The systematic method for constructing Lewis representations is a method for representing chemical bonds between atoms in a molecule. It uses symbols to represent the valence electrons of the atoms involved in the bon...The systematic method for constructing Lewis representations is a method for representing chemical bonds between atoms in a molecule. It uses symbols to represent the valence electrons of the atoms involved in the bond. Using a number of rules in a defined order, it is often better suited to complicated cases than the Lewis representation of atoms. This method allows us to determine the formal charge and oxidation number of each atom in the edifice more efficiently than other methods.展开更多
Inorganic Cs_(2)SnI_(6) perovskite has exhibited substantial potential for light harvesting due to its exceptional optoelectronic properties and remarkable stability in ambient conditions.The charge transport characte...Inorganic Cs_(2)SnI_(6) perovskite has exhibited substantial potential for light harvesting due to its exceptional optoelectronic properties and remarkable stability in ambient conditions.The charge transport characteristics within perovskite films are subject to modulation by various factors,including crystalline orientation,morphology,and crystalline quality.Achieving preferred crystalline orientation and film morphology via a solution-based process is challenging for Cs_(2)SnI_(6) films.In this work,we employed thiourea as an additive to optimize crystal orientation,enhance film morphology,promote crystallization,and achieve phase purity.Thiourea lowers the surface energy of the(222)plane along the(111)direction,confirmed by x-ray diffraction,x-ray photoelectron spectroscopy,ultraviolet photoelectron spectroscopy studies,and density functional theory calculations.Varying thiourea concentration enables a bandgap tuning of Cs_(2)SnI_(6) from 1.52 eV to1.07 eV.This approach provides a novel method for utilizing Cs_(2)SnI_(6) films in high-performance optoelectronic devices.展开更多
目的探讨血府逐瘀胶囊联合顺铂对小鼠Lewis肺癌移植瘤血管新生及血管内皮生长因子A(VEGFA)、血管内皮细胞生长因子受体2(VEGFR2)表达的影响。方法从75只C57BL/6小鼠中随机取15只作为正常组,其余小鼠均进行Lewis肺癌荷瘤造模。将造模成功...目的探讨血府逐瘀胶囊联合顺铂对小鼠Lewis肺癌移植瘤血管新生及血管内皮生长因子A(VEGFA)、血管内皮细胞生长因子受体2(VEGFR2)表达的影响。方法从75只C57BL/6小鼠中随机取15只作为正常组,其余小鼠均进行Lewis肺癌荷瘤造模。将造模成功的60只小鼠随机分为模型组、顺铂组、血府逐瘀胶囊组、血府逐瘀胶囊联合顺铂组,每组15只。血府逐瘀胶囊组给予血府逐瘀胶囊0.36 g/kg灌胃,模型组给予生理盐水灌胃,均2次/d;顺铂组给予2 mg/kg的顺铂腹腔注射,2 d 1次;血府逐瘀胶囊联合顺铂组给予0.36 g/kg血府逐瘀胶囊灌胃(2次/d)和2 mg/kg的顺铂腹腔注射(2 d 1次);正常组不给予任何干预。各组连续干预15 d后,统计存活率,摘取瘤组织并称量瘤重,计算抑瘤率,免疫组化法检测肿瘤组织中微血管数量,ELISA法测定血浆VEGFA、碱性成纤维细胞生长因子(bFGF)水平,免疫印迹法检测肿瘤组织中VEGFA、VEGFR2蛋白表达情况。结果顺铂组和血府逐瘀胶囊联合顺铂组小鼠存活率明显高于模型组和血府逐瘀胶囊组(P均<0.05);血府逐瘀胶囊联合顺铂组瘤重明显低于其他组(P均<0.05),抑瘤率明显高于顺铂组和血府逐瘀胶囊组(P均<0.05),肿瘤组织中微血管数明显少于模型组和血府逐瘀胶囊组(P均<0.05);顺铂组瘤重明显低于模型组和血府逐瘀胶囊组(P均<0.05),抑瘤率明显高于血府逐瘀胶囊组(P<0.05),肿瘤组织中微血管数明显少于其他组(P均<0.05)。顺铂组血浆VEGFA、bFGF水平和肿瘤组织中VEGFA、VEGFR2蛋白相对表达量均明显低于模型组(P均<0.05);血府逐瘀胶囊联合顺铂组血浆bFGF水平和肿瘤组织中VEGFR2蛋白相对表达量均明显低于模型组(P均<0.05)。结论血府逐瘀胶囊联合顺铂对Lewis肺癌荷瘤小鼠具有显著的抑瘤及抑制肿瘤血管新生的作用,其机制可能与VEGFA/VEGFR2信号通路相关。展开更多
目的:对比经上腹左胸手术和Ivor-lewis手术治疗SiewertⅡ型食管胃交界部腺癌(adenocarcinoma of the esophagogastric junction,AEG)在术中和术后各参数中的差别,以及患者预后的差异。方法:回顾性收集320例于河北医科大学第四医院胸外...目的:对比经上腹左胸手术和Ivor-lewis手术治疗SiewertⅡ型食管胃交界部腺癌(adenocarcinoma of the esophagogastric junction,AEG)在术中和术后各参数中的差别,以及患者预后的差异。方法:回顾性收集320例于河北医科大学第四医院胸外科行根治性手术的SiewertⅡ型AEG患者的数据,其中行上腹左胸手术的患者175例,行Ivor-lewis手术的患者145例。比较两组患者的临床病理特征、术中和术后情况、总生存时间(overall survival,OS)和无病生存时间(disease-free survival,DFS),并对影响AEG患者预后的情况进行单因素和多因素分析。结果:两组患者在肿瘤最大直径、pTNM分期、pN分期和下残阳性方面比较有统计学差异(P<0.05);与Ivor-lewis手术相比,行上腹左胸手术患者的术中时间缩短了30 min(P=0.034),术后吻合口瘘发生率更低(1.71%vs 4.83%,P=0.041);相比Ivor-lewis患者,行上腹左胸手术的患者可以获得更好的OS和DFS(P<0.05);单因素和多因素分析显示术前新辅助治疗是SiewertⅡ型AEG患者预后的影响因素(P<0.05)。结论:经上腹左胸手术可以彻底切除肿瘤,保留膈肌的完整,缩短开胸时间,有利于术后快速康复。同时,术后吻合口瘘等并发症的发生率低,有利于及时进行术后辅助治疗,更利于改善AEG患者的预后。展开更多
文摘The systematic method for constructing Lewis representations is a method for representing chemical bonds between atoms in a molecule. It uses symbols to represent the valence electrons of the atoms involved in the bond. Using a number of rules in a defined order, it is often better suited to complicated cases than the Lewis representation of atoms. This method allows us to determine the formal charge and oxidation number of each atom in the edifice more efficiently than other methods.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.12174275,62174113,61874139,61904201,and 11875088)Guangdong Basic and Applied Basic Research Foundation (Grant No.2019B1515120057)。
文摘Inorganic Cs_(2)SnI_(6) perovskite has exhibited substantial potential for light harvesting due to its exceptional optoelectronic properties and remarkable stability in ambient conditions.The charge transport characteristics within perovskite films are subject to modulation by various factors,including crystalline orientation,morphology,and crystalline quality.Achieving preferred crystalline orientation and film morphology via a solution-based process is challenging for Cs_(2)SnI_(6) films.In this work,we employed thiourea as an additive to optimize crystal orientation,enhance film morphology,promote crystallization,and achieve phase purity.Thiourea lowers the surface energy of the(222)plane along the(111)direction,confirmed by x-ray diffraction,x-ray photoelectron spectroscopy,ultraviolet photoelectron spectroscopy studies,and density functional theory calculations.Varying thiourea concentration enables a bandgap tuning of Cs_(2)SnI_(6) from 1.52 eV to1.07 eV.This approach provides a novel method for utilizing Cs_(2)SnI_(6) films in high-performance optoelectronic devices.
文摘目的探讨血府逐瘀胶囊联合顺铂对小鼠Lewis肺癌移植瘤血管新生及血管内皮生长因子A(VEGFA)、血管内皮细胞生长因子受体2(VEGFR2)表达的影响。方法从75只C57BL/6小鼠中随机取15只作为正常组,其余小鼠均进行Lewis肺癌荷瘤造模。将造模成功的60只小鼠随机分为模型组、顺铂组、血府逐瘀胶囊组、血府逐瘀胶囊联合顺铂组,每组15只。血府逐瘀胶囊组给予血府逐瘀胶囊0.36 g/kg灌胃,模型组给予生理盐水灌胃,均2次/d;顺铂组给予2 mg/kg的顺铂腹腔注射,2 d 1次;血府逐瘀胶囊联合顺铂组给予0.36 g/kg血府逐瘀胶囊灌胃(2次/d)和2 mg/kg的顺铂腹腔注射(2 d 1次);正常组不给予任何干预。各组连续干预15 d后,统计存活率,摘取瘤组织并称量瘤重,计算抑瘤率,免疫组化法检测肿瘤组织中微血管数量,ELISA法测定血浆VEGFA、碱性成纤维细胞生长因子(bFGF)水平,免疫印迹法检测肿瘤组织中VEGFA、VEGFR2蛋白表达情况。结果顺铂组和血府逐瘀胶囊联合顺铂组小鼠存活率明显高于模型组和血府逐瘀胶囊组(P均<0.05);血府逐瘀胶囊联合顺铂组瘤重明显低于其他组(P均<0.05),抑瘤率明显高于顺铂组和血府逐瘀胶囊组(P均<0.05),肿瘤组织中微血管数明显少于模型组和血府逐瘀胶囊组(P均<0.05);顺铂组瘤重明显低于模型组和血府逐瘀胶囊组(P均<0.05),抑瘤率明显高于血府逐瘀胶囊组(P<0.05),肿瘤组织中微血管数明显少于其他组(P均<0.05)。顺铂组血浆VEGFA、bFGF水平和肿瘤组织中VEGFA、VEGFR2蛋白相对表达量均明显低于模型组(P均<0.05);血府逐瘀胶囊联合顺铂组血浆bFGF水平和肿瘤组织中VEGFR2蛋白相对表达量均明显低于模型组(P均<0.05)。结论血府逐瘀胶囊联合顺铂对Lewis肺癌荷瘤小鼠具有显著的抑瘤及抑制肿瘤血管新生的作用,其机制可能与VEGFA/VEGFR2信号通路相关。
文摘目的:对比经上腹左胸手术和Ivor-lewis手术治疗SiewertⅡ型食管胃交界部腺癌(adenocarcinoma of the esophagogastric junction,AEG)在术中和术后各参数中的差别,以及患者预后的差异。方法:回顾性收集320例于河北医科大学第四医院胸外科行根治性手术的SiewertⅡ型AEG患者的数据,其中行上腹左胸手术的患者175例,行Ivor-lewis手术的患者145例。比较两组患者的临床病理特征、术中和术后情况、总生存时间(overall survival,OS)和无病生存时间(disease-free survival,DFS),并对影响AEG患者预后的情况进行单因素和多因素分析。结果:两组患者在肿瘤最大直径、pTNM分期、pN分期和下残阳性方面比较有统计学差异(P<0.05);与Ivor-lewis手术相比,行上腹左胸手术患者的术中时间缩短了30 min(P=0.034),术后吻合口瘘发生率更低(1.71%vs 4.83%,P=0.041);相比Ivor-lewis患者,行上腹左胸手术的患者可以获得更好的OS和DFS(P<0.05);单因素和多因素分析显示术前新辅助治疗是SiewertⅡ型AEG患者预后的影响因素(P<0.05)。结论:经上腹左胸手术可以彻底切除肿瘤,保留膈肌的完整,缩短开胸时间,有利于术后快速康复。同时,术后吻合口瘘等并发症的发生率低,有利于及时进行术后辅助治疗,更利于改善AEG患者的预后。
