Determination of deferasirox particle size distribution via laser diffraction and its application in establishing a correlation between particle size and drug dissolution in vitro

Deferasirox is the first-line drug for iron overload due to thalassemia in adults and pediatric patients. It is classified as a type II compound in the Biopharmaceutics Classification System, and thus the particle size of its active pharmaceutical ingredient(API) should be strictly controlled during the manufacturing process. In the present study, laser diffraction was adopted to measure the particle size distribution of deferasirox API. We also developed and validated an accurate and convenient method by investigating important optical parameters and sample dispersing conditions. The relative standard deviation values, namely, d(0.1), d(0.5), d(0.9), and d(4,3), measured via methodology validation and actual sample measurement were < 3%. The dissolution curves of several batches of dispersible tablets prepared using deferasirox with different particle sizes were compared in the four dissolved media to investigate the influence of particle size on drug dissolution in vitro. Results indicated that the particle size distribution of deferasirox API significantly affected the release of its dispersible tablet.

Improvements of Traditional Laser Fraunhofer Diffraction Experiment Using Digital Image Processing Method

We present an improved digital image processing(DIP)method to calculate the widths of single slits.Different from the traditional laser Fraunhofer diffraction experiment in college physical experiments,by performing fast Fourier transform,inverse fast Fourier transform and the nonlinear leastsquare fitting on the diffraction pattern taken by a camera,the DIP method can quickly return an analytic expression,whose period is used to calculate widths of single slits.By comparing the measured results by the DIP method and the successional difference(SD)method,we find that for a single slit whose width is 60372μm,the DIP method is more accurate.Experimental results show that for single slits with widths between 40μm and 160μm,the relative error of the DIP method is less than 2.78%.Also,the DIP method can be used to measure the diameter of filament and fibres online in real time.

Dynamic evolution of low-viscosity fuel particle distribution driven by constant flow

The effects of mass concentration and injection pressure on the atomization characteristics of low-viscosity fuel spray are studied in a constant-volume chamber.Microscopic spray parameters are measured by laser diffraction at different axial and radial positions downstream of the nozzle.The results show that the atomization effect is inhibited linearly with the increase of mass concentration.The increase of injection pressure promotes the droplet breakup.However,the trend gradually weakens and becomes more noticeable at high concentrations.Comparing with the concentration,the influence of the injection pressure on the atomization characteristics is dominant.Although low concentration and high injection pressure can promote the droplet breakup,they also increase the probability of droplet collision,resulting in droplet aggregation.This is more evident in low-viscosity fuels.The droplet size increases in the axial direction owing to the aggregation.However,the diameter decreases in the radial direction owing to the outward deflection of small droplets caused by air turbulence and entrainment.In addition,the high-velocity airflow significantly promotes the droplet breakup near the nozzle and spray axis regions and inhibits the aggregation effect.However,the lower-viscosity fuels keep smaller droplet sizes and better atomization in the whole spraying process,which is easier to realize than the higher-viscosity fuels.Overall,low concentration,high injection pressure,and low viscosity of fuel have beneficial effects on the droplet breakup.This is very important for improving the atomization effect of fuel.

FUNCTIONS OF POLYAMINES IN ROSIN SIZING UNDER NEUTRAL PAPERMAKING CONDITIONS

Functions of the polyamines in neutral rosin sizing were investigated using X-ray photoelectron spectroscopy (XPS) and laser diffraction particle analysis. The polyamine with a higher charge density and a smaller unite size could retain more rosin and cover larger fiber surfaces. The XPS spectra demonstrated that polyallylamine (PAAm) and polyvinylamine (PVAm) could react with a rosin size to form a -OC-N-CO- structure, but polydimethylamino ethyl methacrylate (PDMAEMA) could not. The formation of this structure may be a key step for effective sizing.

Soil particle size range correction for improved calibration relationship between the laser-diffraction method and sieve-pipette method

Particle size fraction(clay, silt, and sand) is an important characteristic that influences several soil functions. The laser-diffraction method(LDM) provides a fast and cost-effective measurement of particle size distribution, but the results usually differ from those obtained by the traditional sieve-pipette method(SPM). This difference can persist even when calibration is applied between the two methods. This partly relates to the different size ranges of particles measured by the two methods as a result of different operational principles, i.e., particle sedimentation according to Stokes’ Law vs. Mie theory for laser beam scattering. The objective of this study was to identify particle size ranges of LDM equivalent to those measured by SPM and evaluate whether new calibration models based on size range correction can be used to improve LDM-estimated particle size fractions, using 51 soil samples with various texture collected from five soil orders in New Zealand. Particle size distribution was determined using both LDM and SPM. Compared with SPM, original data from LDM underestimated the clay fraction(< 2 μm), overestimated the silt fraction(2–53 μm), but provided a good estimation of the sand fraction(53–2 000 μm).Results from three statistical indices, including Pearson’s correlation coefficient, slope, and Lin’s concordance correlation coefficient, showed that the size ranges of < 2 and 2–53 μm defined by SPM corresponded with the < 5 and 5–53 μm size ranges by LDM, respectively. Compared with the traditional calibration(based on the same particle size ranges), new calibration models(based on the corrected size ranges of these two methods) improved the estimation of clay and silt contents by LDM. Compared with soil-specific models(i.e., different models were developed for different soils), a universal model may be more parsimonious for estimating particle size fractions if the samples to be assessed represent multiple soil orders.

A Constitutive Modeling and Experimental Effect of Shock Wave on the Microstructural Sub-strengthening of Granular Copper

Micro-sized copper powder(99.95%;O≤0.3)has been shock-processed with explosives of high detonation velocities of the order of 7.5 km/s to observe the structural and microstructural sub-strengthening.Axisymmetric shock-consolidation technique has been used to obtain conglomerates of granular Cu.The technique involves the cylindrical compaction system wherein the explosive-charge is in direct proximity with the powder whereas the other uses indirect shock pressure with die-plunger geometry.Numeric simulations have been performed on with Eulerian code dynamics.The simulated results show a good agreement with the experimental observation of detonation parameters like detonation velocity,pressure,particle velocity and shock pressure in the reactive media.A pin contactor method has been utilized to calculate the detonation pressure experimentally.Wide angled x-ray diffraction studies reveal that the crystalline structure(FCC)of the shocked specimen matches with the un-shocked specimen.Field emissive scanning electron microscopic examination of the compacted specimens show a good sub-structural strengthening and complement the theoretical considerations.Laser diffraction based particle size analyzer also points towards the reduced particle size of the shock-processed specimen under high detonation velocities.Micro-hardness tests conducted under variable loads of 0.1 kg,0.05 kg and 0.025 kg force with diamond indenter optical micrographs indicate a high order of micro-hardness of the order of 159 Hv.Nitrogen pycnometry used for the density measurement of the compacts shows that a compacted density of the order of 99.3%theoretical mean density has been achieved.

Laser beam characteristic for laser resonators with diffraction optical elements

The matrix eigenvalue method is used to analyze a laser resonator composed of diffraction optical elements. The results show that this type of resonator can separate fundamental mode and high order modes effectively. The output beams can be designed for different requests.

Numerical solutions of Green's integral equation for the diffraction of femtosecond laser pulses through a subwavelength aperture

In this letter, we propose a method for the numerical calculations of the femtosecond laser pulse passed through a subwavelength aperture. The time-dependent laser pulse is decomposed into a series of monochromatic simple harmonic waves. For the light field of the harmonic wave with a single frequency, the numerical calculation is made based on the solution of the Green's integral equation set of the electromagnetic waves. Such numerical solution is iterated for all the waves with different frequencies, and all the numerical solutions are transformed into the light fields in the time domain by inverse Fourier transform. The light intensity distributions transmitted the subwavelength aperture are calculated and the results show the propagation of the light field is along the direction of the medium interface.

Light scattering:A review of particle characterization applications

This review covers the progress of light scattering applications in the field of particle characterization in the past decade. The review addresses static light scattering （the measurement of scattering intensities due to light-particle interaction at various spatial locations）, dynamic light scattering （the measurement of scattering due to light-particle interaction as a function of time）, and scattering tracking analysis （the tracking of particle movement through scattering measurement）.

Development of droplet characteristics prediction models for air induction nozzles based on wind tunnel tests

Nozzle flowrate and spray pressure are two of the most important factors influencing on droplet characteristics.With the aim to develop prediction models for air-induction nozzles(AINs),a series of Billericay Farm Services(BFS)AINs with different orifice diameters in combination with tap water were tested.0.2 MPa,0.3 MPa,0.4 MPa,0.5 MPa,0.6 MPa and 0.7 MPa of spray pressures and 2 m/s,3 m/s,4 m/s and 5 m/s of air speeds were setup.Based on the wind tunnel tests data,prediction models with input variables of nozzle flowrate and spray pressure and output variables of D_(v0.1),D_(v0.5),D_(v0.9),%<150μm(proportion of spray volume contained in droplets with diameter below 150μm),relative span(RS)and coefficient of variation(CV)of D_(v0.5) were developed.The developed models were validated based on wind tunnel experimental data.Results showed that:for D_(v0.1),D_(v0.5),D_(v0.9) and%<150μm,R^(2) were equal to 0.768,0.823,0.868 and 0.811,indicating that the predictive ability for these four parameters is strong.For RS and CV,R^(2) were equal to 0.100 and 0.113,respectively,indicating that the predictive ability for these two parameters is poor.The models developed in the present study are helpful for facilitating the use of AIN in agricultural spray application.