Effect of Jintiange capsule on acute bone atrophy resulting from wrist fractures: A randomized controlled trial

Objective: To investigate the efficacy of Jintiange capsule in the treatment of acute bone atrophy due to wrist fractures. Methods: Participants were randomly allocated into two groups, i.e. the treatment group and the control groups. All patients received functional rehabilitation exercise. Patients in the treatment group received Jintiange capsule orally, while the control group received placebos. At 3 and 6 months after the treatment, Cooney score, hand grip and pinch strength were measured. The visual analogue scale (VAS) was applied, and safety events were recorded. Results: No loss occurred during 6 months of follow-up after treatment. Before the treatment, there was no statistically significant difference between the two groups in Cooney score, hand grip strength, hand pinch strength or VAS score (all P>0.05). At 3 and 6 months after the treatment, the Cooney core, hand grip and pinch strength increased, and the VAS were decreased in all patients. The treatment group showed significantly greater improvement than the control group (P<0.05). In additional, both groups showed few side effects. Conclusions: Jintiange capsule can improve the function of the wrist joint and alleviate the pain of fracture. It is safe and effective for treating acute bone atrophy.

Effect of the Jintiange capsule-assisted internal fixation on fracture healing and bone metabolism activity of patients with Colles fracture

Objective:To study the effect of the Jintiange capsule-assisted internal fixation on fracture healing and bone metabolism activity of patients with Colles fracture.Methods:A total of 120 patients with Colles fracture who received internal fixation in the hospital between July 2014 and May 2016 were collected and divided into control group and observation group according to the random number table method, 60 cases in each group. The control group received regular open reduction and internal fixation, and the observation group received Jintiange capsule-assisted internal fixation. The fracture healing quality as well as calcium phosphorus metabolism index and bone metabolism index levels were compared between the two groups before and after the operation.Results: Before operation, the differences in fracture end parameter levels, peripheral blood calcium and phosphorus metabolism index contents and serum bone metabolism index contents were not statistically significant between the two groups of patients;differences in fracture end radial incline, ulnar inclination and processus styloideus radii height were not statistically significant between the two groups of patients 6 weeks after surgery;peripheral blood Ca, P and ALP contents of observation group 6 weeks after surgery were significantly higher than those of control group, and serum bone formation indexes BGP and OPG contents were higher than those of control group while bone resorption indexes TRACP and CTX contents were significantly lower than those of control group. Conclusions: Jintiange capsule-assisted internal fixation can effectively improve the calcium and phosphorus metabolism, optimize bone formation/bone resorption balance and promote fracture healing in patients with Colles fracture.