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Suprachoroidal injection of ketorolac tromethamine does not cause retinal damage 被引量:1
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作者 Sumeng Liu Wu Liu +2 位作者 Yaling Ma Kegao Liu Meizi Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第35期2770-2777,共8页
Rabbit right eyes were injected with 3 or 6 mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mix... Rabbit right eyes were injected with 3 or 6 mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mixing reaction, oscillation potential, cone cell response, waveform, amplitude, and potential of 30 Hz scintillation response in right eyes before injection, and at 1,2, and 4 weeks after injection. There was no difference between left (control) and right eyes. Under light microscopy, the histomorphology of cells in each retinal layer was normal at 4 weeks following 6 mg ketorolac tromethamine administration. These results indicate that a single suprachoroidal injection of 3 or 6 mg ketorolac tromethamine into rabbits was safe. Suprachoroidal space injection appears to be safe. 展开更多
关键词 nonsteroidal anti-inflammatory drug ketorolac tromethamine segment disease RETINA suprachoroidal space retinal toxicity ELECTRORETINOGRAPHY PHARMACOLOGY regeneration neuralregeneration
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