of recent forms of declarative memory. In course of time, the patients require close supervision due to the loss of cognitive and functional abilities, and at the terminal stages of the disease, all forms of memory are severely impaired with the patients needing nursing home care （World Alzheimer Report, 2013）.

售货机升降系统S型速度控制策略

在传统三闭环控制方式下,售货机升降接货系统易因启停过程中加速度突变产生冲击,导致系统运行不平稳。针对这一问题,文中对传统升降系统加减速控制策略进行改进,加入前馈和微分负反馈,提出一种S型速度曲线控制算法。根据路径规划判别条件将S型速度曲线分为七段式、六段式和四段式3种,并给出各路径约束条件下的参数求解方法和具体执行流程。将该算法运用到升降控制系统中进行仿真和实际工况测试,实验结果表明,与传统三闭环控制相比,文中所提控制策略可以提高售货机升降系统运行的平稳性,减小冲击,使速度曲线更加柔和,并能够保持较好的跟踪性能。

India and the Indo-Pacific Strategy Vision： Orientation, Involvement and Limits

In 2017, the Trump administration formally articulated its vision for the Indo-Pacific strategy, replacing "Asia-Pacific" with"Indo-Pacific"in policy papers and taking measures to promote the realization of an "Indo-Pacific dream". This represents a significant adjustment in US regional policies. An important power in the Indian Ocean region, India is perceived as key to the successful implementation of this Indo-Pacific strategy. Generally speaking, the current Indian government and strategy circle actively support the upgrading of the"Indo-Pacific"concept from a geographical and academic term to a US vision for foreign strategies, anticipating that India could garner significant strategic benefits from it. Given this, New Delhi will continually adapt its foreign policies to the US Indo-Pacific strategy and may even direct the development of the strategy to counter the Belt and Road Initiative, work with other nations to balance China's influence and finally make the rise of India as a great power a reality. Nonetheless, the Indo-pacific strategy is in its early stages, and the content is not completely pro-India currently. On top of this India is still skeptical of the US and will proceed cautiously, leaving room for maneuver in the future,fully tapping into the benefits of the Indo-Pacific strategy and avoiding direct confrontation with China.

Altered microRNA expression in animal models of Huntington’s disease and potential therapeutic strategies

A review of recent animal models of Huntington’s disease showed many microRNAs had altered expression levels in the striatum and cerebral cortex,and which were mostly downregulated.Among the altered microRNAs were miR-9/9*,miR-29b,miR-124a,miR-132,miR-128,miR-139,miR-122,miR-138,miR-23b,miR-135b,miR-181(all downregulated)and miR-448(upregulated),and similar changes had been previously found in Huntington’s disease patients.In the animal cell studies,the altered microRNAs included miR-9,miR-9*,miR-135b,miR-222(all downregulated)and miR-214(upregulated).In the animal models,overexpression of miR-155 and miR-196a caused a decrease in mutant huntingtin mRNA and protein level,lowered the mutant huntingtin aggregates in striatum and cortex,and improved performance in behavioral tests.Improved performance in behavioral tests also occurred with overexpression of miR-132 and miR-124.In the animal cell models,overexpression of miR-22 increased the viability of rat primary cortical and striatal neurons infected with mutant huntingtin and decreased huntingtin-enriched foci of≥2μm.Also,overexpression of miR-22 enhanced the survival of rat primary striatal neurons treated with 3-nitropropionic acid.Exogenous expression of miR-214,miR-146a,miR-150,and miR-125b decreased endogenous expression of huntingtin mRNA and protein in HdhQ111/HdhQ111 cells.Further studies with animal models of Huntington’s disease are warranted to validate these findings and identify specific microRNAs whose overexpression inhibits the production of mutant huntingtin protein and other harmful processes and may provide a more effective means of treating Huntington’s disease in patients and slowing its progression.

“Parenchyma transection-first”strategy is superior to“tunnel-first”strategy in robotic spleen-preserving distal pancreatectomy with conservation of splenic vessels

Background: Creating a tunnel between the pancreas and splenic vessels followed by pancreatic parenchyma transection(“tunnel-first” strategy) has long been used in spleen-preserving distal pancreatectomy(SPDP) with splenic vessel preservation(Kimura’s procedure). However, the operation space is limited in the tunnel, leading to the risks of bleeding and difficulties in suturing. We adopted the pancreatic “parenchyma transection-first” strategy to optimize Kimura’s procedure. Methods: The clinical data of consecutive patients who underwent robotic SPDP with Kimura’s procedure between January 2017 and September 2022 at our center were retrieved. The cohort was classified into a “parenchyma transection-first” strategy(P-F) group and a “tunnel-first” strategy(T-F) group and analyzed. Results: A total of 91 patients were enrolled in this cohort, with 49 in the T-F group and 42 in the P-F group. Compared with the T-F group, the P-F group had significantly shorter operative time(146.1 ± 39.2 min vs. 174.9 ± 46.6 min, P < 0.01) and lower estimated blood loss [40.0(20.0–55.0) m L vs. 50.0(20.0–100.0) m L, P = 0.03]. Failure of splenic vessel preservation occurred in 10.2% patients in the TF group and 2.4% in the P-F group( P = 0.14). The grade 3/4 complications were similar between the two groups( P = 0.57). No differences in postoperative pancreatic fistula, abdominal infection or hemorrhage were observed between the two groups. Conclusions: The pancreatic “parenchyma transection-first” strategy is safe and feasible compared with traditional “tunnel-first strategy” in SPDP with Kimura’s procedure.

A Comparison Between Male and Female in Their Willingness to Communicate and Use of Socio-cognitive Strategies

Willingness to communicate illustrates anyone’s tendency and wish to commence a communication.Besides,socio-cognitive strategies are used when people want to interact with others and face some difficulties.The aim of this study was twofold.The first aim was to investigate the difference in willingness to communicate between Iranian male and female.The second aim was to distinguish the frequency of socio-cognitive strategies used by Iranian advance students based on their gender.To these ends,32 advance learners(16 males and 16 females)were given the willingness to communicate questionnaire developed by MacIntyre,Baker,Clément,and Conrod(2001)and the socio-cognitive strategy use questionnaire.The range of the participants’age was 17-23 in both males and females.To analyze the result of the socio-cognitive strategies use,frequencies were counted.The result showed that although there were some similarities and differences between males and females while using socio-cognitive strategies,the differences were more in social strategies than cognitive ones.After collecting the data from the questionnaires and calculating the means of the two groups,an independent sample T-test was run to compute the significant differences between the two groups.The result of the willingness to communicate questionnaire revealed that males had more tendency in communication than females.Also,the result of the socio-cognitive strategy questionnaire showed that both groups are similar in cognitive strategy use,but they are different in social strategy use.