Small incision lenticule extraction and femtosecond-assisted laser in situ keratomileusis in patients with deep corneal opacity:case series

AIM:To report the safety,efficacy,and accuracy of small-incision lenticule extraction(SMILE)or femtosecondassisted laser in situ keratomileusis(FS-LASIK)for the correction of myopia or myopic astigmatism in patients with deep corneal opacity denoted by anterior segment optical coherence tomography(AS-OCT).METHODS:Four patients with monocular corneal opacity(3 due to mechanical injury,1 due to a firecracker wound)were recruited and treated with refractive surgery(3 for SMILE,1 for FS-LASIK combined with limbal relaxing incision(LRI).Preoperative ocular manifestations,surgical details,postoperative visual outcomes,corneal opacity parameters,and corneal topography were analyzed.RESULTS:Preoperatively,spherical diopter ranged from-3.0 D to-4.75 D with cylinder ranging from-0.75 to-5.0 D,and corrected distance visual acuity(CDVA)ranging from 20/25 to 20/20.One eye’s corneal opacity was located in the central zone and three were in the mid-peripheral optical zone.Three patients underwent uneventful SMILE in both eyes,whilst one patient underwent FS-LASIK for high astigmatism in both eyes and LRI in the right eye.CDVA of the eye with corneal opacity ranged from 20/22to 20/20 one to six weeks postoperatively.Two patients achieved better CDVA and no patients lost Snellen lines.The postoperative diopter was within±0.75 D for all eyes.Significant edema existed above the corneal opacity in one eye and dissipated soon.No eccentric corneal topography or morphological anomaly of the corneal cap or flap was observed.CONCLUSION:The cases demonstrate that SMILE or FS-LASIK is safe and effective to treat myopic astigmatism combined with deep corneal opacity lesions after comprehensive preoperative evaluation and appropriate candidate selection.FS-LASIK combined with LRI is also sufficient for correcting high astigmatism due to corneal scarring.

Corneal flap morphological analysis using anterior segment optical coherence tomography in laser in situ keratomileusis with femtosecond lasers versus mechanical microkeratome

AIM:To assess and compare the flap morphology using anterior segment optical coherence tomography (AS-OCT) in laser in situ keratomileusis(LASIK) with Femto LDV femtosecond lasers versus Hansatome mechanical Microkeratome.· METHODS:AS-OCT (Visante) was used to compare 1 month postoperatively the morphology of the flaps created with Femto LDV femtosecond lasers or Hansatome Microkeratome.The intendedfiap thickness was 110μm and 160μm respectively.The thickness of twenty-five points across each flap,which were 0mm,1.5mm,2.5mm,and 3.5mm to the corneal vertex on the horizontal,vertical,45° and 135° meridian respectively,was evaluated.· RESULTS:One month postoperative,the central flap thickness in the Femto LDV group was 107.43±4.70μm,while 125.90±17.50μm in the Hansatome group.The difference between the actual and the expectedfiap thickness was 5.61±3.84μm and 31.52±12.27μm,respectively.The Hansatome group had presented a statistically significant result (P <0.001).Flap morphology showed a more regular planar shape in the Femto LDV group and a meniscus shape in the Hansatome group.· CONCLUSION:AS-OCT is a direct and fast procedure to assess the flap morphology.The morphology by AS-OCT showed that the flaps created with Femto LDV femtosecond laser were more accurate and regular than the flaps created with Hansatome microkeratome.

Using LaserSight Astrapro Planner 2.2 Z software in corneal topography-guided laser in situ keratomileusis for myopia with asymmetric corneal shape

AIM:To determine the clinical outcomes of laser insitu keratomileusis(LASIK)treatments using LaserSight AstraPro Planner 2.2 Z software for myopia with asymmetric corneal shape.METHODS:Four hundred and eighty-five eyes[243patients;spherical equivalent(SE),-5.93±1.88 diopters(D)]were treated with asymmetric ablations using LaserSight SLX laser(version 5.3,300Hz)were retrospectively analyzed and LaserSight AstraPro Planner2.2 Z software.Preoperative and postoperative uncorrected visual acuities(UCVA),spherical equivalent(SE)refraction,pachymetry,and corneal asphericity(Q value)and decentration were evaluated.RESULTS:At 12mo postoperatively,the decimal UCVA was 1.0 or better in 449(92.6%)eyes.Two eyes(0.4%)lost 1 line of the decimal best spectacle-corrected visual acuity(BCVA),316(65.2%)did not change,149(30.7%)gained 1 line,and 18(3.7%)gained 2 lines or more after surgery.Three hundred and thirty-two eyes(68.5%)were within 0.5 D in SE.The mean tissue saving ablation depth was 4.28±2.86(0-16)μm(median,4μm).The mean attempted remaining central corneal thickness was435.79±29.56μm,the mean postoperative pachymetry was 444.94±28.93μm.The mean preoperative Q value was-0.19±0.18,the postoperative was 0.30±0.48(P=0.000).The mean postoperative decentration was 0.39±0.19 mm.CONCLUSION:Topography-guidedLASIKwithAstraPro Planner 2.2 Z custom ablation planning software in an asymmetric ablation mode was an effective,safe,predictable,and stable refractive procedure for the myopia with asymmetric corneal topography.

Laser in situ keratomileusis in adult patients with anisometropic amblyopia

AIM: To evaluate the increase in corrected distance visual acuity (CDVA) after laser in situ keratomileusis (LASIK) in adults with anisometropic amblyopia. · METHODS: The medical records of consecutive patients diagnosed with anisometropic amblyopia at the time of refractive evaluation who underwent LASIK were retrospectively reviewed. Patients with at least a two-line difference of visual acuity (VA) between the eyes with a spherical refractive error difference of at least 3.00 diopters (D) or an astigmatic difference of at least 2.00D were included. Patients with any other possible reason for amblyopia other than anisometropia or those who had undergone previous amblyopia treatment were excluded. Amblyopic eyes with myopia or myopic astigmatism were considered as group 1, hypermetropia or hypermetropic astigmatism constituted group 2, and mixed astigmatism patients comprised group 3. Uncorrected distance visual acuity (UDVA), subjective manifest refraction, and CDVA were analyzed at 1 week and 1 month, 3, and 6 months. ·RESULTS: The study included 57 eyes of 57 patients. There were 33 eyes in group 1, 12 eyes in group 2, and 12 eyes in group 3. The preoperative mean values for spherical equivalent of subjective manifest refraction (SE) in groups 1, 2, and 3 were (-4.66±1.97)D, (4.40±1.00)D, and (0.15±1.05)D, respectively. Mean CDVA improved 0.1 log units (1 line LogMAR) at 6 months (P <0.05). Sixteen eyes (28%) exhibited an improvement in CDVA in week 1. Fourteen eyes (25% ) experienced two or more lines of CDVA improvement at month 6. There were no statistically significant differences among the groups in terms of CDVA (P >0.05). Moreover, age, the amount ofpreoperative refractive error, and the levels of preoperative corrected and UDVA had no effect on postoperative CDVA improvement (P >0.05). · CONCLUSION: Correction of refractive errors with LASIK produced significant CDVA improvement in adult patients with anisometropic amblyopia and no previous amblyopia treatment.

Three-year results of small incision lenticule extraction and wavefront-guided femtosecond laser-assisted laser in situ keratomileusis for correction of high myopia and myopic astigmatism

AIM: To compare and calculate the 3-year refractive results, higher-order aberrations(HOAs), contrast sensitivity(CS) and dry eye parameters after small incision lenticule extraction(SMILE) and wavefront-guided femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK) for correction of high myopia and myopic astigmatism.METHODS: In this prospective, non-randomized comparative study, 78 eyes with spherical equivalent(SE) of-8.11±1.09 diopters(D) received a SMILE surgery, and 65 eyes with SE of-8.05±1.12 D received a wavefront-guided FS-LASIK surgery with the Visu Max femtosecond laser(Carl Zeiss Meditec, Jena, Germany) for flap cutting. Visual acuity, manifest refraction, CS, HOAs, ocular surface disease index(OSDI) and tear break-up time(TBUT) were evaluated during a 3-year follow-up.RESULTS: The difference of uncorrected distance visual acuity(UDVA) postoperatively was achieved at 1 mo and at3 mo, whereas the difference of the mean UDVA between two groups at 3 y were not statistically significant(t=-1.59,P=0.13). The postoperative change of SE was 0.89 D in the FS-LASIK group(t=5.76, P=0.00), and 0.14 D in the SMILE group(t=0.54, P=0.59) from 1 mo to 3 y after surgery.At 3-year postoperatively, both HOAs and spherical aberrations in the SMILE group were obviously less than those in the FS-LASIK group(P=0.00), but the coma root mean square(RMS) was higher in the SMILE group(0.59±0.26) than in the FS-LASIK group(0.29±0.14, P=0.00).The mesopic CS values between two groups were not statistically significant at 3 y postoperatively. Comparedwith the FS-LASIK group, lower OSDI scores and longer TBUT values were found in the SMILE group at 1 mo and 3 mo postoperatively. With regard to safety, no eye lost any line of CDVA in both groups at 3 y after surgery. CONCLUSION: Both SMILE and wavefront-guided FSLASIK procedures provide good visual outcomes. Both procedures are effective and safe, but SMILE surgery achieve more stable long-term refractive outcome and better control of early postoperative dry eye as compared to FS-LASIK.

Comparison of visual acuity of the patients on the first day after sub-Bowman keratomileusis or laser in situ keratomileusis

AIM:To compare recovery of the visual acuity in patients one day after sub-Bowman keratomileusis(SBK)or laser in situ keratomileusis(LASIK).· METHODS:Data from 5923 eyes in 2968 patients that received LASIK(2755 eyes) or SBK(3168 eyes) were retrospectively analyzed.The eyes were divided into 4groups according to preoperative spherical equivalent:between-12.00 to-9.00 D,extremely high myopia(n =396,including 192 and 204 in SBK and LASIK groups,respectively);-9.00 to-6.00 D,high myopia(n=1822,including 991 and 831 in SBK and LASIK groups,respectively),-6.00 to-3.00 D,moderate myopia(n=3071,including 1658 and 1413 in SBK and LASIK groups,respectively),and-3.00 to 0.00 D,low myopia(n =634,including 327 and 307 in SBK and LASIK groups,respectively).Uncorrected logMAR visual acuity values of patients were assessed under standard natural light.Analysis of variance was used for comparisons among different groups.· RESULTS:Uncorrected visual acuity values were0.0115±0.1051 and 0.0466±0.1477 at day 1 after operation for patients receiving SBK and LASIK,respectively(P<0.01);visual acuity values of 0.1854±0.1842,0.0615±0.1326,-0.0033±0.0978,and-0.0164±0.0972 were obtained for patients in the extremely high,high,moderate,and low myopia groups,respectively(P<0.01).In addition,significant differences in visual acuity at day 1 after operation were found between patients receiving SBK and LASIK in each myopia subgroup.· CONCLUSION:Compared with LASIK,SBK is safer and more effective,with faster recovery.Therefore,SBK is more likely to be accepted by patients than LASIK for better uncorrected visual acuity the day following operation.

Optical and visual quality comparison of implantable collamer lens and femtosecond laser assisted laser in situ keratomileusis for high myopia correction

AIM:To compare clinical outcomes and refractive stability of implantable collamer lens(ICL)implantation and femtosecond laser assisted laser in situ keratomileusis(FSLASIK)for high myopia correction.METHODS:The Optical Quality Analysis System(OQAS)was used to evaluate clinical outcomes objectively after operation for high myopia correction.We compared the two procedures in terms of 1-year changes in uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),safety index,efficacy index,spherical equivalent,modulation transfer function(MTF)cutoff frequency,strehl ratio(SR)and objective scatter index(OSI).RESULTS:At 1 y postoperatively,the safety indices were 1.33±0.27 in ICL group,and 1.17±0.24 in FS-LASIK group.39.58%in the ICL group and 27.59%in the FS-LASIK group gained CDVA in 2 lines or better than that in preoperative CDVA.The efficacy indices were 1.28±0.22 in ICL group,and 1.13±0.26 in FS-LASIK group.The changes of spherical equivalent from 1 wk to 1 y postoperatively was-0.12±0.37 D in ICL group,and-0.79±0.58 D in FS-LASIK group(P<0.05).Spherical equivalent within±0.50 D was achieved in 97.92%in ICL group and 68.97%in FS-LASIK group.MTF cutoff frequency were higher with ICL as compared to FSLASIK(P<0.05)at each postoperative follow-up stage;for postoperative 1 mo later,SR was statistically significant difference between two groups(P<0.05);with no statistically significant difference in OSI between two groups(P>0.05)in postoperative 3 mo later.CONCLUSION:ICL implantation and FS-LASIK procedures both provide good safety and predictability in high myopia correction.ICL implantation provides better clinical outcomes and refractive stability than FS-LASIK.

Comparison of optical quality after implantable collamer lens implantation and wavefront-guided laser in situ keratomileusis

AIM: To compare the optical quality after implantation of implantable collamer lens(ICL) and wavefront-guided laser in situ keratomileusis(WG-LASIK).METHODS: The study included 40 eyes of 22 patients with myopia who accepted ICL implantation and 40 eyes of 20 patients with myopia who received WG-LASIK. Before surgery and three months after surgery, the objective scattering index(OSI), the values of modulation transfer function(MTF) cutoff frequency, Strehl ratio, and the Optical Quality Analysis System(OQAS) values(OVs) were accessed. The higher order aberrations(HOAs) data including coma, trefoil, spherical, 2^(nd) astigmatism and tetrafoil were also obtained. For patients with pupil size <6 mm, HOAs data were analyzed for 4 mm-pupil diameter. For patients with pupil size ≥6 mm, HOAs data were calculated for 6 mm-pupil diameter. Visual acuity, refraction, pupil size and intraocular pressures were also recorded.RESULTS: In both ICL and WG-LASIK group, significant improvements in visual acuities were found postoperatively, with a significant reduction in spherical equivalent(P< 0.001). After the ICL implantation, the OSI decreasedslightly from 2.34±1.92 to 2.24±1.18 with no statistical significance(P=0.62). While in WG-LASIK group, the OSI significantly increased from 0.68±0.43 preoperatively to 0.91±0.53 postoperatively(Wilcoxon signed ranks test, P=0.000). None of the mean MTF cutoff frequency, Strehl ratio, OVs showed statistically significant changes in both ICL and WG-LASIK groups. In the ICL group, there were no statistical differences in the total HOAs for either 4 mmpupil or 6 mm-pupil. In the WG-LASIK group, the HOA parameters increased significantly at 4 mm-pupil. The total ocular HOAs, coma, spherical and 2^(nd) astigmatism were 0.12±0.06, 0.06±0.03, 0.00±0.03, 0.02±0.01, respectively. After the operation, these values were increased into 0.16±0.07, 0.08±0.05,-0.04±0.04, 0.03±0.01 respectively(Wilcoxon signed ranks test, all P<0.05). At 6 mm-pupil, the induction of total HOAs was not statistically significant in the WG-LASIK group. CONCLUSION: ICL implantation has a less disturbance to optical quality than WG-LASIK. The OQAS is a valuable complementary measurement to the wavefront aberrometers in evaluating the optical quality.

Influence of transient intraocular pressure elevation during laser in situ keratomileusis on rabbit retina thickness

AIM: To utilize tissue micro measurement to study the effect of transient high intraocular pressure(IOP)induced by different durations of suction during laser in situ keratomileusis(LASIK) on rabbit retina thickness.·METHODS: Sixty healthy New Zealand white rabbits were randomly divided into a control group, and 3negative-pressure suction groups(20s group, 45 s group,and 3min group) and each group was comprised of 15rabbits(30 eyes); the latter 3 groups were the transient high IOP models. The retinal tissue around the papilledema was separated. Hematoxylin and eosin(HE)staining was carried out to generate slices for light microscopy. The changes in the retina thickness values of each layer were measured for all animals in each group at different postoperative recovery periods and compared with the values recorded for the animals in the control group. The thickness of the retinal tissue showed a normal distribution. The ANOVA was performed by using SPSS13.0 statistic software.·RESULTS: In the comparison between the 20 s and 45 s negative-pressure suction groups and the control group,no significant differences were observed, except at 14 d.Significant difference was observed between the 3min negative-pressure suction group and the control group,and the retina thickness value of each layer reached a peak at 14 d after repair.·CONCLUSION: Conventional negative suction during LASIK may not lead to significant changes in retinal tissue thickness; however, if the suction duration is increased to 3min, it will cause significant changes in retinal tissue thickness.

Dry eye and corneal sensitivity after small incision lenticule extraction and femtosecond laser-assisted in situ keratomileusis:a Meta-analysis

AIM:To assess the corneal sensitivity and the incidences of dry eye after small incision lenticule extraction(SMILE) and femtosecond laser-assisted in situ keratomileusis(FSLASIK).METHODS:The Meta-analysis was performed using Rev Man 5.3.We searched on Pub Med from inception to March 2016.Summary weighted mean difference(WMD) and 95% confidence intervals(CIs) were used to analyze the datum.Random-effects or fixed-effects models were chosen up to between-study heterogeneity.The main outcomes were composed of the Ocular Surface Disease Index(OSDI) scores,tear film break-up time(TBUT),Schirmer Test and corneal sensitivity.RESULTS:Eight eligible studies including 772 eyes(386 in SMILE group and 386 in FS-LASIK group) were identified.The parameters have no significiant difference heterogeneity between SMILE and FS-LASIK group preoperatively.There were significant differences between the two groups in OSDI scores at one and three months postoperatively,in TBUT at one and three months postoperatively,in corneal sensitivity at one week,about one month and three months postoperatively.However,there was no significant difference observed in Schirmer Test at the follow-up periods.CONCLUSION:Compare to FS-LASIK,dry eye and the corneal sensitivity recover better in the SMILE group,in first three months after the surgery.

Effect of Laser in situ Keratomileusis on Accommodation

The accommodative function before and after laser in situ keratomileusis (LASIK) was observed, and the effect of LASIK on accommodation was investigated. In a prospective clinical trial, 48 myopic patients (96 eyes) subject to bilateral LASIK in Refractive Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (China) from March 2006 to June 2006 were selected and studied. Refractions, accommodative range, amplitude of accommodative response and high frequency component (HFC) of accommodative microfluctuations were measured with NEDIK-730A before and one week and 30 days after operation. Dominant and non-dominant eyes were determined by hole-in-card method. It was found that all of the operative eyes showed an uncorrected visual acuity of 0.8 or better one week postoperatively, and 1.0 or better 30 days postoperatively. Compared with those preoperatively, accommodative range and HFC had no significant difference at first week and 30th day after operation in both dominant eyes and non-dominant eyes (P>0.05), but there was a significant difference in the amplitude of accommodative response/accommodative stimulus ratio (A/S) after operation (P<0.01), and no significant difference was found in accommodation between one week and 30 days postoperation. No ocular dominance's change was noted. There was no significant difference in accommodative function between dominant eyes and non-dominant eyes. It was suggested that LASIK produced no significant effect on accommodation.

Comparison of Intraocular Pressures at Different Points in Human's Cornea before and after Laser in situ Keratomileusis with Tono-Pen Tonometer

In order to explore the difference of intraocular pressure(IOP) at different points of cornea before and after laser in situ keratomileusis(LASIK),IOP was measured by Tono-Pen Tonometer at central cornea,pericentral cornea and limbus respectively and analyzed statistically.After LASIK,IOP was dropped significantly at central cornea and pericentral cornea(P<0.05),while no statistically significant change occurred at limbus(P>0.05).There was no statistically significant difference in IOP at different points before LASIK(F=0.110,P=0.896),but statistically significant difference was found after LASIK(F=7.375,P=0.001).It was suggested that reliable IOP after LASIK could be obtained from the limbus by Tono-Pen tonometer.

Posner-Schlossman syndrome induced laser in situ keratomileusis keratectasia–a case report

Dear Editor,I am Dr.Xiu Wang,from Tianjin Medical University Eye Hospital,Tianjin,China.I write to present one case report of Posner-Schlossman syndrome(PSS)induced laser in situ keratomileusis(LASIK)keratectasia.PSS is a condition characterized by recurrent,acute attacks of mild,unilateral,non-granulomatous,anterior

Severe Diffuse Lamellar Keratitis Following Laser <i>in Situ</i>Keratomileusis with an Iatrogenic Double Flap

We present a case of an iatrogenic double flap created during laser in situ keratomileusis using a femtosecond laser microkeratome that resulted in development of severe diffuse lamellar keratitis (DLK). The DLK occurred mainly in the second interface, made by the spatula accidentally and not exposed to femtosecond or excimer lasers. Because of differences in the severity of the interface inflammatory reactions between the two layers exposed to the same spatula, an allergic reaction to detergent, bacteria, or other chemicals could not be assumed to be the main cause of DLK. Our observations in this case may suggest an important association of neural factors with DLK, because the inflammatory reaction occurred mainly in the deep stromal layer at the thick corneal nerves.

Above-average defocus curves in photopic and mesopic vision with multifocal intraocular lenses after laser assisted in situ keratomileusis

Dear Editor,I am Dr.David P Pi?ero from the Department of Optics,Pharmacology and Anatomy of the University of Alicante and from the Department of Ophthalmology of Vithas Medimar(Oftalmar)and Vithas Virgen del Carmen(Qvision)hospitals in Spain.I write to describe a case in which the visual acuity defocus curves(VADC)and contrast sensitivity

The Influence of Keratometry on Visual and Refractive Outcomes after Myopic LASER <i>in Situ</i>Keratomileusis

To evaluate the effect of preoperative keratometry on visual and refractive outcomes after Myopic LASER in Situ Keratomileusis (LASIK) in eyes with preoperative spherical equivalent (SE) of -6.00D or less. Material and Methods: A retrospective study enrolling clinical records of 482 eyes of 275 patients with myopia who underwent LASIK between 2009 and 2016. Subjects were grouped according to the degree of preoperative mean keratometry (Km), into three groups: Group 1 (Flat Cornea): Km ≤ 42.00 diopters (D);Group 2: 42.00 46.00D;Group 3 (Steep Cornea): Km ≥ 46.00D. To evaluate the prognostic impact of keratometry in Myopic LASIK, we considered the results measured at 6 months postoperatively, including uncorrected distance visual acuity (UDVA), postoperative sphere, cylinder, SE and its variation. Results: The mean preoperative SE was -3.91 ± 1.54D, ranging between -0.88 and -6.00D. The percentage of eyes achieving a postoperative SE of ±0.50D was 39.5%, 31.8% and 26% in groups 1, 2 and 3 respectively. Moreover, in group 3, 14.3% of the eyes had a residual SE of -2.00D or greater, contrasting with the groups 1 and 2 with only 6% - 7%. These results were found to be statistically significant. Concerning UDVA, eyes achieving 20/25 or more were 81.5%, 81.8% and 71.5%, and 20/50 or less were 6.7%, 6.2% and 11.7% in groups 1, 2 and 3 respectively. Conclusions: Myopic eyes with steeper corneas seem to have greater tendency to undercorrection, also presenting worse visual outcomes.

Dislocation,fold and striae of comeal flap with laser assisted in situ keratomileusis after ocular trauma:a case report

Objective,To report the occurrence,management and outcome of late-onset traumatic dehiscence and dislocation of laser assisted in situ keratomileusis(LASIK)flaps.Treatment and Results:One patient occurred late-onset LASIK corneal flap dislocation after ocular trauma 7days after surgery.The flap was lifted,stretched,and repositioned after irrigation and scraping of the stromal bed and the underside of the flap.A bandage contact lens was placed,and topical antibiotic and corticosteroids were given postoperatively.The dislocated corneal flap was successfully repositioned in the case.The dislocated flap was repositioned 7 days after the trauma,and the patient recovered his uncorrected visual acuity(UCVA)of 10/20,20/20 day 1 and day 20 after the procedure,of 20/20 20 days later and had a well-positioned flap with a clear interface.Diffuse lamellar keratitis developed in the patients that resolved with the use of topical corticosteroids.Conclusion:Laser in situ keratomileusis corneal flaps are vulnerable to traumatic dehiscence and dislocation,which should be pay more attention to it for us.

Long term changes of posterior corneal elevation after myopic laser in situ keratomileusis

Background: Corneal ectasia is a serious complication after laser in situ keratomileusis(LASIK). Ideally, patients at risk of ectasia should be identified prior to laser as unsuitable for LASIK, however, at present, there is no absolute test, system, or marker that can unequivocally identify patients at risk of developing ectasia. It has been suggested that changes in the forward protrusion of the posterior cornea or posterior corneal elevation(PCE) may be a key to the early detection of ectasia after LASIK. The purpose of this study was to examine the long term changes of the PCE after myopic LASIK using the ORBSCAN~ IIz(Bausch & Lomb, Rochester, USA) and to evaluate the contributory preoperative factors to PCE changes.Methods: This was a retrospective longitudinal case series. Forty-two eyes of 23 consecutive myopic patients who underwent uneventful LASIK surgery 6 years ago were recalled for a postoperative follow-up examination using the ORBSCAN~ IIz to determine the elevation changes to the posterior corneal surface from the preoperative measurements. A forward shift of the posterior surface was given a negative value. Correlation analyses and forward stepwise regression analyses were performed to evaluate the effect of each of the preoperative parameters on the changes in PCE. Statistical and graphical analyses were performed.Results: There was no statistical difference between the mean best-fit sphere(BFS) pre-LASIK and 6 years postop(P=0.25). Forty-two post-LASIK eyes had a mean posterior displacement of -9.38±9.84 μm(range, 12 to-31 μm) 6 years after LASIK. Forward stepwise multiple linear regression analysis indicated that the ablation spherical equivalent(ASE) was the only indicator of the forward shift of the posterior cornea after LASIK.Conclusions: The present study identified a significant forward shift of the posterior cornea 6 years after LASIK. The ASE was the most significant prognostic determinant for forward protrusion of the posterior cornea after LASIK.

Time Course of Q Value after Myopic Laser-assisted In Situ Keratomileusis

Objective To assess the time course of Q value after myopic laser-assisted in situ keratomileusis(LASIK) and preliminarily evaluate the determinants of the difference of Q value between before and after LASIK.Methods We performed a retrospective,longitudinal investigation on patients undergoing wavefront optimized LASIK therapy for emmetropization.A total of 418 eyes from 222 cases were examined preoperatively,and partly followed up at one week(172 eyes),one month(134 eyes) and three months(51 eyes) after surgery.The horizontal,vertical and total Q values of cornea were calculated from eccentricity measured at the central 6-mm corneal zones respectively.Potential determinants of the change of Q value were analyzed using multiple linear regressions.Results The mean Q value was-0.17±0.13 preoperatively,and 0.99±0.70,0.97±0.66,and 0.86±0.41 one week,one and three months postoperatively,respectively.One way analysis of variance(ANOVA) demonstrated significant differences between measurements made before surgery and at all postoperative times(at one week,one and three months;all P<0.0001,Bonferroni post hoc),but no significant differences were found among postoperative groups.Significant differences of Q values between horizontal and vertical meridians were found before surgery and at all postoperative times(all P<0.0001).Multiple regression analysis revealed that change of Q value significantly correlated with manifest refraction spherical equivalent(r=0.116,P<0.0001) and axial length(r=0.264,P<0.0001).Conclusions Over the study period,the primary changes in Q value occur within 1 week after surgery,and then become slightly decreased and nearly stable.Manifest refraction spherical equivalent and axial length play a significant role in the change of postoperative Q value.

EFFECTS OF PREOPERATIVE SOFT CONTACT LENS WEAR ON HIGHER-ORDER ABERRATIONS AFTER LASER IN SITU KERATOMILEUSIS

Objective To evaluate the effects of preoperative soft contact lens (SCL) wear on higher-order aberrations(HOAs)correction after wavefront-guided and conventional laser in situ keratomileusis (LASIK). Methods A prospective randomized double-masked comparative study was conducted in 180 eyes of 90 patients scheduled for LASIK, including 92 eyes of 46 patients with previous SCL wear. The patients were divided into four groups: no SCL-conventional group, SCL-conventional group, no SCL-wavefront group and SCL-wavefront group. Preoperative and postoperative examinations included uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), contrast sensitivity and HOAs. Results The UCVA and BSCVA were 20/20 in all patients at 6 months postoperatively. And 36.3%, 22.7%, 18.1% and 35.4% gained one line or more of BSCVA in no SCL-wavefront group, SCL-wavefront group, no SCL-conventional group and SCL-conventional group, respectively. Both the safety index and efficacy index surpassed one in 4 groups and were highest in no SCL-wavefront group. The increase in root-mean-square (RMS) values of HOAs was significantly lower in no SCL-wavefront group and higher in SCL-wavefront group. At 6 months postoperatively, the increase in RMS of HOAs (RMSh) were 0.67, 1.58, 1.17 and 1.28 in no SCL-wavefront group, SCL-wavefront group, no SCL-conventional group and SCL-conventional group, respectively. Conclusion Preoperative contact lens wear has significant influence on the efficacy of HOAs correction in wavefront-guided LASIK. Patients with contact lens wear preoperatively should be cautious when scheduled for wavefront-guided LASIK.