AIM： To study the influence of frontalis muscle flap suspension on ocular surface by analyzing the clinical features and inflammatory cytokines.METHODS： A prospective, observational case series. Thirty-one eyes of 2...AIM： To study the influence of frontalis muscle flap suspension on ocular surface by analyzing the clinical features and inflammatory cytokines.METHODS： A prospective, observational case series. Thirty-one eyes of 25 patients with severe congenital blepharoptosis who underwent frontalis muscle flap suspension surgery with at least 6 mo of follow-up were included in the study. The main outcome measures were margin reflex distance 1（MRD_1）, degree of lagophthalmos, ocular surface disease index（OSDI）, fluorescein staining（Fl）, tear break-up time（BUT）, Schirmer I test, and inflammatory cytokine assay.RESULTS： The degrees of lagophthalmos significantly increased after surgery. The OSDI scores significantly increased 1wk postoperatively and then decreased 4wk after operation. The Fl scores reflected corneal epithelial defects in sixteen patients at early stage postoperatively. The BUT and Schirmer I test values remained stable and did not show change compared to those before surgery. The inflammatory cytokines in conjunctival epithelial cells（including IL-1β, IL-6, IL-8, TNF-α, and IL-17A） significantly increased 1wk after the surgery（P〈0.001）, then returned to the normal level at 24wk postoperatively. The levels of inflammatory cytokine IL-1β, IL-6, IL-8, TNF-α, and IL-17A elevated significantly and were positively correlated with OSDI and Fl scores.CONCLUSION： Frontalis muscle flap suspension surgery results in lagophthalmos in early period of post-operation and relieved after months. The elevation of inflammatory cytokines level may participate in the occurrence of corneal epithelial defects at the early postoperative stage.展开更多
目的:比较额肌瓣悬吊术与提上睑肌缩短术治疗重度上睑下垂患儿的临床疗效。方法:选取2015年5月-2018年5月笔者医院收治的重度上睑下垂患儿104例(157眼),根据手术方式的不同将所有患儿分为额肌瓣悬吊组(n=52例,73眼,采用额肌瓣悬吊术)和...目的:比较额肌瓣悬吊术与提上睑肌缩短术治疗重度上睑下垂患儿的临床疗效。方法:选取2015年5月-2018年5月笔者医院收治的重度上睑下垂患儿104例(157眼),根据手术方式的不同将所有患儿分为额肌瓣悬吊组(n=52例,73眼,采用额肌瓣悬吊术)和提上睑肌缩短组(n=52例,84眼,采用提上睑肌缩短术),比较两组患者临床疗效,泪膜破裂时间(Breakup time of tear film,BUT)、泪液分泌试验(Schirmer test,SIt)、角膜荧光染色(Fluorescent staining,FL)检查结果,观察两组患者术后并发症发生情况。结果:提上睑肌缩短组患者术后临床总有效率为92.86%(78/84)显著高于额肌瓣悬吊组的82.19%(60/73),差异有统计学意义(P<0.05)。两组患者术后7d、术后1个月FL高于术前(P<0.05),两组患者术后3个月FL与术前比较差异无统计学意义(P>0.05);提上睑肌缩短组术后7d、术后1个月、术后3个月SIt、FL与额肌瓣悬吊组比较差异无统计学意义(P>0.05);提上睑肌缩短组术后7dBUT低于额肌瓣悬吊组(P<0.05),而提上睑肌缩短组术后1个月、术后3个月BUT与额肌瓣悬吊组比较差异无统计学意义(P>0.05)。额肌瓣悬吊组并发症发生率为8.22%(6/73),提上睑肌缩短组为3.57%(3/84),差异无统计学意义(P>0.05)。结论:与额肌瓣悬吊术相比,提上睑肌缩短术治疗重度上睑下垂患儿的疗效更为确切,且安全性与其相当,临床可考虑将提上睑肌缩短术作为治疗重度上睑下垂患儿的首选术式。展开更多
基金Supported by the National Natural Science Foundation of China(No.81670823)
文摘AIM： To study the influence of frontalis muscle flap suspension on ocular surface by analyzing the clinical features and inflammatory cytokines.METHODS： A prospective, observational case series. Thirty-one eyes of 25 patients with severe congenital blepharoptosis who underwent frontalis muscle flap suspension surgery with at least 6 mo of follow-up were included in the study. The main outcome measures were margin reflex distance 1（MRD_1）, degree of lagophthalmos, ocular surface disease index（OSDI）, fluorescein staining（Fl）, tear break-up time（BUT）, Schirmer I test, and inflammatory cytokine assay.RESULTS： The degrees of lagophthalmos significantly increased after surgery. The OSDI scores significantly increased 1wk postoperatively and then decreased 4wk after operation. The Fl scores reflected corneal epithelial defects in sixteen patients at early stage postoperatively. The BUT and Schirmer I test values remained stable and did not show change compared to those before surgery. The inflammatory cytokines in conjunctival epithelial cells（including IL-1β, IL-6, IL-8, TNF-α, and IL-17A） significantly increased 1wk after the surgery（P〈0.001）, then returned to the normal level at 24wk postoperatively. The levels of inflammatory cytokine IL-1β, IL-6, IL-8, TNF-α, and IL-17A elevated significantly and were positively correlated with OSDI and Fl scores.CONCLUSION： Frontalis muscle flap suspension surgery results in lagophthalmos in early period of post-operation and relieved after months. The elevation of inflammatory cytokines level may participate in the occurrence of corneal epithelial defects at the early postoperative stage.
文摘目的:比较额肌瓣悬吊术与提上睑肌缩短术治疗重度上睑下垂患儿的临床疗效。方法:选取2015年5月-2018年5月笔者医院收治的重度上睑下垂患儿104例(157眼),根据手术方式的不同将所有患儿分为额肌瓣悬吊组(n=52例,73眼,采用额肌瓣悬吊术)和提上睑肌缩短组(n=52例,84眼,采用提上睑肌缩短术),比较两组患者临床疗效,泪膜破裂时间(Breakup time of tear film,BUT)、泪液分泌试验(Schirmer test,SIt)、角膜荧光染色(Fluorescent staining,FL)检查结果,观察两组患者术后并发症发生情况。结果:提上睑肌缩短组患者术后临床总有效率为92.86%(78/84)显著高于额肌瓣悬吊组的82.19%(60/73),差异有统计学意义(P<0.05)。两组患者术后7d、术后1个月FL高于术前(P<0.05),两组患者术后3个月FL与术前比较差异无统计学意义(P>0.05);提上睑肌缩短组术后7d、术后1个月、术后3个月SIt、FL与额肌瓣悬吊组比较差异无统计学意义(P>0.05);提上睑肌缩短组术后7dBUT低于额肌瓣悬吊组(P<0.05),而提上睑肌缩短组术后1个月、术后3个月BUT与额肌瓣悬吊组比较差异无统计学意义(P>0.05)。额肌瓣悬吊组并发症发生率为8.22%(6/73),提上睑肌缩短组为3.57%(3/84),差异无统计学意义(P>0.05)。结论:与额肌瓣悬吊术相比,提上睑肌缩短术治疗重度上睑下垂患儿的疗效更为确切,且安全性与其相当,临床可考虑将提上睑肌缩短术作为治疗重度上睑下垂患儿的首选术式。
