CLINICAL SIGNIFICANCES OF THE EXPRESSION OF METALLO- THIONEIN IN FIVE TYPES EPITHELIUM CELL CANCER

Objective： To study the expressions of （CSC）, bladder transitional cell cancer metallothionein and the significances in cervical squamous cell cancer （BTC）, esophageal squamous cell cancer （ESC）, gastral tubular adenocarcinoma （GC） and large intestinal tubular adenocarcinoma （LIC）. Methods： lmmunohistochemical method was used to examine the expression rates of MT in five types of cancer tissue. Results： The expression rates of MT were 75.00% （24/32） in ESC, 52.27% （46/88） in GTC, 59.46% （44/74） in LIC, 64.86% （48/74） in BTC and 58.57% （41/70） in CSC respectively. The positive rates of MT expression were higher in low differentiation and deep muscular group than those in medium or high differentiation and superficial muscular invasion group （P〈0.05）. Conclusion： The expression of MT is related to differentiation degree and invasion degree.

金属硫蛋白在食管癌和胃癌及大肠癌中表达的临床意义

目的探讨金属硫蛋白在食管鳞状细胞癌、胃腺癌、大肠癌中的表达及意义。方法利用SP免疫组织化学技术,检测194例消化管癌组织中金属硫蛋白(MT)表达率。结果 MT在消化管癌总阳性率为58.76%(114/194)。在食管癌、胃癌、肠癌中的阳性率分别为75.00%(24/32),52.27%(46/88),59.46%(44/74)。癌组织浸润深和淋巴结转移者,MT阳性率高于浸润浅组和无淋巴结转移者(P<0.05)。结论 MT表达与癌组织浸润深度和淋巴结转移有关。检测癌组织中MT阳性表达率可以为制定化学治疗方案提供依据。

胃和大肠管状腺癌细胞的超微结构观察

取成人胃和大肠管状腺癌(Ⅱ级)23例,在透射电镜下进行观察,结果表明胃和大肠腺癌的细胞核超微结构基本相同,细胞游离面微绒毛和胞质分泌颗粒等则有许多不同之处,文中对这些异同表现进行了讨论,认为根据它们各自超微结构特点,可以做为追踪转移癌的依据。