Applications of VANETs(Vehicular Ad hoc Networks)have their own requirements and challenges in wireless communication technology.Although regarded as the rst standard for VANETs,IEEE 802.11p is still in the eld-trial ...Applications of VANETs(Vehicular Ad hoc Networks)have their own requirements and challenges in wireless communication technology.Although regarded as the rst standard for VANETs,IEEE 802.11p is still in the eld-trial stage.Recently,LTE V2X(Long-Term Evolution Vehicular to X)appeared as a systematic V2X solution based on TD-LTE(Time Division Long-Term Evolution)4G.It is regarded as the most powerful competitor to 802.11p.We conduct link level simulations of LTE V2X and DSRC(Dedicated Short-Range Communication)for several di erent types of scenarios.Simulation results show that LTE V2X can achieve the same BLER(Block Error Ratio)with a lower SNR(Signal Noise Ratio)than DSRC.A more reliable link can be guaranteed by LTE V2X,which can achieve the same BLER with lower receiving power than DSRC.The coverage area of LTE V2X is larger than that of DSRC.展开更多
BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants signif...BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this mutation.The potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been reached.Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C genotypes.METHODS Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017.NUDT15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were measured.RESULTS A total of 411 Crohn’s disease patients were included.TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 R139C.For CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 RBC.The 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,respectively.CONCLUSION The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C genotypes.Applying 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.展开更多
目的:探究问题导引-目标链接式护理干预对糖尿病患者低血糖发生率的影响。方法:选择2022年2月—2023年1月泰州市第三人民医院收治的86例糖尿病患者为研究对象,采用计算机法以01~086对患者进行编号,设置01~043患者为对照组(n=43),实施常...目的:探究问题导引-目标链接式护理干预对糖尿病患者低血糖发生率的影响。方法:选择2022年2月—2023年1月泰州市第三人民医院收治的86例糖尿病患者为研究对象,采用计算机法以01~086对患者进行编号,设置01~043患者为对照组(n=43),实施常规护理,设置044~086患者为观察组(n=43),实施问题导引-目标链接式护理干预。比较两组血糖水平、糖尿病自我管理行为及低血糖发生率。结果:护理前,两组血糖水平比较,差异无统计学意义(P>0.05);护理后,两组空腹血糖(FBG)、餐后2 h血糖(2 h PBG)及糖化血红蛋白(HbA1c)水平均下降,观察组低于对照组,差异有统计学意义(P<0.05)。护理前,两组糖尿病患者自我管理行为量表(SDSCA)评分比较,差异无统计学意义(P>0.05);护理14 d后,两组SDSCA评分升高,观察组高于对照组,差异有统计学意义(P<0.05);观察组低血糖发生率低于对照组,差异有统计学意义(P<0.05)。结论:在糖尿病患者的护理中采用问题导引-目标链接式护理干预,能有效控制血糖水平,提升患者自护能力,降低低血糖发生率。展开更多
基金This work is supported in part by the National Science and Technology Major Projects of China(No.2017ZX03001014)the National Science Fund for Distinguished Young Scholars(No.61425012)the National Science Foundation Project(No.61300183).
文摘Applications of VANETs(Vehicular Ad hoc Networks)have their own requirements and challenges in wireless communication technology.Although regarded as the rst standard for VANETs,IEEE 802.11p is still in the eld-trial stage.Recently,LTE V2X(Long-Term Evolution Vehicular to X)appeared as a systematic V2X solution based on TD-LTE(Time Division Long-Term Evolution)4G.It is regarded as the most powerful competitor to 802.11p.We conduct link level simulations of LTE V2X and DSRC(Dedicated Short-Range Communication)for several di erent types of scenarios.Simulation results show that LTE V2X can achieve the same BLER(Block Error Ratio)with a lower SNR(Signal Noise Ratio)than DSRC.A more reliable link can be guaranteed by LTE V2X,which can achieve the same BLER with lower receiving power than DSRC.The coverage area of LTE V2X is larger than that of DSRC.
基金Supported by the National Natural Science Foundation of China,No.81573507,No.81473283,No.81173131,and No.81320108027Guangdong Provincial Key Laboratory Construction Foundation,No.2017B030314030+1 种基金The National Key Research and Development Program,No.2016YFC0905003the 111 Project,No.B16047
文摘BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this mutation.The potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been reached.Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C genotypes.METHODS Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017.NUDT15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were measured.RESULTS A total of 411 Crohn’s disease patients were included.TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 R139C.For CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 RBC.The 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,respectively.CONCLUSION The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C genotypes.Applying 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.
文摘目的:探究问题导引-目标链接式护理干预对糖尿病患者低血糖发生率的影响。方法:选择2022年2月—2023年1月泰州市第三人民医院收治的86例糖尿病患者为研究对象,采用计算机法以01~086对患者进行编号,设置01~043患者为对照组(n=43),实施常规护理,设置044~086患者为观察组(n=43),实施问题导引-目标链接式护理干预。比较两组血糖水平、糖尿病自我管理行为及低血糖发生率。结果:护理前,两组血糖水平比较,差异无统计学意义(P>0.05);护理后,两组空腹血糖(FBG)、餐后2 h血糖(2 h PBG)及糖化血红蛋白(HbA1c)水平均下降,观察组低于对照组,差异有统计学意义(P<0.05)。护理前,两组糖尿病患者自我管理行为量表(SDSCA)评分比较,差异无统计学意义(P>0.05);护理14 d后,两组SDSCA评分升高,观察组高于对照组,差异有统计学意义(P<0.05);观察组低血糖发生率低于对照组,差异有统计学意义(P<0.05)。结论:在糖尿病患者的护理中采用问题导引-目标链接式护理干预,能有效控制血糖水平,提升患者自护能力,降低低血糖发生率。
