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Effect of care intervention with a health education form for breastfeeding on breast distension,pain,and lactation in postpartum mothers
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作者 Xi Di Xu-Ling Ge Dan Wang 《World Journal of Clinical Cases》 SCIE 2024年第22期5059-5066,共8页
BACKGROUND Breastfeeding not only meets the nutritional needs of newborn growth and development but also promotes uterine contraction and discharge of lochia,which helps in maternal recovery.However,some mothers exper... BACKGROUND Breastfeeding not only meets the nutritional needs of newborn growth and development but also promotes uterine contraction and discharge of lochia,which helps in maternal recovery.However,some mothers experience abnormal lactation and breast swelling due to a lack of breastfeeding knowledge,painful cesarean incisions,anesthesia,negative emotions,and other factors,resulting in a reduced breastfeeding rate,which adversely affects neonatal and maternal health.AIM To explore the effects of care intervention with a health education form for breastfeeding on breastfeeding-related conditions.METHODS In this study,207 mothers with postpartum breast pain and difficulty lactating were selected and divided into intervention and control groups using a random number table.Both groups of mothers were provided with basic nursing and related treatment measures after delivery.The intervention group additionally received care intervention with a health education form for breastfeeding.The scores of lactation volume,breast distension and pain,breastfeeding rate,breastfeeding self-efficacy,treatment effect,and complication rate of the two groups were compared.RESULTS After treatment,the breast pain score of the intervention group was significantly lower than that of the control group,while the lactation score,score of Breastfeeding Self-Efficacy Scale Short Form scale,parent-child communication score,maternal-infant interaction score,total score of maternal-infant communication,and breastfeeding rate of the intervention group were significantly higher than those of the control group.After intervention,the overall therapeutic effect of the intervention group was better than that of the control group,and the complication rate of the intervention group was lower than that of the control group.CONCLUSION Breastfeeding health education and nursing intervention combined with basic clinical treatment have good clinical effects in managing postpartum breast distension and pain and increasing lactation yield. 展开更多
关键词 BREASTFEEDING Health education Nursing intervention Breast distension and pain lactation
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Study on the Application Effect of Flexible Nursing Care in Patients with Postpartum Urinary Retention and its Effect on Lactation
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作者 Hongyan Zhu 《Journal of Clinical and Nursing Research》 2024年第4期122-127,共6页
Objective: To study the application effect of flexible nursing in patients with postpartum urinary retention and its effect on lactation. Methods: A total of 200 cases of postpartum urinary retention patients admitted... Objective: To study the application effect of flexible nursing in patients with postpartum urinary retention and its effect on lactation. Methods: A total of 200 cases of postpartum urinary retention patients admitted between January 2021 and January 2022 were selected and randomly grouped into two groups, a control group (conventional nursing) and an observation group (flexible nursing), of 100 cases each. The time of onset of lactation, the lactation volume score, urinary indicators, the amount of post-partum hemorrhage, and the quality of life score of the two groups were compared. Results: The observation group’s lactation initiation time (21.41 ± 1.52) h and lactation volume score (2.11 ± 0.52) were better than that of the control group (P < 0.05). The observation group’s first urination time (2.11 ± 0.51) min was lower than the control group, while the urinary retention completely relieved time (33.12 ± 8.61) h, and first urinary volume (262.17 ± 52.41) mL was higher than that of the control group (P < 0.05). The amount of postpartum hemorrhage in the observation group (151.21 ± 22.12) mL was less than that in the control group (P < 0.05). The scores of somatic functioning (86.25 ± 2.20), psychological functioning (91.56 ± 1.45), social functioning (89.25 ± 2.45), and material life (89.75 ± 1.45) of the observation group were higher than those of the control group after nursing (P < 0.05). Conclusion: Flexible nursing care in patients with postpartum urinary retention exhibited significant nursing effects and lactation function was effectively improved. 展开更多
关键词 Flexible nursing Postpartum urinary retention lactation
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Effects of improved amino acid balance diet on lysine mammary utilization, whole body protein turnover and muscle protein breakdown on lactating sows
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作者 Sai Zhang Juan C.Marini +4 位作者 Vengai Mavangira Andrew Claude Julie Moore Mahmoud A.Mohammad Nathalie L.Trottier 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第5期2031-2043,共13页
Background The study objective was to test the hypothesis that low crude protein(CP)diet with crystalline amino acids(CAA)supplementation improves Lys utilization efficiency for milk production and reduces protein tur... Background The study objective was to test the hypothesis that low crude protein(CP)diet with crystalline amino acids(CAA)supplementation improves Lys utilization efficiency for milk production and reduces protein turnover and muscle protein breakdown.Eighteen lactating multiparous Yorkshire sows were allotted to 1 of 2 isocaloric diets(10.80 MJ/kg net energy):control(CON;19.24%CP)and reduced CP with“optimal”AA profile(OPT;14.00%CP).Sow body weight and backfat were recorded on d 1 and 21 of lactation and piglets were weighed on d 1,14,18,and 21 of lactation.Between d 14 and 18,a subset of 9 sows(CON=4,OPT=5)was infused with a mixed solution of 3-[methyl-2H3]histidine(bolus injection)and[13C]bicarbonate(priming dose)first,then a constant 2-h[13C]bicarbonate infusion followed by a 6-h primed constant[1-13C]lysine infusion.Serial blood and milk sampling were performed to determine plasma and milk Lys enrichment,Lys oxidation rate,whole body protein turnover,and muscle protein breakdown.Results Over the 21-d lactation period,compared to CON,sows fed OPT had greater litter growth rate(P<0.05).Compared to CON,sows fed OPT had greater efficiency of Lys(P<0.05),Lys mammary flux(P<0.01)and whole-body protein turnover efficiency(P<0.05).Compared to CON,sows fed OPT tended to have lower whole body protein breakdown rate(P=0.069).Muscle protein breakdown rate did not differ between OPT and CON(P=0.197).Conclusion Feeding an improved AA balance diet increased efficiency of Lys and reduced whole-body protein turnover and protein breakdown.These results imply that the lower maternal N retention observed in lactating sows fed improved AA balance diets in previous studies may be a result of greater partitioning of AA towards milk rather than greater body protein breakdown. 展开更多
关键词 Amino acid efficiency lactating sows Protein breakdown Protein turnover Reduced protein diet
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Postpartum depression and partner support during the period of lactation:Correlation research and its influencing factors
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作者 Ji-Ming Ruan Ling-Juan Wu 《World Journal of Psychiatry》 SCIE 2024年第1期119-127,共9页
BACKGROUND Postpartum depression(PPD)not only affects the psychological and physiological aspects of maternal health but can also affect neonatal growth and development.Partners who are in close contact with parturien... BACKGROUND Postpartum depression(PPD)not only affects the psychological and physiological aspects of maternal health but can also affect neonatal growth and development.Partners who are in close contact with parturient women play a key role in communication and emotional support.This study explores the PPD support relationship with partners and its influencing factors,which is believed to establish psychological well-being and improve maternal partner support.AIM To explore the correlation between PPD and partner support during breastfeeding and its influencing factors.METHODS Convenience sampling was used to select lactating women(200 women)who underwent postpartum examinations at the Huzhou Maternity and Child Health Care Hospital from July 2022 to December 2022.A cross-sectional survey was conducted on the basic information(general information questionnaire),depression level[edinburgh postnatal depression scale(EPDS)],and partner support score[dyadic coping inventory(DCI)]of the selected subjects.Pearson’s correlation analysis was used to analyze the correlation between PPD and DCI in lactating women.Factors affecting PPD levels during lactation were analyzed using multiple linear regression.RESULTS The total average score of EPDS in 200 lactating women was(9.52±1.53),and the total average score of DCI was(115.78±14.90).Dividing the EPDS,the dimension scores were:emotional loss(1.91±0.52),anxiety(3.84±1.05),and depression(3.76±0.96).Each dimension of the DCI was subdivided into:Pressure communication(26.79±6.71),mutual support(39.76±9.63),negative support(24.97±6.68),agent support(6.87±1.92),and joint support(17.39±4.19).Pearson’s correlation analysis demonstrated that the total mean score and individual dimension scores of EPDS during breastfeeding were inversely correlated with the total score of partner support,stress communication,mutual support,and cosupport(P<0.05).The total mean score of the EPDS and its dimensions were positively correlated with negative support(P<0.05).Multiple linear regression analysis showed that the main factors affecting PPD during breastfeeding were marital harmony,newborn health,stress communication,mutual support,negative support,cosupport,and the total score of partner support(P<0.05).CONCLUSION PPD during breastfeeding was associated with marital harmony,newborn health,stress communication,mutual support,negative support,joint support,and the total DCI score. 展开更多
关键词 lactation period PUERPERA Postpartum depression Partner support CORRELATION
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Effects of potassium lactate on sensory attributes,bacterial community succession and biogenic amines formation in Rugao ham
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作者 Renyong Liao Ying Wang +4 位作者 Qiang Xia Changyu Zhou Fang Geng Daodong Pan Jinxuan Cao 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期198-210,共13页
To deepen the understanding in the effect of potassium lactate on the sensory quality and safety of Rugao ham,sensory attributes,physicochemical parameters,total volatile basic nitrogen(TVBN),microorganism community a... To deepen the understanding in the effect of potassium lactate on the sensory quality and safety of Rugao ham,sensory attributes,physicochemical parameters,total volatile basic nitrogen(TVBN),microorganism community and biogenic amines of Rugao ham manufactured with different potassium lactate levels(0%,0.5%,1%,2%)were investigated;the relationship between microbial community and the formation of TVBN and biogenic amines was further evaluated.With the increase of potassium lactate from 0%to 2%,the increased sensory scores and the decreased total aerobic bacterial count and TVBN were observed;the abundance of Staphylococcus increased,while the content of Halomonas decreased.LDA effect size(LEf Se)and correlations analysis showed that Staphylococcus equorum and Lactobacillus fermentum could be the key species to improve sensory scores and decrease biogenic amines and TVBN.Metabolic pathway analysis further showed that amino acids metabolism and nitrogen metabolism were mainly involved in decreasing TVBN and biogenic amines in the treatment of 2%potassium lactate. 展开更多
关键词 Rugao ham Potassium lactate Biogenic amines Microbial community Metabolic pathways
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Changes in milk fat globule membrane proteins along lactation stage of Laoshan dairy goat
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作者 Chuozi Liang Zhongna Yu +8 位作者 Guangming Zhu Yixuan Li Xueheng Sun Hongning Jiang Qijing Du Rongbo Fan Jun Wang Yongxin Yang Rongwei Han 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第5期1737-1748,共12页
The milk fat globule membrane(MFGM)is a complex structure with numerous functions,and its composition is affected by many factors.There have been few systematic investigations on goat MFGM proteome profiling during la... The milk fat globule membrane(MFGM)is a complex structure with numerous functions,and its composition is affected by many factors.There have been few systematic investigations on goat MFGM proteome profiling during lactation.Individual milk samples from 15 healthy dairy goats were obtained at six lactation time points for investigation of the MFGM proteome using both data-independent acquisition(DIA)and data-dependent acquisition(DDA)proteomics techniques combined with multivariate statistical analysis.Using the DIA method,890 variably abundant MFGM proteins were discovered throughout the lactation cycle.From 1 to 240 d,butyrophilin subfamily 1 member A1,lipoprotein lipase,perilipin-2,and adipose triglyceride lipase were upregulated,while APOE,complement C3,clusterin,and IgG were downregulated.Furthermore,from 1 to 90 d,annexin A1,annexin A2,and antithrombin-ll were downregulated,then upregulated by d 240.Albumin had a high degree of connectedness,indicating that it was a key protein,according to protein-protein interaction research.Overall,our findings gave new insights into the biological features of MFGM protein in goat milk throughout lactation,which may aid in the creation of specialized MFGM products and infant formula. 展开更多
关键词 GOAT milk fat globule membrane protein data-independent acquisition(DIA) data-dependent acquisition(DDA) lactation PROTEOMICS
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Lactation breast abscess treated with Gualou Xiaoyong decoction and painless lactation manipulation:A case report and review of literature 被引量:2
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作者 Li-Hua Jin Hui-Ling Zheng +4 位作者 Yun-Xia Lin Yi Yang Jia-Li Liu Rui-Lan Li Hui-Jun Ye 《World Journal of Clinical Cases》 SCIE 2023年第8期1847-1856,共10页
BACKGROUND Breast abscess during lactation is a severe complication of acute mastitis,which can lead to discomfort,high fever,breast fistula,sepsis,septic shock,breast damage,disease persistence and frequent hospitali... BACKGROUND Breast abscess during lactation is a severe complication of acute mastitis,which can lead to discomfort,high fever,breast fistula,sepsis,septic shock,breast damage,disease persistence and frequent hospitalization.Breast abscesses may also lead the mother to discontinue breastfeeding,thereby harming the infant’s health.The predominant pathogenic bacteria are Staphylococcus aureus,Staphylococcus epidermidis and Streptococcus.The incidence of breastfeeding abscesses in breastfeeding women ranges between 4.0%and 11.0%.In cases of breast abscess,the rate of cessation of lactation is 41.0%.In instances of breast fistula,the rate of cessation of lactation is very high(66.7%).Furthermore,50.0%of women with breast abscesses must be hospitalized and treated with intravenous antibiotics.Treatment includes antibiotics,abscess puncture and surgical incision and drainage.The patients suffer from stress,pain and easily induced breast scarring;the disease’s progression is prolonged and recurrent,interfering with infant feeding.Consequently,it is crucial to discover an adequate cure.CASE SUMMARY A 28-year-old woman with a breast abscess was treated with Gualou Xiaoyong decoction and painless breast opening manipulation 24 d after cesarean delivery.On the 2nd d of treatment,the patient’s breast mass was significantly reduced,the pain was significantly reduced,and the general asthenia was improved.All conscious symptoms disappeared after 3 d,breast abscesses faded after 12 d of treatment,inflammation images disappeared after 27 d,and normal lactation images were restored.CONCLUSION In treating breast abscesses during breastfeeding,the combination of Gualou Xiaoyong decoction and painless lactation provides a positive therapeutic impact.This disease’s treatment offers the advantages of a short course of treatment,no need to discontinue breastfeeding and the ability to rapidly mitigate symptoms,which can be used as a reference in clinical practice. 展开更多
关键词 lactation breast abscess Gualou Xiaoyong decoction Painless lactation manipulation Literature review Case report
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基于优化极限学习机模型的反应堆中子通量与k_(eff)预测方法研究
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作者 陈镜宇 刘喜洋 +2 位作者 赵鹏程 刘紫静 李卫 《核技术》 EI CAS CSCD 北大核心 2024年第10期178-187,共10页
通过模拟和扩展人类智能,人工智能能够解决预测反应堆k_(eff)和中子通量等问题。本研究选用国际原子能机构(International Atomic Energy Agency,IAEA)反应堆作为研究对象,以稳态时的堆芯中子通量和k_(eff)为预测量,通过堆芯物理分析程... 通过模拟和扩展人类智能,人工智能能够解决预测反应堆k_(eff)和中子通量等问题。本研究选用国际原子能机构(International Atomic Energy Agency,IAEA)反应堆作为研究对象,以稳态时的堆芯中子通量和k_(eff)为预测量,通过堆芯物理分析程序ADPRES生成数据样本后,利用极限学习机(Extreme Learning Machine,ELM)构建中子通量和k_(eff)的基础神经网络模型,随后通过随机森林(Random Forest,RF)评估特征值重要程度以建立各模型最佳输入特征子集,采用遍历方法确定隐藏层最佳神经元数目,最后使用鲸鱼优化算法(Whale Optimization Algorithm,WOA)对其初始权值与阈值进行优化,进一步提高了模型的精度。研究结果显示:经降维优化处理后,神经网络的预测能力有较大提升,其中k_(eff)的预测精度提高了两个量级,中子通量的预测误差降低了87.24%,并且减少了模型训练时间。本文构建方法对快速评估堆芯物理特性有一定参考意义。 展开更多
关键词 极限学习机 鲸鱼优化算法 中子通量 k_(eff) 参数预测方法 随机森林
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Jugular arginine supplementation increases lactation performance and nitrogen utilization efficiency in lactating dairy cows 被引量:4
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作者 Luoyang Ding Yizhao Shen +6 位作者 Yifan Wang Gang Zhou Xin Zhang Mengzhi Wang Juan J.Loor Lianmin Chen Jun Zhang 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2019年第2期510-518,共9页
Background: Enhancing the post-ruminal supply of arginine(Arg), a semi-essential amino acid(AA), elicits positive effects on milk production. Our objective was to determine the effects of Arg infusion on milk producti... Background: Enhancing the post-ruminal supply of arginine(Arg), a semi-essential amino acid(AA), elicits positive effects on milk production. Our objective was to determine the effects of Arg infusion on milk production parameters and aspects of nitrogen(N) absorption and utilization in lactating dairy cows. Six lactating Chinese Holstein cows of similar body weight(508 ± 14 kg), body condition score(3.0 ± 0), parity(4.0 ± 0), milk yield(30.6 ±1.8 kg) and days in milk(20 ± 2 d) were randomly assigned to 3 treatments in a replicated 3 × 3 Latin square design with 21 d for each period(1 week for infusion and 2 weeks for washout). Treatments were 1) Control: saline;2) Arg group: saline + 9.42 g/L L-Arg;3) Alanine(Ala) group: saline + 19.31 g/L L-Ala(iso-nitrogenous to the Arg group). Milk production and composition, dry matter intake, apparent absorption of N, profiles of amino acids(AA) in blood,urea N in urine, milk, and blood, and gene expression of AA transporters were determined.Results: Compared with the Control or Ala group, the infusion of Arg led to greater expression of AA transporters(SLC7 A2 and SLC7 A8) and apparent uptake of free AA in the mammary gland, and was accompanied by greater milk yield, milk protein yield and milk efficiency(calculated by dividing milk yield over feed intake), together with lower concentration of urea N [regarded as an indicator of N utilization efficiency(NUE)] in blood and milk. Furthermore, in the cows infused with Arg, the NUE was higher and the concentration of urea N in urine was lower than those in the Ala group, although no differences were detected in NUE and urea N in urine between the Control and Arg group.The infusion of Ala had no effect on those indices compared with the Control.Conclusions: Overall, enhancing the post-ruminal supply of Arg via the jugular vein had a positive effect on the synthesis of milk protein at least in part by increasing gene expression of some AA transporters and uptake of free AA by mammary gland. 展开更多
关键词 AMINO acid transporters ARGININE lactation MILK protein
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Effects of the dietary nonfiber carbohydrate content on lactation performance, rumen fermentation, and nitrogen utilization in mid-lactation dairy cows receiving corn stover 被引量:3
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作者 Zihai Wei Baoxin Zhang Jianxin Liu 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2018年第3期699-705,共7页
Background: Corn stover(CS) is an abundant source of feed for livestock in China. However, it is low in nutritional value that we have been seeking technologies to improve. Previous studies show that non-fiber carbohy... Background: Corn stover(CS) is an abundant source of feed for livestock in China. However, it is low in nutritional value that we have been seeking technologies to improve. Previous studies show that non-fiber carbohydrate(NFC)might limit the utilization of a CS diet by lactating dairy cows. Thus, this study was conducted to investigate the lactation performance and rumen fermentation characteristics in lactating cows consuming CS with two contents of NFC compared to an alfalfa hay-containing diet. Twelve Holstein cows were used in a replicated 3 × 3 Latin square design with three dietary treatments:(1) low-NFC diet(NFC = 35.6%, L-NFC),(2) high-NFC diet(NFC = 40.1%,H-NFC), and(3) alfalfa hay diet(NFC = 38.9%, AH).Results: Intake of DM was lower for cows fed H-NFC compared to L-NFC and AH, while the milk yield was higher in AH than in H-NFC and L-NFC(P < 0.01). The feed efficiency(milk yield/DM intake, 1.15 vs. 1.08, P < 0.01) were greater for cows fed H-NFC than L-NFC. The contents of milk protein and lactose were not different among the groups(P > 0.11), but milk fat content was higher for cows fed H-NFC and L-NFC compared to AH(P < 0.01). The rumen ammonia nitrogen concentration and the concentrations of urea nitrogen in blood and milk were lower for cows fed H-NFC and AH compared to L-NFC(P < 0.05). The concentrations of rumen propionate and total volatile fatty acids were different among groups(P < 0.05) with higher concentration for cows fed AH compared to H-NFC and L-NFC, and acetate concentration tended to be different among groups(P = 0.06).Conclusions: From the results obtained in this study, it was inferred that the increased NFC content in a diet containing corn stover can improve the feed efficiency and benefit the nitrogen conversion. 展开更多
关键词 Corn STOVER Dairy COWS lactation performance Nonfiber CARBOHYDRATE RUMEN fermentation
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Identification Effects of Pedometer on Estrus of Holstein Cows during Peak Lactation Period 被引量:5
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作者 Jiang Xiaoxin Deng Shuangyi +2 位作者 Liu Wei Wei Xingyuan Ai Li 《Animal Husbandry and Feed Science》 CAS 2014年第2期63-65,共3页
[Objective]The paper was to discuss identification effects of pedometer on estrus of Holstein cows during peak lactation period. [Method]The estrus of Holstein cows during peak lactation period were identified by manu... [Objective]The paper was to discuss identification effects of pedometer on estrus of Holstein cows during peak lactation period. [Method]The estrus of Holstein cows during peak lactation period were identified by manual observation and pedometer monitoring. [Result]Compared with manual observation,the detection rate of estrus in Holstein cows using pedometer monitoring was increased by 24. 01%,which reduced the labor cost and enhanced accuracy rate. [Conclusion]The research could provide reliable basis for estrus identification of cows. 展开更多
关键词 PEDOMETER Holstein cows Peak lactation period ESTRUS
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Effects of Chinese herbs on lactation of rat and performance of offspring 被引量:3
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作者 SHI Baoming SHAN Anshan 《Journal of Northeast Agricultural University(English Edition)》 CAS 2007年第1期22-26,共5页
An experiment was conducted to study the effects of different Chinese herbs on lactation in the rat. Seventy-two Sprague Dawley female rats at gestation day 18 were assigned to 9 groups randomly, with 8 rats each. Con... An experiment was conducted to study the effects of different Chinese herbs on lactation in the rat. Seventy-two Sprague Dawley female rats at gestation day 18 were assigned to 9 groups randomly, with 8 rats each. Control rats were offered basal diets until the end of the weaning period. Rats in the other 8 groups were administered diets supplemented with 1% Medulla tetmpanacis (MT), Astragalus membranacens (AM), Vaccaria segetalis (VS), Leonurus heterophyllus sweet (LHS), Radix rehmarmiae preparata (RRP), Squama man/t/s (SM), Schisandra chinensis (SC), Ligustrum lucidum (LL), respectively. After parturition, the litter size was culled to 8 pups per dam. Pup weight and milk yield were significantly higher in the VS, LHS, AM and SM groups than these in the control group during middle and late lactation (P〈0.05 or P〈0.01). The weight and feed intake were not different in the dams fed either diet. 展开更多
关键词 RAT lactation Chinese herbs
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Lactate metabolism in neurodegenerative diseases 被引量:4
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作者 Chaoguang Yang Rui-Yuan Pan +1 位作者 Fangxia Guan Zengqiang Yuan 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期69-74,共6页
Lactate,a byproduct of glycolysis,was thought to be a metabolic waste until the discovery of the Warburg effect.Lactate not only functions as a metabolic substrate to provide energy but can also function as a signalin... Lactate,a byproduct of glycolysis,was thought to be a metabolic waste until the discovery of the Warburg effect.Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions.The Astrocyte-Neuron Lactate Shuttle has cla rified that lactate plays a pivotal role in the central nervous system.Moreover,protein lactylation highlights the novel role of lactate in regulating transcription,cellular functions,and disease development.This review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases,thus providing optimal pers pectives for future research. 展开更多
关键词 Alzheimer's disease Astrocyte-Neuron lactate Shuttle brain central nervous system glucose metabolism GLYCOLYSIS NEUROINFLAMMATION Parkinson's disease protein lactylation signaling molecule
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Lactate:a prospective target for therapeutic intervention in psychiatric disease 被引量:2
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作者 Yanhui Cai Haiyun Guo +1 位作者 Tianle Han Huaning Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1473-1479,共7页
Although antipsychotics that act via monoaminergic neurotransmitter modulation have considera ble therapeutic effect,they cannot completely relieve clinical symptoms in patients suffering from psychiatric disorde rs.T... Although antipsychotics that act via monoaminergic neurotransmitter modulation have considera ble therapeutic effect,they cannot completely relieve clinical symptoms in patients suffering from psychiatric disorde rs.This may be attributed to the limited range of neurotransmitters that are regulated by psychotropic drugs.Recent findings indicate the need for investigation of psychotropic medications that target less-studied neurotransmitte rs.Among these candidate neurotransmitters,lactate is developing from being a waste metabolite to a glial-neuronal signaling molecule in recent years.Previous studies have suggested that cerebral lactate levels change considerably in numerous psychiatric illnesses;animal experiments have also shown that the supply of exogenous la ctate exerts an antidepressant effect.In this review,we have described how medications targeting newer neurotransmitte rs offer promise in psychiatric diseases;we have also summarized the advances in the use of lactate(and its corresponding signaling pathways)as a signaling molecule.In addition,we have described the alterations in brain lactate levels in depression,anxiety,bipolar disorder,and schizophrenia and have indicated the challenges that need to be overcome before brain lactate can be used as a therapeutic target in psychopharmacology. 展开更多
关键词 ANTIDEPRESSANT ANXIETY bipolar disorder depression lactatE psychiatric disease PSYCHOPHARMACOLOGY SCHIZOPHRENIA signal molecular THERAPEUTICS
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Effect of reduced energy density of close-up diets on dry matter intake,lactation performance and energy balance in multiparous Holstein cows 被引量:2
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作者 Wenming Huang Yujia Tian +5 位作者 Yajing Wang Aminamu Simayi Amingguli Yasheng Zhaohai Wu Shengli Li Zhijun Cao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2015年第1期47-54,共8页
Energy intake prepartum is critically important to health, milk performance, and profitability of dairy cows. The objective of this study was to determine the effect of reduced energy density of dose-up diets on dry m... Energy intake prepartum is critically important to health, milk performance, and profitability of dairy cows. The objective of this study was to determine the effect of reduced energy density of dose-up diets on dry matter intake (DMI), lactation performance and energy balance (EB) in multiparous Holstein cows which were housed in a free-stall barn and fed for ad libitum intake. Thirty-nine dry cows were blocked and assigned randomly to three groups fed a high energy density diet [HD, n = 13; 6.8 MJ of net energy for lactation (NEL)/kg; 14.0% crude protein (CP) ], or a middle energy density diet (MD, n = 13; 6.2 MJ NEh/kg; 14.0% CP), or a low energy density diet (LD, n = 13; 5.4 MJ NEh/kg; 14.0% CP) from d 21 before expected day of calving. After parturition, all cows were fed the same lactation diet to d 70 in milk (DIM). The DMI and NEE intake prepartum were decreased by the reduced energy density diets (P 〈 0.05). The LD group consumed 1.3 last 24 h before calving. The milk yield and the postpartum kg/d (DM) more diet compared with HD group in the DMI were increased by the reduced energy density diet prepartum (P 〈 0.05). The changes in BCS and BW prepartum and postpartum were not affected by prepartum diets HD group had higher milk fat content and lower lactose content compared with LD group during the first 3 wk of lactation (P 〈 0.05). The energy consumption for HD, MD and LD groups were 149.8%, 126.2% and 101.1 % of their calculated energy requirements prepartum (P 〈 0.05), and 72.7%, 73.1% and 7.5.2% during the first 4 wk postpartum, respectively. In conclusion, the low energy density prepartum diet was effective in controlling NF_L intake prepartum, and was beneficial in increasing DMI and milk yield, and alleviating negative EB postpartum. 展开更多
关键词 Dietary energy density Dry matter intake Energy balance lactation performance Transition cow
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Effects of Supplemental Dietary Energy Source on Feed Intake, Lactation Performance, and Serum Indices of Early-Lactating Holstein Cows in a Positive Energy Balance 被引量:2
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作者 Xueyan Lin Guimei Liu +4 位作者 Zhengyan Yin Yun Wang Qiuling Hou Kerong Shi Zhonghua Wang 《Advances in Bioscience and Biotechnology》 2017年第2期68-77,共10页
The present study investigated the effects of the supplemental dietary energy source on early lactating cows in a positive energy balance. Cows in the control group were fed a basal total mixed ration containing high-... The present study investigated the effects of the supplemental dietary energy source on early lactating cows in a positive energy balance. Cows in the control group were fed a basal total mixed ration containing high-quality hay as forage, and the dietary concentrate to forage ratio was 45:65. The corn supplementation resulted in a significant decrease in the milk fat content (P P = 0.15), whereas the fat supplementation resulted in a decreasing trend of the milk protein and lactose content (P ≤ 0.1). Additionally, the corn supplementation significantly decreased the serum 5-hydroxytryptamine level (P < 0.05). The results support the proposal that the source of supplemental dietary energy has varying effects on feed intake, lactation performance, and the intermediate metabolism of early lactating cows in a positive energy balance. 5-Hydroxytryptamine secretion may be associated with the varying effects of the source of supplemental dietary energy. 展开更多
关键词 DAIRY COW lactation Energy Source 5-HYDROXYTRYPTAMINE
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Effects of Diets with Different Corn-to-Soybean Ratios on Performance of Lactational Rex Rabbits 被引量:1
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作者 SUN Li-na GU Zi-lin LIU Ya-juan LI Su-min 《Animal Husbandry and Feed Science》 CAS 2010年第1期24-26,31,共4页
[ Objective] To study the effects of diets with different com-to-soybean ratios on production performance of lactational Rex rabbits and select the best feed formula. [Method] A total of 80 lactational healthy Rex rab... [ Objective] To study the effects of diets with different com-to-soybean ratios on production performance of lactational Rex rabbits and select the best feed formula. [Method] A total of 80 lactational healthy Rex rabbits (similar age, body weight and delivery time) were randomly divided into five groups, 16 in each group. The Rex rabbits in group I were fed with corn-based meal diet, group II with soybean-based meal diet, group III with the developed corn-soybean meal diet, group IV with corn-soybean meal free diet, and group CK with conventional corn-soybean meal diet. During the lactation period, the changes in the lactation performance, growth rate of baby rabbits, weight and feed costs were observed. [ Result] The lactation performance of mother rabbits and the growth rate of baby rabbits in the experimental groups were similar to that in the control group. The weaning survival rate of the group III was the highest, but it was not significantly higher than that of the control group. The weaning survival rate of the other three groups was lower than that of the control group (P〈0.05). The weight loss of mother rabbits in the group I, II and III was not significantly different from that of the control group, but the weight loss of the group IV was higher than that of the control group ( P 〈 0.01 ). [ Conclusion] Diets with appropriate corn-to-soybean ratios not only reduce feed costs but also give the best feeding effects. 展开更多
关键词 lactational Rex rabbits lactation performance Growth rate WEIGHT Feed costs
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Reduced protein diet with near ideal amino acid profile improves energy efficiency and mitigate heat production associated with lactation in sows 被引量:4
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作者 Sai Zhang Jay S.Johnson +1 位作者 Mu Qiao Nathalie L.Trottier 《Journal of Animal Science and Biotechnology》 CAS CSCD 2020年第2期587-601,共15页
Background:The study objective was to test the hypothesis that 1)lowering dietary crude protein(CP)increases dietary energetic efficiency and reduces metabolic heat associated with lactation,and 2)excessive dietary le... Background:The study objective was to test the hypothesis that 1)lowering dietary crude protein(CP)increases dietary energetic efficiency and reduces metabolic heat associated with lactation,and 2)excessive dietary leucine(Leu)supplementation in a low CP diet decreases dietary energetic efficiency and increases metabolic heat associated with lactation.Methods:Fifty-four lactating multiparous Yorkshire sows were allotted to 1 of 3 isocaloric diets(10.80 MJ/kg net energy):1)control(CON;18.75%CP),2)reduced CP with a near ideal or optimal AA profile(OPT;13.75%CP)and 3)diet OPT with excessive Leu(OPTLEU;14.25%CP).Sow body weight and backfat were recorded on day 1 and 21 of lactation and piglets were weighed on day 1,4,8,14,18,and 21 of lactation.Energy balance was measured on sows during early(day 4 to 8)and peak(day 14 to18)lactation,and milk was sampled on day 8 and 18.Results:Over 21-day lactation,sows fed OPT lost body weight and body lipid(P<0.05).In peak lactation,sows fed OPT had higher milk energy output(P<0.05)than CON.Sows fed OPTLEU tended(P=0.07)to have less milk energy output than OPT and did not differ from CON.Maternal energy retention was lower(P<0.05)in OPT and OPTLEU compared to CON sows,and did not differ between OPTLEU and OPT sows.Sows fed OPT had higher(P<0.05)apparent energy efficiency for milk production compared to CON.Heat production associated with lactation was lower(P<0.05)or tended to be lower(P=0.082),respectively,in OPT and OPTLEU compared to CON sows.Conclusion:The OPT diet,in peak lactation,improved dietary energy utilization for lactation due to less urinary energy and metabolic heat loss,and triggered dietary energy deposition into milk at the expense of maternal lipid mobilization.Leucine supplementation above requirement may reduce dietary energy utilization for lactation by decreasing the energy partitioning towards milk,partially explaining the effectiveness of OPT diet over CON diets. 展开更多
关键词 Amino acid Energy balance Heat production lactating sows LEUCINE Reduced protein diet
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Pregnancy and lactation-associated osteoporosis with pyogenic spondylitis:A case report
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作者 Kai Zhai Lei Wang +2 位作者 Ai-Fang Wu Ying Qian Wei-Min Huang 《World Journal of Clinical Cases》 SCIE 2023年第17期4187-4193,共7页
BACKGROUND This case report presents a patient with pyogenic spondylitis(PS)associated with lactation-related osteoporosis during pregnancy.The 34-year-old female patient experienced low back pain for one month,beginn... BACKGROUND This case report presents a patient with pyogenic spondylitis(PS)associated with lactation-related osteoporosis during pregnancy.The 34-year-old female patient experienced low back pain for one month,beginning one month postpartum,with no history of trauma or fever.Dual-energy X-ray absorptiometry of the lumbar spine revealed a Z-score of-2.45,leading to a diagnosis of pregnancy and lactation-associated osteoporosis(PLO).The patient was advised to cease breastfeeding and take oral calcium and active vitamin D.Despite these interventions,her symptoms worsened,and she had difficulty walking one week later,prompting her to revisit our hospital.CASE SUMMARY Lumbar magnetic resonance imaging(MRI)scans showed abnormal signals in the L4 and L5 vertebral bodies and intervertebral space,while an enhancement scan displayed abnormal enhanced high signals around the L4/5 intervertebral disc,suggesting a lumbar infection.A needle biopsy was performed for bacterial culture and pathological examination,culminating in a final diagnosis of pregnancy and lactation-related osteoporosis with PS.Following treatment with antiosteoporotic medications and antibiotics,the patient’s pain gradually subsided,and she returned to normal life within five months.PLO is a rare condition that has garnered increasing attention in recent years.Spinal infections during lactation in pregnancy are also relatively uncommon.CONCLUSION Both conditions primarily manifest as low back pain but require distinct treatments.In clinical practice,when diagnosing patients with pregnancy and lactation-associated osteoporosis,the possibility of spinal infection should be considered.A lumbar MRI should be conducted as needed to prevent delays in diagnosis and treatment. 展开更多
关键词 PREGNANCY lactation OSTEOPOROSIS Pyogenic spondylitis Case report
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Effects of Acupoint Massage Combined with Cupping Therapy on Postpartum Lactation and Mastitis in Puerpera 被引量:2
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作者 Fan Liyun Wu Youjuan Sun Shanghui 《World Journal of Integrated Traditional and Western Medicine》 2019年第1期50-54,共5页
OBJECTIVE: To explore the effects of acupoint massage combined with cupping therapy on postpartum lactation and mastitis. METHODS: A total of 360 women who had breastfeeding needs after hospitalization in the Second P... OBJECTIVE: To explore the effects of acupoint massage combined with cupping therapy on postpartum lactation and mastitis. METHODS: A total of 360 women who had breastfeeding needs after hospitalization in the Second People's Hospital of Hefei were selected from August to December in 2018. A total of 180 women who had no contraindications and were willing to cooperate were included in the observation group, and 180 women who were unwilling to participate in the intervention were the control group. Routine postpartum care was performed on both groups of pregnant women, and acupoint massage and cupping therapy were performed on the maternal women in the observation group. During the hospitalization period, the starting time of lactation in the 2 groups, and the lactation volume at 1 day, 2 days, and 3 days after delivery, and the incidence of mastitis and cracked nipple, and the situation of exclusive breastfeeding were recorded and analyzed. Comparative analysis of the effects of acupoint massage combined with cupping therapy on postpartum lactation and mastitis in primipara were made. RESULTS: In the observation group, 145 women had a moderate amount of lactation 1 day after delivery, and the lactation amount of remaining 35 cases were small. There were 22 women with a high amount of lactation 2 days after delivery, and 132 women had a moderate amount of lactation, and the lactation amount of the remaining 26 cases were small. 138 women had a high amount of lactation 3 days after delivery, and 37 women had a moderate amount of lactation, and the lactation amount of the remaining 5 cases were small. All the women in the observation group did not have cracked nipple or mastitis, and the postpartum effect was significantly better than that of the control group(P < 0.05). CONCLUSION: Acupoint massage combined with cupping therapy can promote early lactation, increase breastfeeding rate, and reduce the incidence of mastitis. 展开更多
关键词 ACUPRESSURE CUPPING MATERNITY lactation MASTITIS
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