Metabolic Regulatory and Anti-oxidative Effects of Modified Bushen Huoxue Decoction(补肾活血方) on Experimental Rabbit Model of Osteoarthritis

Objective： To observe the metabolic, regulatory and anti-oxidative effects of modified Bushen Huoxue Decoction （BSHXD, 补肾活血方）, a Chinese herbal medicine for Kidney （Shen）-reinforcement and bloodactivation, on an osteoarthritis （OA） rabbit model. Methods： A rabbit model for knee joint OA was established by the classic Huith＇s method. The OA model rabbits were randomized into 5 groups： the model control group, the positive control group treated with glucosamine sulfate, and the three BSHXD treated groups treated respectively with low, moderate, and high doses of BSHXD. In addition, a normal control group and a sham-operated group were set up. Experimental animals were sacrificed after a 7-week treatment, and pathological changes in cartilaginous tissue were estimated using the Mankin criteria. Hydroxyproline （Hyp） and malonaldehyde （MDA） contents in blood serum and urine, as well as superoxide dismutase （SOD） activity and nitric oxide （NO） content in blood serum and knee joint synovial homogenates were detected. Results： Mankin scoring showed insignificant statistical differences between the various treatment groups （P〉0.05）, but all were better than the model control group （P〈0.05）. Serum and udnary contents of Hyp and MDA as well as serum and synovial levels of NO were significantly lower, but the SOD activity in blood serum and synovial tissue was higher in the BSHXD treated groups than in the model group （P〈0.01）; the effect of BSHXD was dose-dependent to some extent. Coaclasloa： The modified BSHXD shows an effect of improving cartilage metabolism in experimental rabbits with OA, and possesses osteo-chondric protective effects in antagonizing peroxidation injury.

A case of primary open-angle glaucoma

In this case,the acupuncture treatment for open-angle glaucoma patient achieved a significant result.The acupoints Jingming(睛明BL1),Qiuhou(球后Extra),Fengchi(风池GB20),and Taichong(太冲LR3)were used as the main ones plus some symptomatic acupoints.After one course of treatment,the left eye pressure decreased by 12 mmHg compared with that before treatment,the left eye vision improved,and the fundus oozing was significantly reduced.After two courses of treatment,the left eye pressure was below 20 mmHg,left eye vision obviously improved,and the fundus oozing completely disappeared.