Th17/Treg、Th1/Th2联合NEWS2评分预测肺炎病情进展效能研究

目的研究辅助性T淋巴细胞17/调节性T淋巴细胞(Th17/Treg)、辅助性T淋巴细胞1/辅助性T淋巴细胞2(Th1/Th2)联合国家早期预警评分2(NEWS2)预测肺炎病情进展的效能。方法选取2020年4月—2023年3月收治的105例肺炎,根据病情进展情况分为未进展组、进展组,比较2组Th17/Treg、Th1/Th2、NEWS2评分,采用多因素Logistic回归分析建立多指标联合预测肺炎病情进展的模型,使用Stata 10.0软件确定最佳截断值及该位置的预测准确度,绘制受试者工作特征(ROC)曲线,用曲线下面积(AUC)评价各协变量及联合预测因子预测肺炎病情进展的效能。结果进展组Th17/Treg、NEWS2评分高于未进展组,Th1/Th2低于未进展组(P<0.01);Th17/Treg、NEWS2评分升高是肺炎病情进展的独立危险因素,Th1/Th2升高是肺炎病情进展的独立保护因素(P<0.01);将原始协变量拟合,生成新联合预测因子New-pre,其最佳截断值为0.102,此时预测准确率为97.00%;绘制ROC曲线显示,New-pre预测肺炎病情进展的AUC(0.916)高于Th17/Treg(0.704)、Th1/Th2(0.747)、NEWS2评分(0.819)(P<0.05)。结论肺炎病情进展患者Th17/Treg、NEWS2评分升高,Th1/Th2降低,三者联合可作为预测个体病情进展定量方案,可为临床治疗、病情进展评估提供参考依据。

表达外源基因SPAM1重组CAV-2溶瘤病毒的构建与拯救

旨在研究犬腺病毒-2型(canine adenovirus type 2,CAV-2)作为溶瘤病毒的潜力并进一步探索精子黏附因子(SPAM1)协同CAV-2重塑肿瘤微环境在肿瘤免疫治疗中的应用价值。本研究以P15A-CAV-2反向遗传操作平台为基础,使用RED/ET同源重组系统构建携带SPAM1外源基因的中间载体,使用中间载体将CAV-2骨架载体E3区域缺失并替换SPAM1外源基因表达盒。再利用合成引物敲除kmccdB反向筛选表达盒构建P15A-CAV-2-mCMV-SPAM1-SV40 polyA感染性克隆质粒并在MDCK-E1A细胞系中拯救重组溶瘤病毒,对重组病毒体外溶瘤效应进行验证。根据测序与酶切验证结果证明,本研究成功构建并拯救出稳定表达外源基因SPAM1的重组溶瘤病毒1株;IFA试验证明,重组毒株能够高水平稳定表达外源基因且外源蛋白具有可弥散分布于细胞间的特点。缺失E3区域表达外源基因SPAM1的重组溶瘤病毒通过光镜观察和CCK8检测发现具有对犬癌细胞系A72强烈的杀伤效应。综上,本研究成功构建1株具有良好溶瘤效应的重组CAV-2,为后续应用于宠物肿瘤治疗奠定了基础。

城镇生活污水处理厂A^(2)O工艺运行状态的快速判别

为解决现有城镇生活污水处理工艺运行状态判别不全面、不及时的问题,以A^(2)O工艺为例,对运行状态的判别方法进行了系统研究。提出了通过末端污染物监控指标、工艺参数、污水处理设施电耗、污泥排放量、设备运转状态判别工艺运行状态的思路,确定了工艺运行状态的常规和间接判别方法。在此基础上,以工艺运行参数、泥水性状指标、设备运行状态为切入点,分析了正常状态、异常现象、异常原因及故障解决措施的关联,设计了一款可以快速识别、分析故障的软件,为A^(2)O工艺运行状态的快速判别提供了一种可行的途径。

Superconducting joints using reacted multifilament MgB_(2)wires:A technology toward cryogen-free MRI magnets

The development of superconducting joining technology for reacted magnesium diboride(MgB_(2))conductors remains a critical challenge for the advancement of cryogen-free MgB_(2)-based magnets for magnetic resonance imaging(MRI).Herein,the fabrication of superconducting joints using reacted carbon-doped multifilament MgB_(2)wires for MRI magnets is reported.To achieve successful superconducting joints,the powder-in-mold method was employed,which involved tuning the filament protection mechanism,the powder compaction pressure,and the heat treatment condition.The fabricated joints demonstrated clear superconducting-to-normal transitions in self-field,with effective magnetic field screening up to 0.5 T at 20 K.To evaluate the interface between one of the MgB_(2)filaments and the MgB_(2)bulk within the joint,serial sectioning was conducted for the first time in this type of superconducting joint.The serial sectioning revealed space formation at the interface,potentially caused by the volume shrinkage associated with the MgB_(2)formation or the combined effect of the volume shrinkage and the different thermal expansion coefficients of the MgB_(2)bulk,the filament,the mold,and the sealing material.These findings are expected to be pivotal in developing MgB_(2)superconducting joining technology for MRI magnet applications through interface engineering.

钙离子在牙釉质矿化中的作用

牙釉质的矿化形成是一个信号分子贯穿始终的过程,釉质矿化通过细胞内多种离子与信号通道的紧密调节和上皮与间充质的相互作用,最终使牙釉质成为人体中矿化程度最高、最硬的组织。Ca^(2+)作为细胞内重要的第二信使分子,在生物矿化中调节许多过程,其中就包括调节釉质蛋白的表达。在牙釉质的基本结构羟基磷灰石晶体中,约含有60%质量的Ca^(2+),由此可见Ca^(2+)是牙釉质的关键和必需成分。因此,Ca^(2+)的正常转运在牙釉质矿化过程中起着关键作用。

面向任务的无人智能清扫车系统设计

近年来,自主清扫系统,例如机器人吸尘器,因其能够自主导航和清洁室内空间的能力,越来越受到社会的欢迎。然而,这些系统的应用仍受限于其清洁范围有限、无法适应各种环境等问题。本研究旨在解决这些局限性,通过提出一种基于ROS2框架的面向任务的智能清扫车系统。该系统利用ROS2的模块化、灵活性和进程间通信等优势,以增强清扫系统的性能和适应性。主要目标是开发一种能够高效、有效地清洁室内空间的系统。研究的关键步骤包括对自主清扫系统和ROS2的文献进行分析,设计和开发硬件架构,实现ROS2软件组件,以及对系统的性能进行严格的测试和评估。

钌铱电极与BDD电极处理以氯化钠为电解质的染料废水的对比研究

本文以钌铱电极和BDD电极为研究对象,以氯化钠为电解质,考察了两种电极对染料废水中难降解有机物的去除差异,研究电流密度、pH值和氯化钠浓度对染料去除的影响,探究染料降解过程中的自由基贡献。结果表明:钌铱电极和BDD电极均能有效去除染料,但BDD电极的效率更高。最适宜的去除条件为电流密度为10mA/cm^(2)、pH值为5和氯化钠浓度为2g/L,此条件下反应速率常数可达2.964min^(-1)。·OH被证实对污染物的去除贡献最大。

国外某油田玻璃钢管道失效原因分析

国外某油田用于输送水源井水的玻璃钢管道频繁失效泄漏,对油田的正常生产造成严重影响。通过对玻璃钢管道施工安装质量、管道制造质量、水源井运行工况及流体介质组成等因素逐项分析,推断玻璃钢失效的主要原因是水源井水中含有的酸性物质对玻璃钢管材的环氧树脂具有腐蚀作用、井水的伴生气所含CO_(2)对玻璃钢发生化学及物理腐蚀造成的,同时,井水实际温度高于设计温度加速了玻璃钢的老化失效。结合以上原因,建议的解决措施为根据最新分析化验的水源井水的组分及运行参数,优化玻璃钢的原材料类型,开发出耐高温、耐酸及耐CO_(2)腐蚀的新型玻璃钢管道。

基于六偏磷酸钠-Fe^(2+)的铁盐脱氮反应器运行性能及微生物学特征研究

以实验室高效反硝化反应器中的反硝化污泥作为接种污泥,启动自养型六偏磷酸钠-Fe^(2+)脱氮反应器,试验采用模拟废水通过88 d的不间断运行,研究了铁盐脱氮工艺的脱氮效能及其微生物学特性。结果表明,当反应器硝态氮容积负荷为0.42 kg/(m^(3)·d)时,最高稳定氮去除负荷为0.41 kg/(m^(3)·d);当Fe^(2+)容积负荷为4.92 kg/(m^(3)·d)时,最大铁去除负荷为2.77 kg/(m^(3)·d)。反应器稳定运行时硝态氮、Fe^(2+)的去除率分别达94.6%、52.6%,最佳效能可维持28 d。反应器运行到第82天时,颗粒污泥由黄色变为灰褐色,颗粒解体,污泥比活性逐渐升高,比反硝化活性由0.71 mg[N]/(g[VSS]·h)升高到2.3 mg[N]/(g[VSS]·h),同比上升224%;比铁氧化活性由7.3 mg[Fe]/(g[VSS]·h)升高到15 mg[Fe]/(g[VSS]·h),同比上升105%。六偏磷酸钠-Fe^(2+)脱氮作为一种新型自养反硝化技术,不仅增强了活细菌的生物活性和反硝化活性,还延长了铁盐脱氮污泥反硝化的高效期。

GENERALIZED OPERATORS AND P(φ)_2 QUANTUM FIELDS

In this paper by Sobolev imbedding theorem and characterization theorem of generalized operators the existence of P(φ)2 quantum fields as generalized operators is obtained and a rigorous mathematical interpretation of renormalization procedure is given under white noise theory.

New 3-mode bosonic operator realization of SU(2) Lie algebra:From the point of view of squeezing

We consider the quantum mechanical SU（2） transformation e^2λJzJ±e^-2λJz = e^±2λJ±as if the meaning of squeezing with e^±2λ being squeezing parameter. By studying SU（2） operators （J±, Jz） from the point of view of squeezing we find that （J±,Jz） can also be realized in terms of 3-mode bosonic operators. Employing this realization, we find the natural representation （the eigenvectors of J＋ or J-） of the 3-mode squeezing operator e^2λJz. The idea of considering quantum SU（2） transformation as if squeezing is liable for us to obtain the new bosonic operator realization of SU（2） and new squeezing operators.

The two-mode quantum Fresnel operator and the multiplication rule of 2D Collins diffraction formula

By using the two-mode Fresnel operator we derive a multiplication rule of two-dimensional （2D） Collins diffraction formula, the inverse of 2D Collins diffraction integration can also be conveniently derived in this way in the context of quantum optics theory.

THE EXISTENCE AND BLOW-UP OF THE RADIAL SOLUTIONS OF A(k_(1),k_(2))-HESSIAN SYSTEM INVOLVING A NONLINEAR OPERATOR AND GRADIENT

In this paper,we are concerned with the existence of the positive bounded and blow-up radial solutions of the(k1,k2)-Hessian system■where G is a nonlinear operator,Ki=Ski(λ(D^(2) z_(i)))+ψ_(i)(|x|)|▽_(zi)|^(ki),i=1,2.Under the appropriate conditions on gi and g2,our main results are obtained by using the monotone iterative method and the Arzela-Ascoli theorem.Furthermore,our main results also extend the previous existence results for both the single equation and systems.

THE L^2-BOUNDEDNESS OF PSEUDODIFFERENTIAL OPERATORS WITH NONSMOOTH COEFFICIENT SYMBOLS

1. Introduction In application of nonlinear boundary value problems, it is sometimes important to know that L~2-boundedness of a class of pseudo-differential operators with symbols whioh have nonsmooth coefficients. In [2], Coifman and Meyer proved that the operator σ(x, D) is bounded in L~2(R~n) if its symbold (x, ξ) satisfies:

Eigenfunction expansion method of upper triangular operator matrixand application to two-dimensional elasticity problems based onstress formulation

This paper studies the eigenfunction expansion method to solve the two dimensional （2D） elasticity problems based on the stress formulation. The fundamental system of partial differential equations of the 2D problems is rewritten as an upper tri angular differential system based on the known results, and then the associated upper triangular operator matrix matrix is obtained. By further research, the two simpler com plete orthogonal systems of eigenfunctions in some space are obtained, which belong to the two block operators arising in the operator matrix. Then, a more simple and conve nient general solution to the 2D problem is given by the eigenfunction expansion method. Furthermore, the boundary conditions for the 2D problem, which can be solved by this method, are indicated. Finally, the validity of the obtained results is verified by a specific example.

Numerical Integration Based on Bivariate Quartic Quasi-Interpolation Operators

In this paper,we propose a method to deal with numerical integral by using two kinds of C^2 quasi-interpolation operators on the bivariate spline space,and also dis- cuss the convergence properties and error estimates.Moreover,the proposed method is applied to the numerical evaluation of 2-D singular integrals.Numerical exper- iments will be carried out and the results will be compared with some previously published results.

考虑工人能力和工时随机波动的装配线平衡研究

工人的能力差异和操作工时的随机波动是装配线平衡过程进行工位设计和人员分配的难题。针对工人能力有差异且工时具有波动特征的装配线平衡问题展开研究,依据工人的能力和成本差异将工人划分为不同的等级,并结合操作工时的随机波动特征,以最小化给定完工概率下的产线节拍和人工成本为目标构建装配线平衡模型,并运用非快速支配排序遗传算法(NSGA-2)设计模型求解算法,通过设计动态遗传参数、改进精英保留策略提升算法性能,最后结合某打印机装配线实际案例以及不同规模算例,验证了所构建模型和算法的有效性。

信号处理系统中RapidIO网络配置管理方法研究

随着航电系统一体化平台的发展,航电系统中的RapidIO多采用串行I/O和基于交换的拓扑结构。设计了一种基于RapidIO交换网络的信号处理系统,采用PowerPC8548E作为I^(2)C的主设备完成RapidIO交换设备的上电初始化,依据系统的RapidIO网络配置,利用RapidIO维护操作实现对网络上设备枚举和路由配置等功能。这种配置方法灵活,性能优良,不仅能满足系统的应用需求,同时使系统在可重构性、可扩展性、可维护性等性能指标上均获得了显著的改善。

填料塔中有机胺溶液脱除CO_(2)性能研究

在鲍尔环填料塔中,以有机胺溶液为吸收剂,脱除模拟烟气中的CO_(2)。考察了有机胺溶液质量分数、溶液pH、烟气流量、溶液喷淋量、入口CO_(2)体积分数、液气比、吸收温度及填料层高度等关键参数对CO_(2)脱除率的影响。结果表明,CO_(2)脱除率随有机胺溶液质量分数、溶液pH、溶液喷淋量、液气比及填料层高度的增加而增大,随烟气流量和入口CO_(2)体积分数的增大而减小,随吸收温度的升高先增大后减小。在有机胺溶液质量分数为20%,溶液pH为11.0,烟气流量为2.5 m^(3)/h,溶液喷淋量为9 L/h,入口CO_(2)体积分数为8%,液气比为3.6~4.8 L/m^(3),吸收温度为30℃,填料高度为1.70 m的条件下,CO_(2)脱除率超过90%。本研究成果可为有机胺溶液脱除CO_(2)的工业应用提供数据支撑。