40 human endometrial tissues of benign diseases were diviided into 8 groups (phases),and 50 BDF1 mousy endometrial tissues were divided into 5 groups (phases).Immunohistochenical staining was performed to show the PCN...40 human endometrial tissues of benign diseases were diviided into 8 groups (phases),and 50 BDF1 mousy endometrial tissues were divided into 5 groups (phases).Immunohistochenical staining was performed to show the PCNA (proliferating cell nuclear antigen)positive cell .In human ,the results suggested that the PCNA layer(48%)of mid-proliferative hpase.The PCNA labelled index was low in superficial epithelium.But in mouse, the results suggested that the Pcna labelled index was the highest(22%)in endometrium of estrus and the labelled cells were distributed mainly in superficial epithelium (60%).The results suggested that times that times and positions of cellular proliferation in endometrial tissues of human and mouse differed greatly.展开更多
Objective： To get better recognition of central neurocytoma and diminish misdiagnosis. Methods： A retrospective review identified 15 cases of central neurocytoma. All cases of central neurocytoma were analyzed for t...Objective： To get better recognition of central neurocytoma and diminish misdiagnosis. Methods： A retrospective review identified 15 cases of central neurocytoma. All cases of central neurocytoma were analyzed for their clinical symptoms, pathologic changes, immunohistochemical staining, prognosis and differential diagnosis. Clinical follow up was performed. Results： There were 8 males and 7 females aged 10-64 years （median 32.93 years）. The most common presenting symptoms were those related to increased intracranial pressure （ICP）, including headache （100%）, papilledema （93 %） and vomiting （80%）. All tumors were located in the ventricular system. The tumors were composed of uniform cells with round nuclei and a fine chromatin pattern, and in some areas, small cells with perinuclear halo could be seen. In particular, the anuclear areas may have a fine fibrillary matrix （neuropil）. Nuclear atypia and vascular proliferation appeared in two cases, respectively. Focal necrosis could be seen in one case. Immunohistochemical findings included expression of synaptophysin （15/15）, neuron specific enolase （12/15） and glial fibrillary acidic protein （GFAP） （3/15）. MIB-1 proliferation index ranged from 0.8- 12.5%, and was more than 2% in 3 of 15 cases assessed. Follow-up information of 11 patients was available. Conclusions： Central neurocytoma has a favorable prognosis in general, but in some cases, the clinical course could be aggressive. Increase of GFAP positivity, proliferation index and vascular proliferation might suggest a more malignant process.展开更多
文摘40 human endometrial tissues of benign diseases were diviided into 8 groups (phases),and 50 BDF1 mousy endometrial tissues were divided into 5 groups (phases).Immunohistochenical staining was performed to show the PCNA (proliferating cell nuclear antigen)positive cell .In human ,the results suggested that the PCNA layer(48%)of mid-proliferative hpase.The PCNA labelled index was low in superficial epithelium.But in mouse, the results suggested that the Pcna labelled index was the highest(22%)in endometrium of estrus and the labelled cells were distributed mainly in superficial epithelium (60%).The results suggested that times that times and positions of cellular proliferation in endometrial tissues of human and mouse differed greatly.
基金supported by the Natural Science Foundation of Chongqing Science and Technology Committee (CSTC,2006BB5298)Sci & Tech Project of Chongqing Municipal Education Commission(KJ080302)
文摘Objective： To get better recognition of central neurocytoma and diminish misdiagnosis. Methods： A retrospective review identified 15 cases of central neurocytoma. All cases of central neurocytoma were analyzed for their clinical symptoms, pathologic changes, immunohistochemical staining, prognosis and differential diagnosis. Clinical follow up was performed. Results： There were 8 males and 7 females aged 10-64 years （median 32.93 years）. The most common presenting symptoms were those related to increased intracranial pressure （ICP）, including headache （100%）, papilledema （93 %） and vomiting （80%）. All tumors were located in the ventricular system. The tumors were composed of uniform cells with round nuclei and a fine chromatin pattern, and in some areas, small cells with perinuclear halo could be seen. In particular, the anuclear areas may have a fine fibrillary matrix （neuropil）. Nuclear atypia and vascular proliferation appeared in two cases, respectively. Focal necrosis could be seen in one case. Immunohistochemical findings included expression of synaptophysin （15/15）, neuron specific enolase （12/15） and glial fibrillary acidic protein （GFAP） （3/15）. MIB-1 proliferation index ranged from 0.8- 12.5%, and was more than 2% in 3 of 15 cases assessed. Follow-up information of 11 patients was available. Conclusions： Central neurocytoma has a favorable prognosis in general, but in some cases, the clinical course could be aggressive. Increase of GFAP positivity, proliferation index and vascular proliferation might suggest a more malignant process.
