BACKGROUND This paper introduces a case of recurrent keratoacanthoma(KA).KA is a selfhealing disease.Recurrence after surgical resection is rare.In this case,the local application of retinoic acid ointment after the s...BACKGROUND This paper introduces a case of recurrent keratoacanthoma(KA).KA is a selfhealing disease.Recurrence after surgical resection is rare.In this case,the local application of retinoic acid ointment after the second operation achieved a good prognosis after 2 years of follow-up.CASE SUMMARY A 76-year-old male patient was admitted to the hospital for"lower lip rupture and scab for 3 mo".Treatment:A rectangular incision was made in the healthy tissue about 3 mm outside the periphery of the lower lip mass,and a modified Bernard sliding flap was designed to completely remove the mass.Pathology showed(lower lip)KA.When the patient returned 6 mo after surgery,the middle mucosa of the lower lip had a bulge with a diameter of about 0.5 cm.The boundary was still clear,the surface was ulcerated.A recurrence of lower lip KA was suspected and a fan-shaped incision was performed in the healthy tissue about 5 mm outside the lesion to completely resect.Pathological showed lower lip KA had recurred.Topical application of tretinoin cream was applied once a day for 3 mo.The lower lip wounds were clean at the 2-year postoperative follow-up and the mucosa was normal.CONCLUSION Adjuvant retinoic acid treatment after KA surgical resection can achieve good results.展开更多
Background: There has been a longstanding debate regarding whether keratoacanthomas (KAs) are neoplastic or reactive/inflammatory lesions. Aim: The aim of this case report is to, within the aforementioned debate, offe...Background: There has been a longstanding debate regarding whether keratoacanthomas (KAs) are neoplastic or reactive/inflammatory lesions. Aim: The aim of this case report is to, within the aforementioned debate, offer support in favor of the potential reactive nature of keratoacanthomas. Case Presentation: A 64-year-old male presented with an eruption of 25 keratoacanthomas within a red ink tattoo. Eruptions were partially resolved over a matter of months, and completely resolved with treatment using oral Acitretin therapy. We believe this to be the third such reported case of eruptive KAs within only the red ink portions of a tattoo. Prior cases involved 2 and 8 KAs each. Discussion: Multiple studies suggest that KAs are neoplastic in nature and very distinct from cutaneous squamous cell carcinoma. Especially interesting is the finding that KAs have increased expression of apoptotic genes;this is particularly notable because of the tendency for these lesions to spontaneously involute. Skin tumorigenesis can occur in predisposed individuals after carcinogen exposure, thus red ink possesses theoretical potential as a carcinogen. KAs could be seen in this case as in fact a reactive neoplasm.展开更多
The incidences of nonmelanoma skin cancer are increasing worldwide, and the ongoing war on its treatment necessitates the development of effective and non-invasive methods. Through basic and clinical research, non-inv...The incidences of nonmelanoma skin cancer are increasing worldwide, and the ongoing war on its treatment necessitates the development of effective and non-invasive methods. Through basic and clinical research, non-invasive treatments like Curaderm have been developed, leading to improved quality of life for patients. Excipients, previously considered inactive ingredients, play a crucial role in enhancing the performance of topical formulations. The development of Curaderm emphasizes the importance of understanding the interactions between active ingredients, excipients, and the biological system to create effective and affordable pharmaceutical formulations. The systematic approach taken in the development of Curaderm, starting from the observation of the anticancer activity of natural solasodine glycosides and progressing through toxicological and efficacy studies in cell culture, animals, and humans, has provided insights into the pharmacokinetics and pharmacodynamics of solasodine glycosides. It is crucial to determine these pharmacological parameters within the skin’s biological system for maximal effectiveness and cost-effectiveness of a skin cancer treatment. Curaderm, as a topical treatment for nonmelanoma skin cancer, offers benefits beyond those obtained from other topical treatments, providing hope for improved quality of life for patients.展开更多
文摘BACKGROUND This paper introduces a case of recurrent keratoacanthoma(KA).KA is a selfhealing disease.Recurrence after surgical resection is rare.In this case,the local application of retinoic acid ointment after the second operation achieved a good prognosis after 2 years of follow-up.CASE SUMMARY A 76-year-old male patient was admitted to the hospital for"lower lip rupture and scab for 3 mo".Treatment:A rectangular incision was made in the healthy tissue about 3 mm outside the periphery of the lower lip mass,and a modified Bernard sliding flap was designed to completely remove the mass.Pathology showed(lower lip)KA.When the patient returned 6 mo after surgery,the middle mucosa of the lower lip had a bulge with a diameter of about 0.5 cm.The boundary was still clear,the surface was ulcerated.A recurrence of lower lip KA was suspected and a fan-shaped incision was performed in the healthy tissue about 5 mm outside the lesion to completely resect.Pathological showed lower lip KA had recurred.Topical application of tretinoin cream was applied once a day for 3 mo.The lower lip wounds were clean at the 2-year postoperative follow-up and the mucosa was normal.CONCLUSION Adjuvant retinoic acid treatment after KA surgical resection can achieve good results.
文摘Background: There has been a longstanding debate regarding whether keratoacanthomas (KAs) are neoplastic or reactive/inflammatory lesions. Aim: The aim of this case report is to, within the aforementioned debate, offer support in favor of the potential reactive nature of keratoacanthomas. Case Presentation: A 64-year-old male presented with an eruption of 25 keratoacanthomas within a red ink tattoo. Eruptions were partially resolved over a matter of months, and completely resolved with treatment using oral Acitretin therapy. We believe this to be the third such reported case of eruptive KAs within only the red ink portions of a tattoo. Prior cases involved 2 and 8 KAs each. Discussion: Multiple studies suggest that KAs are neoplastic in nature and very distinct from cutaneous squamous cell carcinoma. Especially interesting is the finding that KAs have increased expression of apoptotic genes;this is particularly notable because of the tendency for these lesions to spontaneously involute. Skin tumorigenesis can occur in predisposed individuals after carcinogen exposure, thus red ink possesses theoretical potential as a carcinogen. KAs could be seen in this case as in fact a reactive neoplasm.
文摘The incidences of nonmelanoma skin cancer are increasing worldwide, and the ongoing war on its treatment necessitates the development of effective and non-invasive methods. Through basic and clinical research, non-invasive treatments like Curaderm have been developed, leading to improved quality of life for patients. Excipients, previously considered inactive ingredients, play a crucial role in enhancing the performance of topical formulations. The development of Curaderm emphasizes the importance of understanding the interactions between active ingredients, excipients, and the biological system to create effective and affordable pharmaceutical formulations. The systematic approach taken in the development of Curaderm, starting from the observation of the anticancer activity of natural solasodine glycosides and progressing through toxicological and efficacy studies in cell culture, animals, and humans, has provided insights into the pharmacokinetics and pharmacodynamics of solasodine glycosides. It is crucial to determine these pharmacological parameters within the skin’s biological system for maximal effectiveness and cost-effectiveness of a skin cancer treatment. Curaderm, as a topical treatment for nonmelanoma skin cancer, offers benefits beyond those obtained from other topical treatments, providing hope for improved quality of life for patients.
