This paper examines the stability of the transition from the early decelerating stage of the Universe to the recent accelerating stage for the perfect fluid cosmological locally rotationally symmetric(LRS) Bianchi-I m...This paper examines the stability of the transition from the early decelerating stage of the Universe to the recent accelerating stage for the perfect fluid cosmological locally rotationally symmetric(LRS) Bianchi-I model in f(R, T) theory. To determine the solution of field equations, the idea of a timevarying deceleration parameter(DP) which yields a scale factor, for which the Universe attains a phase transition scenario and is consistent with recent cosmological observations, is used. The time-dependent DP yields a scale factor a=exp■, where β and k are respectively arbitrary and integration constants. By using the recent cons_traints(H_0 _= 73.8, and q_0 =-0.54) from Type Ia Supernova(SN Ia) data in combination with Baryonic Acoustic Oscillations(BAO) and Cosmic Microwave Background(CMB) observations(Giostri et al.), we obtain the values of β = 0.0062 and k = 0.000016 for which we have derived a cosmological model from the early decelerated phase to the present accelerating phase. By applying_ other r_ecent constraints(H_0 = 73.8, q_0 =-0.73) from SNe Ia Union data(Cunha), we obtain the values of β = 0.0036 and k = 0.000084 for which we have derived a cosmological model in the accelerating phase only. We have compared both models with experimental data. The stability of the background solution has been examined also for the metric perturbations alongside the properties of future singularities in a Universe ruled by dark energy with phantom type fluid. We demonstrate the presence of a stable fixed point with a condition of state ω <-1 and numerically affirm this is really a late-time attractor in the ghost overwhelmed Universe. Some physical and geometric properties of the model are found and examined.展开更多
The exact solutions of the Einstein field equations for dark energy (DE) in Locally Rotationally Symmetric (LRS) Bianchi type-I metric under the assumption on the anisotropy of the fluid are obtained for exponential v...The exact solutions of the Einstein field equations for dark energy (DE) in Locally Rotationally Symmetric (LRS) Bianchi type-I metric under the assumption on the anisotropy of the fluid are obtained for exponential volumetric expansion within the frame work of Lyra manifold for uniform and time varying displacement field. The isotropy of the fluid and space is examined.展开更多
We have studied Locally Rotationally Symmetric (LRS) Bianchi type-I cosmological model filled with anisotropic fluid in general theory of relativity. The solutions of the field equations are obtained by using special ...We have studied Locally Rotationally Symmetric (LRS) Bianchi type-I cosmological model filled with anisotropic fluid in general theory of relativity. The solutions of the field equations are obtained by using special form of deceleration parameter which gives early deceleration and late time accelerating cosmological model. The geometrical and physical aspect of the model is also studied.展开更多
目的探讨长链非编码RNA(lncRNA)-N1LR在脑缺血再灌注损伤后血脑屏障的作用机制。方法原代小鼠脑微血管内皮细胞常规培养,经氧糖剥夺/复糖复氧(OGD/R)处理模拟脑缺血再灌注损伤,实验分对照组、OGD组、lncRNA-N1LR过表达组(OGD处理后转染...目的探讨长链非编码RNA(lncRNA)-N1LR在脑缺血再灌注损伤后血脑屏障的作用机制。方法原代小鼠脑微血管内皮细胞常规培养,经氧糖剥夺/复糖复氧(OGD/R)处理模拟脑缺血再灌注损伤,实验分对照组、OGD组、lncRNA-N1LR过表达组(OGD处理后转染质粒lncRNA-N1LR过表达)、lncRNA-N1LR沉默组(OGD处理后转染质粒lncRNA-N1LR沉默)。采用逆转录聚合酶链反应检测各组中lncRNA-N1LR mRNA、紧密连接蛋白5(claudin-5)及闭合蛋白(occludin)mRNA表达水平;异硫氰酸荧光素-葡聚糖(FITC-dextran)渗透法检测血脑屏障通透性;免疫蛋白印迹法检测claudin-5、occludin蛋白表达。结果与对照组比较,OGD组lncRNA-N1LR mRNA、occludin、claudin-5 mRNA表达水平下降(0.31±0.01 vs 1.00±0.10,0.42±0.03 vs 1.01±0.13,0.38±0.03 vs 1.00±0.15,P<0.05),血脑屏障FITC-dextran通透性明显升高(58.79±3.04 vs 8.87±0.63,P<0.01)。与OGD组比较,lncRNA-N1LR过表达组lncRNA-N1LR mRNA、occludin、claudin-5 mRNA表达水平升高(0.67±0.07 vs 0.31±0.01,0.92±0.02 vs 0.42±0.03,0.70±0.08 vs 0.38±0.03,P<0.05),血脑屏障FITC-dextran通透性降低(41.57±2.43 vs 58.79±3.04,P<0.05)。与OGD组比较,lncRNA-N1LR沉默组lncRNA-N1LR mRNA、occludin、claudin-5 mRNA表达水平降低(0.21±0.02 vs 0.31±0.01,0.31±0.03 vs 0.42±0.03,0.22±0.02 vs 0.38±0.03,P<0.05),血脑屏障FITC-dextran通透性升高(72.34±1.43 vs 58.79±3.04,P<0.05)。结论LncRNA-N1LR上调可能通过降低血脑屏障通透性发挥神经保护作用。展开更多
Second-generation high-temperature superconducting(HTS)conductors,specifically rare earth-barium-copper-oxide(REBCO)coated conductor(CC)tapes,are promising candidates for high-energy and high-field superconducting app...Second-generation high-temperature superconducting(HTS)conductors,specifically rare earth-barium-copper-oxide(REBCO)coated conductor(CC)tapes,are promising candidates for high-energy and high-field superconducting applications.With respect to epoxy-impregnated REBCO composite magnets that comprise multilayer components,the thermomechanical characteristics of each component differ considerably under extremely low temperatures and strong electromagnetic fields.Traditional numerical models include homogenized orthotropic models,which simplify overall field calculation but miss detailed multi-physics aspects,and full refinement(FR)ones that are thorough but computationally demanding.Herein,we propose an extended multi-scale approach for analyzing the multi-field characteristics of an epoxy-impregnated composite magnet assembled by HTS pancake coils.This approach combines a global homogenization(GH)scheme based on the homogenized electromagnetic T-A model,a method for solving Maxwell's equations for superconducting materials based on the current vector potential T and the magnetic field vector potential A,and a homogenized orthotropic thermoelastic model to assess the electromagnetic and thermoelastic properties at the macroscopic scale.We then identify“dangerous regions”at the macroscopic scale and obtain finer details using a local refinement(LR)scheme to capture the responses of each component material in the HTS composite tapes at the mesoscopic scale.The results of the present GH-LR multi-scale approach agree well with those of the FR scheme and the experimental data in the literature,indicating that the present approach is accurate and efficient.The proposed GH-LR multi-scale approach can serve as a valuable tool for evaluating the risk of failure in large-scale HTS composite magnets.展开更多
In this note,we investigate conformal Killing vectors(CKVs)of locally rotationally symmetric(LRS)Bianchi type V spacetimes.Subject to some integrability conditions,CKVs up to implicit functions of(t,x)are obtained.Sol...In this note,we investigate conformal Killing vectors(CKVs)of locally rotationally symmetric(LRS)Bianchi type V spacetimes.Subject to some integrability conditions,CKVs up to implicit functions of(t,x)are obtained.Solving these integrability conditions in some particular cases,the CKVs are completely determined,obtaining a classification of LRS Bianchi type V spacetimes.The inheriting conformal Killing vectors of LRS Bianchi type V spacetimes are also discussed.展开更多
文摘This paper examines the stability of the transition from the early decelerating stage of the Universe to the recent accelerating stage for the perfect fluid cosmological locally rotationally symmetric(LRS) Bianchi-I model in f(R, T) theory. To determine the solution of field equations, the idea of a timevarying deceleration parameter(DP) which yields a scale factor, for which the Universe attains a phase transition scenario and is consistent with recent cosmological observations, is used. The time-dependent DP yields a scale factor a=exp■, where β and k are respectively arbitrary and integration constants. By using the recent cons_traints(H_0 _= 73.8, and q_0 =-0.54) from Type Ia Supernova(SN Ia) data in combination with Baryonic Acoustic Oscillations(BAO) and Cosmic Microwave Background(CMB) observations(Giostri et al.), we obtain the values of β = 0.0062 and k = 0.000016 for which we have derived a cosmological model from the early decelerated phase to the present accelerating phase. By applying_ other r_ecent constraints(H_0 = 73.8, q_0 =-0.73) from SNe Ia Union data(Cunha), we obtain the values of β = 0.0036 and k = 0.000084 for which we have derived a cosmological model in the accelerating phase only. We have compared both models with experimental data. The stability of the background solution has been examined also for the metric perturbations alongside the properties of future singularities in a Universe ruled by dark energy with phantom type fluid. We demonstrate the presence of a stable fixed point with a condition of state ω <-1 and numerically affirm this is really a late-time attractor in the ghost overwhelmed Universe. Some physical and geometric properties of the model are found and examined.
文摘The exact solutions of the Einstein field equations for dark energy (DE) in Locally Rotationally Symmetric (LRS) Bianchi type-I metric under the assumption on the anisotropy of the fluid are obtained for exponential volumetric expansion within the frame work of Lyra manifold for uniform and time varying displacement field. The isotropy of the fluid and space is examined.
文摘We have studied Locally Rotationally Symmetric (LRS) Bianchi type-I cosmological model filled with anisotropic fluid in general theory of relativity. The solutions of the field equations are obtained by using special form of deceleration parameter which gives early deceleration and late time accelerating cosmological model. The geometrical and physical aspect of the model is also studied.
文摘目的探讨长链非编码RNA(lncRNA)-N1LR在脑缺血再灌注损伤后血脑屏障的作用机制。方法原代小鼠脑微血管内皮细胞常规培养,经氧糖剥夺/复糖复氧(OGD/R)处理模拟脑缺血再灌注损伤,实验分对照组、OGD组、lncRNA-N1LR过表达组(OGD处理后转染质粒lncRNA-N1LR过表达)、lncRNA-N1LR沉默组(OGD处理后转染质粒lncRNA-N1LR沉默)。采用逆转录聚合酶链反应检测各组中lncRNA-N1LR mRNA、紧密连接蛋白5(claudin-5)及闭合蛋白(occludin)mRNA表达水平;异硫氰酸荧光素-葡聚糖(FITC-dextran)渗透法检测血脑屏障通透性;免疫蛋白印迹法检测claudin-5、occludin蛋白表达。结果与对照组比较,OGD组lncRNA-N1LR mRNA、occludin、claudin-5 mRNA表达水平下降(0.31±0.01 vs 1.00±0.10,0.42±0.03 vs 1.01±0.13,0.38±0.03 vs 1.00±0.15,P<0.05),血脑屏障FITC-dextran通透性明显升高(58.79±3.04 vs 8.87±0.63,P<0.01)。与OGD组比较,lncRNA-N1LR过表达组lncRNA-N1LR mRNA、occludin、claudin-5 mRNA表达水平升高(0.67±0.07 vs 0.31±0.01,0.92±0.02 vs 0.42±0.03,0.70±0.08 vs 0.38±0.03,P<0.05),血脑屏障FITC-dextran通透性降低(41.57±2.43 vs 58.79±3.04,P<0.05)。与OGD组比较,lncRNA-N1LR沉默组lncRNA-N1LR mRNA、occludin、claudin-5 mRNA表达水平降低(0.21±0.02 vs 0.31±0.01,0.31±0.03 vs 0.42±0.03,0.22±0.02 vs 0.38±0.03,P<0.05),血脑屏障FITC-dextran通透性升高(72.34±1.43 vs 58.79±3.04,P<0.05)。结论LncRNA-N1LR上调可能通过降低血脑屏障通透性发挥神经保护作用。
基金Project supported by the National Natural Science Foundation of China(Nos.11932008 and 12272156)the Fundamental Research Funds for the Central Universities(No.lzujbky-2022-kb06)+1 种基金the Gansu Science and Technology ProgramLanzhou City’s Scientific Research Funding Subsidy to Lanzhou University of China。
文摘Second-generation high-temperature superconducting(HTS)conductors,specifically rare earth-barium-copper-oxide(REBCO)coated conductor(CC)tapes,are promising candidates for high-energy and high-field superconducting applications.With respect to epoxy-impregnated REBCO composite magnets that comprise multilayer components,the thermomechanical characteristics of each component differ considerably under extremely low temperatures and strong electromagnetic fields.Traditional numerical models include homogenized orthotropic models,which simplify overall field calculation but miss detailed multi-physics aspects,and full refinement(FR)ones that are thorough but computationally demanding.Herein,we propose an extended multi-scale approach for analyzing the multi-field characteristics of an epoxy-impregnated composite magnet assembled by HTS pancake coils.This approach combines a global homogenization(GH)scheme based on the homogenized electromagnetic T-A model,a method for solving Maxwell's equations for superconducting materials based on the current vector potential T and the magnetic field vector potential A,and a homogenized orthotropic thermoelastic model to assess the electromagnetic and thermoelastic properties at the macroscopic scale.We then identify“dangerous regions”at the macroscopic scale and obtain finer details using a local refinement(LR)scheme to capture the responses of each component material in the HTS composite tapes at the mesoscopic scale.The results of the present GH-LR multi-scale approach agree well with those of the FR scheme and the experimental data in the literature,indicating that the present approach is accurate and efficient.The proposed GH-LR multi-scale approach can serve as a valuable tool for evaluating the risk of failure in large-scale HTS composite magnets.
文摘In this note,we investigate conformal Killing vectors(CKVs)of locally rotationally symmetric(LRS)Bianchi type V spacetimes.Subject to some integrability conditions,CKVs up to implicit functions of(t,x)are obtained.Solving these integrability conditions in some particular cases,the CKVs are completely determined,obtaining a classification of LRS Bianchi type V spacetimes.The inheriting conformal Killing vectors of LRS Bianchi type V spacetimes are also discussed.
