[Objectives]To explore the pharmacological effects of Gardenia jasminoides and its potential benefits on eye skin.[Methods]TCMSP and SymMap databases were used to screen the active components and corresponding targets...[Objectives]To explore the pharmacological effects of Gardenia jasminoides and its potential benefits on eye skin.[Methods]TCMSP and SymMap databases were used to screen the active components and corresponding targets of G.jasminoides.Human eye skin-related targets were screened,and the active component-target network and protein-protein interaction(PPI)network were established.Gene ontology(GO)analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis were performed.[Results]Twenty-six active compounds were screened out from G.jasminoides,and 277 targets were obtained.From the Gencards database,26652 disease targets were retrieved and 205 related gene targets were screened.The active component-action target network of G.jasminoides constructed by Cytoscape software revealed the potential of G.jasminoides to play a role in multiple biological pathways.In addition,PPI-network analysis,GO function analysis and KEGG pathway enrichment analysis revealed that the active components of G.jasminoides mainly regulate the biological processes such as inflammatory response,oxidative stress and apoptosis,involving MAPK,NF-κB and other important signaling pathways.[Conclusions]This study provides a theoretical basis for the eye skin protection of G.jasminoides and an important clue for future drug development.展开更多
AIM:To evaluate the efficacy and safety of one-stitch anastomosis through the skin with bicanalicular silicone tube intubation in repairing of bicanalicular laceration.METHODS:The clinical data of 15 consecutive patie...AIM:To evaluate the efficacy and safety of one-stitch anastomosis through the skin with bicanalicular silicone tube intubation in repairing of bicanalicular laceration.METHODS:The clinical data of 15 consecutive patients with both superior and inferior canalicular laceration in one eye who underwent surgical repair using one-stitch anastomosis through the skin and bicanalicular stent were retrospective studied.All the operations were performed under surgical microscope,5-0 silk sutures were used and were with bicanalicular silicone tube(diameter was 8mm) intubation,for one lacerated canaliculi one-stitch anastomosis through the skin.The stents were left in place for 3 months postoperatively and then removed.The follow-up period was 3-36 months(average 14 months). RESULTS:In 15 patients,13 patients were cured entirely,1 patient was meliorated,1 patient with no effects.All patients had got good recovery of eyelid laceration with no traumatic deformity in eyelid and canthus.Complication was seen in one case,for not followed the doctor’s guidance to come back to hospital to had the suture removed on the 7thday after operation,when he came at the 15thday,the inferior canalicular wall and eyelid skin were corroded by the suture caused 2mm wound,and the inside silicone tube was exposed,a promptly repair with 10-0 nylon suture was done,the wound healed in a week.There were no early tube protrusions and punctal slits in the patients.CONCLUSION:One-stitch anastomosis through the skin with bicanalicular silicone tube intubation is a good method in repair of bicanalicular laceration in one eye,the cut ends can be anastomosed directly,and with excellent cosmetic results,it is acceptable for the patients.For there is no suture remained in the wound permanently,so there is no suture-related granuloma which may cause obstruction or stenosis of canaliculi.It is simple,economical,effective and safe.展开更多
To evaluate the efficacy of online learning and explore the impact of long-term use of electronic products on facial skin as well as eyes.A cross-sectional survey was conducted to 180 sophomores in Xi′an Jiaotong Uni...To evaluate the efficacy of online learning and explore the impact of long-term use of electronic products on facial skin as well as eyes.A cross-sectional survey was conducted to 180 sophomores in Xi′an Jiaotong University by cluster random sampling from September to October 2021.The questionnaire covering study condition,skin lesion and Ocular Surface Disease Index.χ_(2) test was used to compare the facial skin condition among different groups,and spearman correlation test was used to test the correlation of rank data.During online education,students′learning pressure is reduced,their autonomy is improved,and the learning efficiency is reduced.There were differences in the incidence of facial itching and papules among different groups.Duration of use of electronic products was positively correlated with the facial itching,with an r value of 0.231(P<0.05);the proportion of pigmentation in non-blue light protection groups(12.8%)was higher than that in blue light protection groups(1.7%),the difference was statistically significant(χ_(2)=8.384,P<0.05).The prevalence of dry eye among college students is 66.7%,and the proportion of moderate to severe dry eye is 34.5%.The study autonomy has been improved during online teaching.Long-term use of electronic products and no blue light protection have an impact on facial skin.Students should enhance the knowledge of skin-care and eye-care and develop better habits.展开更多
Background/Purpose: In the frame of a development of a formulation to be used in perineal massage in pregnant women, a screening program was built up among compositions with elasticising properties. Methods: This was ...Background/Purpose: In the frame of a development of a formulation to be used in perineal massage in pregnant women, a screening program was built up among compositions with elasticising properties. Methods: This was an open-label, controlled study in 21 volunteers. The participants applied once, on the volar surface of both forearms, five formulations with elasticising properties (test products 1 to 5) and a reference standard (test product 6). The formulations were applied on three sites on each forearm that were randomly assigned. Skin elasticising parameters were evaluated using the Dermal Torque Meter, at baseline and 30 minutes after application. Results: Among the test products, only test product 2 significantly increased skin elasticity compared with the baseline value, with a trend toward superiority?versus the reference standard (+24% vs.?+13%, respectively). There was a significant increase in elastic recovery of 23% with test product 2, compared with a significant increase of 13% with the reference standard. Conclusion: Test product 2, comprising a thiolated compound and a mixture of esters of fatty acids, had the greatest elasticising effect. Compared with the other tested formulations, product 2 led to a greater increase in extensibility and faster elastic recovery of the skin on the volar surface of the forearm.展开更多
目的:观察利多卡因氯己定气雾剂对皮肤裂伤的作用和可行性。方法:选取2016年6月-2017年5月于我院急诊科就诊的300例头面部、颈部皮肤裂伤患者,按随机数字表法分为观察组和对照组,各150例。观察组采用利多卡因氯己定气雾剂术前局部表面...目的:观察利多卡因氯己定气雾剂对皮肤裂伤的作用和可行性。方法:选取2016年6月-2017年5月于我院急诊科就诊的300例头面部、颈部皮肤裂伤患者,按随机数字表法分为观察组和对照组,各150例。观察组采用利多卡因氯己定气雾剂术前局部表面均匀浸润麻醉和术后均匀喷洒,成膜后不包扎。对照组术前采用利多卡因注射液1 m L+0.9%氯化钠注射液1 m L局部伤口周围皮下注射浸润麻醉和清创缝合后常规包扎,定期换药。比较两组的麻醉起效时间和术中伤口疼痛程度、伤口愈合效果、愈合满意程度。结果 :两组麻醉起效时间、术中伤口疼痛程度比较、伤口的愈合效果及伤口愈合满意情况比较无统计学差异(P>0.05)。结论:利多卡因氯己定气雾剂与常规包扎处理比较,对伤口的保护没有差别,这样既减少耗材和麻药的浪费,又可发挥术前局部麻醉和术后预防感染作用,同时不影响患者的形象,值得大力推广应用。展开更多
文摘[Objectives]To explore the pharmacological effects of Gardenia jasminoides and its potential benefits on eye skin.[Methods]TCMSP and SymMap databases were used to screen the active components and corresponding targets of G.jasminoides.Human eye skin-related targets were screened,and the active component-target network and protein-protein interaction(PPI)network were established.Gene ontology(GO)analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis were performed.[Results]Twenty-six active compounds were screened out from G.jasminoides,and 277 targets were obtained.From the Gencards database,26652 disease targets were retrieved and 205 related gene targets were screened.The active component-action target network of G.jasminoides constructed by Cytoscape software revealed the potential of G.jasminoides to play a role in multiple biological pathways.In addition,PPI-network analysis,GO function analysis and KEGG pathway enrichment analysis revealed that the active components of G.jasminoides mainly regulate the biological processes such as inflammatory response,oxidative stress and apoptosis,involving MAPK,NF-κB and other important signaling pathways.[Conclusions]This study provides a theoretical basis for the eye skin protection of G.jasminoides and an important clue for future drug development.
文摘AIM:To evaluate the efficacy and safety of one-stitch anastomosis through the skin with bicanalicular silicone tube intubation in repairing of bicanalicular laceration.METHODS:The clinical data of 15 consecutive patients with both superior and inferior canalicular laceration in one eye who underwent surgical repair using one-stitch anastomosis through the skin and bicanalicular stent were retrospective studied.All the operations were performed under surgical microscope,5-0 silk sutures were used and were with bicanalicular silicone tube(diameter was 8mm) intubation,for one lacerated canaliculi one-stitch anastomosis through the skin.The stents were left in place for 3 months postoperatively and then removed.The follow-up period was 3-36 months(average 14 months). RESULTS:In 15 patients,13 patients were cured entirely,1 patient was meliorated,1 patient with no effects.All patients had got good recovery of eyelid laceration with no traumatic deformity in eyelid and canthus.Complication was seen in one case,for not followed the doctor’s guidance to come back to hospital to had the suture removed on the 7thday after operation,when he came at the 15thday,the inferior canalicular wall and eyelid skin were corroded by the suture caused 2mm wound,and the inside silicone tube was exposed,a promptly repair with 10-0 nylon suture was done,the wound healed in a week.There were no early tube protrusions and punctal slits in the patients.CONCLUSION:One-stitch anastomosis through the skin with bicanalicular silicone tube intubation is a good method in repair of bicanalicular laceration in one eye,the cut ends can be anastomosed directly,and with excellent cosmetic results,it is acceptable for the patients.For there is no suture remained in the wound permanently,so there is no suture-related granuloma which may cause obstruction or stenosis of canaliculi.It is simple,economical,effective and safe.
文摘To evaluate the efficacy of online learning and explore the impact of long-term use of electronic products on facial skin as well as eyes.A cross-sectional survey was conducted to 180 sophomores in Xi′an Jiaotong University by cluster random sampling from September to October 2021.The questionnaire covering study condition,skin lesion and Ocular Surface Disease Index.χ_(2) test was used to compare the facial skin condition among different groups,and spearman correlation test was used to test the correlation of rank data.During online education,students′learning pressure is reduced,their autonomy is improved,and the learning efficiency is reduced.There were differences in the incidence of facial itching and papules among different groups.Duration of use of electronic products was positively correlated with the facial itching,with an r value of 0.231(P<0.05);the proportion of pigmentation in non-blue light protection groups(12.8%)was higher than that in blue light protection groups(1.7%),the difference was statistically significant(χ_(2)=8.384,P<0.05).The prevalence of dry eye among college students is 66.7%,and the proportion of moderate to severe dry eye is 34.5%.The study autonomy has been improved during online teaching.Long-term use of electronic products and no blue light protection have an impact on facial skin.Students should enhance the knowledge of skin-care and eye-care and develop better habits.
文摘Background/Purpose: In the frame of a development of a formulation to be used in perineal massage in pregnant women, a screening program was built up among compositions with elasticising properties. Methods: This was an open-label, controlled study in 21 volunteers. The participants applied once, on the volar surface of both forearms, five formulations with elasticising properties (test products 1 to 5) and a reference standard (test product 6). The formulations were applied on three sites on each forearm that were randomly assigned. Skin elasticising parameters were evaluated using the Dermal Torque Meter, at baseline and 30 minutes after application. Results: Among the test products, only test product 2 significantly increased skin elasticity compared with the baseline value, with a trend toward superiority?versus the reference standard (+24% vs.?+13%, respectively). There was a significant increase in elastic recovery of 23% with test product 2, compared with a significant increase of 13% with the reference standard. Conclusion: Test product 2, comprising a thiolated compound and a mixture of esters of fatty acids, had the greatest elasticising effect. Compared with the other tested formulations, product 2 led to a greater increase in extensibility and faster elastic recovery of the skin on the volar surface of the forearm.
文摘目的:观察利多卡因氯己定气雾剂对皮肤裂伤的作用和可行性。方法:选取2016年6月-2017年5月于我院急诊科就诊的300例头面部、颈部皮肤裂伤患者,按随机数字表法分为观察组和对照组,各150例。观察组采用利多卡因氯己定气雾剂术前局部表面均匀浸润麻醉和术后均匀喷洒,成膜后不包扎。对照组术前采用利多卡因注射液1 m L+0.9%氯化钠注射液1 m L局部伤口周围皮下注射浸润麻醉和清创缝合后常规包扎,定期换药。比较两组的麻醉起效时间和术中伤口疼痛程度、伤口愈合效果、愈合满意程度。结果 :两组麻醉起效时间、术中伤口疼痛程度比较、伤口的愈合效果及伤口愈合满意情况比较无统计学差异(P>0.05)。结论:利多卡因氯己定气雾剂与常规包扎处理比较,对伤口的保护没有差别,这样既减少耗材和麻药的浪费,又可发挥术前局部麻醉和术后预防感染作用,同时不影响患者的形象,值得大力推广应用。
