In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control compa...In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control comparative study was performed for FMPF and traditional cerebrovascular risk factors on 110 cases of old ischemic cerebrovascular disease and 110 controls matched on age, sex and living condition. The results showed that cerebrovascular risk factors were more prevalent in case group than in control group. In the case group, FMPF was significantly higher than in control group. There was a significant positive correlation between hypertension and fibrin monomer polymerization velocity (FMPV), hypertension and fibrinogen (Fbg), alcohol consumption and Fbg, but no significant correlation between diabetic mellitus, smoking and FMPF was found. Among the parameters of blood lipids, there were significant positive correlations between total cholesterol (TC) and parameters of FMPF to varying degrees, triglycerides (TG) and FMPV, TG and Fbg. Our results also showed there were significant linear trends between TC and FMPV (P<0. 001), TC and Fbg (P=0. 0087), TG and FMPV/Amax (maximum absorbance)(P=0. 0143) respectively. Multiple logistic regression analysis revealed that FMPF in case group remained significantly higher than control group after adjustment of all risk factors that were significant in univariate analysis. It was concluded that there is a possible pathophysiological link between FMPF and cerebrovascular risk factors. An elevated FMPF is associated with ischemic cerebrovascular disease and an independent risk factor of this disease. In old people, detection of FMPF might be a useful screening to identify individuals at increased cerebrothrombotic risk.展开更多
The concept of ageing society includes the quantitative factor that there will be more and more older people according to population transitions. But, at the same time, qualitative factors such as quality of life, ide...The concept of ageing society includes the quantitative factor that there will be more and more older people according to population transitions. But, at the same time, qualitative factors such as quality of life, identity changes and the experience of high changes in the subjectivity need to be included alongside these quantitative factors. So, the purpose and significance of the paper indicate that is necessary to ensure structures that can tolerate the new scenarios of this current generation of older people, who seek new life options, renewed emotional perspectives and transgenerational confrontation with traditional models of ageing and grandparenthood.展开更多
文摘In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control comparative study was performed for FMPF and traditional cerebrovascular risk factors on 110 cases of old ischemic cerebrovascular disease and 110 controls matched on age, sex and living condition. The results showed that cerebrovascular risk factors were more prevalent in case group than in control group. In the case group, FMPF was significantly higher than in control group. There was a significant positive correlation between hypertension and fibrin monomer polymerization velocity (FMPV), hypertension and fibrinogen (Fbg), alcohol consumption and Fbg, but no significant correlation between diabetic mellitus, smoking and FMPF was found. Among the parameters of blood lipids, there were significant positive correlations between total cholesterol (TC) and parameters of FMPF to varying degrees, triglycerides (TG) and FMPV, TG and Fbg. Our results also showed there were significant linear trends between TC and FMPV (P<0. 001), TC and Fbg (P=0. 0087), TG and FMPV/Amax (maximum absorbance)(P=0. 0143) respectively. Multiple logistic regression analysis revealed that FMPF in case group remained significantly higher than control group after adjustment of all risk factors that were significant in univariate analysis. It was concluded that there is a possible pathophysiological link between FMPF and cerebrovascular risk factors. An elevated FMPF is associated with ischemic cerebrovascular disease and an independent risk factor of this disease. In old people, detection of FMPF might be a useful screening to identify individuals at increased cerebrothrombotic risk.
文摘The concept of ageing society includes the quantitative factor that there will be more and more older people according to population transitions. But, at the same time, qualitative factors such as quality of life, identity changes and the experience of high changes in the subjectivity need to be included alongside these quantitative factors. So, the purpose and significance of the paper indicate that is necessary to ensure structures that can tolerate the new scenarios of this current generation of older people, who seek new life options, renewed emotional perspectives and transgenerational confrontation with traditional models of ageing and grandparenthood.
文摘目的 探讨椎-基底动脉迂曲与老年血管源性头晕/眩晕脑梗死的关系。方法 选取2022年1月至2023年10月太原西山医院神经内科住院的老年血管源性头晕/眩晕脑梗死患者160例,根据头颅磁共振血管成像检查是否存在椎-基底动脉异常将其分为迂曲组和非迂曲组,每组各80例。比较两组患者的一般临床资料、血管病危险因素、美国国立卫生研究院卒中量表扩展版(expanded-National Institutes of Health stroke scale,e-NIHSS)评分。迂曲组根据椎-基底动脉形态又分为单纯异常组和混合异常组,分析对相关脑梗死的影响程度。结果 迂曲组患者的高血压、椎动脉优势、吸烟史的比例和e-NIHSS评分均显著高于非迂曲组(P<0.05)。多因素Logistic回归分析结果显示,高血压病史、椎动脉优势、吸烟史均是伴有椎-基底动脉异常老年血管源性头晕/眩晕脑梗死患者的独立危险因素(P<0.05)。单纯异常组中54.3%为中重度脑卒中患者,混合异常组中58.8%为中重度脑卒中患者,两组比较差异无统计学意义(χ^(2)=0.029,P=0.864)。结论 高血压病史、椎动脉优势、吸烟史是伴有椎-基底动脉迂曲的老年血管源性头晕/眩晕脑梗死的独立危险因素,此类患者神经功能缺损评分更高。
