Docetaxel-based combination chemotherapy remains the predominant treatment for castration-resistant prostate cancer. However, taxane-related drug resistance and neurotoxicity have prompted us to develop substitute tre...Docetaxel-based combination chemotherapy remains the predominant treatment for castration-resistant prostate cancer. However, taxane-related drug resistance and neurotoxicity have prompted us to develop substitute treatment strategies. Eg5 （kinesin spindle protein）, which is crucial for bipolar spindle formation and duplicated chromosome separation during the early phase of mitosis, has emerged as an attractive target for cancer chemotherapy. The aim of this study was to investigate the anticancer efficacy of $-（methoxytrityl）-L-cysteine （S（MeO）TLC）, a novel Eg5 inhibitor in prostate cancer. Eg5 expression was examined in human prostate cancer cell lines and tissue microarrays were constructed from clinical specimens. Antiproliferative activity of S（MeO）TLC in prostate cancer cells was assessed by a cell viability assay. The anticancer effect and inhibitory mechanism of S（MeO）TLC in prostate cancer cells was further explored by Hoechst staining, flow cytometry and immunofluorescence. In addition, the antitumor effect of S（MeO）TLC on subcutaneous xenograft models was assessed. Eg5 expression was identified in PC3, DU145 and LNCaP cells. More than half of prostate cancer clinical specimens displayed Eg5 expression. S（Me0）TLC exhibited more powerful anticancer activity in prostate cancer cells compared with the other four Eg5 inhibitors tested. S（MeO）TLC induced cell death after arresting dividing cells at mitosis with distinct monopolar spindle formation. S（MeO）TLC exhibited its significant inhibitory activity （P〈0.05） on subcutaneous xenograft models also through induction of mitotic arrest. We conclude that Eg5 is a good target for prostate cancer chemotherapy, and S（MeO）TLC is a potent promising anticancer agent in prostate cancer.展开更多
For a higher-dimensional integrable nonlinear dynamical system, there are abundant coherent soliton excitations. With the aid of an improved projective Riccati equation approach, the paper obtains several types of exa...For a higher-dimensional integrable nonlinear dynamical system, there are abundant coherent soliton excitations. With the aid of an improved projective Riccati equation approach, the paper obtains several types of exact solutions to the （2＋l）-dimenslonal dispersive long-wave equation, including multiple-soliton solutions, periodic soliton solutions, and Weierstrass function solutions. From these solutions, apart from several multisoliton excitations, we derive some novel features of wave structures by introducing some types of lower-dimensional patterns.展开更多
In this paper, based on new auxiliary nonlinear ordinary differential equation with a sixtb-aegree nonnneal term, we study the （2＋l ）-dimensional Davey-Stewartson equation and new types of travelling wave solutions...In this paper, based on new auxiliary nonlinear ordinary differential equation with a sixtb-aegree nonnneal term, we study the （2＋l ）-dimensional Davey-Stewartson equation and new types of travelling wave solutions are obtained, which include new bell and kink profile solitary wave solutions, triangular periodic wave solutions, and singular solutions. The method used here can be also extended to many other nonlinear partial differential equations.展开更多
Based on the computerized symbolic system Mapte, a new generalized expansion method of Riccati equation for constructing non-travelling wave and coefficient functions' soliton-like solutions is presented by a new ...Based on the computerized symbolic system Mapte, a new generalized expansion method of Riccati equation for constructing non-travelling wave and coefficient functions' soliton-like solutions is presented by a new general ansatz. Making use of the method, we consider the (2+1)-dimensional breaking soliton equation, ut + buxxy + 4buvx+4buxv = O,uv=vx, and obtain rich new families of the exact solutions of the breaking sofiton equation, including then on-traveilin~ wave and constant function sofiton-like solutions, singular soliton-like solutions, and triangular function solutions.展开更多
In this work, we reveal a novel phenomenon that the localized coherent structures of some (2+1)-dimensional physical models possess chaotic and fractal behaviors. To clarify these interesting phenomena, we take the (...In this work, we reveal a novel phenomenon that the localized coherent structures of some (2+1)-dimensional physical models possess chaotic and fractal behaviors. To clarify these interesting phenomena, we take the (2+l)-dimensional modified dispersive water-wave system as a concrete example. Starting from a variable separation approach,a general variable separation solution of this system is derived. Besides the stable located coherent soliton excitations like dromions, lumps, rings, peakons, and oscillating soliton excitations, some new excitations with chaotic and fractal behaviors are derived by introducing some types of lower dimensional chaotic and fractal patterns.展开更多
A new algorithm for symbolic computation of polynomial-type conserved densities for nonlinear evolution systems is presented. The algorithm is implemented in Maple. The improved algorithm is more efficient not only in...A new algorithm for symbolic computation of polynomial-type conserved densities for nonlinear evolution systems is presented. The algorithm is implemented in Maple. The improved algorithm is more efficient not only in removing the redundant terms of the genera/form of the conserved densities but also in solving the conserved densities with the associated flux synchronously without using Euler operator. Furthermore, the program conslaw.mpl can be used to determine the preferences for a given parameterized nonlinear evolution systems. The code is tested on several well-known nonlinear evolution equations from the soliton theory.展开更多
文摘Docetaxel-based combination chemotherapy remains the predominant treatment for castration-resistant prostate cancer. However, taxane-related drug resistance and neurotoxicity have prompted us to develop substitute treatment strategies. Eg5 （kinesin spindle protein）, which is crucial for bipolar spindle formation and duplicated chromosome separation during the early phase of mitosis, has emerged as an attractive target for cancer chemotherapy. The aim of this study was to investigate the anticancer efficacy of $-（methoxytrityl）-L-cysteine （S（MeO）TLC）, a novel Eg5 inhibitor in prostate cancer. Eg5 expression was examined in human prostate cancer cell lines and tissue microarrays were constructed from clinical specimens. Antiproliferative activity of S（MeO）TLC in prostate cancer cells was assessed by a cell viability assay. The anticancer effect and inhibitory mechanism of S（MeO）TLC in prostate cancer cells was further explored by Hoechst staining, flow cytometry and immunofluorescence. In addition, the antitumor effect of S（MeO）TLC on subcutaneous xenograft models was assessed. Eg5 expression was identified in PC3, DU145 and LNCaP cells. More than half of prostate cancer clinical specimens displayed Eg5 expression. S（Me0）TLC exhibited more powerful anticancer activity in prostate cancer cells compared with the other four Eg5 inhibitors tested. S（MeO）TLC induced cell death after arresting dividing cells at mitosis with distinct monopolar spindle formation. S（MeO）TLC exhibited its significant inhibitory activity （P〈0.05） on subcutaneous xenograft models also through induction of mitotic arrest. We conclude that Eg5 is a good target for prostate cancer chemotherapy, and S（MeO）TLC is a potent promising anticancer agent in prostate cancer.
基金The project supported by National Natural Science Foundation of China under Grant No. 10272071, the Natural Science Foundation of Zhejiang Province under Grant No. Y604106, and the Key Academic Discipline of Zhejiang Province under Grant No. 200412.The authors are in debt to Prof. J.F. Zhang and Dr. W.H. Huang for their helpful suggestions and fruitful discussions.
文摘For a higher-dimensional integrable nonlinear dynamical system, there are abundant coherent soliton excitations. With the aid of an improved projective Riccati equation approach, the paper obtains several types of exact solutions to the （2＋l）-dimenslonal dispersive long-wave equation, including multiple-soliton solutions, periodic soliton solutions, and Weierstrass function solutions. From these solutions, apart from several multisoliton excitations, we derive some novel features of wave structures by introducing some types of lower-dimensional patterns.
基金The project supported by National Natural Science Foundation of China and the Natural Science Foundation of Shandong Province of China
文摘In this paper, based on new auxiliary nonlinear ordinary differential equation with a sixtb-aegree nonnneal term, we study the （2＋l ）-dimensional Davey-Stewartson equation and new types of travelling wave solutions are obtained, which include new bell and kink profile solitary wave solutions, triangular periodic wave solutions, and singular solutions. The method used here can be also extended to many other nonlinear partial differential equations.
文摘Based on the computerized symbolic system Mapte, a new generalized expansion method of Riccati equation for constructing non-travelling wave and coefficient functions' soliton-like solutions is presented by a new general ansatz. Making use of the method, we consider the (2+1)-dimensional breaking soliton equation, ut + buxxy + 4buvx+4buxv = O,uv=vx, and obtain rich new families of the exact solutions of the breaking sofiton equation, including then on-traveilin~ wave and constant function sofiton-like solutions, singular soliton-like solutions, and triangular function solutions.
文摘In this work, we reveal a novel phenomenon that the localized coherent structures of some (2+1)-dimensional physical models possess chaotic and fractal behaviors. To clarify these interesting phenomena, we take the (2+l)-dimensional modified dispersive water-wave system as a concrete example. Starting from a variable separation approach,a general variable separation solution of this system is derived. Besides the stable located coherent soliton excitations like dromions, lumps, rings, peakons, and oscillating soliton excitations, some new excitations with chaotic and fractal behaviors are derived by introducing some types of lower dimensional chaotic and fractal patterns.
文摘A new algorithm for symbolic computation of polynomial-type conserved densities for nonlinear evolution systems is presented. The algorithm is implemented in Maple. The improved algorithm is more efficient not only in removing the redundant terms of the genera/form of the conserved densities but also in solving the conserved densities with the associated flux synchronously without using Euler operator. Furthermore, the program conslaw.mpl can be used to determine the preferences for a given parameterized nonlinear evolution systems. The code is tested on several well-known nonlinear evolution equations from the soliton theory.
