Cumulative sum analysis score and phacoemulsification competency learning curve

AIM： To use the cumulative sum analysis score（CUSUM） to construct objectively the learning curve of phacoemulsification competency.METHODS： Three second-year residents and an experienced consultant were monitored for a series of 70 phacoemulsification cases each and had their series analysed by CUSUM regarding posterior capsule rupture（PCR） and best-corrected visual acuity. The acceptable rate for PCR was 〈5%（lower limit h） and the unacceptable rate was 〉10%（upper limit h）. The acceptable rate for bestcorrected visual acuity worse than 20/40 was 〈10%（lower limit h） and the unacceptable rate was 〉20%（upper limit h）. The area between lower limit h and upper limit h is called the decision interval. RESULTS： There was no statistically significant difference in the mean age, sex or cataract grades between groups. The first trainee achieved PCR CUSUM competency at his 22 nd case. His best-corrected visual acuity CUSUM was in the decision interval from his third case and stayed there until the end, never reaching competency. The second trainee achieved PCR CUSUM competency at his 39^ th case. He could reach best-corrected visual acuity CUSUM competency at his 22 ^nd case. The third trainee achieved PCR CUSUM competency at his 41 st case. He reached bestcorrected visual acuity CUSUM competency at his 14 ^th case.CONCLUSION： The learning curve of competency in phacoemulsification is constructed by CUSUM and in average took 38 cases for each trainee to achieve it.

Brain Storm Optimization Based Clustering for Learning Behavior Analysis

Recently,online learning platforms have proven to help people gain knowledge more conveniently.Since the outbreak of COVID-19 in 2020,online learning has become a mainstream mode,as many schools have adopted its format.The platforms are able to capture substantial data relating to the students’learning activities,which could be analyzed to determine relationships between learning behaviors and study habits.As such,an intelligent analysis method is needed to process efficiently this high volume of information.Clustering is an effect data mining method which discover data distribution and hidden characteristic from uncharacterized online learning data.This study proposes a clustering algorithm based on brain storm optimization(CBSO)to categorize students according to their learning behaviors and determine their characteristics.This enables teaching to be tailored to taken into account those results,thereby,improving the education quality over time.Specifically,we use the individual of CBSO to represent the distribution of students and find the optimal one by the operations of convergence and divergence.The experiments are performed on the 104 students’online learning data,and the results show that CBSO is feasible and efficient.

Assessment of glaucoma using extreme learning machine and fractal feature analysis

Dear Sir,Iam Dr.Kavitha S,from the Department of Electronics and Communication Engineering,Nandha Engineering College,Erode,Tamil Nadu,India.I write to present the detection of glaucoma using extreme learning machine(ELM)and fractal feature analysis.Glaucoma is the second most frequent cause of permanent blindness in industrial

Survey and Analysis of Chinese Learning Needs of International Students-A Case Study of International Students Majoring in MBA and MPA in a College of The Belt and Road

This study investigated the Chinese learning motivation,learning goals and learning strategies of 26 international students majoring in MBA and MPA at a university with The belt and road college,mainly by questionnaire and interview method,supplemented by classroom observation method.The survey found that 20 of the 24 international students were zero-start Chinese learners,and their learning motivation was mainly"instrumental"and"intrinsic",and they had high enthusiasm for Chinese language and Chinese culture.They have a high enthusiasm for Chinese language and culture,and will actively solve the difficulties they encounter in learning Chinese.At the same time,this study conducted a questionnaire survey on the needs of international students in terms of curriculum and content,teaching materials,teaching assessment and extracurricular activities,combined with the results of individual and group interviews and classroom observations,to summarize the real needs of international students in various aspects of Chinese language learning,so as to provide teaching reference for teachers teaching international students,and to provide a reference for colleges and universities to develop Chinese teaching programs.The survey will provide a basis for the colleges and universities to formulate Chinese teaching programs and coordinate teaching activities,so as to help international students learn Chinese better.

Predicting Stock Movement Using Sentiment Analysis of Twitter Feed with Neural Networks

External factors, such as social media and financial news, can have wide-spread effects on stock price movement. For this reason, social media is considered a useful resource for precise market predictions. In this paper, we show the effectiveness of using Twitter posts to predict stock prices. We start by training various models on the Sentiment 140 Twitter data. We found that Support Vector Machines (SVM) performed best (0.83 accuracy) in the sentimental analysis, so we used it to predict the average sentiment of tweets for each day that the market was open. Next, we use the sentimental analysis of one year’s data of tweets that contain the “stock market”, “stocktwits”, “AAPL” keywords, with the goal of predicting the corresponding stock prices of Apple Inc. (AAPL) and the US’s Dow Jones Industrial Average (DJIA) index prices. Two models, Boosted Regression Trees and Multilayer Perceptron Neural Networks were used to predict the closing price difference of AAPL and DJIA prices. We show that neural networks perform substantially better than traditional models for stocks’ price prediction.

A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease

AIM： To study a more accurate quantification of hepatic fibrosis which would provide dinically useful information for monitoring the progression of chronic liver disease. METHODS： Using a cDNA microarray containing over 22000 clones, we analyzed the gene-expression profiles of non-cancerous liver in 74 patients who underwent hepatic resection. We calculated the ratio of azanstained： total area, and determined the morphologic fibrosis index （MFI）, as a mean of 9 section-images. We used the MFI as a reference standard to evaluate our method for assessing liver fibrosis. RESULTS： We identified 39 genes that collectively showed a good correlation （r 〉 0.50） between geneexpression and the severity of liver fibrosis. Many of the identified genes were involved in immune responses and cell signaling. To quantify the extent of liver fibrosis, we developed a new genetic fibrosis index （GFI） based on gene-expression profiling of 4 clones using a linear support vector regression analysis. This technique, based on a supervised learning analysis, correctly quantified the various degrees of fibrosis in both 74 training samples （r = 0.76, 2.2% vs 2.8%, P 〈 0.0001） and 12 independent additional test samples （r = 0.75, 9.8% vs 8.6%, P 〈 0.005）. It was far better in assessing liver fibrosis than blood markers such as prothrombin time （r = -0.53）, type IV collagen 7s （r = 0.48）, hyaluronic acid （r = 0.41）, and aspartate aminotransferase to platelets ratio index （APRI） （r = 0.38）. CONCLUSION： Our cDNA microarray-based strategy may help clinicians to precisely and objectively monitor the severity of liver fibrosis.

Sentiment Analysis of Code-Mixed Bambara-French Social Media Text Using Deep Learning Techniques

The global growth of the Internet and the rapid expansion of social networks such as Facebook make multilingual sentiment analysis of social media content very necessary. This paper performs the first sentiment analysis on code-mixed Bambara-French Facebook comments. We develop four Long Short-term Memory（LSTM）-based models and two Convolutional Neural Network（CNN）-based models, and use these six models, Na？ve Bayes, and Support Vector Machines（SVM） to conduct experiments on a constituted dataset. Social media text written in Bambara is scarce. To mitigate this weakness, this paper uses dictionaries of character and word indexes to produce character and word embedding in place of pre-trained word vectors. We investigate the effect of comment length on the models and perform a comparison among them. The best performing model is a one-layer CNN deep learning model with an accuracy of 83.23 %.

MobSafe:Cloud Computing Based Forensic Analysis for Massive Mobile Applications Using Data Mining

With the explosive increase in mobile apps, more and more threats migrate from traditional PC client to mobile device. Compared with traditional Win＋Intel alliance in PC, Android＋ARM alliance dominates in Mobile Internet, the apps replace the PC client software as the major target of malicious usage. In this paper, to improve the security status of current mobile apps, we propose a methodology to evaluate mobile apps based on cloud computing platform and data mining. We also present a prototype system named MobSafe to identify the mobile app＇s virulence or benignancy. Compared with traditional method, such as permission pattern based method, MobSafe combines the dynamic and static analysis methods to comprehensively evaluate an Android app. In the implementation, we adopt Android Security Evaluation Framework （ASEF） and Static Android Analysis Framework （SAAF）, the two representative dynamic and static analysis methods, to evaluate the Android apps and estimate the total time needed to evaluate all the apps stored in one mobile app market. Based on the real trace from a commercial mobile app market called AppChina, we can collect the statistics of the number of active Android apps, the average number apps installed in one Android device, and the expanding ratio of mobile apps. As mobile app market serves as the main line of defence against mobile malwares, our evaluation results show that it is practical to use cloud computing platform and data mining to verify all stored apps routinely to filter out malware apps from mobile app markets. As the future work, MobSafe can extensively use machine learning to conduct automotive forensic analysis of mobile apps based on the generated multifaceted data in this stage.

Online Learning Behavior Analysis and Prediction Based on Spiking Neural Networks

The vast amount of data generated by large-scale open online course platforms provide a solid foundation for the analysis of learning behavior in the field of education.This study utilizes the historical and final learning behavior data of over 300000 learners from 17 courses offered on the edX platform by Harvard University and the Massachusetts Institute of Technology during the 2012-2013 academic year.We have developed a spike neural network to predict learning outcomes,and analyzed the correlation between learning behavior and outcomes,aiming to identify key learning behaviors that significantly impact these outcomes.Our goal is to monitor learning progress,provide targeted references for evaluating and improving learning effectiveness,and implement intervention measures promptly.Experimental results demonstrate that the prediction model based on online learning behavior using spiking neural network achieves an impressive accuracy of 99.80%.The learning behaviors that predominantly affect learning effectiveness are found to be students’academic performance and level of participation.

Methods for Population-Based eQTL Analysis in Human Genetics

Gene expression is a critical process in biological system that is influenced and modulated by many factors including genetic variation. Expression Quantitative Trait Loci（e QTL） analysis provides a powerful way to understand how genetic variants affect gene expression. For genome wide e QTL analysis, the number of genetic variants and that of genes are large and thus the search space is tremendous. Therefore, e QTL analysis brings about computational and statistical challenges. In this paper, we provide a comprehensive review of recent advances in methods for e QTL analysis in population-based studies. We first present traditional pairwise association methods, which are widely used in human genetics. To account for expression heterogeneity, we investigate the methods for correcting confounding factors. Next, we discuss newly developed statistical learning methods including Lasso-based models. In the conclusion, we provide an overview of future method development in analyzing e QTL associations. Although we focus on human genetics in this review, the methods are applicable to many other organisms.

Analysis of Learner’s Behavior Characteristics Based on Open University Online Teaching

The analysis on the learning behavior characteristics based on big data is beneficial for improving the learning resource construction,teaching mode and interactive mode of online course platforms.Multiple aspects of analysis were conducted on nearly three million pieces of learning behavior data,which is from seven courses of 3,315 learners in the same major at a university.According to the quantity of course resources and policy of course scoring,four typical learning behaviors were selected,and the correlation between final exam results and learning behavior were analyzed.The analysis of behavior influences on the final exam results were also conducted.The analytical results give suggestions for online teaching and learning.

LEARN algorithm:a novel option for predicting non-alcoholic steatohepatitis

Background:There is an unmet need for accurate non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH).Since impedance-based measurements of body composition are simple,repeatable and have a strong association with non-alcoholic fatty liver disease(NAFLD)severity,we aimed to develop a novel and fully automatic machine learning algorithm,consisting of a deep neural network based on impedance-based measurements of body composition to identify NASH[the bioeLectrical impEdance Analysis foR Nash(LEARN)algorithm].Methods:A total of 1,259 consecutive subjects with suspected NAFLD were screened from six medical centers across China,of which 766 patients with biopsy-proven NAFLD were included in final analysis.These patients were randomly subdivided into the training and validation groups,in a ratio of 4:1.The LEARN algorithm was developed in the training group to identify NASH,and subsequently,tested in the validation group.Results:The LEARN algorithm utilizing impedance-based measurements of body composition along with age,sex,pre-existing hypertension and diabetes,was able to predict the likelihood of having NASH.This algorithm showed good discriminatory ability for identifying NASH in both the training and validation groups[area under the receiver operating characteristics(AUROC):0.81,95%CI:0.77-0.84 and AUROC:0.80,95%CI:0.73-0.87,respectively].This algorithm also performed better than serum cytokeratin-18 neoepitope M30(CK-18 M30)level or other non-invasive NASH scores(including HAIR,ION,NICE)for identifying NASH(P value<0.001).Additionally,the LEARN algorithm performed well in identifying NASH in different patient subgroups,as well as in subjects with partial missing body composition data.Conclusions:The LEARN algorithm,utilizing simple easily obtained measures,provides a fully automated,simple,non-invasive method for identifying NASH.

Measuring air traffic complexity based on small samples

Air traffic complexity is an objective metric for evaluating the operational condition of the airspace. It has several applications, such as airspace design and traffic flow management.Therefore, identifying a reliable method to accurately measure traffic complexity is important. Considering that many factors correlate with traffic complexity in complicated nonlinear ways,researchers have proposed several complexity evaluation methods based on machine learning models which were trained with large samples. However, the high cost of sample collection usually results in limited training set. In this paper, an ensemble learning model is proposed for measuring air traffic complexity within a sector based on small samples. To exploit the classification information within each factor, multiple diverse factor subsets（FSSs） are generated under guidance from factor noise and independence analysis. Then, a base complexity evaluator is built corresponding to each FSS. The final complexity evaluation result is obtained by integrating all results from the base evaluators. Experimental studies using real-world air traffic operation data demonstrate the advantages of our model for small-sample-based traffic complexity evaluation over other stateof-the-art methods.