L1A(first language acquisition)is expected to shed light on the L2(second language)teaching.However,how far L1A correlates with second language teaching is an argument that never ends.Hence,the hypotheses on L1A and i...L1A(first language acquisition)is expected to shed light on the L2(second language)teaching.However,how far L1A correlates with second language teaching is an argument that never ends.Hence,the hypotheses on L1A and its connection with L2 Teaching are analyzed,along with a discussion on the relationship between L1A,L2A and L2 Teaching.The limitation of L1A to L2T is elaborated from the aspect of literacy,age and time distinction.展开更多
Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life ...Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.展开更多
Native language plays an important role in foreign language learning,especially when the learners are beginners.This report examines(i)the most likely factors that affects A1 language learners’reliance on their nativ...Native language plays an important role in foreign language learning,especially when the learners are beginners.This report examines(i)the most likely factors that affects A1 language learners’reliance on their native and(ii)the overt,negative transfer of native language in A1 language learning in phonetic and morphological domains,with specific look into Chinese Mandarin’s influences on A1 English learners.It concludes that the most likely factor affecting A1 language learners’reliance on their native language is low proficiency and that negative native transfer affects can be found in all areas of linguistics,particularly in the domains of phonology and morphology.展开更多
This study aims at investigating the effect of using L 1 （Arabic Language） while teaching a target language （English Language） on the achievement in General English of foundation year students in King Abdulaziz Un...This study aims at investigating the effect of using L 1 （Arabic Language） while teaching a target language （English Language） on the achievement in General English of foundation year students in King Abdulaziz University. To achieve the purpose of the study, the researcher used an experimental design： an experimental group and a control group. The independent variable is using L1 while teaching English in very limited and specified areas. The dependent variable is students＇ achievement in general English. The statistics used is the t-test. The population of the study was all students enrolled in the foundation year 1431/1432 in the ELI （English Language Institute） at King Abdulaziz University. The sample of the study consisted of 50 students taking North Star in the sections A and B as a university requirement in the foundation year 1431/1432 in King Abdulaziz University. The results of the study were in favor of banning Arabic in the English language classroom as shown in the mean scores of the control and experimental groups in the tables. It is recommended that teachers and instructors should be trained to use teaching strategies that help them use English only in the English language classroom.展开更多
＂Monitor Model＂ explains the process and its situation from five different parts： the acquisition/learning,monitor, natural order, input, and affective filter. The Input Hypothesis, as one part of＂Monitor Model＂ ...＂Monitor Model＂ explains the process and its situation from five different parts： the acquisition/learning,monitor, natural order, input, and affective filter. The Input Hypothesis, as one part of＂Monitor Model＂ proposedby Stephen D. Krashen, suggests that the comprehensible input plays a key role in the language acquisition.Nowadays, the Input Hypothesis, with ＂i＋l＂ as its core proposal, influences Chinese foreign language teachingfrom various aspects. But there are also many disputes. In this paper, the author intends to elaborate on its maincontents, characteristics, influences on foreign language teaching, existing defects, and so on, aiming to achieve thegoal of reviewing of this theory and its influence in China.展开更多
The role of the native language in second language acquisition has long been a hotly debated issue in the area of SLA.Variousstudies on the subject are reviewed and controversial views are examined in the paper,referr...The role of the native language in second language acquisition has long been a hotly debated issue in the area of SLA.Variousstudies on the subject are reviewed and controversial views are examined in the paper,referring to Behaviorism,Contrastive Analysis Hy-pothesis,Error Analysis Hypothesis,Creative Construction Hypothesis,Common Underlying Proficiency Hypothesis,and MarkednessTheory,etc.,so as to provide a more comprehensive and deeper analysis of the role L1 plays in L2 acquisition.展开更多
To uncover how different backgrounds influence teacher beliefs,a multiple case study was done to three pre-service and three in-service EFL teachers through semi-structured interviews.The results show that pre-service...To uncover how different backgrounds influence teacher beliefs,a multiple case study was done to three pre-service and three in-service EFL teachers through semi-structured interviews.The results show that pre-service and in-service teachers hold a general belief that while English exposure is important,the use of Chinese as the L1 is complementary.Nonetheless,teachers’rationale reflects influence from prior learning experience,teacher education and classroom practice.The findings provide implications for career development of EFL teachers.展开更多
Throughout decades of foreign language(L2) teaching,a recurring issue has been the role of the first language(L1) in the classroom.A long-term and wide-ranging debate persists regarding practical and theoretical quest...Throughout decades of foreign language(L2) teaching,a recurring issue has been the role of the first language(L1) in the classroom.A long-term and wide-ranging debate persists regarding practical and theoretical questions about the significance of the L1’ s obvious influence on the L2 being learned.Although many feel that the L1 should not be used in the classroom,other researchers, teachers,and learners do see a role for the L1 and support its use as a communication strategy and instructional tool.This article will look at the historical background of this topic,and describe how the L1 is currently being used in the L2 classroom,including in written translation activities.A specific explanation will also be given about the benefits of using translation for assessing reading comprehension.展开更多
lin-12-like抑制/增强子(suppressor/enhancer of lin-12-like,SEL1L)分子可以参与调控多种肿瘤进展;同时,其作为内质网相关降解途径(endoplasmic reticulum-associated degradation,ERAD)的重要组成,还参与调控蛋白质合成,与内质网应激...lin-12-like抑制/增强子(suppressor/enhancer of lin-12-like,SEL1L)分子可以参与调控多种肿瘤进展;同时,其作为内质网相关降解途径(endoplasmic reticulum-associated degradation,ERAD)的重要组成,还参与调控蛋白质合成,与内质网应激(ER stress)及其引起的未折叠蛋白反应(unfolded protein response,UPR)密切相关。在肿瘤微环境中,ERAD不仅参与调控肿瘤细胞的生物学行为,对肿瘤进展发挥重要作用;其还参与对免疫细胞增殖分化、功能以及代谢途径的调节,影响免疫细胞发挥抗肿瘤免疫作用。因此,深入了解探索肿瘤微环境中SEL1L分子及ERAD的潜在机制,可为肿瘤发生、发展及免疫治疗提供新理论和新靶点。本文就SEL1L分子及其参与的内质网相关降解途径在肿瘤进展与免疫调节中的作用进行简要综述。展开更多
The target of much language teaching and learning is to make students approximate to native speakers.The only rightful speak ers of a language are its native speakers.Contrary to these contemporary views,however,this ...The target of much language teaching and learning is to make students approximate to native speakers.The only rightful speak ers of a language are its native speakers.Contrary to these contemporary views,however,this paper argues that the obligation of the lan guage teacher is to help students to use L2 effectively not to simply imitate native speaker.A successful L2 user who comes from the group of L2 learners can be a model for students.Therefore,non-native teachers with a high degree of language proficiency and good teaching skills can be ideal and qualified language teachers.展开更多
文摘L1A(first language acquisition)is expected to shed light on the L2(second language)teaching.However,how far L1A correlates with second language teaching is an argument that never ends.Hence,the hypotheses on L1A and its connection with L2 Teaching are analyzed,along with a discussion on the relationship between L1A,L2A and L2 Teaching.The limitation of L1A to L2T is elaborated from the aspect of literacy,age and time distinction.
基金supported by the National Natural Science Foundation of China,Nos.81730033,82171193(to XG)the Key Talent Project for Strengthening Health during the 13^(th)Five-Year Plan Period,No.ZDRCA2016069(to XG)+1 种基金the National Key R&D Program of China,No.2018YFC2001901(to XG)Jiangsu Provincial Medical Key Discipline,No.ZDXK202232(to XG)。
文摘Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.
文摘Native language plays an important role in foreign language learning,especially when the learners are beginners.This report examines(i)the most likely factors that affects A1 language learners’reliance on their native and(ii)the overt,negative transfer of native language in A1 language learning in phonetic and morphological domains,with specific look into Chinese Mandarin’s influences on A1 English learners.It concludes that the most likely factor affecting A1 language learners’reliance on their native language is low proficiency and that negative native transfer affects can be found in all areas of linguistics,particularly in the domains of phonology and morphology.
文摘This study aims at investigating the effect of using L 1 （Arabic Language） while teaching a target language （English Language） on the achievement in General English of foundation year students in King Abdulaziz University. To achieve the purpose of the study, the researcher used an experimental design： an experimental group and a control group. The independent variable is using L1 while teaching English in very limited and specified areas. The dependent variable is students＇ achievement in general English. The statistics used is the t-test. The population of the study was all students enrolled in the foundation year 1431/1432 in the ELI （English Language Institute） at King Abdulaziz University. The sample of the study consisted of 50 students taking North Star in the sections A and B as a university requirement in the foundation year 1431/1432 in King Abdulaziz University. The results of the study were in favor of banning Arabic in the English language classroom as shown in the mean scores of the control and experimental groups in the tables. It is recommended that teachers and instructors should be trained to use teaching strategies that help them use English only in the English language classroom.
文摘＂Monitor Model＂ explains the process and its situation from five different parts： the acquisition/learning,monitor, natural order, input, and affective filter. The Input Hypothesis, as one part of＂Monitor Model＂ proposedby Stephen D. Krashen, suggests that the comprehensible input plays a key role in the language acquisition.Nowadays, the Input Hypothesis, with ＂i＋l＂ as its core proposal, influences Chinese foreign language teachingfrom various aspects. But there are also many disputes. In this paper, the author intends to elaborate on its maincontents, characteristics, influences on foreign language teaching, existing defects, and so on, aiming to achieve thegoal of reviewing of this theory and its influence in China.
文摘The role of the native language in second language acquisition has long been a hotly debated issue in the area of SLA.Variousstudies on the subject are reviewed and controversial views are examined in the paper,referring to Behaviorism,Contrastive Analysis Hy-pothesis,Error Analysis Hypothesis,Creative Construction Hypothesis,Common Underlying Proficiency Hypothesis,and MarkednessTheory,etc.,so as to provide a more comprehensive and deeper analysis of the role L1 plays in L2 acquisition.
文摘To uncover how different backgrounds influence teacher beliefs,a multiple case study was done to three pre-service and three in-service EFL teachers through semi-structured interviews.The results show that pre-service and in-service teachers hold a general belief that while English exposure is important,the use of Chinese as the L1 is complementary.Nonetheless,teachers’rationale reflects influence from prior learning experience,teacher education and classroom practice.The findings provide implications for career development of EFL teachers.
文摘Throughout decades of foreign language(L2) teaching,a recurring issue has been the role of the first language(L1) in the classroom.A long-term and wide-ranging debate persists regarding practical and theoretical questions about the significance of the L1’ s obvious influence on the L2 being learned.Although many feel that the L1 should not be used in the classroom,other researchers, teachers,and learners do see a role for the L1 and support its use as a communication strategy and instructional tool.This article will look at the historical background of this topic,and describe how the L1 is currently being used in the L2 classroom,including in written translation activities.A specific explanation will also be given about the benefits of using translation for assessing reading comprehension.
文摘lin-12-like抑制/增强子(suppressor/enhancer of lin-12-like,SEL1L)分子可以参与调控多种肿瘤进展;同时,其作为内质网相关降解途径(endoplasmic reticulum-associated degradation,ERAD)的重要组成,还参与调控蛋白质合成,与内质网应激(ER stress)及其引起的未折叠蛋白反应(unfolded protein response,UPR)密切相关。在肿瘤微环境中,ERAD不仅参与调控肿瘤细胞的生物学行为,对肿瘤进展发挥重要作用;其还参与对免疫细胞增殖分化、功能以及代谢途径的调节,影响免疫细胞发挥抗肿瘤免疫作用。因此,深入了解探索肿瘤微环境中SEL1L分子及ERAD的潜在机制,可为肿瘤发生、发展及免疫治疗提供新理论和新靶点。本文就SEL1L分子及其参与的内质网相关降解途径在肿瘤进展与免疫调节中的作用进行简要综述。
文摘The target of much language teaching and learning is to make students approximate to native speakers.The only rightful speak ers of a language are its native speakers.Contrary to these contemporary views,however,this paper argues that the obligation of the lan guage teacher is to help students to use L2 effectively not to simply imitate native speaker.A successful L2 user who comes from the group of L2 learners can be a model for students.Therefore,non-native teachers with a high degree of language proficiency and good teaching skills can be ideal and qualified language teachers.
