OBJECTIVE： To identify global research trends in neuroimaging diagnosis for cerebral infarction using a bibliometric analysis of the Web of Science. DATA RETRIEVAL： We performed a bibliometric analysis of data retri...OBJECTIVE： To identify global research trends in neuroimaging diagnosis for cerebral infarction using a bibliometric analysis of the Web of Science. DATA RETRIEVAL： We performed a bibliometric analysis of data retrieval for neuroimaging diagnosis for cerebral infarction containing the key words ＂CT, magnetic resonance imaging, MRI, transcranial Doppler, transvaginal color Doppler, digital subtraction angiography, and cerebral infarction＂ using the Web of Science. SELECTION CRITERIA： Inclusion criteria were： （a） peer-reviewed articles on neuroimaging diagnosis for cerebral infarction which were published and indexed in the Web of Science; （b） original research articles and reviews; and （c） publication between 2004-2011. Exclusion criteria were： （a） articles that required manual searching or telephone access; and （b） corrected papers or book chapters. MAIN OUTCOME MEASURES： （1）Annual publication output; （2） distribution according to country; （3） distribution according to institution; （4） top cited publications; （5） distribution according to journals; and （6） comparison of study results on neuroimaging diagnosis for cerebral infarction. RESULTS： Imaging has become the predominant method used in diagnosing cerebral infarction. The most frequently used clinical imaging methods were digital subtraction angiography, CT, MRI, and transcranial color Doppler examination. Digital subtraction angiography is used as the gold standard. However, it is a costly and time-consuming invasive diagnosis that requires some radiation exposure, and is poorly accepted by patients. As such, it is mostly adopted in interventional therapy in the clinic. CT is now accepted as a rapid, simple, and reliable non-invasive method for use in diagnosis of cerebrovascular disease and preoperative appraisal. Ultrasonic Doppler can be used to reflect the hardness of the vascular wall and the nature of the plaque more clearly than CT and MRI. CONCLUSION： At present, there is no unified standard of classification of cerebral infarction imaging. Detection of clinical super-acute cerebral infarction remains controversial due to its changes on imaging, lack of specificity, and its similarity to a space-occupying lesion. Neuroimaging diagnosis for cerebral infarction remains a highly active area of research and development.展开更多
BACKGROUND: Over 355 patients have received ortho- topic liver transplantation ( OLT) at this hospital since 1993. Preoperative imaging studies of both hepatic vessels and parenchyma in these recipients bettered surgi...BACKGROUND: Over 355 patients have received ortho- topic liver transplantation ( OLT) at this hospital since 1993. Preoperative imaging studies of both hepatic vessels and parenchyma in these recipients bettered surgical plan- ning or even precluded the necessity of surgery. Here we report our preliminary results of modified magnetic reso- nance angiography ( MRA ) using sensitivity encoding ( SENSE) through comparative study with conventional digital subtraction angiography (DSA) and CT arterial por- tography (CTAP). METHODS: Sixteen patients with suspected liver diseases were included in the study. All of them received both dy- namic MRI of the liver using SENSE and digital DSA with CTAP within a two-week interval. The four-phase MRA was reconstructed from source images of the coronal dy- namic study. The arterial phase of the modified MRA was compared with DSA in the evaluation of hepatic arteries and the portal phase compared with CT portography recon- structed from source images of CTAP. In dynamic study of the liver, a fixed dose (20 ml) of contrast medium and scan timing were used. RESULTS: The main branches and variations of the hepatic arterial system were well shown on the modified MRA, al- though the marginal branches of hepatic arteries were of poor quality. The figures of portal veins on MRA were as clear as or superior to those of CTAP. In addition, the su- prarenal inferior vena cava (IVC) was well demonstrated on MRA and/or non contrast-enhanced coronal balanced fast-field echo (b-FFE) scan sequence in most cases. MRI detected most parenchymal lesions of the liver and hemo- dynamics of these lesions could be evaluated on source ima- ges of the modified MRA. MRI/MRA also serendipitously revealed several extrahepatic disease entities or variations that were not found on DSA/CTAP. CONCLUSIONS: The modified MRA using SENSE is a cost-effective modality of examination for the demonstra- tion of the whole hepatic vascular system. Combined with MRI, it has the potential as a one-stop imaging modality in the preoperative evaluation in fields such as OLT.展开更多
AIM: To assess the value of gemstone spectral imaging(GSI) in efficacy evaluation in hepatocellular cancer(HCC) after transcatheter arterial chemoembolization(TACE) treatment.METHODS: Thirty patients with HCC underwen...AIM: To assess the value of gemstone spectral imaging(GSI) in efficacy evaluation in hepatocellular cancer(HCC) after transcatheter arterial chemoembolization(TACE) treatment.METHODS: Thirty patients with HCC underwent GSI, including nonenhanced, arterial, portalvenous and delayed phase scans, after TACE treatment. Arterial phase images were acquired with GSI for reconstruction of virtual nonenhanced images and color overlay images. Digital subtraction angiography(DSA) was performed in all these patients. Two blinded and independent readers evaluated the data in two reading sessions; standard nonenhanced, arterial, portalvenous, and delayed phase images were read in session A, and the optimal monochromatic images, iodine/water based images and spectrum features were read in session B. Sensitivity and specificity were calculated with the DSA data as the reference standard. The sensitivity and specificity were compared using the χ2 test.RESULTS: DSA revealed 154 lesions in 30 patients, and 100 of them had blood supply. Overall sensitivity and specificity were 72%( 72/100) and 77.8 %(42/54) for session A, and 97%(97/100) and 94.4%(51/54) for session B, respectively. The sensitivity and specificity of the two reading sessions were significantly different(χ2 = 23.04, χ2 = 7.11, P < 0.05).CONCLUSION: Compared with conventional CT, GSI could significantly improve the detection of small and multiple lesions without increasing the radiation dose. Based on spectrum features, GSI could assess tumor homogeneity and more accurately identify residual tumors and recurrent or metastatic lesions during efficacy evaluation and follow-up in HCC after TACE treatment.展开更多
Information about hepatic perfusion is used in clinical liver disease diagnosis. An image analy-sis system can help physicians make efficient and accurate diagnosis. The objective of this study is to propose an image ...Information about hepatic perfusion is used in clinical liver disease diagnosis. An image analy-sis system can help physicians make efficient and accurate diagnosis. The objective of this study is to propose an image analysis method for the quantification of the hepatic perfusion based on contrast-enhanced ultrasound imaging (CEUI). The proposed method contains frame selection, image registration, digital subtraction and grey-scale calculation. Then, by processing an image sequence, a time-intensity curve (TIC) for hepatic perfusion is derived. The kernel of this image analysis technology is digital subtrac-tion and its accuracy is improved by frame selec-tion and image registration. The advantage of this method is that it can obtain the perfusion information of the whole liver which is rarely ob-tained by traditional image analysis technology;therefore, it is a supplement of the traditional image analysis method. This method is applied on the quantification of a rabbit’s hepatic perfu-sion and the result shows the efficiency of it.展开更多
It is challenging to attempt to obtain CT perfusion (CTP) images of the hyperdense tissues, which could conceal the density of contrast material during perfusion study. We report a new technique of subtraction CTP (SC...It is challenging to attempt to obtain CT perfusion (CTP) images of the hyperdense tissues, which could conceal the density of contrast material during perfusion study. We report a new technique of subtraction CTP (SCTP) to compensate the shortcomings. SCTP post-processed by perfusion software for the data of post-perfusion images subtracting pre-perfusion corresponding images slice by slice in CTP source images is technically feasible without any adverse effects on patients. It provides a new functional imaging with quantitatively hemodynamic indexes of tissue microcirculation and reflects accurately the change of blood flow in tissues and organs.展开更多
BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic schistosomiasis.AIM To evaluate the efficacy of d...BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic schistosomiasis.AIM To evaluate the efficacy of digital subtraction angiography image overlay tech-nology(DIT)in guiding the TIPS procedure.METHODS We conducted a retrospective analysis of patients who underwent TIPS at our hospital,comparing outcomes between an ultrasound-guided group and a DIT-guided group.Our analysis focused on the duration of the portosystemic shunt puncture,the number of punctures needed,the total surgical time,and various clinical indicators related to the surgery.RESULTS The study included 52 patients with esophagogastric varices due to chronic hepatic schistosomiasis.Results demonstrated that the DIT-guided group expe-rienced significantly shorter puncture times(P<0.001)and surgical durations(P=0.022)compared to the ultrasound-guided group.Additionally,postoperative assessments showed significant reductions in aspartate aminotransferase,B-type natriuretic peptide,and portal vein pressure in both groups.Notably,the DIT-guided group also showed significant reductions in total bilirubin(P=0.001)and alanine aminotransferase(P=0.023).CONCLUSION The use of DIT for guiding TIPS procedures highlights its potential to enhance procedural efficiency and reduce surgical times in the treatment of esophagogastric variceal bleeding in patients with chronic hepatic schistoso-miasis.展开更多
Purpose K-edge imaging based on the photon counting detectors(PCDs)is an effective enhanced imaging method because the PCDs are conducive to the K-edge imaging due to the adjustable energy thresholds.The energy bins s...Purpose K-edge imaging based on the photon counting detectors(PCDs)is an effective enhanced imaging method because the PCDs are conducive to the K-edge imaging due to the adjustable energy thresholds.The energy bins significantly affect the image quality of the K-edge imaging,but the conventional energy bins used for K-edge imaging are continuous which weaken the K-edge signal and decline the image quality.Hence,how to get a better K-edge signal by the optimized energy bins is the key point for the K-edge imaging based on the PCDs.Method This paper experimentally studied the influence of the energy bins used for the K-edge imaging based on the PCDs.The conventional energy bins were determined by the theoretical-attenuation method(TAM),and the optimized energy bins were determined by the threshold-scan method(TSM).For the phantom and mice imaging,we performed both the K-edge subtraction algorithm and the K-edge decomposition algorithm on the projections obtained by the energy bins which were determined by the TAM and TSM.The image quality was compared using the CNR of the objective area.Results The experimental results showed that the energy bins identified by the TSM had a better performance than the TAM in both imaging methods.The TSM improved the CNR by~39%than the TAM in the phantom results and could better highlight the areas where the contrast agents are enriched(such as the kidney).Conclusions The optimized energy bins can better highlight the K-edge signal than the conventional energy bins which can improve the image quality and have the potential to reduce the amount of the contrast agents.展开更多
The deep_sea floor images are acquired under non_uniform illumination,the effects of which bring up many difficulties for image segmentation.The paper compares three methods of removing non_uniform illumination effect...The deep_sea floor images are acquired under non_uniform illumination,the effects of which bring up many difficulties for image segmentation.The paper compares three methods of removing non_uniform illumination effects.The effectiveness and robustness are evaluated on three test images with high_,moderate_ and low_density grains,respectively.The results show that local filtering algorithm does not remove the non_uniform illumination effects completely.The image subtracting algorithm will lose some of the dynamic range of the original data.The enhanced image stretching algorithm is the most effective one.展开更多
文摘OBJECTIVE： To identify global research trends in neuroimaging diagnosis for cerebral infarction using a bibliometric analysis of the Web of Science. DATA RETRIEVAL： We performed a bibliometric analysis of data retrieval for neuroimaging diagnosis for cerebral infarction containing the key words ＂CT, magnetic resonance imaging, MRI, transcranial Doppler, transvaginal color Doppler, digital subtraction angiography, and cerebral infarction＂ using the Web of Science. SELECTION CRITERIA： Inclusion criteria were： （a） peer-reviewed articles on neuroimaging diagnosis for cerebral infarction which were published and indexed in the Web of Science; （b） original research articles and reviews; and （c） publication between 2004-2011. Exclusion criteria were： （a） articles that required manual searching or telephone access; and （b） corrected papers or book chapters. MAIN OUTCOME MEASURES： （1）Annual publication output; （2） distribution according to country; （3） distribution according to institution; （4） top cited publications; （5） distribution according to journals; and （6） comparison of study results on neuroimaging diagnosis for cerebral infarction. RESULTS： Imaging has become the predominant method used in diagnosing cerebral infarction. The most frequently used clinical imaging methods were digital subtraction angiography, CT, MRI, and transcranial color Doppler examination. Digital subtraction angiography is used as the gold standard. However, it is a costly and time-consuming invasive diagnosis that requires some radiation exposure, and is poorly accepted by patients. As such, it is mostly adopted in interventional therapy in the clinic. CT is now accepted as a rapid, simple, and reliable non-invasive method for use in diagnosis of cerebrovascular disease and preoperative appraisal. Ultrasonic Doppler can be used to reflect the hardness of the vascular wall and the nature of the plaque more clearly than CT and MRI. CONCLUSION： At present, there is no unified standard of classification of cerebral infarction imaging. Detection of clinical super-acute cerebral infarction remains controversial due to its changes on imaging, lack of specificity, and its similarity to a space-occupying lesion. Neuroimaging diagnosis for cerebral infarction remains a highly active area of research and development.
文摘BACKGROUND: Over 355 patients have received ortho- topic liver transplantation ( OLT) at this hospital since 1993. Preoperative imaging studies of both hepatic vessels and parenchyma in these recipients bettered surgical plan- ning or even precluded the necessity of surgery. Here we report our preliminary results of modified magnetic reso- nance angiography ( MRA ) using sensitivity encoding ( SENSE) through comparative study with conventional digital subtraction angiography (DSA) and CT arterial por- tography (CTAP). METHODS: Sixteen patients with suspected liver diseases were included in the study. All of them received both dy- namic MRI of the liver using SENSE and digital DSA with CTAP within a two-week interval. The four-phase MRA was reconstructed from source images of the coronal dy- namic study. The arterial phase of the modified MRA was compared with DSA in the evaluation of hepatic arteries and the portal phase compared with CT portography recon- structed from source images of CTAP. In dynamic study of the liver, a fixed dose (20 ml) of contrast medium and scan timing were used. RESULTS: The main branches and variations of the hepatic arterial system were well shown on the modified MRA, al- though the marginal branches of hepatic arteries were of poor quality. The figures of portal veins on MRA were as clear as or superior to those of CTAP. In addition, the su- prarenal inferior vena cava (IVC) was well demonstrated on MRA and/or non contrast-enhanced coronal balanced fast-field echo (b-FFE) scan sequence in most cases. MRI detected most parenchymal lesions of the liver and hemo- dynamics of these lesions could be evaluated on source ima- ges of the modified MRA. MRI/MRA also serendipitously revealed several extrahepatic disease entities or variations that were not found on DSA/CTAP. CONCLUSIONS: The modified MRA using SENSE is a cost-effective modality of examination for the demonstra- tion of the whole hepatic vascular system. Combined with MRI, it has the potential as a one-stop imaging modality in the preoperative evaluation in fields such as OLT.
文摘AIM: To assess the value of gemstone spectral imaging(GSI) in efficacy evaluation in hepatocellular cancer(HCC) after transcatheter arterial chemoembolization(TACE) treatment.METHODS: Thirty patients with HCC underwent GSI, including nonenhanced, arterial, portalvenous and delayed phase scans, after TACE treatment. Arterial phase images were acquired with GSI for reconstruction of virtual nonenhanced images and color overlay images. Digital subtraction angiography(DSA) was performed in all these patients. Two blinded and independent readers evaluated the data in two reading sessions; standard nonenhanced, arterial, portalvenous, and delayed phase images were read in session A, and the optimal monochromatic images, iodine/water based images and spectrum features were read in session B. Sensitivity and specificity were calculated with the DSA data as the reference standard. The sensitivity and specificity were compared using the χ2 test.RESULTS: DSA revealed 154 lesions in 30 patients, and 100 of them had blood supply. Overall sensitivity and specificity were 72%( 72/100) and 77.8 %(42/54) for session A, and 97%(97/100) and 94.4%(51/54) for session B, respectively. The sensitivity and specificity of the two reading sessions were significantly different(χ2 = 23.04, χ2 = 7.11, P < 0.05).CONCLUSION: Compared with conventional CT, GSI could significantly improve the detection of small and multiple lesions without increasing the radiation dose. Based on spectrum features, GSI could assess tumor homogeneity and more accurately identify residual tumors and recurrent or metastatic lesions during efficacy evaluation and follow-up in HCC after TACE treatment.
文摘Information about hepatic perfusion is used in clinical liver disease diagnosis. An image analy-sis system can help physicians make efficient and accurate diagnosis. The objective of this study is to propose an image analysis method for the quantification of the hepatic perfusion based on contrast-enhanced ultrasound imaging (CEUI). The proposed method contains frame selection, image registration, digital subtraction and grey-scale calculation. Then, by processing an image sequence, a time-intensity curve (TIC) for hepatic perfusion is derived. The kernel of this image analysis technology is digital subtrac-tion and its accuracy is improved by frame selec-tion and image registration. The advantage of this method is that it can obtain the perfusion information of the whole liver which is rarely ob-tained by traditional image analysis technology;therefore, it is a supplement of the traditional image analysis method. This method is applied on the quantification of a rabbit’s hepatic perfu-sion and the result shows the efficiency of it.
文摘It is challenging to attempt to obtain CT perfusion (CTP) images of the hyperdense tissues, which could conceal the density of contrast material during perfusion study. We report a new technique of subtraction CTP (SCTP) to compensate the shortcomings. SCTP post-processed by perfusion software for the data of post-perfusion images subtracting pre-perfusion corresponding images slice by slice in CTP source images is technically feasible without any adverse effects on patients. It provides a new functional imaging with quantitatively hemodynamic indexes of tissue microcirculation and reflects accurately the change of blood flow in tissues and organs.
基金Jinshan Science and Technology Committee(the data collection for this study was partially funded by the project),No.2021-3-05.
文摘BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic schistosomiasis.AIM To evaluate the efficacy of digital subtraction angiography image overlay tech-nology(DIT)in guiding the TIPS procedure.METHODS We conducted a retrospective analysis of patients who underwent TIPS at our hospital,comparing outcomes between an ultrasound-guided group and a DIT-guided group.Our analysis focused on the duration of the portosystemic shunt puncture,the number of punctures needed,the total surgical time,and various clinical indicators related to the surgery.RESULTS The study included 52 patients with esophagogastric varices due to chronic hepatic schistosomiasis.Results demonstrated that the DIT-guided group expe-rienced significantly shorter puncture times(P<0.001)and surgical durations(P=0.022)compared to the ultrasound-guided group.Additionally,postoperative assessments showed significant reductions in aspartate aminotransferase,B-type natriuretic peptide,and portal vein pressure in both groups.Notably,the DIT-guided group also showed significant reductions in total bilirubin(P=0.001)and alanine aminotransferase(P=0.023).CONCLUSION The use of DIT for guiding TIPS procedures highlights its potential to enhance procedural efficiency and reduce surgical times in the treatment of esophagogastric variceal bleeding in patients with chronic hepatic schistoso-miasis.
基金supported by National Key R&D Program of China(Grant No.2016YFC0100400)Science and Tech-nology Service network Initiative of Chinese Academy of Sciences(Grant No.KFJ-STS-QYZD-193)+1 种基金Instrument Developing Project of Chinese Academy of Sciences(Grant No.YZ201511)National Natu-ral Science Foundation of China(Grant No.11975250)
文摘Purpose K-edge imaging based on the photon counting detectors(PCDs)is an effective enhanced imaging method because the PCDs are conducive to the K-edge imaging due to the adjustable energy thresholds.The energy bins significantly affect the image quality of the K-edge imaging,but the conventional energy bins used for K-edge imaging are continuous which weaken the K-edge signal and decline the image quality.Hence,how to get a better K-edge signal by the optimized energy bins is the key point for the K-edge imaging based on the PCDs.Method This paper experimentally studied the influence of the energy bins used for the K-edge imaging based on the PCDs.The conventional energy bins were determined by the theoretical-attenuation method(TAM),and the optimized energy bins were determined by the threshold-scan method(TSM).For the phantom and mice imaging,we performed both the K-edge subtraction algorithm and the K-edge decomposition algorithm on the projections obtained by the energy bins which were determined by the TAM and TSM.The image quality was compared using the CNR of the objective area.Results The experimental results showed that the energy bins identified by the TSM had a better performance than the TAM in both imaging methods.The TSM improved the CNR by~39%than the TAM in the phantom results and could better highlight the areas where the contrast agents are enriched(such as the kidney).Conclusions The optimized energy bins can better highlight the K-edge signal than the conventional energy bins which can improve the image quality and have the potential to reduce the amount of the contrast agents.
文摘The deep_sea floor images are acquired under non_uniform illumination,the effects of which bring up many difficulties for image segmentation.The paper compares three methods of removing non_uniform illumination effects.The effectiveness and robustness are evaluated on three test images with high_,moderate_ and low_density grains,respectively.The results show that local filtering algorithm does not remove the non_uniform illumination effects completely.The image subtracting algorithm will lose some of the dynamic range of the original data.The enhanced image stretching algorithm is the most effective one.
