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Chronology of Key Events In Sino-Pakistani Relations
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《Beijing Review》 2006年第23期64-,共1页
On May 21,1951, China and Pakistan established diplomatic relations. In April 1955, Chinese Premier Zhou Enlai held talks with Pakistani Prime Minister M. Ali during the Bandung Conference in Indonesia, and both sides... On May 21,1951, China and Pakistan established diplomatic relations. In April 1955, Chinese Premier Zhou Enlai held talks with Pakistani Prime Minister M. Ali during the Bandung Conference in Indonesia, and both sides agreed that bilateral ties should be strengthened. In October 1956, at the invitation of the Chinese Government, Pakistani Prime Minister H.E.Sulawadi paid an official visit to China. 展开更多
关键词 Chronology of key events In Sino-Pakistani Relations In
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Timeline of Key Events
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《Beijing Review》 2010年第15期17-17,共1页
March 28 Underground water floods the pit of Wangjialing Coal Mine at approximately 1:40 p.m.,and 108 workers escape while 153 others remain trapped in the shaft.
关键词 Timeline of key events
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Key export events of 5 locally owned brands
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《中国汽车(英文版)》 2007年第3期11-,共1页
关键词 THAN key export events of 5 locally owned brands
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Mitogen-activated protein kinase signal pathways play an important role in right ventricular hypertrophy of tetralogy of Fallot 被引量:9
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作者 ZHANG Hong-shan WU Qing-yu +2 位作者 XU Ming ZHOU Yu-xiang SHUI Chao-xiang 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第13期2243-2249,共7页
Background Tetralogy of Fallot (TOF) is the most common malformation of children with an incidence of approximately 10% of congenital heart disease patients. There can be a wide spectrum to the severity of the anato... Background Tetralogy of Fallot (TOF) is the most common malformation of children with an incidence of approximately 10% of congenital heart disease patients. There can be a wide spectrum to the severity of the anatomic defects, which include ventricular septal defect, aortic override, right ventricular outflow tract obstruction, and right ventricular hypertrophy. We examined the relationship between right ventricular hypertrophy in patients with TOF and the gene expression of factors in the mitogen-activated protein kinase (MAPK) signal pathway. Methods To gain insight into the characteristic gene(s) involved in molecular mechanisms of right ventricular hypertrophy in TOF, differential mRNA and micro RNA expression profiles were assessed using expression-based micro array technology on right ventricular biopsies from young TOF patients who underwent primary correction and on normal heart tissue. We then analyzed the gene expression of the MAPK signal pathway using reverse transcription-polymerase chain reaction (RT-PCR) in normals and TOF patients. Results Using the micro RNA chip V3.0 and human whole genome oligonucleotide microarray VI.0 to detect the gene expression, we found 1068 genes showing altered expression of at least two-fold in TOF patients compared to the normal hearts, and 47 micro RNAs that showed a significant difference of at least two-fold in TOF patients. We then analyzed these mRNAs and micro RNAs by target gene predicting software Microcosm Targets version 5.0, and determined those mRNA highly relevant to the right ventricular hypertrophy by RT-PCR method. There were obvious differences in the gene expression of factors in the MAPK signal pathway when using RT-PCR, which was consistent to the results of the cDNA microarray.Conclusion The upregulation of genes in the MAPK signal pathway may be the key events that contribute to right ventricular hypertrophy and stunted angiogenesis in patients with TOF. 展开更多
关键词 tetralogy of Fallot gene expression heart development mitogen-activated protein kinases MICROARRAY micro RNA mRNA Conclusion The upregulation of genes in the MAPK signal pathway may be the key events that contribute to rightventricular hypertrophy and stunted angiogenesis in patients with TOF.
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