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Local Inhibition of Chlorhexidinum on Lewis Pulm onaryCarcinom a in Mice
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作者 XIONG Jiongxin , HUANG Tao QIU Dengbo Department of General Surgery, Xiehe Hospital, Tongji Medical University, Wuhan 430022 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1999年第3期223-225,共3页
C 57 inbred mice ( n =100) were employed to develop animal models of Lewis pulmonary carcinoma. The study on the tumor inhibition was performed by infiltrative injection of 3.5 % Cy or chlorhexidinum of two di... C 57 inbred mice ( n =100) were employed to develop animal models of Lewis pulmonary carcinoma. The study on the tumor inhibition was performed by infiltrative injection of 3.5 % Cy or chlorhexidinum of two different concentrations around the tumor respectively. The survival, survival rate, tumor growth rate, and pulmonary metastasis node number were compared. The results showed that the inhibitory effects of 0.1 % and 0.5 % chlorhexidinum were the same as that of 3.5 % Cy, but the toxic and side effects were obviously reduced as compared with 3.5 % Cy. The optimal concentration of chlorhexidinum was 0.5 %. This provides a new approach for infiltrative injection of the tumor for clinical use. 展开更多
关键词 chlorhexidinum lewis pulmonary carcinoma
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