期刊文献+
共找到40,730篇文章
< 1 2 250 >
每页显示 20 50 100
Rising utilization of stable isotopes in tree rings for climate change and forest ecology 被引量:1
1
作者 Ru Huang Chenxi Xu +3 位作者 Jussi Grießinger Xiaoyu Feng Haifeng Zhu Achim Bräuning 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第1期103-116,共14页
Analyses of stable isotopes(C,O,H)in tree rings are increasingly important cross-disciplinary programs.The rapid development in this field documented in an increasing number of publications requires a comprehensive re... Analyses of stable isotopes(C,O,H)in tree rings are increasingly important cross-disciplinary programs.The rapid development in this field documented in an increasing number of publications requires a comprehensive review.This study includes a bibliometric analysis-based review to better understand research trends in tree ring stable isotope research.Overall,1475 publications were selected from the Web of Science Core Collection for 1974-2023.The findings are that:(1)numbers of annual publications and citations increased since 1974.From 1974 to 1980,there were around two relevant publications per year.However,from 2020 to 2022,this rose sharply to 109 publications per year.Likewise,average article citations were less than four per year before 1990,but were around four per article per year after 2000;(2)the major subjects using tree ring stable isotopes include forestry,geosciences,and environmental sciences,contributing to 42.5%of the total during 1974-2023;(3)the top three most productive institutions are the Chinese Academy of Sciences(423),the Swiss Federal Institute for Forest,Snow and Landscape Research(227),and the University of Arizona(204).These achievements result from strong collaborations;(4)review papers,for example,(Dawson et al.,Annu Rev Ecol Syst 33:507-559,2002)and(McCarroll and Loader,Quat Sci Rev 23:771-801,2004),are among the most cited,with more than 1000 citations;(5)tree ring stable isotope studies mainly focus on climatology and ecology,with atmospheric CO_(2) one of the most popular topics.Since 2010,precipitation and drought have received increasing attention.Based on this analysis,the research stages,key findings,debated issues,limitations and direc-tions for future research are summarized.This study serves as an important attempt to understand the progress on the use of stable isotopes in tree rings,providing scientific guid-ance for young researchers in this field. 展开更多
关键词 Tree rings Stable isotopes Web of Science BIBLIOMETRIC
下载PDF
Signed Zero-Divisor Graphs Over Commutative Rings
2
作者 Lu Lu Lihua Feng Weijun Liu 《Communications in Mathematics and Statistics》 SCIE CSCD 2024年第3期463-477,共15页
In this paper,we define signed zero-divisor graphs over commutative rings and investigate the interplay between the algebraic properties of the rings and the combinatorial properties of their corresponding signed zero... In this paper,we define signed zero-divisor graphs over commutative rings and investigate the interplay between the algebraic properties of the rings and the combinatorial properties of their corresponding signed zero-divisor graphs.We investigate the structure of signed zero-divisor graphs,the relation between ideals and signed zero-divisor graphs,and the adjacency matrices and the spectra of signed zero-divisor graphs. 展开更多
关键词 ring IDEAL Signed graph Adjacency matrix
原文传递
Cover story: Neuromodulation Brings Sunshine to Diseased Brains
3
《General Psychiatry》 CSCD 2024年第1期32-32,共1页
Various invasive and non-invasive brain modulation methods are widely used to regulate sensory,cognitive,and motor functions both within local and large brain networks.This special issue provides innovative studies to... Various invasive and non-invasive brain modulation methods are widely used to regulate sensory,cognitive,and motor functions both within local and large brain networks.This special issue provides innovative studies to optimize relevant methods and understand their neural mechanisms,paving the way for personalized neuromodulation of cognitive function.The cover of this issue uses the image of the four heavenly Kings in Chinese culture who are in charge of good weather.It compares the process of neuroregulation technology that integrates the principles of sound,light electricity or magnetism in treating the diseased brain,to the moment when these gods cast their spells to bring sunshine and peace to the human brain in the midst of lightning and thunder. 展开更多
关键词 SUNSHINE LIGHTNING rings
下载PDF
Effectivity and safety of trifocal intraocular lenses and capsular tension rings implantation for cataract patients with axial high myopia
4
作者 Shan Hua Qiu-Xia Xie +1 位作者 Hu Wang Jing-Xiang Zhong 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第3期499-508,共10页
●AIM:To assess effectivity and safety of trifocal intraocular lenses(IOLs)and capsular tension rings in treating cataract patients with axial high myopia.●METHODS:A prospective nonrandomized controlled clinical tria... ●AIM:To assess effectivity and safety of trifocal intraocular lenses(IOLs)and capsular tension rings in treating cataract patients with axial high myopia.●METHODS:A prospective nonrandomized controlled clinical trial was conducted.Totally 98 eyes(74 patients)who underwent femtosecond laser-assisted cataract surgery(FLACS)with trifocal IOLs were enrolled in the study and followed up for 2y after surgery:46 eyes(33 patients)with capsular tension ring implantation in the long axial lengths(AL)group(26<AL<29 mm)and 52 eyes(41 patients)in the normal AL group(22<AL<24.5 mm).Postoperative outcomes about effectivity and safety,including the subjective and objective visual quality,and postoperative complications were assessed.●RESULTS:Uncorrected distance visual acuity at 5 m and uncorrected intermediate visual acuity at 60 and 80 cm in the long AL group were significantly worse than those in the normal AL group at 3mo postoperatively(P<0.05).The differences in reading speed,spectacle independence and potential visual complaints between the two groups were not statistically significant(P>0.05).The dysfunctional lens index and total modulation transfer function(MTF)average height were similar between the two groups.The postoperative internal coma aberrations in the axial high myopia eyes were significantly higher than that in the normal AL group(P<0.05).The total satisfaction score in the long AL group(91.32±2.76)was slightly higher than that in the normal AL group(90.36±3.47),but there was no difference(P=0.136).A statistically negative correlation was found between corrected distance visual acuity(CDVA)and dysfunctional lens index(r=-0.382,P=0.009),and between CDVA and the total MTF average height(r=-0.374,P=0.01).But there was no significant correlation between CDVA and total satisfaction score(r=0.059,P=0.696).Postoperative complications mainly presented as posterior capsular opacity(PCO),retinal detachment and cystoid macular edema.There was no difference in the incidence of fundus disease(6.5%vs 3.8%,P=0.663)or PCO(17.4%vs 7.7%,P=0.217)between the two groups at two years.●CONCLUSION:The utilization of trifocal IOL and capsular tension ring implantation is beneficial for cataract patients with axial high myopia undergoing FLACS.This approach not only ensures excellent subjective feelings and objective visual quality,but also does not increase the incidence of postoperative complications. 展开更多
关键词 trifocal intraocular lenses capsular tension ring axial high myopia CATARACT visual quality
下载PDF
Nil G-*-Clean Rings
5
作者 LI Xiao-xuan YIN Xiao-bin 《安徽师范大学学报(自然科学版)》 2024年第6期520-526,532,共8页
A ring is called nil G-*-clean ring if each of its elements is a sum of a G-projection and a nilpotent.In this paper,we study the basic properties of this ring and some relations with other rings.We prove that R is ni... A ring is called nil G-*-clean ring if each of its elements is a sum of a G-projection and a nilpotent.In this paper,we study the basic properties of this ring and some relations with other rings.We prove that R is nil G-*-clean if(G(R)+J)/J=G(R/J)=and only if is nil,and is nil G-*-clean. 展开更多
关键词 nil-clean ring nil G-clean ring *-ring R/J nil*-clean ring nil G-*-clean ring
下载PDF
Mapping the landscape of gastric signet ring cell carcinoma:Overcoming hurdles and charting new paths for advancement
6
作者 Shu-Yuan Wang Jing-Hang Wang +4 位作者 Run-Kai Chen Zhen Yuan Hao Cui Bo Wei Jian-Xin Cui 《World Journal of Clinical Oncology》 2025年第2期94-109,共16页
BACKGROUND In recent years,the global prevalence of gastric cancer(GC)has witnessed a progressive decrease,accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma(GSRCC).As precision medici... BACKGROUND In recent years,the global prevalence of gastric cancer(GC)has witnessed a progressive decrease,accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma(GSRCC).As precision medicine concepts progress,GSRCC,a distinct sub-type of GC,has drawn considerable attention from researchers.However,there still persist some controversies regarding the associated research findings.AIM To summarize the current obstacles and potential future directions for research on GSRCC.METHODS To begin with,all literature related to GSRCC published from January 1,2004 to December 31,2023 was subjected to bibliometric analysis in this article.Additionally,this paper analyzed the research data using CiteSpace,GraphPad Prism v8.0.2,and VOSviewer,which was obtained from the Web of Science Core Collection database.The analysis results were visually represented.RESULTS This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC,including cited references,authors,journals,countries,institutions,and keywords.The popular keywords and clusters contain"prognosis","survival","expression","histology",and"chemotherapy".CONCLUSION The prognosis,precise definition and classification,as well as chemoresistance of GSRCC,continue to be crucial areas of ongoing research,whose directions are closely tied to advancements in molecular biology research on GSRCC. 展开更多
关键词 Gastric cancer Signet ring cell carcinoma Bibliometric analysis CITESPACE VOSviewer
下载PDF
(m,n)-coherent Rings and FP(m,n)-projective Modules
7
作者 Tan Lingling Zhang Yixia Zhou Panyue 《数学理论与应用》 2024年第4期1-18,共18页
In this paper,we introduce the notions of_((m,n))-coherent rings and FP_((m,n))-projective modules for nonnegative integers m,n.We prove that(FP_((m,n))-Proj,(FPn-id)_(≤m))is a complete cotorsion pair for any m,n≥0 ... In this paper,we introduce the notions of_((m,n))-coherent rings and FP_((m,n))-projective modules for nonnegative integers m,n.We prove that(FP_((m,n))-Proj,(FPn-id)_(≤m))is a complete cotorsion pair for any m,n≥0 and it is hereditary if and only if the ring R is a left n-coherent ring for all m≥0 and n≥1.Moreover,we study the existence of FP_((m,n))-Proj covers and envelopes and obtain that if FP_((m,n))-Proj is closed under pure quotients,then FP_((m,n))-Proj is covering for any n≥2.As applications,we obtain that every R-module has an epic FP_((m,n))-Proj-envelope if and only if the left FP_((m,n))-global dimension of R is at most 1 and FP_((m,n))-Proj is closed under direct products. 展开更多
关键词 (m n)-coherent ring FP(m n)-projective module COVER ENVELOPE Cotorsion pair
下载PDF
Towards a blank design method for manufacturing big-tapered profiled ring disk by spinning-rolling process
8
作者 Xuechao LI Lianggang GUO +1 位作者 Xiaoqing CHEN Heng LI 《Chinese Journal of Aeronautics》 2025年第1期70-86,共17页
The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficien... The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficiency and low-cost manufacturing of the component.Blank design is the key part of plastic forming process design.For spinning-rolling process,the shape and size of the blank play a crucial role in process stability,deformation behavior and dimensional accuracy.So this work proposes a blank design method to determine the geometry structure and sizes of the blank.The mathematical model for calculating the blank size has been deduced based on volume conservation and neutral layer length invariance principle.The FE simulation and corresponding trial production of an actual big-tapered profiled ring disk show that the proposed blank design method is applicative.In order to obtain a preferred blank,the influence rules of blank size determined by different deformation degrees(rolling ratio k)on the spinning-rolling process are revealed by comprehensive FE simulations.Overall considering the process stability,circularity of the deformed ring disk and forming forces,a reasonable range of deformation degree(rolling ratio k)is recommended for the blank design of the new spinning-rolling process. 展开更多
关键词 Blank design method Spinning-rolling process Big-tapered profiled ring disk Rolling ratio Intelligent FE simulation
原文传递
Comparison of evolution laws of stress and strain fields in hot rolling of titanium alloy large rings with different sizes 被引量:3
9
作者 王敏 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2011年第7期1611-1619,共9页
For hot rolling of titanium alloy large rings,evolution laws of stress and strain fields in rings with various sizes were explored and compared based on a reliable coupled thermo-mechanical three-dimensional (3D) fi... For hot rolling of titanium alloy large rings,evolution laws of stress and strain fields in rings with various sizes were explored and compared based on a reliable coupled thermo-mechanical three-dimensional (3D) finite element (FE) model.The results show that for forming processes of different rings,as γ^-(the equivalent distribution ratio of feed amount per revolution of a process) decreases,the final peak Mises stress may transfer from the biting point at the driver roll side to that at the idle roll side,and the final peak equivalent plastic strain may transfer from the outside surface to the inside surface;as L^- (the equivalent deformation zone length of a process) increases,the final peak Mises stress may appear in the middle layer.The final positions of peak Mises stress and equivalent plastic strain are the combined effects of the above two aspects.In the deformation zone of a deformed ring,the surface layers are in the 3D compressive stress state,while the middle layer is in the 1D compressive and 2D tensile stress state or 2D compressive and 1D tensile stress state;the whole ring is in the 1D compressive and 2D tensile strain state. 展开更多
关键词 titanium alloy hot rolling of large rings stress and strain modeling and simulation finite element
下载PDF
On Left A-Injective Rings 被引量:1
10
作者 陈建龙 《Chinese Quarterly Journal of Mathematics》 CSCD 1992年第1期25-31,共7页
The main results of this paper are following theorems: (1)A left A-injective ring satisfying the ascending chain condition on right annihilator is QF ring. (2)A left A-injective ring satisfying the ascending hain cond... The main results of this paper are following theorems: (1)A left A-injective ring satisfying the ascending chain condition on right annihilator is QF ring. (2)A left A-injective ring satisfying the ascending hain condition on left annihilator is QF ring. (3)If R satisfies the following conditions: (ⅰ) r(A∩B)=r(A)+r(B), for each pair of left ils A,B;(ⅱ) rl(I)=I, for every right ideal I. Then R is semiperfect ring and has essential left s. In particular, any right CF left A-injective (or E(_RR) is projective left R-module) is QF ring 展开更多
关键词 A-injective ring chain condition QF rin
下载PDF
Weak M-Armendariz rings
11
作者 张翠萍 陈建龙 《Journal of Southeast University(English Edition)》 EI CAS 2009年第1期142-146,共5页
For a monoid M, this paper introduces the weak M- Armendariz rings which are a common generalization of the M- Armendariz rings and the weak Armendariz rings, and investigates their properties. Moreover, this paper pr... For a monoid M, this paper introduces the weak M- Armendariz rings which are a common generalization of the M- Armendariz rings and the weak Armendariz rings, and investigates their properties. Moreover, this paper proves that: a ring R is weak M-Armendariz if and only if for any n, the n-by-n upper triangular matrix ring Tn (R) over R is weak M- Armendariz; if I is a semicommutative ideal of ring R such that R/I is weak M-Armendariz, then R is weak M-Armendariz, where M is a strictly totally ordered monoid; if a ring R is semicommutative and M-Armendariz, then R is weak M × N- Armendariz, where N is a strictly totally ordered monoid; a finitely generated Abelian group G is torsion-free if and only if there exists a ring R such that R is weak G-Armendariz. 展开更多
关键词 semicommutative rings M-Armendariz rings weak Armendariz rings weak M-Armendariz rings
下载PDF
Wilson病Kayser-Fleischer环相关因素分析 被引量:4
12
作者 王共强 张龙 +2 位作者 马心锋 韩丽 韦玉国 《医学研究杂志》 2013年第7期98-101,共4页
目的探讨Wilson病(Wilson's disease,WD)角膜Kayser-Fleischer(K-F)环临床特点及相关因素。方法对116例WD患者K-F环进行量化分级,运用SPSS19.0软件进行Logistic回归分析探讨K-F环分级与临床资料、生化指标的相关性。结果 116例WD患... 目的探讨Wilson病(Wilson's disease,WD)角膜Kayser-Fleischer(K-F)环临床特点及相关因素。方法对116例WD患者K-F环进行量化分级,运用SPSS19.0软件进行Logistic回归分析探讨K-F环分级与临床资料、生化指标的相关性。结果 116例WD患者K-F环总阳性率90.5%,其中脑型阳性率最高(96.8%),其次肝型阳性率75%,症状前型阳性率66.7%。K-F环分级大小与临床严重程度呈正相关(P<0.05);与病程、临床类型、Sco、CP、肝功能等指标无相关性(P>0.05)。结论 K-F环可能是WD一个相对独立的临床体征,其分级大小可作为WD病情严重程度判断的指标之一。 展开更多
关键词 WILSON病 肝豆状核变性 K-F环 LOGISTIC回归分析
下载PDF
KG_2 over Rings with Division Rings of Quotients
13
作者 陈一宏 韩冰 《Journal of Beijing Institute of Technology》 EI CAS 2002年第4期433-435,共3页
A presentation of hyperbolic unitary group is an important part in the unitary group. The group KG 2,n (R) plays an elementary role in presentation of unitary group. It is proved that KG 2,n(R)=1 for n≥2 over a... A presentation of hyperbolic unitary group is an important part in the unitary group. The group KG 2,n (R) plays an elementary role in presentation of unitary group. It is proved that KG 2,n(R)=1 for n≥2 over a ring R with division ring of quotients, using a new method, and a presentation of GE n(R) is given. 展开更多
关键词 KG 2 n(R) group ring with division ring of quotients general Stainberg group
下载PDF
Exchange general rings
14
作者 黄青鹤 陈建龙 《Journal of Southeast University(English Edition)》 EI CAS 2006年第4期589-592,共4页
The exchange rings without unity, first introduced by Ara, are further investigated. Some new characterizations and properties of exchange general rings are given. For example, a general ring I is exchange if and only... The exchange rings without unity, first introduced by Ara, are further investigated. Some new characterizations and properties of exchange general rings are given. For example, a general ring I is exchange if and only if for any left ideal L of I and a^-= a^-2 ∈I/L, there exists w ∈ r. ureg(I) such that w^- = a^-; E(R, I) ( the ideal extension of a ring R by its ideal I) is an exchange ring if and only if R and I are both exchange. Furthermore, it is presented that if I is a two-sided ideal of a unital ring R and I is an exchange general ring, then every central element of I is a clean element in 1. 展开更多
关键词 exchange ring clean element stable range one ideal extension
下载PDF
A Note on the Supersemiprime Rings and Supersemiprime Radical
15
作者 张福利 《Chinese Quarterly Journal of Mathematics》 CSCD 2002年第3期105-106,共2页
In this paper, we give an answer to an open p roblem which was proposed in . We show that the supersemiprime radical is e qual to the near nil radical which was defined by XIE Bang_jie in .
关键词 supersemiprime ring supersemiprime radical near nil radical near nil semisimple ring
下载PDF
On right GP-V-rings 被引量:1
16
作者 杨春兰 《浙江大学学报(理学版)》 CAS CSCD 北大核心 2009年第3期249-253,共5页
主要研究GP-V-环(GP—V-模),它是P—V-环(P—V-模)的推广.讨论了这一类环的某些性质,例如:设R是GP—V-环,则对主右理想U=αR的任意极大子理想K,存在n∈Z^+和R的极大右理想H使得H∩α^nR=K∩α^nR;右GP—V-环的每个主右理想... 主要研究GP-V-环(GP—V-模),它是P—V-环(P—V-模)的推广.讨论了这一类环的某些性质,例如:设R是GP—V-环,则对主右理想U=αR的任意极大子理想K,存在n∈Z^+和R的极大右理想H使得H∩α^nR=K∩α^nR;右GP—V-环的每个主右理想都是幂等的;右GP—V-环的直和项仍是右GP—V-环;等等.此外,还讨论了右GP—V-环什么时候是Von Neumann正则环. 展开更多
关键词 GP—V-环 GP-内射 Von Neumann正则环
下载PDF
On Weakly Semicommutative Rings 被引量:8
17
作者 CHEN WEI-XING CUI SHU-YING 《Communications in Mathematical Research》 CSCD 2011年第2期179-192,共14页
A ring R is said to be weakly semicommutative if for any a,b∈R, ab=0 implies aRb(?)Nil(R),where Nil(R) is the set of all nilpotent elements in R. In this note,we clarify the relationship between weakly semicom... A ring R is said to be weakly semicommutative if for any a,b∈R, ab=0 implies aRb(?)Nil(R),where Nil(R) is the set of all nilpotent elements in R. In this note,we clarify the relationship between weakly semicommutative rings and NI-rings by proving that the notion of a weakly semicommutative ring is a proper generalization of NI-rings.We say that a ring R is weakly 2-primal if the set of nilpotent elements in R coincides with its Levitzki radical,and prove that if R is a weakly 2-primal ring which satisfiesα-condition for an endomorphismαof R(that is,ab=0(?)aα(b)=0 where a,b∈R) then the skew polynomial ring R[x;α] is a weakly 2-primal ring,and that if R is a ring and I is an ideal of R such that I and R/I are both weakly semicommutative then R is weakly semicommutative. Those extend the main results of Liang et al.2007(Taiwan Residents J.Math.,11(5)(2007), 1359-1368) considerably.Moreover,several new results about weakly semicommutative rings and NI-rings are included. 展开更多
关键词 weakly semicommutative ring weakly 2-primal ring NLring Armen- dariz ring
下载PDF
Extensions of McCoy Rings 被引量:8
18
作者 应志领 陈建龙 雷震 《Northeastern Mathematical Journal》 CSCD 2008年第1期85-94,共10页
A ring R is said to be right McCoy if the equation f(x)g(x) = 0, where y(x) and g(x) are nonzero polynomials of R[x], implies that there exists nonzero s E R such that f(x)s = 0. It is proven that no proper ... A ring R is said to be right McCoy if the equation f(x)g(x) = 0, where y(x) and g(x) are nonzero polynomials of R[x], implies that there exists nonzero s E R such that f(x)s = 0. It is proven that no proper (triangular) matrix ring is one-sided McCoy. It is shown that for many polynomial extensions, a ring R is right Mccoy if and only if the polynomial extension over R is right Mccoy. 展开更多
关键词 matrix ring McCoy ring polynomial ring upper triangular matrix ring
下载PDF
KG2 over Rings with Division Rings of Quotients
19
作者 陈一宏 韩冰 《Journal of Beijing Institute of Technology》 EI CAS 2002年第4期433-435,共页
A presentation of hyperbolic unitary group is an important part in the unitary group. The group KG 2,n (R) plays an elementary role in presentation of unitary group. It is proved that KG 2,n(R)=1 for n≥2 over a... A presentation of hyperbolic unitary group is an important part in the unitary group. The group KG 2,n (R) plays an elementary role in presentation of unitary group. It is proved that KG 2,n(R)=1 for n≥2 over a ring R with division ring of quotients, using a new method, and a presentation of GE n(R) is given. 展开更多
关键词 KG 2 n(R) group ring with division ring of quotients general Stainberg group
全文增补中
Anti-rods/rings autoantibody generation in hepatitis Cpatients during interferon-α/ribavirin therapy 被引量:4
20
作者 Gerson Dierley Keppeke S John Calise +1 位作者 Edward KL Chan Luis Eduardo C Andrade 《World Journal of Gastroenterology》 SCIE CAS 2016年第6期1966-1974,共9页
Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effe... Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon. 展开更多
关键词 Rods and rings AUTOANTIBODIES Hepatitis C RIBAVIRIN INTERFERON-Α
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部