Objective:To evaluate whether Ding Kun Dan(DKD)can improve the vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET)outcomes in patients with predicted poor ovarian response(POR)safely ...Objective:To evaluate whether Ding Kun Dan(DKD)can improve the vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET)outcomes in patients with predicted poor ovarian response(POR)safely and effectively.Methods:Prospective,multicenter,randomized controlled trial;A total of 278 POR patients were randomized in DKD group or immediate treatment group.Both groups received IVF or ICSI as a standard treatment while in the DKD group,DKD was administrated for 3 months before the IVF/ICSI cycle.The primary outcome was the ongoing pregnancy rate.The secondary outcomes include clinical pregnancy rate,biochemical pregnancy rate,total gonadotropin(Gn)dosage and duration,estradiol(E2)and progesterone(P)levels on human chorionic gonadotropin(hCG)trigger day,cycle cancellation rate,number of oocytes retrieved,high-quality embryo rate and any adverse events.Results:Compared to the immediate IVF treatment group,oral administration of DKD for 3 months before IVF led to a significant increase in ongoing pregnancy rate(30.0%v.s.17.6%,P<0.05),biochemical pregnancy rate(39.2%vs.25.2%,P<0.05),clinical pregnancy rate(36.7%vs.22.7%,P<0.05)and high-quality embryo rate(40.8%vs.32.4%,P<0.05),and a significant decrease in Gn duration(P<0.05).However,no significant differences were found in total dosage of Gn,number of retrieved oocytes,cycle cancellation rate,E2 level and P level on hCG trigger days(P>0.05).No serious adverse events occurred during the intervention period in either group.Conclusion:DKD is a safe and effective intervention to improve the IVF/ICSI-ET outcomes in patients with POR.展开更多
Prof. Huang Kun is an internationally renowned specialist in solid state physics and semi-conductors. He is a CAS member and also a foreign member of the Swedish Academy of Sciences and a fellow of the Third World Aca...Prof. Huang Kun is an internationally renowned specialist in solid state physics and semi-conductors. He is a CAS member and also a foreign member of the Swedish Academy of Sciences and a fellow of the Third World Academy of Sciences. He received China's 2001 Supreme Scientific and Technological Award on February,2002, for his lifetime achievements.展开更多
Together with Prof. Wang Xuan from Peking University, CAS physicist Huang Kun received Supreme Scientific and Technological (S&T) Award in 2001 from Chinese President Jiang Zeming in Beijing on February 2. Eac... Together with Prof. Wang Xuan from Peking University, CAS physicist Huang Kun received Supreme Scientific and Technological (S&T) Award in 2001 from Chinese President Jiang Zeming in Beijing on February 2. Each gets five million yuan (US$ 602,000) as part of the award for their lifetime achievements.……展开更多
Okaze de la Unua Azia Kongreso de Esperanto enanhajo deinio,raportistino Wang Yuqinel Esperanto-redakcio deina Radio Internacia intervjuis s-ron Puramo Chong,prezidanton deKorea Esperanto-Asocio kaj sekretarion de KAEM.
Okaze de la 1-a Azia Kongreso de Esperanto,raportistino Wang Yuqin el Esperanto-redakcio deCina Radio Internacia faris intervjuon kun s-ino Doiieko,redaktorino de"Esperanto en Azio",la organo de KAEM.
基金This study was supported by the National Natural Science Foundation of China Nos.81774351the Tianjin Health&Family Planning Commission(Tianjin scientific research project of priority area of traditional Chinese medicine,Nos.2018008)Shanxi Guangyuyuan TCM Co.,Ltd.
文摘Objective:To evaluate whether Ding Kun Dan(DKD)can improve the vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET)outcomes in patients with predicted poor ovarian response(POR)safely and effectively.Methods:Prospective,multicenter,randomized controlled trial;A total of 278 POR patients were randomized in DKD group or immediate treatment group.Both groups received IVF or ICSI as a standard treatment while in the DKD group,DKD was administrated for 3 months before the IVF/ICSI cycle.The primary outcome was the ongoing pregnancy rate.The secondary outcomes include clinical pregnancy rate,biochemical pregnancy rate,total gonadotropin(Gn)dosage and duration,estradiol(E2)and progesterone(P)levels on human chorionic gonadotropin(hCG)trigger day,cycle cancellation rate,number of oocytes retrieved,high-quality embryo rate and any adverse events.Results:Compared to the immediate IVF treatment group,oral administration of DKD for 3 months before IVF led to a significant increase in ongoing pregnancy rate(30.0%v.s.17.6%,P<0.05),biochemical pregnancy rate(39.2%vs.25.2%,P<0.05),clinical pregnancy rate(36.7%vs.22.7%,P<0.05)and high-quality embryo rate(40.8%vs.32.4%,P<0.05),and a significant decrease in Gn duration(P<0.05).However,no significant differences were found in total dosage of Gn,number of retrieved oocytes,cycle cancellation rate,E2 level and P level on hCG trigger days(P>0.05).No serious adverse events occurred during the intervention period in either group.Conclusion:DKD is a safe and effective intervention to improve the IVF/ICSI-ET outcomes in patients with POR.
文摘Prof. Huang Kun is an internationally renowned specialist in solid state physics and semi-conductors. He is a CAS member and also a foreign member of the Swedish Academy of Sciences and a fellow of the Third World Academy of Sciences. He received China's 2001 Supreme Scientific and Technological Award on February,2002, for his lifetime achievements.
文摘 Together with Prof. Wang Xuan from Peking University, CAS physicist Huang Kun received Supreme Scientific and Technological (S&T) Award in 2001 from Chinese President Jiang Zeming in Beijing on February 2. Each gets five million yuan (US$ 602,000) as part of the award for their lifetime achievements.……
文摘Okaze de la Unua Azia Kongreso de Esperanto enanhajo deinio,raportistino Wang Yuqinel Esperanto-redakcio deina Radio Internacia intervjuis s-ron Puramo Chong,prezidanton deKorea Esperanto-Asocio kaj sekretarion de KAEM.
文摘Okaze de la 1-a Azia Kongreso de Esperanto,raportistino Wang Yuqin el Esperanto-redakcio deCina Radio Internacia faris intervjuon kun s-ino Doiieko,redaktorino de"Esperanto en Azio",la organo de KAEM.
