基于SAPAD-Kano的高校电动自行车充电服务系统设计研究

目的针对目前各高校日益重视电动自行车充电服务系统建设,但用户实际充电体验不佳的问题,从用户行为角度研究服务系统设计以提升用户体验满意度。方法调研用户行为并梳理出不同行为情景,基于SAPAD模型分析用户充电行为过程,通过“核心意义簇-物”的映射分析得到功能服务模块,引入Kano模型分类并筛选出符合用户需求的功能服务模块。结果重构高校电动自行车充电站服务系统,以Z高校为例重新设计充电站布局、充电桩设备与微信小程序,制作充电桩模型,发放5点李克特量表满意度问卷以对比设计前后的用户评分,显示用户满意度显著提高。结论基于SAPAD-Kano模型的服务系统设计方法能够实现用户行为、用户需求与功能设计间的映射,并确保功能设计与用户需求的吻合度,为相似设计及评估提供参考。

基于Kano-FAST的瓦楞纸激光印刷设备设计研究

目的推动印刷行业朝更高效的方向迈进,提高印刷设备的易操作性和视觉识别性。方法将Kano和FAST(Function Analysis System Technique)模型引入瓦楞纸激光打印设备设计的前期应用需求分析中,通过问卷的方法获取用户的基本要求,并划分为几个子类型,进而建立Kano的二维功能属性模型。采用FAST法建立功能树,辅助使用Kano模型,从而更精准地分析用户需求,并更好地根据其需求进行优化设计。结果综合运用设计原理,针对性地挖掘瓦楞纸激光印刷设备在造型识别性、操作易用性、生产安全性上存在的问题,进而输出更优解。结论该设计方法的引入有助于为同类型的印刷设备设计提供参考,并引起更多相关厂家的重视,推动印刷行业向更积极的方向发展。

酒店与民宿的服务质量要素属性比较研究--整合SERQUAL和Kano模型

目前,住宿业服务质量研究多集中在体系构建和影响因素研究,对住宿业及其业态在服务质量要素的深入认识方面不足。文章以SERVQUAL模型量表为基础,借助Kano模型对酒店和民宿两种业态的服务质量要素的属性进行实证分析。结果显示:(1)民宿与酒店服务质量指标属性一致化情况仅为36.36%,差异化却达63.64%,指标属性差异大。(2)酒店与民宿中最能增加满意度的指标均集中在完备的服务设施方面,属于有形性维度。同时二者最能消除不满意的指标虽不一致,但是都属于可靠性维度。(3)酒店服务质量指标属性中较为突出的必备属性和魅力属性,二者占比高于民宿中的占比,而民宿服务质量指标属性中较为突出的是必备属性和无差异属性。对各业态服务质量指标属性的划分,深化了服务质量的认识,并为改进提供了方向。同时,进一步挖掘与各属性相对应的消费者相关需求,针对不同业态服务质量指标属性的特征,在形成细分市场的基础上为满足消费者需求偏好开辟了道路。

Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.

Animal models of Alzheimer's disease:Current strategies and new directions

Animal models constructed using pathogenic factors have significantly advanced drug development for Alzheimer's disease(AD).These predominantly transgenic models,mainly in mice,replicate pathological phenotypes through gene mutations associated with familial AD cases,thus serving as vital tools for assessing drug efficacy and for performing mechanistic studies.However,the speciesspecific differences and complex,heterogeneous nature of AD etiology pose considerable challenges for the translatability of these animal models,limiting their utility in drug development.This review offers a comprehensive analysis of widely employed rodent(mice and rats)and non-rodent models(Danio rerio(zebrafish),Drosophila melanogaster,and Caenorhabditis elegans),detailing their phenotypic features and specific research applications.This review also examines the limitations inherent in these models and introduces various strategies for expanding AD modeling across diverse species,emphasizing recent advancement in non-human primates(NHPs)as valuable models.Furthermore,potential insights from the integration of innovative technologies in AD research are discussed,while providing valuable perspectives on the future development of AD animal models.

基于Kano-FBS模型的智能桌面便签机设计

为帮助办公人群更高效率地完成工作并获得更多乐趣,同时缓解工作压力,将使用便利贴记事这一行为向智能化趋势靠拢,文章首先基于Kano模型深入分析智能桌面便签机用户需求,确定功能特性类型,并明确相对重要的用户体验需求。其次采用FBS模型将关键需求与产品设计相对应,确保设计方案的合理性。最后通过理论模型的应用得到更具创新性和实用性的设计方案,提高用户工作效率的同时增添趣味性,为办公用品创新发展和改进提供有针对性的指导。

A Model of Grand Unified Theory: Suggested Solution for CP-Violation Using Ideas of Phase Paths

This study demonstrates that beyond standard model (BSM) cosmic fundamental interactions—weak, strong, and electromagnetic forces—can be unified through a common basis of representation. This unification allows for the derivation of the fine structure constant with running points of α(t) ≈ 1/(136.9038) at high energy scales, based on electroweak interactions. Through the application of the Ising model, the running point of the elementary charge e at high energy scales is determined, and Coulomb’s law is actually derived from the Yukawa potential. Theoretically, based on S. Weinberg’s electroweak interaction theory, this study unifies the strong and electromagnetic forces by representing them with rYuka, and further advances the reconstruction of the SU(3)C×SU(1)L×U(1)EMframework on the basis of electroweak interaction concepts. In fact, the cosmic fundamental forces can interchange at the mass gap, defined as the Yukawa turning phase at rYuka ≃1.9404 fm, with the SU(3)Diag structural constant fijk on glueballs calculated, estimating a spectrum mass gap of ∆0 > 0.

基于Kano模型的城市地下综合体空间要素感知测量及优化--以成都SKP为例

城市地下综合体兼具地下空间和综合性建筑特征,在物理、心理层面都具有特殊性与复杂性。文章通过测量地下综合体空间要素的感知属性和质量状态,评估当前实践方法是否匹配使用者需求。以成都SKP为例,借助经学科适应性改进的Kano模型,通过问卷获取使用者在要素升级、降级和维持现状情景下的感知评价,识别各空间要素对满意度的影响机制,据此将空间要素划分为基本型、魅力型、期望型、反向型、双向型和无差别型六类。最后结合感知力和满意度,提出针对“高感知力+低满意度”“高感知力+高满意度”“低感知力+低满意度”和“低感知力+高满意度”四类特征空间要素的优化顺序和路径建议。

基于KANO-SEM模型的改良旗袍设计需求分析

为明确顾客对于改良旗袍的核心设计需求,提升顾客的穿着体验满意度,文章对改良旗袍设计过程中影响顾客满意度的需求要素进行挖掘,共提炼出7项需求类别和29项需求要素。通过Kano模型对这些要素进行归类分析,并借助四象限图优化要素的属性,建立结构方程模型来确定重要性程度,进而分析在改良旗袍设计中各需求要素的优先级顺序。研究得出,顾客在改良旗袍设计中更加注重版型合体性、襟形及袖形方面的设计需求;在款式设计方面,顾客对于方襟、连肩袖、圆领的满意度最高;在版型工艺方面,顾客对于胸部较合体、滚边工艺的需求较高;在面料方面,顾客更加看重面料的透气性能。

Evaluating the role of large language models in inflammatory bowel disease patient information

This letter evaluates the article by Gravina et al on ChatGPT’s potential in providing medical information for inflammatory bowel disease patients.While promising,it highlights the need for advanced techniques like reasoning+action and retrieval-augmented generation to improve accuracy and reliability.Emphasizing that simple question and answer testing is insufficient,it calls for more nuanced evaluation methods to truly gauge large language models’capabilities in clinical applications.

基于Kano-FAST-E的鞋面压合机优化设计

目的降低鞋面压合机设备作业过程中的失误率、优化人机交互体验。方法基于Kano模型调研分析作业人员与企业经理对当前设备的使用感受及需求;利用FAST理论重新定义设备的功能区域并指导设计展开;基于人机工程学理论(E),对设计方案的功能布局和结构尺寸进行优化,提升人机操作效率;利用眼动试验对改进前后的功能布局进行对比分析验证,并借助李克特量表对设计方案进行用户满意度评价。结果完成鞋面压合机的优化设计实践,提升了设备的人机性能和用户满意度,有效提高了作业人员认读效率、减少视觉疲劳和错误操作。结论改进后的鞋面压合机赋予了工人更加安全、高效且人性化的操作模式,验证了Kano-FAST-E的设计策略对该设备的人机优化设计具有指导意义,也为同类设备的开发实践提供参考。

Solving the Olbers’s Paradox, Explaining the “Red-Shift”, and Challenging the Relativities by “Sun Matters Theory” and “Sun Model of Universe”, an Evolution of the Einstein’s Static Universe Model

Olbers’s paradox, known as the dark night paradox, is an argument in astrophysics that the darkness of the night sky conflicts with the assumption of an infinite and eternal static universe. Big-Bang theory was used to partially explain this paradox, while introducing new problems. Hereby, we propose a better theory, named Sun Matters Theory, to explain this paradox. Moreover, this unique theory supports and extended the Einstein’s static universe model proposed by Albert Einstein in 1917. Further, we proposed our new universe model, “Sun Model of Universe”. Based on the new model and novel theory, we generated innovative field equation by upgrading Einstein’s Field Equation through adding back the cosmological constant, introducing a new variable and modifying the gravitationally-related concepts. According to the Sun Model of Universe, the dark matter and dark energy comprise the so-called “Sun Matters”. The observed phenomenon like the red shift is explained as due to the interaction of ordinary light with Sun Matters leading to its energy and frequency decrease. In Sun Model, our big universe consists of many universes with ordinary matter at the core mixed and surrounded with the Sun Matters. In those universes, the laws of physics may be completely or partially different from that of our ordinary universe with parallel civilizations. The darkness of night can be easily explained as resulting from the interaction of light with the Sun Matters leading to the sharp decrease in the light intensity. Sun Matters also scatter the light from a star, which makes it shining as observed by Hubble. Further, there is a kind of Sun Matters named “Sun Waters”, surrounding every starts. When lights pass by the sun, the Sun Waters deflect the lights to bend the light path. According to the Sun Model, it is the light bent not the space bent that was proposed in the theory of relativities.

Hubble Tension Explanation from This Cosmological Model AΛΩ (Slow Bang Model, SB)

In this article we present a model of Hubble-Lemaître law using the notions of a transmitter (galaxy) and a receiver (MW) coupled to a model of the universe (Slow Bang Model, SB), based on a quantum approach of the evolution of space-time as well as an equation of state that retains all the infinitesimal terms. We find an explanation of the Hubble tension H0. Indeed, we have seen that this constant depends on the transceiver pair which can vary from the lowest observable value, from photons of the CMB (theoretical [km/s/Mpc]) to increasingly higher values depending on the earlier origin of the formation of the observed galaxy or cluster (ETG ~0.3 [Gy], ~74 [km/s/Mpc]). We have produced a theoretical table of the values of the constant according to the possible pairs of transmitter/receiver in the case where these galaxies follow the Hubble flow without large disturbance. The calculated theoretical values of the constant are in the order of magnitude of all values mentioned in past studies. Subsequently, we applied the models to 9 galaxies and COMA cluster and found that the models predict acceptable values of their distances and Hubble constant since these galaxies mainly follow the Hubble flow rather than the effects of a galaxy cluster or a group of clusters. In conclusion, we affirm that this Hubble tension does not really exist and it is rather the understanding of the meaning of this constant that is questioned.

融合Kano-MD-SG的气体安全检测仪设计研究

目的解决气体安全检测仪研发中市场需求差异化高、研发投入有限等问题。方法首先,采用改进的Kano模型对研发人员和用户进行需求调研,确定设计需求;其次,基于模块化设计理念,确立功能与造型之间的对应关系,提出了“基础单元+外壳造型”的开发策略;最后,结合材料与工艺,运用形状文法生成大量造型方案,优选并确定最终方案。结果构建集成了Kano模型、模块化设计、形状文法的产品创新设计方法,准确获得了研发需求,完成了气体安全检测仪的创新设计。结论该创新设计方法有效解决了气体安全检测仪研发中的现实问题,为安全装备类产品提供了多元化设计思路。

结合KANO-FBS-TRIZ模型的居家办公家具设计方法与实践

为弥补市面上的居家办公家具功能与种类方面的缺漏,以20~35岁职场青壮年群体为研究对象。首先通过桌面研究与线下访谈提炼需求关键词并利用KJ法绘制亲和图以划分需求维度;其次借助KANO模型判别需求类型,提炼关键需求功能点导入FBS模型,进而转化为结构要素为设计提供参考。最终基于上述研究结果并结合TRIZ理论提出居家办公家具的设计方案。基于KANO-FBS-TRIZ模型的居家办公家具的创新设计着眼于居家办公者的使用需求,采用量化与质性相结合的研究方法,优化现有家庭办公类家具设计,丰富现有设计方法研究,为相关产品的研发提供理论与实践参考。

Kano-FAST模型在校园户外家具需求研究的应用

为解决校园户外家具功能单一问题,改善用户的使用体验,提出将Kano-FAST模型应用在校园户外家具需求研究上,可准确把握用户真实需求进行校园户外家具的改进设计。以南京林业大学为例,通过实地观察、人物访谈等方法对南林校园户外家具现存的问题和需求进行分析,采用KJ法进行需求汇总并对获取的16项用户需求进行维度分类,引入Kano模型对获取的需求进行优先级排序,最终筛选出2项必备需求、2项期望需求和7项魅力需求,采用FAST功能分析法对Kano模型筛选出的需求进行功能-设计元素映射分析,建立FAST功能树。通过南京林业大学户外家具需求研究的案例可证明,基于Kano-FAST模型的用户需求研究可以帮助设计师明确校园户外家具不同需求的重要程度,更能针对用户痛点进行需求转化,可以为今后校园户外家具设计研究提供思路。

Analysis of Porter’s Five Forces Competitive Model in China’s Property Rights Trading Market

In recent years,China’s property rights trading market has been extremely competitive,but there are also new contradictions and challenges.This paper aims to analyze the external and internal competitive market of the property rights market through Porter’s five forces competition model,then find out the problems and defects in the development,thereby promoting the better development and progress of China’s property rights trading market.

基于Kano-FBS模型的家用哺乳椅设计研究

为满足哺乳期女性居家哺乳的多样化需求,并有效缓解其养育婴孩所带来的压力,文章从哺乳期女性的生理特征和哺乳过程出发,运用文献研究法和行为观察法,提取了哺乳期女性生理特征及哺乳需求。采用Kano模型深入分析用户需求,确定功能特性类型,并明确了相对重要的用户需求。采用FBS模型对关键性需求进行“功能—行为—结构”映射,以确保设计方案的合理性。通过模型的应用,得到了更具创新性和实用性的设计方案。该方案提升了用户的哺乳体验,为哺乳坐具的改进与创新提供了针对性的指导和启示。

Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration

Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivotal to basic cellular processes.Close to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and localization.In this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in diseases.Furthermore,we have focused on N-acetyltransferase 9 and its role in microtubule stability.We have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative diseases.We have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.

基于KANO与SERVOQUAL模型的澳门城市大学AR技术文创产品设计

以校园文创产品包装为载体,运用半结构访谈结合KANO模型与SERVOQUAL模型的量表,结合用户行为偏好,研究利用AR技术实现用户体验的提升,指导了基于增强现实的AR互动文创产品的设计实践,使AR交互展示激发出用户较为满意的愉悦感和沉浸感。