目的 在高体重指数(body mass index, BMI)率快速增长的情况下,分析1990-2019年中国归因于高BMI的2型糖尿病疾病负担。方法 基于2019年全球疾病负担研究数据,分性别、年龄组分析1990-2019年中国因高BMI造成的2型糖尿病疾病负担,并利用Jo...目的 在高体重指数(body mass index, BMI)率快速增长的情况下,分析1990-2019年中国归因于高BMI的2型糖尿病疾病负担。方法 基于2019年全球疾病负担研究数据,分性别、年龄组分析1990-2019年中国因高BMI造成的2型糖尿病疾病负担,并利用Joinpoint回归模型分析标化后的归因死亡率和归因伤残调整寿命年(disability-adjusted life year, DALY)率的变化趋势。结果 1990-2019年间,我国2型糖尿病患病率从2928.78/10万增至6328.79/10万,归因高BMI的2型糖尿病死亡人数从1.05万增至4.75万,标化死亡率从1.25/10万增至2.39/10万;归因DALY从77.18万人年增至373.76万人年,标化后的归因DALY率从80.21/10万增至181.54/10万,早死损失寿命年(years of life lost, YLL)和伤残损失寿命年(year lived with disability, YLD)及其标化率也呈大幅增长。1990-2019年间,我国归因于高BMI的2型糖尿病标化死亡率和标化DALY率的年平均变化百分比分别为2.28%和2.81%,均有统计学意义(P<0.05),且男性均高于女性。男性标化后的归因DALY率和归因死亡率分别在2010年和2014年超过女性。年龄分层结果显示,50岁以上人群高BMI导致的2型糖尿病疾病负担更加严重,15~49岁人群归因于高BMI的YLD率增幅最大,达到323.99%。结论 1990-2019年间,中国归因于高BMI的2型糖尿病疾病负担显著增加。需加大防控力度,有效管理人群体重指数,并对高危人群采取重点干预,以减轻2型糖尿病疾病负担。展开更多
目的分析2000—2019年我国肝癌发病与死亡趋势,为我国肝癌防治策略的制订提供科学依据。方法收集2000—2019年全球健康数据交换(the Global Health Data Exchange,GHDx)数据库中我国肝癌发病与死亡个案信息,运用JoinPoint回归模型以平...目的分析2000—2019年我国肝癌发病与死亡趋势,为我国肝癌防治策略的制订提供科学依据。方法收集2000—2019年全球健康数据交换(the Global Health Data Exchange,GHDx)数据库中我国肝癌发病与死亡个案信息,运用JoinPoint回归模型以平均年度变化百分比(average annual percent change,AAPC)和年度变化百分比(annual percent change,APC)分别描述全人群、不同性别及不同年龄肝癌发病与死亡的变化趋势。结果2000—2019年我国肝癌发病和死亡总例数分别为4322652例和4093855例,标化发病率和死亡率分别为11.31/10万和9.68/10万。2000—2019年我国肝癌的发病率呈下降趋势(AAPC=-2.11%),其中2000—2002年和2002—2005年均呈下降趋势,APC分别为-10.55%和-15.45%;2005—2010年和2010—2019年均呈上升趋势,APC分别为0.44%和3.39%;男性和女性人群的发病率均呈下降趋势(AAPC=-1.95%,-2.43%)。2000—2019我国肝癌的死亡率呈下降趋势(AAPC=-2.41%),其中2000—2005年呈下降趋势,APC为-13.52%,2005—2012年和2012—2019年均呈上升趋势,APC分别为0.18%和3.64%;男性和女性人群的死亡率均呈下降趋势(AAPC=-2.34%,-2.60%)。我国肝癌的年龄别发病率及死亡率随着年龄的增长呈不断上升的趋势(AAPC=5.94%,7.10%),其中男性年龄别发病率在10~40岁之间增长较快,80岁之后增长速度有所下降,女性则整体呈上升趋势;男性年龄别死亡率在5~10岁之间增长率较大,女性则随着年龄的增长整体呈上升趋势。结论2000—2019年我国肝癌发病率及死亡率整体呈下降趋势,男性的发病率和死亡率大于女性,且随年龄增长呈上升趋势,男性及老年人群是肝癌重点关注人群。展开更多
目的了解铁岭市城区居民肝癌死亡趋势,为肝癌防治工作提供依据。方法对铁岭市2007-2015年银州区、清河区肝癌死亡资料进行分析,用Joinpoint Regression Program 4.3.1分析变化趋势。结果铁岭市2007-2015年城区肝癌死亡1030例,年均粗死...目的了解铁岭市城区居民肝癌死亡趋势,为肝癌防治工作提供依据。方法对铁岭市2007-2015年银州区、清河区肝癌死亡资料进行分析,用Joinpoint Regression Program 4.3.1分析变化趋势。结果铁岭市2007-2015年城区肝癌死亡1030例,年均粗死亡率为25.91/10万(标化死亡率16.89/10万),男性(39.02/10万)高于女性(12.96/10万)(P<0.001)。Joinpoint分析显示2007-2015年肝癌标化死亡率年均下降1.63%(P=0.008)。40岁之后肝癌死亡率增高,75岁之后死亡率显著增高。结论铁岭市2007-2015年城区肝癌死亡率呈下降趋势,但对中老年人群的危害仍很严重,应继续加强防控力度。展开更多
BACKGROUND Pancreatic cancer,as the one of most fatal malignancies,remains a critical issue in the global burden of disease.AIM To estimate trends in pancreatic cancer incidence and mortality worldwide in the last thr...BACKGROUND Pancreatic cancer,as the one of most fatal malignancies,remains a critical issue in the global burden of disease.AIM To estimate trends in pancreatic cancer incidence and mortality worldwide in the last three decades.METHODS A descriptive epidemiological study was done.Pancreatic cancer incidence and mortality data were obtained from the database of the World Health Organization.Analysis of pancreatic cancer incidence and mortality during 2020 was performed.The age-standardized rates(ASRs,expressed per 100000)were presented.To estimate trends of incidence and mortality of pancreatic cancer,joinpoint regression analysis was used:the average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.Additionally,analysis was performed by sex and age.In this paper,the trend analysis included only countries with high and medium data quality.RESULTS A total of 495773(262865 male and 232908 female)new cases and 466003(246840 male and 219163 female)deaths from pancreatic cancer were reported worldwide in 2020.In both sexes,most of the new cases(191348;38.6%of the total)and deaths(182074;39.1%of the total)occurred in the Western Pacific Region.In both sexes,the highest ASRs were found in the European Region,while the lowest rates were reported in the South-East Asia Region.The general pattern of rising pancreatic cancer incidence and mortality was seen across countries worldwide in observed period.Out of all countries with an increase in pancreatic cancer incidence,females in France and India showed the most marked rise in incidence rates(AAPC=+3.9%and AAPC=+3.7%,respectively).Decreasing incidence trends for pancreatic cancer were observed in some countries,but without significance.Out of all countries with an increase in pancreatic cancer mortality rates,Turkmenistan showed the most marked rise both in males(AAPC=+10.0%,95%CI:7.4–12.5)and females(AAPC=+6.4%,95%CI:3.5–9.5).The mortality trends of pancreatic cancer were decreasing in both sexes only in Canada and Mexico.CONCLUSION Further research is needed to explain the cause of large international differences in incidence and mortality trends of pancreatic cancer in last three decades.展开更多
BACKGROUND Hanging is one of the most commonly used methods for suicide in both sexes worldwide.In a number of countries,hanging mortality has increased over the last decades.Nevertheless,there is a scarcity of studie...BACKGROUND Hanging is one of the most commonly used methods for suicide in both sexes worldwide.In a number of countries,hanging mortality has increased over the last decades.Nevertheless,there is a scarcity of studies that have explored the patterns and trends for mortality of suicide by hanging on global,regional and national levels,as most evaluations are limited to certain populations.AIM To assess the trends of suicide mortality by hanging,strangulation,and suffocation in Serbia,from 1991 to 2020.METHODS This nationwide study,with epidemiological descriptive study design,was carried out based on official data.The age-standardized rates(ASRs,expressed per 100000 persons)were calculated by direct standardization,using the World Standard Population.Mortality trends from suicide by hanging were assessed using the joinpoint regression analysis:The average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.Age-period-cohort analysis was performed to address the possible underlying reasons for the observed suicide trends.RESULTS Over the 30-year period studied,there were 24340 deaths by hanging(17750 males and 6590 females)in Serbia.In 2020,the ASR of deaths by hanging was 4.5 per 100000 persons in both sexes together(7.6 in males vs 1.7 in females).The trends of suicide mortality by hanging decreased significantly between 1991 and 2020 in both males(AAPC=-1.7%per year;95%CI:-2.0 to-1.4)and females(AAPC=-3.5%per year;95%CI:-3.9 to-3.1).Mortality rates of suicide by hanging had a continuously decreasing tendency in both sexes together in all age groups:The only exception was among males in 40-49 age group,with an increasing trend of suicide by hanging from 1991 to 2011(by+0.3%per year).CONCLUSION The trends in suicide mortality by hanging have been decreasing in Serbia in the last three decades in both sexes,but this was more pronounced in women than in men.Despite the decreasing trends observed in mortality of suicide by hanging,further research is needed for better clarification of trends and help in suicide prevention in the future.展开更多
BACKGROUND Studies exploring suicide mortality on a global scale are sparse,and most evaluations were limited to certain populations.AIM To assess global,regional and national trends of suicide mortality.METHODS Suici...BACKGROUND Studies exploring suicide mortality on a global scale are sparse,and most evaluations were limited to certain populations.AIM To assess global,regional and national trends of suicide mortality.METHODS Suicide mortality data for the period 2000-2019 were obtained from the mortality database of the World Health Organization and the Global Burden of Disease Study.Age-standardized rates(ASRs;expressed per 100000)were presented.To assess trends of suicide mortality,joinpoint regression analysis was used:The average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.RESULTS A total of 759028(523883 male and 235145 female)suicide deaths were reported worldwide in 2019.The global ASR of mortality of suicide was 9.0/100000 population in both sexes(12.6 in males vs 5.4 in females).In both sexes,the highest rates were found in the region of Africa(ASR=11.2),while the lowest rates were reported in Eastern Mediterranean(ASR=6.4).Globally,from 2000 to 2019,ASRs of mortality of suicide had a decreasing tendency in both sexes together[AAPC=-2.4%per year;95%CI:(-2.6)-(-2.3)].The region of the Americas experienced a significant increase in suicide mortality over 2000-2019 unlike other regions that had a declining trend.Out of all 133 countries with a decline in suicide mortality,Barbados(AAPC=-10.0%),Grenada(AAPC=-8.5%),Serbia(AAPC=-7.6%),and Venezuela(AAPC=-6.2%)showed the most marked reduction in mortality rates.Out of all 26 countries with a rise in suicide mortality,Lesotho(AAPC=+6.0%),Cyprus(AAPC=+5.1%),Paraguay(AAPC=+3.0%),Saudi Arabia(AAPC=+2.8%),Brunei(AAPC=+2.6%),Greece(AAPC=+2.6%),Georgia(AAPC=+2.1%),and Mexico(AAPC=+2.0%),are among those with the highest increase in mortality.CONCLUSION Decreasing trends in suicide mortality were observed in most countries across the world.Unfortunately,the mortality of suicide showed an increasing trend in a number of populations.Further research should explore the reasons for these unfavorable trends,in order to consider and recommend more efforts for suicide prevention in these countries.展开更多
Hepatitis A virus(HAV)is transmitted via the fecal-oral route,causing not only self-limited infectious hepatitis,but also epidemics through close personal contact(s).HAV infection is prevalent worldwide,and it is esti...Hepatitis A virus(HAV)is transmitted via the fecal-oral route,causing not only self-limited infectious hepatitis,but also epidemics through close personal contact(s).HAV infection is prevalent worldwide,and it is estimated that HAV infections account for 1.4 million sporadic or epidemic cases per year worldwide[1].展开更多
文摘目的 在高体重指数(body mass index, BMI)率快速增长的情况下,分析1990-2019年中国归因于高BMI的2型糖尿病疾病负担。方法 基于2019年全球疾病负担研究数据,分性别、年龄组分析1990-2019年中国因高BMI造成的2型糖尿病疾病负担,并利用Joinpoint回归模型分析标化后的归因死亡率和归因伤残调整寿命年(disability-adjusted life year, DALY)率的变化趋势。结果 1990-2019年间,我国2型糖尿病患病率从2928.78/10万增至6328.79/10万,归因高BMI的2型糖尿病死亡人数从1.05万增至4.75万,标化死亡率从1.25/10万增至2.39/10万;归因DALY从77.18万人年增至373.76万人年,标化后的归因DALY率从80.21/10万增至181.54/10万,早死损失寿命年(years of life lost, YLL)和伤残损失寿命年(year lived with disability, YLD)及其标化率也呈大幅增长。1990-2019年间,我国归因于高BMI的2型糖尿病标化死亡率和标化DALY率的年平均变化百分比分别为2.28%和2.81%,均有统计学意义(P<0.05),且男性均高于女性。男性标化后的归因DALY率和归因死亡率分别在2010年和2014年超过女性。年龄分层结果显示,50岁以上人群高BMI导致的2型糖尿病疾病负担更加严重,15~49岁人群归因于高BMI的YLD率增幅最大,达到323.99%。结论 1990-2019年间,中国归因于高BMI的2型糖尿病疾病负担显著增加。需加大防控力度,有效管理人群体重指数,并对高危人群采取重点干预,以减轻2型糖尿病疾病负担。
文摘目的分析2000—2019年我国肝癌发病与死亡趋势,为我国肝癌防治策略的制订提供科学依据。方法收集2000—2019年全球健康数据交换(the Global Health Data Exchange,GHDx)数据库中我国肝癌发病与死亡个案信息,运用JoinPoint回归模型以平均年度变化百分比(average annual percent change,AAPC)和年度变化百分比(annual percent change,APC)分别描述全人群、不同性别及不同年龄肝癌发病与死亡的变化趋势。结果2000—2019年我国肝癌发病和死亡总例数分别为4322652例和4093855例,标化发病率和死亡率分别为11.31/10万和9.68/10万。2000—2019年我国肝癌的发病率呈下降趋势(AAPC=-2.11%),其中2000—2002年和2002—2005年均呈下降趋势,APC分别为-10.55%和-15.45%;2005—2010年和2010—2019年均呈上升趋势,APC分别为0.44%和3.39%;男性和女性人群的发病率均呈下降趋势(AAPC=-1.95%,-2.43%)。2000—2019我国肝癌的死亡率呈下降趋势(AAPC=-2.41%),其中2000—2005年呈下降趋势,APC为-13.52%,2005—2012年和2012—2019年均呈上升趋势,APC分别为0.18%和3.64%;男性和女性人群的死亡率均呈下降趋势(AAPC=-2.34%,-2.60%)。我国肝癌的年龄别发病率及死亡率随着年龄的增长呈不断上升的趋势(AAPC=5.94%,7.10%),其中男性年龄别发病率在10~40岁之间增长较快,80岁之后增长速度有所下降,女性则整体呈上升趋势;男性年龄别死亡率在5~10岁之间增长率较大,女性则随着年龄的增长整体呈上升趋势。结论2000—2019年我国肝癌发病率及死亡率整体呈下降趋势,男性的发病率和死亡率大于女性,且随年龄增长呈上升趋势,男性及老年人群是肝癌重点关注人群。
文摘目的了解铁岭市城区居民肝癌死亡趋势,为肝癌防治工作提供依据。方法对铁岭市2007-2015年银州区、清河区肝癌死亡资料进行分析,用Joinpoint Regression Program 4.3.1分析变化趋势。结果铁岭市2007-2015年城区肝癌死亡1030例,年均粗死亡率为25.91/10万(标化死亡率16.89/10万),男性(39.02/10万)高于女性(12.96/10万)(P<0.001)。Joinpoint分析显示2007-2015年肝癌标化死亡率年均下降1.63%(P=0.008)。40岁之后肝癌死亡率增高,75岁之后死亡率显著增高。结论铁岭市2007-2015年城区肝癌死亡率呈下降趋势,但对中老年人群的危害仍很严重,应继续加强防控力度。
基金Supported by Ministry of Education,Science and Technological development,Republic of Serbia,2011-2020,No.175042.
文摘BACKGROUND Pancreatic cancer,as the one of most fatal malignancies,remains a critical issue in the global burden of disease.AIM To estimate trends in pancreatic cancer incidence and mortality worldwide in the last three decades.METHODS A descriptive epidemiological study was done.Pancreatic cancer incidence and mortality data were obtained from the database of the World Health Organization.Analysis of pancreatic cancer incidence and mortality during 2020 was performed.The age-standardized rates(ASRs,expressed per 100000)were presented.To estimate trends of incidence and mortality of pancreatic cancer,joinpoint regression analysis was used:the average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.Additionally,analysis was performed by sex and age.In this paper,the trend analysis included only countries with high and medium data quality.RESULTS A total of 495773(262865 male and 232908 female)new cases and 466003(246840 male and 219163 female)deaths from pancreatic cancer were reported worldwide in 2020.In both sexes,most of the new cases(191348;38.6%of the total)and deaths(182074;39.1%of the total)occurred in the Western Pacific Region.In both sexes,the highest ASRs were found in the European Region,while the lowest rates were reported in the South-East Asia Region.The general pattern of rising pancreatic cancer incidence and mortality was seen across countries worldwide in observed period.Out of all countries with an increase in pancreatic cancer incidence,females in France and India showed the most marked rise in incidence rates(AAPC=+3.9%and AAPC=+3.7%,respectively).Decreasing incidence trends for pancreatic cancer were observed in some countries,but without significance.Out of all countries with an increase in pancreatic cancer mortality rates,Turkmenistan showed the most marked rise both in males(AAPC=+10.0%,95%CI:7.4–12.5)and females(AAPC=+6.4%,95%CI:3.5–9.5).The mortality trends of pancreatic cancer were decreasing in both sexes only in Canada and Mexico.CONCLUSION Further research is needed to explain the cause of large international differences in incidence and mortality trends of pancreatic cancer in last three decades.
基金Supported by Ministry of Education,Science and Technological Development,Republic of Serbia, 2011–2020, No. 175042
文摘BACKGROUND Hanging is one of the most commonly used methods for suicide in both sexes worldwide.In a number of countries,hanging mortality has increased over the last decades.Nevertheless,there is a scarcity of studies that have explored the patterns and trends for mortality of suicide by hanging on global,regional and national levels,as most evaluations are limited to certain populations.AIM To assess the trends of suicide mortality by hanging,strangulation,and suffocation in Serbia,from 1991 to 2020.METHODS This nationwide study,with epidemiological descriptive study design,was carried out based on official data.The age-standardized rates(ASRs,expressed per 100000 persons)were calculated by direct standardization,using the World Standard Population.Mortality trends from suicide by hanging were assessed using the joinpoint regression analysis:The average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.Age-period-cohort analysis was performed to address the possible underlying reasons for the observed suicide trends.RESULTS Over the 30-year period studied,there were 24340 deaths by hanging(17750 males and 6590 females)in Serbia.In 2020,the ASR of deaths by hanging was 4.5 per 100000 persons in both sexes together(7.6 in males vs 1.7 in females).The trends of suicide mortality by hanging decreased significantly between 1991 and 2020 in both males(AAPC=-1.7%per year;95%CI:-2.0 to-1.4)and females(AAPC=-3.5%per year;95%CI:-3.9 to-3.1).Mortality rates of suicide by hanging had a continuously decreasing tendency in both sexes together in all age groups:The only exception was among males in 40-49 age group,with an increasing trend of suicide by hanging from 1991 to 2011(by+0.3%per year).CONCLUSION The trends in suicide mortality by hanging have been decreasing in Serbia in the last three decades in both sexes,but this was more pronounced in women than in men.Despite the decreasing trends observed in mortality of suicide by hanging,further research is needed for better clarification of trends and help in suicide prevention in the future.
基金Supported by the Ministry of Education,Science and Technological development,Republic of Serbia, 2011–2020, No. 175042
文摘BACKGROUND Studies exploring suicide mortality on a global scale are sparse,and most evaluations were limited to certain populations.AIM To assess global,regional and national trends of suicide mortality.METHODS Suicide mortality data for the period 2000-2019 were obtained from the mortality database of the World Health Organization and the Global Burden of Disease Study.Age-standardized rates(ASRs;expressed per 100000)were presented.To assess trends of suicide mortality,joinpoint regression analysis was used:The average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.RESULTS A total of 759028(523883 male and 235145 female)suicide deaths were reported worldwide in 2019.The global ASR of mortality of suicide was 9.0/100000 population in both sexes(12.6 in males vs 5.4 in females).In both sexes,the highest rates were found in the region of Africa(ASR=11.2),while the lowest rates were reported in Eastern Mediterranean(ASR=6.4).Globally,from 2000 to 2019,ASRs of mortality of suicide had a decreasing tendency in both sexes together[AAPC=-2.4%per year;95%CI:(-2.6)-(-2.3)].The region of the Americas experienced a significant increase in suicide mortality over 2000-2019 unlike other regions that had a declining trend.Out of all 133 countries with a decline in suicide mortality,Barbados(AAPC=-10.0%),Grenada(AAPC=-8.5%),Serbia(AAPC=-7.6%),and Venezuela(AAPC=-6.2%)showed the most marked reduction in mortality rates.Out of all 26 countries with a rise in suicide mortality,Lesotho(AAPC=+6.0%),Cyprus(AAPC=+5.1%),Paraguay(AAPC=+3.0%),Saudi Arabia(AAPC=+2.8%),Brunei(AAPC=+2.6%),Greece(AAPC=+2.6%),Georgia(AAPC=+2.1%),and Mexico(AAPC=+2.0%),are among those with the highest increase in mortality.CONCLUSION Decreasing trends in suicide mortality were observed in most countries across the world.Unfortunately,the mortality of suicide showed an increasing trend in a number of populations.Further research should explore the reasons for these unfavorable trends,in order to consider and recommend more efforts for suicide prevention in these countries.
文摘Hepatitis A virus(HAV)is transmitted via the fecal-oral route,causing not only self-limited infectious hepatitis,but also epidemics through close personal contact(s).HAV infection is prevalent worldwide,and it is estimated that HAV infections account for 1.4 million sporadic or epidemic cases per year worldwide[1].
